Ravi Kane, PhD, MS

Research Program

Discovery and Developmental Therapeutics
Phone Number

404-385-4608
Email Address

ravi.kane@chbe.gatech.edu

Biography

Ravi Kane, PhD, MS, is a professor in the School of Chemical and Biomolecular Engineering and Garry Betty/ V Foundation Chair at the Georgia Institute of Technology. He is also a GRA Eminent Scholar in Cancer Nanotechnology.

Dr. Kane is a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute.

Education

Dr. Kane received his Master of Science and his PhD in chemical engineering from Massachusetts Institute of Technology.

Titles & Roles

Professor

School of Chemical and Biomolecular Engineering, Georgia Institute of Technology

Research

Dr. Kane's research interests include vaccine design, the development of methods to modulate Wnt signaling and the development of imaging techniques and targeted treatments for cancer.

Grants

View Grants

Grant Number	Title
5R01AI168408-03	Engineering Protein Antigens and their Presentation from Multivalent Scaffolds
5R01GM154933-02	Guided Intracellular Delivery using Precise Area Introduction and Transfection (PAINT)

Publications

Title/Journal	Authors	Publication Date
Merbecovirus S2 subunit vaccines elicit cross reactive antibodies and provide partial protection against MERS coronavirus. Npj viruses	PJ Halfmann, JS Lee, A Duffy, B Huang, JE Yang, ER Wright, Y Kawaoka, RS Kane	07/29/2025
Facile generation of drug-like conformational antibodies specific for amyloid fibrils. Nature chemical biology	AA Desai, JM Zupancic, H Trzeciakiewicz, JE Gerson, KN DuBois, ME Skinner, LM Sharkey, N McArthur, SP Ferris, NN Bhatt, EK Makowski, MD Smith, H Chen, J Huang, C Jerez, YH Kuo, RS Kane, NM Kanaan, HL Paulson, PM Tessier	06/01/2025
Potent bivalent nanobody constructs that protect against the SARS-CoV-2 XBB variant. Npj viruses	PJ Halfmann, JS Lee, N McArthur, O Gupta, Y Kawaoka, RS Kane	03/13/2025
A modular cell-free protein biosensor platform using split T7 RNA polymerase. Science advances	MA McSweeney, AT Patterson, K Loeffler, R Cuellar Lelo de Larrea, MP McNerney, RS Kane, MP Styczynski	02/21/2025
Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice. Nature communications	PJ Halfmann, RS Patel, K Loeffler, A Yasuhara, LA Van De Velde, JE Yang, J Chervin, C Troxell, M Huang, N Zheng, ER Wright, PG Thomas, PC Wilson, Y Kawaoka, RS Kane	01/07/2025
Generation of nanobodies with conformational specificity for tau oligomers that recognize tau aggregates from human Alzheimer's disease samples. Biomaterials science	N McArthur, JD Squire, OJ Onyeachonam, NN Bhatt, C Jerez, AL Holberton, PM Tessier, LB Wood, R Kayed, RS Kane	11/19/2024
Single immunization with an influenza hemagglutinin nanoparticle-based vaccine elicits durable protective immunity. Bioengineering & translational medicine	S Chiba, T Maemura, K Loeffler, SJ Frey, C Gu, A Biswas, M Hatta, Y Kawaoka, RS Kane	09/01/2024
A modular cell-free protein biosensor platform using split T7 RNA polymerase. bioRxiv : the preprint server for biology	MA McSweeney, AT Patterson, K Loeffler, RCL de Larrea, MP McNerney, RS Kane, MP Styczynski	07/19/2024
Introduction. Annual review of chemical and biomolecular engineering	MF Doherty, RA Segalman, RS Kane	07/01/2024
Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine. Nature communications	PJ Halfmann, K Loeffler, A Duffy, M Kuroda, JE Yang, ER Wright, Y Kawaoka, RS Kane	02/12/2024
Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates. Biotechnology progress	N McArthur, B Kang, FG Rivera Moctezuma, AT Shaikh, K Loeffler, NN Bhatt, M Kidd, JM Zupancic, AA Desai, N Djeddar, A Bryksin, PM Tessier, R Kayed, LB Wood, RS Kane	01/01/2024
Optogenetic control of Wnt signaling models cell-intrinsic embryogenic patterning using 2D human pluripotent stem cell culture. Development (Cambridge, England)	NA Repina, HJ Johnson, X Bao, JA Zimmermann, DA Joy, SZ Bi, RS Kane, DV Schaffer	07/15/2023
Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrils. bioRxiv : the preprint server for biology	AA Desai, JM Zupancic, H Trzeciakiewicz, JE Gerson, KN DuBois, ME Skinner, LM Sharkey, N McArthur, SP Ferris, NN Bhatt, EK Makowski, MD Smith, H Chen, J Huang, C Jerez, RS Kane, NM Kanaan, HL Paulson, PM Tessier	07/04/2023
A multivalent Plasmodium falciparum circumsporozoite protein-based nanoparticle malaria vaccine elicits a robust and durable antibody response against the junctional epitope and the major repeats. Bioengineering & translational medicine	G Pendyala, JM Calvo-Calle, A Moreno, RS Kane	07/01/2023
Broad Protection Against Clade 1 Sarbecoviruses After a Single Immunization with Cocktail Spike-Protein-Nanoparticle Vaccine. Research square	PJ Halfmann, K Loeffler, A Duffy, M Kuroda, Y Kawaoka, RS Kane	06/29/2023
Introduction. Annual review of chemical and biomolecular engineering	MF Doherty, RA Segalman, RS Kane	06/08/2023
Engineering active lysostaphin variants that incorporate noncanonical amino acids and characterizing the effects of site-specific PEGylation. Biotechnology and bioengineering	T Batugal, G Pendyala, L Tomasovic, C Varner, JD Caplin, AM Page, M Davis, SW Satola, AJ García, RS Kane	06/01/2023
Nanovaccines Displaying the Influenza Virus Hemagglutinin in an Inverted Orientation Elicit an Enhanced Stalk-Directed Antibody Response. Advanced healthcare materials	SJ Frey, JM Carreño, D Bielak, A Arsiwala, CG Altomare, C Varner, T Rosen-Cheriyan, G Bajic, F Krammer, RS Kane	05/01/2023
Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates. Frontiers in immunology	JM Zupancic, MD Smith, H Trzeciakiewicz, ME Skinner, SP Ferris, EK Makowski, MJ Lucas, N McArthur, RS Kane, HL Paulson, PM Tessier	01/01/2023
Editorial overview: Nanobiotechnology. Current opinion in biotechnology	PM Tessier, RS Kane	12/01/2022
Multivalent S2-based vaccines provide broad protection against SARS-CoV-2 variants of concern and pangolin coronaviruses. EBioMedicine	PJ Halfmann, SJ Frey, K Loeffler, M Kuroda, T Maemura, T Armbrust, JE Yang, YJ Hou, R Baric, ER Wright, Y Kawaoka, RS Kane	12/01/2022
Potent neutralization of SARS-CoV-2 including variants of concern by vaccines presenting the receptor-binding domain multivalently from nanoscaffolds. Bioengineering & translational medicine	PJ Halfmann, A Castro, K Loeffler, SJ Frey, S Chiba, Y Kawaoka, RS Kane	09/01/2021
Refocusing the Immune Response to Selected Epitopes on a Zika Virus Protein Antigen by Nanopatterning. Advanced healthcare materials	A Castro, JM Carreño, J Duehr, F Krammer, RS Kane	08/01/2021
Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization. Communications biology	S Chiba, SJ Frey, PJ Halfmann, M Kuroda, T Maemura, JE Yang, ER Wright, Y Kawaoka, RS Kane	05/19/2021
The Design of Vaccines Based on the Shielding of Antigenic Site Ø of a Respiratory Syncytial Virus Fusion Protein Immunogen. Advanced healthcare materials	SJ Frey, C Varner, A Arsiwala, MG Currier, ML Moore, RS Kane	02/01/2021
Protocol to Fabricate Engineered Illumination Devices for Optogenetic Control of Cellular Signaling Dynamics. STAR protocols	NA Repina, HJ Johnson, T McClave, RS Kane, DV Schaffer	12/18/2020
β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells. Proceedings of the National Academy of Sciences of the United States of America	AB Rosenbloom, M Tarczyński, N Lam, RS Kane, LJ Bugaj, DV Schaffer	11/17/2020
CL6mN: Rationally Designed Optogenetic Photoswitches with Tunable Dissociation Dynamics. ACS synthetic biology	A Mukherjee, C Sudrik, Y Hu, M Arha, M Stathos, J Baek, DV Schaffer, RS Kane	09/18/2020
Glycosylation as a tool for rational vaccine design. Biotechnology and bioengineering	V Hariharan, RS Kane	08/01/2020
Engineered Illumination Devices for Optogenetic Control of Cellular Signaling Dynamics. Cell reports	NA Repina, T McClave, HJ Johnson, X Bao, RS Kane, DV Schaffer	06/09/2020
One-pot synthesis of heterodimeric agonists that activate the canonical Wnt signaling pathway. Chemical communications (Cambridge, England)	A Mukherjee, ME Stathos, C Varner, A Arsiwala, S Frey, Y Hu, DM Smalley, DV Schaffer, RS Kane	03/26/2020
"Trim"ming PolyQ proteins with engineered PML. Biotechnology and bioengineering	N Dhar, A Arsiwala, S Murali, RS Kane	02/01/2020
Quantitative Study of the Interaction of Multivalent Ligand-Modified Nanoparticles with Breast Cancer Cells with Tunable Receptor Density. ACS nano	J Wang, J Min, SA Eghtesadi, RS Kane, A Chilkoti	01/28/2020
Nanopatterning protein antigens to refocus the immune response. Nanoscale	A Arsiwala, C Varner, JN McCaffery, A Kell, G Pendyala, A Castro, V Hariharan, A Moreno, RS Kane	08/15/2019
Nature-inspired design and evolution of anti-amyloid antibodies. The Journal of biological chemistry	MC Julian, LA Rabia, AA Desai, A Arsiwala, JE Gerson, HL Paulson, RS Kane, PM Tessier	05/24/2019
Designing Multivalent Ligands to Control Biological Interactions: From Vaccines and Cellular Effectors to Targeted Drug Delivery. Chemistry, an Asian journal	A Arsiwala, A Castro, S Frey, M Stathos, RS Kane	01/18/2019
Understanding How Wnt Influences Destruction Complex Activity and β-Catenin Dynamics. iScience	A Mukherjee, N Dhar, M Stathos, DV Schaffer, RS Kane	08/31/2018
Tunable aggregation of gold-silica janus nanoparticles to enable contrast-enhanced multiwavelength photoacoustic imaging in vivo. Nanoscale	JH Park, DS Dumani, A Arsiwala, S Emelianov, RS Kane	08/16/2018
Bionanotechnology for vaccine design. Current opinion in biotechnology	S Frey, A Castro, A Arsiwala, RS Kane	08/01/2018
Synthesis of multivalent polymer-aptamer conjugates with enhanced inhibitory potency. International journal of nanomedicine	JT Martin, M Douaisi, A Arsiwala, M Arha, RS Kane	01/01/2018
Optogenetic tools for cell biological applications. Journal of thoracic disease	A Mukherjee, NA Repina, DV Schaffer, RS Kane	12/01/2017
At Light Speed: Advances in Optogenetic Systems for Regulating Cell Signaling and Behavior. Annual review of chemical and biomolecular engineering	NA Repina, A Rosenbloom, A Mukherjee, DV Schaffer, RS Kane	06/07/2017
Biocatalytic Nanocomposites for Combating Bacterial Pathogens. Annual review of chemical and biomolecular engineering	X Wu, SJ Kwon, J Kim, RS Kane, JS Dordick	06/07/2017
Nanostructured glycan architecture is important in the inhibition of influenza A virus infection. Nature nanotechnology	SJ Kwon, DH Na, JH Kwak, M Douaisi, F Zhang, EJ Park, JH Park, H Youn, CS Song, RS Kane, JS Dordick, KB Lee, RJ Linhardt	01/01/2017
Wall Teichoic Acids Are Involved in the Medium-Induced Loss of Function of the Autolysin CD11 against Clostridium difficile. Scientific reports	X Wu, EE Paskaleva, KK Mehta, JS Dordick, RS Kane	10/19/2016

Awards

Dr. Kane won the Biotechnology Progress Award for Excellence in Biological Engineering Publication in 2014. Previously, he was elected to AIMBE College of Fellows in 2013. In 2011, Dr. Kane received the Trustees' Outstanding Teacher Award, RPI. In 2004, he was named to the TR 100, a list of the world's top 100 young innovators, by MIT's Technology Review.