Andrew L. Hong, MD

Research Program

Cell and Molecular Biology
Email Address

andrew.hong2@emory.edu

Biography

Andrew L. Hong, MD, is an associate pofessor in the Department of Pediatrics at Emory University School of Medicine. Dr. Hong is a board-certified pediatric oncologist at Children's Healthcare of Atlanta. Prior to joining Emory, he was on faculty at Dana-Farber/Boston Children's Cancer and Blood Disorders Center as an instructor of pediatrics.

Education

Dr. Hong received his medical degree from University of Chicago Pritzker School of Medicinein Chicago, Illinois. He completed his pediatrics internship and residency at Boston Children's Hospital and Boston Medical Center in Boston, Massachusetts. He then completed a fellowship in Pediatric Hematology and Oncology at Boston Children's Hospital and Dana-Farber Cancer Institute.

Titles & Roles

Associate Professor, Department of Pediatrics

Emory University School of Medicine

Research

Dr. Hong's research focuses on high risk solid tumors (e.g. kidney cancers, soft tissue sarcomas and brain tumors). These cancers represent the areas of greatest need in Pediatric Oncology. His work uses functional genomic techniques (e.g. RNAi, CRISPR-Cas9) and the latest sequencing technologies (e.g. long range phased sequencing, scRNAseq, ATACseq) to identify new therapeutics and mechanisms in pediatric cancers.

View Current Clinical Trials


A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT Phase II Conditions Anaplastic Kidney Wilms Tumor, Recurrent Kidney Wilms Tumor, Stage II Kidney Wilms Tumor, Stage III Kidney Wilms Tumor, Stage IV Kidney Wilms Tumor Location Winship Cancer Institute

Grants

View Grants

Grant Number	Title
1R01CA289761-01A1	Functional consequences of SMARCB1 variants

Publications

Title/Journal	Authors	Publication Date
SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity Nature Communications	GW Cooper, BP Lee, WJ Kim, Y Su, VZ Chen, E Salas, X Yang, RE Lintner, F Piccioni, AO Giacomelli, TP Howard, P Bagchi, KN Conneely, DE Root, B Liang, JC Gumbart, WC Hahn, DU Gorkin, JA Biegel, SN Chi, AL Hong	04/08/2026
Relapsed rhabdoid tumours and other non-nephroblastoma childhood and adolescent kidney tumours: perspectives from the HARMONICA collaboration Nature Reviews Urology	MV Ortiz, FSPL Wens, AL Hong, P Quarello, AC Verschuur, ET Tracy, NC Daw, JS Dome, AL Walz, J Sprokkerieft, GAM Tytgat, A Kentsis, J Libes-Bander, PJ Schoettler, D Perotti, J Drost, R Venkatramani, JI Geller, MM van den Heuvel-Eibrink	01/02/2026
Finding a brush when you expect a broom: a novel model of paediatric Wilms tumour evolution Nature Reviews Urology	AL Hong, EA Mullen	08/19/2025
Updated favourable-histology Wilms tumour risk stratification: rationale for future Children’s Oncology Group clinical trials Nature Reviews Urology	DJ Benedetti, NG Cost, PF Ehrlich, N Evageliou, E Fialkowski, LN Parsons, KL Vallance, LA Renfro, AL Hong, JH Aldrink, L Pater, AC Paulino, JK Sandberg, EA Smith, AL Treece, JS Dome, JI Geller, EA Mullen	06/20/2025
SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity Research Square	GW Cooper, BP Lee, WJ Kim, Y Su, VZ Chen, E Salas, E Salas, X Yang, X Yang, RE Lintner, F Piccioni, AO Giacomelli, TP Howard, P Bagchi, KN Conneely, DE Root, B Liang, WC Hahn, DU Gorkin, JA Biegel, SN Chi, AL Hong	03/26/2025
Hallmark discoveries in the biology of non-Wilms tumour childhood kidney cancers Nature Reviews Urology	D Perotti, MJ O'Sullivan, AL Walz, J Davick, R Al-Saadi, DJ Benedetti, J Brzezinski, S Ciceri, NG Cost, JS Dome, J Drost, N Evageliou, R Furtwängler, N Graf, M Maschietto, EA Mullen, AJ Murphy, MV Ortiz, JN van der Beek, A Verschuur, J Wegert, R Williams, F Spreafico, JI Geller, MM van den Heuvel-Eibrink, AL Hong	01/29/2025
Histone H3E50K remodels chromatin to confer oncogenic activity and support an EMT phenotype NAR Cancer	K Sad, DV Fawwal, CY Jones, EJ Hill, KT Skinner, ML Adams, S Lustenberger, RS Lee, SV Lohano, SR Elayavalli, J Farhi, CC Mehta, LD Lemon, MB Fasken, AL Hong, SA Sloan, AH Corbett, JM Spangle	01/15/2025
Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity bioRxiv (Cold Spring Harbor Laboratory)	JJ Kwon, J Dilly, S Liu, E Kim, Y Bian, S Dharmaiah, TH Tran, KS Kapner, SH Ly, X Yang, D Rabara, TJ Waybright, AO Giacomelli, AL Hong, S Misek, B Wang, A Ravi, JG Doench, R Beroukhim, CT Lemke, KM Haigis, D Esposito, DE Root, DV Nissley, AG Stephen, F McCormick, DK Simanshu, WC Hahn, AJ Aguirre	10/25/2024
Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin Communications Biology	K Mittal, GW Cooper, BP Lee, Y Su, KT Skinner, J Shim, HC Jonus, WJ Kim, M Doshi, D Almanza, BD Kynnap, AL Christie, X Yang, GS Cowley, BA Leeper, CL Morton, B Dwivedi, T Lawrence, M Rupji, P Keskula, S Meyer, CM Clinton, M Bhasin, BD Crompton, YY Tseng, JS Boehm, KL Ligon, DE Root, AJ Murphy, DM Weinstock, PC Gokhale, JM Spangle, MN Rivera, EA Mullen, K Stegmaier, KC Goldsmith, WC Hahn, AL Hong	04/08/2024
Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children’s Oncology Group AREN18B5-Q Nature Communications	AJ Murphy, C Cheng, J Williams, TI Shaw, EM Pinto, K Dieseldorff-Jones, J Brzezinski, LA Renfro, B Tornwall, V Huff, AL Hong, EA Mullen, B Crompton, JS Dome, CV Fernandez, JI Geller, PF Ehrlich, H Mulder, N Oak, J Maciezsek, CM Jablonowski, AM Fleming, P Pichavaram, CL Morton, J Easton, KE Nichols, MR Clay, T Santiago, J Zhang, J Yang, GP Zambetti, Z Wang, AM Davidoff, X Chen	12/18/2023
Hallmark discoveries in the biology of Wilms tumour Nature Reviews Urology	D Perotti, RD Williams, J Wegert, J Brzezinski, M Maschietto, S Ciceri, D Gisselsson, S Gadd, AL Walz, R Furtwaengler, J Drost, R Al-Saadi, N Evageliou, SL Gooskens, AL Hong, AJ Murphy, MV Ortiz, MJ O'Sullivan, EA Mullen, MM van den Heuvel-Eibrink, CV Fernandez, N Graf, PE Grundy, JI Geller, JS Dome, EJ Perlman, M Gessler, V Huff, K Pritchard-Jones	10/17/2023
Genetics of ABCB1 in Cancer Cancers	KT Skinner, AM Palkar, AL Hong	08/24/2023
Children's Oncology Group's 2023 blueprint for research: Renal tumors Pediatric Blood & Cancer	JI Geller, AL Hong, KL Vallance, N Evageliou, JH Aldrink, NG Cost, AL Treece, LA Renfro, EA Mullen	07/21/2023
The Genetic and Epigenetic Features of Bilateral Wilms Tumor Predisposition: A Report from the Children's Oncology Group AREN18B5-Q Study Research Square	AJ Murphy, C Cheng, J Williams, TI Shaw, EM Pinto, K Dieseldorff-Jones, J Brzezinski, LA Renfro, B Tornwall, V Huff, AL Hong, EA Mullen, B Crompton, JS Dome, CV Fernandez, JI Geller, PF Ehrlich, H Mulder, N Oak, J Maciezsek, C Jablonowski, AM Fleming, P Pichavaram, CL Morton, J Easton, KE Nichols, MR Clay, T Santiago, J Zhang, J Yang, GP Zambetti, Z Wang, AM Davidoff, X Chen	03/16/2023
Inflammation or Infiltration? Infiltrative Cardiovascular Chloroma Presenting With Syncope and Heart Block Circulation Cardiovascular Imaging	HC Wilson, S Hashemi, HS Sabnis, AL Hong, EC Michelfelder	01/01/2023
The tumor microenvironment and immune targeting therapy in pediatric renal tumors Pediatric Blood & Cancer	AB Hont, B Dumont, KS Sutton, J Anderson, A Kentsis, J Drost, AL Hong, A Verschuur	11/30/2022
Targeting MLL Methyltransferases Enhances the Antitumor Effects of PI3K Inhibition in Hormone Receptor–positive Breast Cancer Cancer Research Communications	RB Jones, J Farhi, M Adams, KK Parwani, GW Cooper, M Zecevic, RS Lee, AL Hong, JM Spangle	11/16/2022
SMARCB1-Deficient Cancers: Novel Molecular Insights and Therapeutic Vulnerabilities Cancers	GW Cooper, AL Hong	07/27/2022
Recent Advances in Renal Medullary Carcinoma International Journal of Molecular Sciences	Y Su, AL Hong	06/26/2022
Mismatched Unrelated Donor Hematopoietic Stem Cell Transplantation Rescues Marrow Failure From Acute Leukemia Therapy in a Patient With Previously Undiagnosed Ligase IV Syndrome Journal of Pediatric Hematology/Oncology	DM Fridlyand, S Chandrakasan, A Aljudi, WK Aumann, E Westfall, B Kirwan, EW Bryson, FG Keller, SD Arnold, AL Hong, M Pauly, KM Williams	06/01/2022
Haplotype-resolved germline and somatic alterations in renal medullary carcinomas Genome Medicine	KT Tan, H Kim, J Carrot-Zhang, Y Zhang, WJ Kim, G Kugener, JA Wala, TP Howard, YY Chi, R Beroukhim, H Li, G Ha, SL Alper, EJ Perlman, EA Mullen, WC Hahn, M Meyerson, AL Hong	07/14/2021
SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization Cell Reports	C Dai, JP Rennhack, TE Arnoff, M Thaker, ST Younger, JG Doench, AY Huang, A Yang, AJ Aguirre, B Wang, E Mun, JT O'Connell, Y Huang, K Labella, JA Talamas, J Li, N Ilic, J Hwang, AL Hong, AL Hong, AO Giacomelli, O Gjoerup, DE Root, WC Hahn	07/01/2021
A first-generation pediatric cancer dependency map Nature Genetics	NV Dharia, G Kugener, LM Guenther, CF Malone, AD Durbin, AL Hong, TP Howard, P Bandopadhayay, CS Wechsler, I Fung, AC Warren, JM Dempster, JM Krill-Burger, BR Paolella, P Moh, N Jha, A Tang, P Montgomery, JS Boehm, WC Hahn, CWM Roberts, JM McFarland, A Tsherniak, TR Golub, F Vazquez, K Stegmaier	03/22/2021
Progress Update in Pediatric Renal Tumors Current Oncology Reports	J Jain, KS Sutton, AL Hong	02/16/2021
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell reports	JE Neggers, BR Paolella, A Asfaw, MV Rothberg, TA Skipper, A Yang, RL Kalekar, JM Krill-Burger, NV Dharia, G Kugener, J Kalfon, C Yuan, N Dumont, A Gonzalez, M Abdusamad, YY Li, LF Spurr, WW Wu, AD Durbin, BM Wolpin, F Piccioni, DE Root, JS Boehm, AD Cherniack, A Tsherniak, AL Hong, WC Hahn, K Stegmaier, TR Golub, F Vazquez, AJ Aguirre	12/15/2020
Making the most of small samples: Optimization of tissue allocation of pediatric solid tumors for clinical and research use Pediatric Blood & Cancer	RS Pinches, CM Clinton, A Ward, SC Meyer, A Al-Ibraheemi, SJ Forrest, GR Strand, H Detert, A Piche-Schulman, K Gill, T Restrepo, R Tavares Proulx, AR Perez-Atayde, SO Vargas, R Shaikh, C Weldon, S Alexandrescu, AL Hong, AF O'Neill, M Hollowell, MH Harris, KA Janeway, BD Crompton, AJ Church	07/15/2020
Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine Clinical Cancer Research	TP Howard, EM Oberlick, MG Rees, TE Arnoff, MT Pham, L Brenan, M DoCarmo, AL Hong, G Kugener, HC Chou, Y Drosos, KM Mathias, P Ramos, B Seashore-Ludlow, AO Giacomelli, X Wang, BB Freeman, K Blankenship, L Hoffmann, HL Tiv, PC Gokhale, CM Johannessen, EA Stewart, SL Schreiber, WC Hahn, CWM Roberts	07/06/2020