Liyong Lin, PhD, FAAPM, DABR

Research Program

Discovery and Developmental Therapeutics
Phone Number

404-778-3473
Email Address

liyong.lin@emory.edu

Biography

Liyong Lin, PhD, FAAPM, DABR, is a professor in the Department of Radiation Oncology at Emory University School of Medicine. An ABR board-certified medical physicist, Dr. Lin's expertise includes commissioning, quality assurance, optimization and Monte Carlo characterization of pencil beam scanning proton therapy systems.

Dr. Lin is a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute.

Education

Dr. Lin received his PhD in Medical Physics from the University of Wisconsin-Madison. He then completed a two-year clinical postdoc at University of Florida Proton Therapy Institute.

Titles & Roles

Professor, Department of Radiation Oncology

Emory University School of Medicine
Adjunct Professor, Nuclear and Radiological Engineering, and Medical Physics

The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology

Research

Dr. Lin's current research interest is in:

developing Monte Carlo proton dose calculation platforms for open collaboration, teaming with peer institutions, AAPM/NRG and industry to provide access to independent validation of proton planning and delivery,
developing Monte Carlo based integrated biological optimization (dose rate and LET) to enable highest quality care, especially proton SBRT & FLASH,
and quality assurance of Monte Carlo dose calculation, optimization and image guidance proton therapy (IGPT).

Publications

Title/Journal	Authors	Publication Date
Requirements and study design for the next proton FLASH clinical trials: an international multidisciplinary Delphi consensus. International journal of radiation oncology, biology, physics	YL Klaver, MS Hoogeman, QR Lu, JD Bradley, JI Choi, MJ Ferris, C Grau, C Guha, H Lin, L Lin, AE Mascia, AM Moerman, PR Poulsen, LZ Shi, BS Sørensen, S Tian, MC Vozenin, CD Willey, S Zhou, RA Amos, M Hawkins, CB Simone	03/31/2025
Embracing the Future of Clinical Trials in Radiation Therapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions. International journal of radiation oncology, biology, physics	Y Xiao, S Benedict, Y Cui, C Glide-Hurst, S Graves, X Jia, SF Kry, H Li, L Lin, M Matuszak, M Newpower, H Paganetti, XS Qi, E Roncali, Y Rong, G Sgouros, CB Simone, JJ Sunderland, PA Taylor, L Tchelebi, M Weldon, JW Zou, EJ Wuthrick, M Machtay, QT Le, JC Buchsbaum	01/22/2025
Characterizing devices for validation of dose, dose rate, and LET in ultra high dose rate proton irradiations. Medical physics	N Harrison, S Charyyev, C Oancea, A Stanforth, E Gelover, S Zhou, WS Dynan, T Zhang, S Biegalski, L Lin	11/01/2024
A Novel Inverse Algorithm To Solve the Integrated Optimization of Dose, Dose Rate, and Linear Energy Transfer of Proton FLASH Therapy With Sparse Filters. International journal of radiation oncology, biology, physics	N Harrison, M Kang, R Liu, S Charyyev, N Wahl, W Liu, J Zhou, KA Higgins, CB Simone, JD Bradley, WS Dynan, L Lin	07/01/2024
Deep learning-based Fast Volumetric Image Generation for Image-guided Proton FLASH Radiotherapy. Research square	CW Chang, Y Lei, T Wang, S Tian, J Roper, L Lin, J Bradley, T Liu, J Zhou, X Yang	07/26/2023
An Integrated Physical Optimization Framework for Proton Stereotactic Body Radiation Therapy FLASH Treatment Planning Allows Dose, Dose Rate, and Linear Energy Transfer Optimization Using Patient-Specific Ridge Filters. International journal of radiation oncology, biology, physics	R Liu, S Charyyev, N Wahl, W Liu, M Kang, J Zhou, X Yang, F Baltazar, M Palkowitsch, K Higgins, W Dynan, J Bradley, L Lin	07/15/2023
Measurement of the time structure of FLASH beams using prompt gamma rays and secondary neutrons as surrogates. Physics in medicine and biology	S Charyyev, R Liu, X Yang, J Zhou, A Dhabaan, WS Dynan, C Oancea, L Lin	07/12/2023
Feasibility study of hybrid inverse planning with transmission beams and single-energy spread-out Bragg peaks for proton FLASH radiotherapy. Medical physics	C Ma, X Yang, CW Chang, R Liu, D Bohannon, L Lin, T Liu, S Tian, J Zhou	06/01/2023
MicroRNA-650 Regulates the Pathogenesis of Alzheimer's Disease Through Targeting Cyclin-Dependent Kinase 5. Molecular neurobiology	L Lin, X Liu, X Cheng, Y Li, M Gearing, A Levey, X Huang, Y Li, P Jin, X Li	05/01/2023
Characterization of 250 MeV Protons from the Varian ProBeam PBS System for FLASH Radiation Therapy. International journal of particle therapy	S Charyyev, CW Chang, M Zhu, L Lin, K Langen, A Dhabaan	01/01/2023
Proton liver stereotactic body radiation therapy: Treatment techniques and dosimetry feasibility from a single institution. Journal of radiosurgery and SBRT	J Zhou, M Kang, Y Wang, KA Higgins, CB Simone, P Patel, MW McDonald, L Lin, D Bohannon	01/01/2023
Proton stereotactic body radiation therapy as a new treatment regimen: Technical development and limitation with initial clinical experience. Journal of radiosurgery and SBRT	L Lin, FF Yin, KA Higgins, S Ryu, CB Simone	01/01/2023
Validation of a deep learning-based material estimation model for Monte Carlo dose calculation in proton therapy. Physics in medicine and biology	CW Chang, S Zhou, Y Gao, L Lin, T Liu, JD Bradley, T Zhang, J Zhou, X Yang	10/19/2022
Dual-energy CT based mass density and relative stopping power estimation for proton therapy using physics-informed deep learning. Physics in medicine and biology	CW Chang, Y Gao, T Wang, Y Lei, Q Wang, S Pan, A Sudhyadhom, JD Bradley, T Liu, L Lin, J Zhou, X Yang	05/26/2022
Onboard cone-beam CT-based replan evaluation for head and neck proton therapy. Journal of applied clinical medical physics	A Stanforth, L Lin, JJ Beitler, JR Janopaul-Naylor, CW Chang, RH Press, SA Patel, J Zhao, B Eaton, EE Schreibmann, J Jung, D Bohannon, T Liu, X Yang, MW McDonald, J Zhou	05/01/2022
Dosimetric Uncertainties in Dominant Intraprostatic Lesion Simultaneous Boost Using Intensity Modulated Proton Therapy. Advances in radiation oncology	J Zhou, X Yang, CW Chang, S Tian, T Wang, L Lin, Y Wang, JR Janopaul-Naylor, P Patel, JD Demoor, D Bohannon, A Stanforth, B Eaton, MW McDonald, T Liu, SA Patel	01/01/2022
Synthetic dual-energy CT for MRI-only based proton therapy treatment planning using label-GAN. Physics in medicine and biology	R Liu, Y Lei, T Wang, J Zhou, J Roper, L Lin, MW McDonald, JD Bradley, WJ Curran, T Liu, X Yang	03/09/2021
A novel proton counting detector and method for the validation of tissue and implant material maps for Monte Carlo dose calculation. Physics in medicine and biology	S Charyyev, CW Chang, J Harms, C Oancea, ST Yoon, X Yang, T Zhang, J Zhou, L Lin	02/02/2021
Learning-Based Stopping Power Mapping on Dual-Energy CT for Proton Radiation Therapy. International journal of particle therapy	T Wang, Y Lei, J Harms, B Ghavidel, L Lin, JJ Beitler, M McDonald, WJ Curran, T Liu, J Zhou, X Yang	01/01/2021
NRG Oncology Survey of Monte Carlo Dose Calculation Use in US Proton Therapy Centers. International journal of particle therapy	L Lin, PA Taylor, J Shen, J Saini, M Kang, CB Simone, JD Bradley, Z Li, Y Xiao	01/01/2021
Optimization of hexagonal-pattern minibeams for spatially fractionated radiotherapy using proton beam scanning. Medical physics	S Charyyev, M Artz, G Szalkowski, CW Chang, A Stanforth, L Lin, R Zhang, CC Wang	08/01/2020
Technical Note: Integrating an open source Monte Carlo code "MCsquare" for clinical use in intensity-modulated proton therapy. Medical physics	W Deng, JE Younkin, K Souris, S Huang, K Augustine, M Fatyga, X Ding, M Cohilis, M Bues, J Shan, J Stoker, L Lin, J Shen, W Liu	06/01/2020
A standardized commissioning framework of Monte Carlo dose calculation algorithms for proton pencil beam scanning treatment planning systems. Medical physics	CW Chang, S Huang, J Harms, J Zhou, R Zhang, A Dhabaan, R Slopsema, M Kang, T Liu, M McDonald, K Langen, L Lin	04/01/2020
The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation. Aging	L Lin, Y Li, M Liu, Q Li, Q Liu, R Li	01/29/2020
Predicted Secondary Malignancies following Proton versus Photon Radiation for Oropharyngeal Cancers. International journal of particle therapy	V Jain, P Irmen, S O'Reilly, JH Vogel, L Lin, A Lin	01/01/2020
Nuclear halo measurements for accurate prediction of field size factor in a Varian ProBeam proton PBS system. Journal of applied clinical medical physics	J Harms, CW Chang, R Zhang, L Lin	01/01/2020