Xiulei Mo
PhD
Dr. Mo's research interests include understanding and targeting “undruggable” loss-of-function tumor suppressor genes through system biology approach to identify rewired cell signaling network and vulnerabilities, and through chemical biology approach to discover small molecules that restore tumor suppressor function in cancer.
Titles and Roles
- Assistant Professor, Department of Pharmacology and Chemical Biology
- Emory University School of Medicine
- Research Program
- Discovery and Developmental Therapeutics
Biography
Xiulei Mo, PhD, is an Assistant Professor in the Department of Pharmacology and Chemical Biology at Emory University School of Medicine.
Dr. Mo is a member of the Discovery and Developmental Therapeutics research program at Winship Cancer Institute of Emory University.
Education
Dr. Mo earned his PhD in Biomedical Science from Auburn University in Auburn, Alabama. He completed his post-doctoral training in Pharmacology at Emory University in Atlanta, Georgia.
Research
The long-term goal of Dr. Mo's research is to understand the molecular basis underlying tumor initiation, progression and drug resistance, and to bridge the gap between vast cancer genomic dataset and unmet clinical need. A major focus of Dr. Mo's research is to understand and target "undruggable" loss-of-function tumor suppressor genes through system biology approach to identify rewired cell signaling network and vulnerabilities, and through chemical biology approach to discover small molecules to restore tumor suppressor function in cancer.
Using SMAD4 tumor suppressor gene as an example, Dr. Mo’s research is focusing on (1) providing mechanistic insight to understand how SMAD4 loss-of-function mutation drive tumorigenesis and cancer development in context-dependent manner in various tumor lineages, such as pancreatic and colon cancer, and (2) discovery of small molecular glue to restore mutant SMAD4 tumor suppressive functions.
Publications
Publications Publication Date