Biography
Anna M. Kenney, PhD, is an associate professor in the Department of Pediatrics at Emory School of Medicine. Dr. Kenney is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute. Dr. Kenney received her PhD in Neuroscience from Yale University in 1998. She completed her post-doctoral Research in Pediatric Oncology at Dana-Farber Cancer Institute/Harvard Medical School in 2003.Education
Titles & Roles
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Associate Professor, Department of PediatricsEmory University School of Medicine
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Director, Pediatric Neuro-oncology Basic Research ProgramChildren's Healthcare of Atlanta, Egleston
Research
Dr. Kenney's research focuses on cell cycle control in cerebellar development and medulloblastoma, a pediatric brain tumor that arises in the cerebellum. These tumors are the most common solid malignancy of childhood. Current treatments for medulloblastomas include surgical resection, chemotherapy, and cranio-spinal irradiation. These therapies lead to a 60% "cure" rate, but survivors are left with life long devastating side effects as a result of these treatment, including cognitive declines, seizures, developmental delays, and premature aging. By gaining increased insight into the cellular and molecular mechanisms that drive tumor establishment and growth, it is Dr. Kenney's hope to identify genes and proteins whose activity could in the future be modulated by drugs and novel small molecules, thereby ameliorating the need for irradiation and chemotherapy.
Publications
| Title/Journal | Authors | Publication Date |
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The LIN28B-let-7-PBK pathway is essential for group 3 medulloblastoma tumor growth and survival. Molecular oncology |
SW Shahab, CM Roggeveen, J Sun, H Kunhiraman, LF McSwain, K Juraschka, SA Kumar, O Saulnier, MD Taylor, M Schniederjan, RW Schnepp, TJ MacDonald, AM Kenney | 09/01/2023 |
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Author Correction: YB1 modulates the DNA damage response in medulloblastoma. Scientific reports |
LF McSwain, CE Pillsbury, R Haji-Seyed-Javadi, SK Rath, V Chen, T Huang, SW Shahab, H Kunhiraman, J Ross, GA Price, A Dey, D Hambardzumyan, T MacDonald, DS Yu, CC Porter, AM Kenney | 06/15/2023 |
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YB1 modulates the DNA damage response in medulloblastoma. Scientific reports |
LF McSwain, CE Pillsbury, R Haji-Seyed-Javadi, SK Rath, V Chen, T Huang, SW Shahab, H Kunhiraman, J Ross, GA Price, A Dey, D Hambardzumyan, T MacDonald, DS Yu, CC Porter, AM Kenney | 05/19/2023 |
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Acta neuropathologica communications |
H Kunhiraman, L McSwain, SW Shahab, TR Gershon, TJ MacDonald, AM Kenney | 04/08/2023 |
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Medulloblastoma and the DNA Damage Response. Frontiers in oncology |
LF McSwain, KK Parwani, SW Shahab, D Hambardzumyan, TJ MacDonald, JM Spangle, AM Kenney | 01/01/2022 |
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Ten-eleven translocation protein 1 modulates medulloblastoma progression. Genome biology |
H Kim, Y Kang, Y Li, L Chen, L Lin, ND Johnson, D Zhu, MH Robinson, L McSwain, BG Barwick, X Yuan, X Liao, J Zhao, Z Zhang, Q Shu, J Chen, EG Allen, AM Kenney, RC Castellino, EG Van Meir, KN Conneely, PM Vertino, P Jin, J Li | 04/29/2021 |
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Proceedings of the National Academy of Sciences of the United States of America |
J Kim, A Dey, A Malhotra, J Liu, SI Ahn, YJ Sei, AM Kenney, TJ MacDonald, Y Kim | 09/29/2020 |
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Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma. Scientific reports |
MH Robinson, V Maximov, S Lallani, H Farooq, MD Taylor, RD Read, AM Kenney | 09/20/2019 |
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Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma. Nature communications |
V Maximov, Z Chen, Y Wei, MH Robinson, CJ Herting, NS Shanmugam, VA Rudneva, KC Goldsmith, TJ MacDonald, PA Northcott, D Hambardzumyan, AM Kenney | 06/03/2019 |
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Molecular and cellular biology |
NW Eyrich, CR Potts, MH Robinson, V Maximov, AM Kenney | 04/15/2019 |
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Atoh1/MATH1 Adds Up to Ciliogenesis for Transducing SHH Signaling in the Cerebellum. Developmental cell |
RC Castellino, AM Kenney | 01/28/2019 |
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p53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma. Molecular cancer research : MCR |
Y Wei, V Maximov, SA Morrissy, MD Taylor, DC Pallas, AM Kenney | 01/01/2019 |
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Science advances |
H Zheng, WM Yu, J Shen, S Kang, D Hambardzumyan, JY Li, Y Shen, AM Kenney, J Chen, CK Qu | 10/01/2018 |
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miR miR on the wall, who's the most malignant medulloblastoma miR of them all? Neuro-oncology |
X Wang, BL Holgado, V Ramaswamy, S Mack, K Zayne, M Remke, X Wu, L Garzia, C Daniels, AM Kenney, MD Taylor | 02/19/2018 |
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Oncogene |
J Wen, J Lee, A Malhotra, R Nahta, AR Arnold, MC Buss, BD Brown, C Maier, AM Kenney, M Remke, V Ramaswamy, MD Taylor, RC Castellino | 10/20/2016 |
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Oncogene |
A Dey, M Robitaille, M Remke, C Maier, A Malhotra, A Gregorieff, JL Wrana, MD Taylor, S Angers, AM Kenney | 08/11/2016 |
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Molecular cancer research : MCR |
A Malhotra, A Dey, N Prasad, AM Kenney | 01/01/2016 |
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Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature |
PA Northcott, DJ Shih, J Peacock, L Garzia, AS Morrissy, T Zichner, AM Stütz, A Korshunov, J Reimand, SE Schumacher, R Beroukhim, DW Ellison, CR Marshall, AC Lionel, S Mack, A Dubuc, Y Yao, V Ramaswamy, B Luu, A Rolider, FM Cavalli, X Wang, M Remke, X Wu, RY Chiu, A Chu, E Chuah, RD Corbett, GR Hoad, SD Jackman, Y Li, A Lo, KL Mungall, KM Nip, JQ Qian, AG Raymond, NT Thiessen, RJ Varhol, I Birol, RA Moore, AJ Mungall, R Holt, D Kawauchi, MF Roussel, M Kool, DT Jones, H Witt, A Fernandez-L, AM Kenney, RJ Wechsler-Reya, P Dirks, T Aviv, WA Grajkowska, M Perek-Polnik, CC Haberler, O Delattre, SS Reynaud, FF Doz, SS Pernet-Fattet, BK Cho, SK Kim, KC Wang, W Scheurlen, CG Eberhart, M Fèvre-Montange, A Jouvet, IF Pollack, X Fan, KM Muraszko, GY Gillespie, C Di Rocco, L Massimi, EM Michiels, NK Kloosterhof, PJ French, JM Kros, JM Olson, RG Ellenbogen, K Zitterbart, L Kren, RC Thompson, MK Cooper, B Lach, RE McLendon, DD Bigner, A Fontebasso, S Albrecht, N Jabado, JC Lindsey, S Bailey, N Gupta, WA Weiss, L Bognár, A Klekner, TE Van Meter, T Kumabe, T Tominaga, SK Elbabaa, JR Leonard, JB Rubin, LM Liau, EG Van Meir, M Fouladi, H Nakamura, G Cinalli, M Garami, P Hauser, AG Saad, A Iolascon, S Jung, CG Carlotti, R Vibhakar, YS Ra, S Robinson, M Zollo, CC Faria, JA Chan, ML Levy, PH Sorensen, M Meyerson, SL Pomeroy, YJ Cho, GD Bader, U Tabori, CE Hawkins, E Bouffet, SW Scherer, JT Rutka, D Malkin, SC Clifford, SJ Jones, JO Korbel, SM Pfister, MA Marra, MD Taylor | 08/02/2012 |
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Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups. Acta neuropathologica |
DW Ellison, J Dalton, M Kocak, SL Nicholson, C Fraga, G Neale, AM Kenney, DJ Brat, A Perry, WH Yong, RE Taylor, S Bailey, SC Clifford, RJ Gilbertson | 03/01/2011 |
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Cancer research |
B Bhatia, PA Northcott, D Hambardzumyan, B Govindarajan, DJ Brat, JL Arbiser, EC Holland, MD Taylor, AM Kenney | 09/15/2009 |
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Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas. Cancer research |
OJ Becher, D Hambardzumyan, EI Fomchenko, H Momota, L Mainwaring, AM Bleau, AM Katz, M Edgar, AM Kenney, C Cordon-Cardo, RG Blasberg, EC Holland | 04/01/2008 |
Awards
Dr. Kenney has received the following awards and honors:
- American Brain Tumor Association post-doctoral fellowship, 1999-2001
- The Medical Foundation, Inc. postdoctoral fellowship, 2001-2003
- Dana-Farber Pediatric Oncology departmental award, 2002
- The Sontag Foundation Distinguished Scientist award, 2003-2007
- Handler Foundation award for new investigators at MSKCC, 2006-present
- Alex’s Lemonade Stand Foundation for Childhood Cancer Young Investigator Award, 2006-2008
- Children’s Brain Tumor Foundation Award, 2007-2009
- Pediatric Brain Tumor Foundation Award, 2007-2008
- Childhood Brain Tumor Foundation of MD award, 2008-2009
- Alex’s Lemonade Stand Innovation Award, 2009-2011
- National Brain Tumor Society Award, 2009-2013
- Childhood Brain Tumor Foundation Award, 2010-2013
- James S. McDonnell Foundation 21st Century Science Initiative Award, 2010-2014