Ignacio Sanz, MD

Research Program

Cancer Immunology
Phone Number

404-712-2945
Email Address

ignacio.sanz@emory.edu

Biography

Ignacio Sanz, MD, is Mason I. Lowance Professor of Medicine and Pediatrics and chief of the Division of Rheumatology at Emory University School of Medicine. Dr. Sanz serves as director of The Lowance Center for Human Immunology at Emory University and the Children's Healthcare of Atlanta. He is also a Georgia Research Alliance Distinguished Scholar in Human Immunology. Prior to his arrival at Emory, he was chief of the Division of Immunology and Rheumatology at the University of Rochester in Rochester, New York, where he also served as director of the University of Rochester Program for Biodefense of Immunocompromised Populations from 2006-2011 and director of the Rochester Center for Translational Immunology and Infectious Diseases from 2009-2012.

Dr. Sanz is a member of the Cancer Immunology Research Program at Winship Cancer Institute. He is also a member of the Immune Tolerance Network Steering Committee and chair of the Autoimmunity Centers of Excellence Mechanistic Studies Committee. He was a member of the National Institute of Allergy and Infectious Diseases (NIAID) Allergy and Immunology Study Section and has also participated in multiple special review panels and ad-hoc reviews. He has been an invited participant in special workshops on immunotherapy, HIV and type 1 diabetes.

Education

Dr. Sanz earned his medical degree at University of Santander Medical School in Santander, Spain. He completed his residency in internal medicine at the National Center for Medical Research in Madrid, Spain. He then went on to a postdoctoral fellowship at Southwestern Medical School in Dallas, Texas and completed his training with a fellowship in rheumatology at University of Texas Health Sciences Center in San Antonio, Texas.

Titles & Roles

Mason I. Lowance Professor of Medicine and Pediatrics

Emory University School of Medicine
Chief, Division of Rheumatology, Department of Medicine

Emory University School of Medicine
Director, The Lowance Center for Human Immunology

Emory University/Children's Healthcare of Atlanta

Research

Dr. Sanz's research interest is in understanding how the immune system goes awry in autoimmune diseases and ends up attacking our own tissues rather than concentrating on fighting infections. In particular, he is very interested in understanding the roles played in autoimmune diseases by B cells and their effector progeny, the plasma cells responsible for producing the autoantibodies that in many cases cause the disease. His research concentrates on systemic lupus erythematosus, but he is also investigating other autoimmune diseases such as Sjogren's syndrome, rheumatoid arthritis and type 1 diabetes. His work also has applications to the enhancement of vaccine responses and cancer immunotherapy.

Grants

View Grants

Grant Number	Title
2P01AI125180-06	Plasma Cells in Health and Disease
2U19AI110483-11	Regulation of B cell Responses in SLE and Other Autoimmune Diseases
2UM1AI109565-08	Immune Tolerance Network
3P01AI125180-08S1	Plasma Cells in Health and Disease
3U54CA260563-02S1	Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity
3U54CA260563-02S1	Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity
3U54CA260563-02S2	Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity
3U54CA260563-02S3	Administrative Supplement for Emory SeroNet "Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity"
4U54CA260563-02	Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity
5P01AI125180-07	Plasma Cells in Health and Disease
5P01AI125180-08	Plasma Cells in Health and Disease
5R01AR077926-04	B cell depletion to prevent autoimmunity
5UM1AI109565-10	Immune Tolerance Network

Publications

Title/Journal	Authors	Publication Date
Hypomorphic RAG2 Deficiency Promotes Selection of Self-Reactive B Cells. Journal of clinical immunology	CD Thouvenel, CM Tipton, Y Yamazaki, TT Zhang, S Rylaarsdam, JR Hom, C Snead, C Zhu, QZ Li, YN Lee, T Kawai, N Haque, MT Zimmermann, SM Ponnan, SW Jackson, RG James, I Sanz, LD Notarangelo, TR Torgerson, HD Ochs, DJ Rawlings, EJ Allenspach	01/15/2025
Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE. Nature immunology	CE Faliti, TTP Van, FA Anam, N Cheedarla, ME Williams, AK Mishra, SY Usman, MC Woodruff, G Kraker, MC Runnstrom, S Kyu, D Sanz, H Ahmed, M Ghimire, A Morrison-Porter, H Quehl, NS Haddad, W Chen, S Cheedarla, AS Neish, JD Roback, R Antia, J Hom, CM Tipton, JM Lindner, E Ghosn, S Khurana, CD Scharer, A Khosroshahi, FE Lee, I Sanz	01/01/2025
SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination. Nature medicine	DC Nguyen, IT Hentenaar, A Morrison-Porter, D Solano, NS Haddad, C Castrillon, MC Runnstrom, PA Lamothe, J Andrews, D Roberts, S Lonial, I Sanz, FE Lee	01/01/2025
Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis. Immunity	CE Faliti, M Mesina, J Choi, S Bélanger, MA Marshall, CM Tipton, S Hicks, P Chappa, MA Cardenas, M Abdel-Hakeem, TC Thinnes, C Cottrell, CD Scharer, WR Schief, D Nemazee, MC Woodruff, JM Lindner, I Sanz, S Crotty	12/10/2024
Transient anti-interferon autoantibodies in the airways are associated with recovery from COVID-19. Science translational medicine	BR Babcock, A Kosters, DJ Eddins, MSB Donaire, S Sarvadhavabhatla, V Pae, F Beltran, VW Murray, G Gill, G Xie, BS Dobosh, VD Giacalone, RM Tirouvanziam, RP Ramonell, SA Jenks, I Sanz, FE Lee, NR Roan, SA Lee, EEB Ghosn	11/06/2024
Disruption of memory B-cell trafficking by belimumab in patients with systemic lupus erythematosus. Rheumatology (Oxford, England)	EJ Arends, M Zlei, CM Tipton, J Cotic, Z Osmani, FJ de Bie, SWA Kamerling, A van Maurik, R Dimelow, YI Gregan, NL Fox, TJ Rabelink, DA Roth, I Sanz, JJM van Dongen, C van Kooten, YKO Teng	09/01/2024
Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria. Immunity	KA Hagadorn, ME Peterson, H Kole, B Scott, J Skinner, A Diouf, E Takashima, A Ongoiba, S Doumbo, D Doumtabe, S Li, P Sekar, M Yan, C Zhu, H Nagaoka, BN Kanoi, QZ Li, C Long, EO Long, K Kayentao, SA Jenks, I Sanz, T Tsuboi, B Traore, S Bolland, K Miura, PD Crompton, CS Hopp	08/13/2024
Patients taking benralizumab, dupilumab, or mepolizumab have lower postvaccination SARS-CoV-2 immunity. The Journal of allergy and clinical immunology	MC Runnstrom, PA Lamothe, CE Faliti, N Cheedarla, A Moreno, MS Suthar, R Nahata, M Ravindran, NS Haddad, A Morrison-Porter, H Quehl, RP Ramonell, M Woodruff, F Anam, R Zhang, C Swenson, C Polito, W Neveu, R Patel, N Smirnova, DC Nguyen, C Kim, I Hentenaar, S Kyu, S Usman, T Ngo, Z Guo, H Wu, JL Daiss, J Park, KE Manning, B Wali, ML Ellis, S Sharma, F Holguin, S Cheedarla, AS Neish, JD Roback, I Sanz, F Eun-Hyung Lee	08/01/2024
MENSA, a Media Enriched with Newly Synthesized Antibodies, to Identify SARS-CoV-2 Persistence and Latent Viral Reactivation in Long-COVID. medRxiv : the preprint server for health sciences	NS Haddad, A Morrison-Porter, H Quehl, V Capric, PA Lamothe, F Anam, MC Runnstrom, AD Truong, AN Dixit, MC Woodruff, A Chen, J Park, DC Nguyen, I Hentenaar, CY Kim, S Kyu, B Stewart, E Wagman, H Geoffroy, D Sanz, KS Cashman, RP Ramonell, M Cabrera-Mora, DN Alter, JD Roback, MC Horwath, JB O'Keefe, AW Dretler, R Gripaldo, SM Yeligar, T Natoli, V Betin, R Patel, K Vela, MR Hernandez, S Usman, J Varghese, A Jalal, S Lee, SN Le, RT Amoss, JL Daiss, I Sanz, FE Lee	07/07/2024
Factors associated with immune responses to SARS-CoV-2 vaccination in individuals with autoimmune diseases. JCI insight	E Anderson, M Powell, E Yang, A Kar, TM Leung, C Sison, R Steinberg, R Mims, A Choudhury, C Espinosa, J Zelmanovich, NC Okoye, EJ Choi, G Marder, S Narain, PK Gregersen, M Mackay, B Diamond, T Levy, TP Zanos, A Khosroshahi, I Sanz, ET Luning Prak, A Bar-Or, J Merrill, C Arriens, G Pardo, J Guthridge, J James, A Payne, PJ Utz, JM Boss, C Aranow, A Davidson	06/04/2024
The Majority of SARS-CoV-2 Plasma Cells are Excluded from the Bone Marrow Long-Lived Compartment 33 Months after mRNA Vaccination. Research square	F Lee, D Nguyen, I Hentenaar, A Morrison-Porter, D Solano, N Haddad, C Castrillon, P Lamothe, J Andrews, D Roberts, S Lonial, I Sanz	03/13/2024
The Majority of SARS-CoV-2 Plasma Cells are Excluded from the Bone Marrow Long-Lived Compartment 33 Months after mRNA Vaccination. medRxiv : the preprint server for health sciences	DC Nguyen, IT Hentenaar, A Morrison-Porter, D Solano, NS Haddad, C Castrillon, PA Lamothe, J Andrews, D Roberts, S Lonial, I Sanz, FE Lee	03/05/2024
Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus. Nature communications	W Chen, SH Hong, SA Jenks, FA Anam, CM Tipton, MC Woodruff, JR Hom, KS Cashman, CE Faliti, X Wang, S Kyu, C Wei, CD Scharer, T Mi, S Hicks, L Hartson, DC Nguyen, A Khosroshahi, S Lee, Y Wang, R Bugrovsky, Y Ishii, FE Lee, I Sanz	03/01/2024
Systems biology of B cells in COVID-19. Seminars in immunology	MC Woodruff, CE Faliti, I Sanz	03/01/2024
Majority of human circulating IgG plasmablasts stop blasting in a cell-free pro-survival culture. Scientific reports	DC Nguyen, C Saney, IT Hentenaar, M Cabrera-Mora, V Capric, MC Woodruff, J Andrews, S Lonial, I Sanz, FE Lee	02/13/2024
Majority of human circulating plasmablasts stop blasting: A probable misnomer. bioRxiv : the preprint server for biology	DC Nguyen, C Saney, IT Hentenaar, M Cabrera-Mora, MC Woodruff, J Andrews, S Lonial, I Sanz, FE Lee	09/13/2023
Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses. Cell reports	M Duan, DC Nguyen, CJ Joyner, CL Saney, CM Tipton, J Andrews, S Lonial, C Kim, I Hentenaar, A Kosters, E Ghosn, A Jackson, S Knechtle, S Maruthamuthu, S Chandran, T Martin, R Rajalingam, F Vincenti, C Breeden, I Sanz, G Gibson, FE Lee	07/25/2023
Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID. Nature communications	MC Woodruff, KS Bonham, FA Anam, TA Walker, CE Faliti, Y Ishii, CY Kaminski, MC Ruunstrom, KR Cooper, AD Truong, AN Dixit, JE Han, RP Ramonell, NS Haddad, ME Rudolph, S Yalavarthi, V Betin, T Natoli, S Navaz, SA Jenks, Y Zuo, JS Knight, A Khosroshahi, FE Lee, I Sanz	07/14/2023
SLE Antibody-Secreting Cells Are Characterized by Enhanced Peripheral Maturation and Survival Programs. Research square	W Chen, SH Hong, SA Jenks, FA Anam, CM Tipton, MC Woodruff, JR Hom, KS Cashman, CE Faliti, X Wang, S Kyu, C Wei, CD Scharer, T Mi, S Hicks, L Hartson, DC Nguyen, A Khosroshahi, S Lee, Y Wang, R Bugrovsky, Y Ishii, FE Lee, I Sanz	06/27/2023
Poor immunogenicity upon SARS-CoV-2 mRNA vaccinations in autoimmune SLE patients is associated with pronounced EF-mediated responses and anti-BAFF/Belimumab treatment. medRxiv : the preprint server for health sciences	CE Faliti, FA Anam, N Cheedarla, MC Woodruff, SY Usman, MC Runnstrom, TTP Van, S Kyu, H Ahmed, A Morrison-Porter, H Quehl, NS Haddad, W Chen, S Cheedarla, AS Neish, JD Roback, R Antia, A Khosroshahi, FE Lee, I Sanz	06/12/2023
Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype. Mucosal immunology	RP Ramonell, M Brown, MC Woodruff, JM Levy, SK Wise, J DelGaudio, M Duan, CL Saney, S Kyu, KS Cashman, JR Hom, CF Fucile, AF Rosenberg, CM Tipton, I Sanz, GC Gibson, FE Lee	06/01/2023
A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans. Immunity	A Nellore, E Zumaquero, CD Scharer, CF Fucile, CM Tipton, RG King, T Mi, B Mousseau, JE Bradley, F Zhou, S Mutneja, PA Goepfert, JM Boss, TD Randall, I Sanz, AF Rosenberg, FE Lund	04/11/2023
Isoform-specific knockdown of long and intermediate prolactin receptors interferes with evolution of B-cell neoplasms. Communications biology	A Taghi Khani, A Kumar, A Sanchez Ortiz, KC Radecki, S Aramburo, SJ Lee, Z Hu, B Damirchi, MY Lorenson, X Wu, Z Gu, W Stohl, I Sanz, E Meffre, M Müschen, SJ Forman, JL Koff, AM Walker, S Swaminathan	03/20/2023
Transcriptional reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral load. Blood advances	DJ Eddins, J Yang, A Kosters, VD Giacalone, X Pechuan-Jorge, JD Chandler, J Eum, BR Babcock, BS Dobosh, MR Hernández, F Abdulkhader, GL Collins, DY Orlova, RP Ramonell, I Sanz, C Moussion, F Eun-Hyung Lee, RM Tirouvanziam, EEB Ghosn	03/14/2023
Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses. bioRxiv : the preprint server for biology	M Duan, DC Nguyen, CJ Joyner, CL Saney, CM Tipton, J Andrews, S Lonial, C Kim, I Hentenaar, A Kosters, E Ghosn, A Jackson, S Knechtle, S Maruthamuthu, S Chandran, T Martin, R Rajalingam, F Vincenti, C Breeden, I Sanz, G Gibson, F Eun-Hyung Lee	01/20/2023
Mild antecedent COVID-19 associated with symptom-specific post-acute sequelae. PloS one	TA Walker, AD Truong, A Summers, AN Dixit, FC Goldstein, I Hajjar, MR Echols, MC Woodruff, ED Lee, S Tekwani, K Carroll, I Sanz, FE Lee, JE Han	01/01/2023
Clinical Determinants of Childhood Onset Systemic Lupus Erythematosus among Early and Peri-Adolescent Age Groups. Children (Basel, Switzerland)	MC Nelson, S Chandrakasan, L Ponder, I Sanz, B Goldberg, EA Ogbu, K Rouster-Stevens, S Prahalad	11/30/2022
Dysregulated naive B cells and de novo autoreactivity in severe COVID-19. Nature	MC Woodruff, RP Ramonell, NS Haddad, FA Anam, ME Rudolph, TA Walker, AD Truong, AN Dixit, JE Han, M Cabrera-Mora, MC Runnstrom, R Bugrovsky, J Hom, EC Connolly, I Albizua, V Javia, KS Cashman, DC Nguyen, S Kyu, A Singh Saini, M Piazza, CM Tipton, A Khosroshahi, G Gibson, GS Martin, CL Maier, A Esper, SA Jenks, FE Lee, I Sanz	11/01/2022
Autoantibodies targeting LINE-1-encoded ORF1p are associated with systemic lupus erythematosus diagnosis but not disease activity. Clinical and experimental rheumatology	B Antiochos, M Paz, J Li, DW Goldman, M Petri, E Darrah, K Cashman, I Sanz, KH Burns, D Ardeljan, F Andrade, A Rosen	09/01/2022
COVID-19 and plasma cells: Is there long-lived protection? Immunological reviews	DC Nguyen, PA Lamothe, MC Woodruff, AS Saini, CE Faliti, I Sanz, FE Lee	08/01/2022
Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies. Open forum infectious diseases	JC Figueiredo, FR Hirsch, LH Kushi, WN Nembhard, JM Crawford, N Mantis, L Finster, NM Merin, A Merchant, KL Reckamp, GY Melmed, J Braun, D McGovern, S Parekh, DA Corley, N Zohoori, BC Amick, R Du, PK Gregersen, B Diamond, E Taioli, C Sariol, A Espino, D Weiskopf, A Gifoni, J Brien, W Hanege, M Lipsitch, DA Zidar, A Scheck McAlearney, A Wajnberg, J LaBaer, E Yvonne Lewis, RA Binder, AM Moormann, C Forconi, S Forrester, J Batista, J Schieffelin, D Kim, G Biancon, J VanOudenhove, S Halene, R Fan, DH Barouch, G Alter, S Pinninti, SB Boppana, SK Pati, M Latting, AH Karaba, J Roback, R Sekaly, A Neish, AM Brincks, DA Granger, AB Karger, B Thyagarajan, SN Thomas, SL Klein, AL Cox, T Lucas, D Furr-Holden, K Key, N Jones, J Wrammerr, M Suthar, S Yu Wong, NM Bowman, V Simon, LD Richardson, R McBride, F Krammer, M Rana, J Kennedy, K Boehme, C Forrest, SW Granger, CD Heaney, M Knight Lapinski, S Wallet, RS Baric, L Schifanella, M Lopez, S Fernández, E Kenah, AR Panchal, WJ Britt, I Sanz, M Dhodapkar, R Ahmed, LA Bartelt, AJ Markmann, JT Lin, RS Hagan, MC Wolfgang, J Skarbinski	06/01/2022
Somatic Diversification of Rearranged Antibody Gene Segments by Intra- and Interchromosomal Templated Mutagenesis. Journal of immunology (Baltimore, Md. : 1950)	GA Dale, DJ Wilkins, J Rowley, CD Scharer, CM Tipton, J Hom, JM Boss, V Corces, I Sanz, J Jacob	05/01/2022
Distinguishing immune activation and inflammatory signatures of multisystem inflammatory syndrome in children (MIS-C) versus hemophagocytic lymphohistiocytosis (HLH). The Journal of allergy and clinical immunology	D Kumar, CA Rostad, P Jaggi, DS Villacis Nunez, C Prince, A Lu, L Hussaini, TH Nguyen, S Malik, LA Ponder, SPV Shenoy, EJ Anderson, M Briones, I Sanz, S Prahalad, S Chandrakasan	05/01/2022
Response under pressure: deploying emerging technologies to understand B-cell-mediated immunity in COVID-19. Nature methods	MC Woodruff, DC Nguyen, CE Faliti, AS Saini, FE Lee, I Sanz	04/01/2022
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting. Life science alliance	CJ Joyner, AM Ley, DC Nguyen, M Ali, A Corrado, C Tipton, CD Scharer, T Mi, MC Woodruff, J Hom, JM Boss, M Duan, G Gibson, D Roberts, J Andrews, S Lonial, I Sanz, FE Lee	03/01/2022
Altered B cell phenotype and CD27+ memory B cells are associated with clinical features and environmental exposure in Colombian systemic lupus erythematosus patients. Frontiers in medicine	C Hurtado, DF Rojas-Gualdrón, R Urrego, K Cashman, EM Vásquez-Trespalacios, JC Díaz-Coronado, M Rojas, S Jenks, G Vásquez, I Sanz	01/01/2022
The intersection of COVID-19 and autoimmunity. The Journal of clinical investigation	JS Knight, R Caricchio, JL Casanova, AJ Combes, B Diamond, SE Fox, DA Hanauer, JA James, Y Kanthi, V Ladd, P Mehta, AM Ring, I Sanz, C Selmi, RP Tracy, PJ Utz, CA Wagner, JY Wang, WJ McCune	12/15/2021
Delayed Kinetics of IgG, but Not IgA, Antispike Antibodies in Transplant Recipients following SARS-CoV-2 Infection. Journal of the American Society of Nephrology : JASN	P Cravedi, P Ahearn, L Wang, T Yalamarti, S Hartzell, Y Azzi, MC Menon, A Jain, M Billah, M Fernandez-Vina, HM Gebel, ES Woodle, NS Haddad, A Morrison-Porter, FE Lee, I Sanz, E Akalin, A Girnita, JS Maltzman	12/01/2021
B cell subset composition segments clinically and serologically distinct groups in chronic cutaneous lupus erythematosus. Annals of the rheumatic diseases	SA Jenks, C Wei, R Bugrovsky, A Hill, X Wang, FM Rossi, K Cashman, MC Woodruff, LD Aspey, SS Lim, G Bao, C Drenkard, I Sanz	09/01/2021
Plasma cell survival: The intrinsic drivers, migratory signals, and extrinsic regulators. Immunological reviews	DC Nguyen, M Duan, M Ali, A Ley, I Sanz, FE Lee	09/01/2021
Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa. Mucosal immunology	A Corrado, RP Ramonell, MC Woodruff, C Tipton, S Wise, J Levy, J DelGaudio, ME Kuruvilla, KR Magliocca, D Tomar, S Garimalla, CD Scharer, JM Boss, H Wu, S Gumber, C Fucile, G Gibson, A Rosenberg, I Sanz, FE Lee	09/01/2021
Analysis of Tweets Containing Information Related to Rheumatological Diseases on Twitter. International journal of environmental research and public health	A Abbasi-Perez, MA Alvarez-Mon, C Donat-Vargas, MA Ortega, J Monserrat, A Perez-Gomez, I Sanz, M Alvarez-Mon	08/28/2021
Heterofunctional Particles as Single Cell Sensors to Capture Secreted Immunoglobulins and Isolate Antigen-Specific Antibody Secreting Cells. Advanced healthcare materials	K Ramirez, S Kyu, D Nguyen, SY Han, YL Lee, J Bradley, T Randall, I Sanz, FE Lee, T Sulchek	08/01/2021
Relaxed peripheral tolerance drives broad de novo autoreactivity in severe COVID-19. medRxiv : the preprint server for health sciences	MC Woodruff, RP Ramonell, AS Saini, NS Haddad, FA Anam, ME Rudolph, R Bugrovsky, J Hom, KS Cashman, DC Nguyen, S Kyu, M Piazza, CM Tipton, SA Jenks, FE Lee, I Sanz	07/27/2021
One-Stop Serum Assay Identifies COVID-19 Disease Severity and Vaccination Responses. ImmunoHorizons	NS Haddad, DC Nguyen, ME Kuruvilla, A Morrison-Porter, F Anam, KS Cashman, RP Ramonell, S Kyu, AS Saini, M Cabrera-Mora, A Derrico, D Alter, JD Roback, M Horwath, JB O'Keefe, HM Wu, AI Wong, AW Dretler, R Gripaldo, AN Lane, H Wu, HY Chu, S Lee, M Hernandez, V Engineer, J Varghese, R Patel, A Jalal, V French, I Guysenov, CE Lane, T Mengistsu, KE Normile, O Mnzava, S Le, I Sanz, JL Daiss, FE Lee	05/17/2021
Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus. The Journal of experimental medicine	J Hartl, L Serpas, Y Wang, A Rashidfarrokhi, OA Perez, B Sally, V Sisirak, C Soni, A Khodadadi-Jamayran, A Tsirigos, I Caiello, C Bracaglia, S Volpi, GM Ghiggeri, AS Chida, I Sanz, MY Kim, HM Belmont, GJ Silverman, RM Clancy, PM Izmirly, JP Buyon, B Reizis	05/03/2021
Impact of autoimmune cytopenias on severity of childhood-onset systemic lupus erythematosus: A single-center retrospective cohort study. Lupus	EA Ogbu, S Chandrakasan, K Rouster-Stevens, LA Greenbaum, I Sanz, SE Gillespie, C Marion, K Okeson, S Prahalad	01/01/2021
Antibody Profiles According to Mild or Severe SARS-CoV-2 Infection, Atlanta, Georgia, USA, 2020. Emerging infectious diseases	WT Hu, JC Howell, T Ozturk, K Benameur, LC Bassit, R Ramonell, KS Cashman, S Pirmohammed, JD Roback, VC Marconi, I Yang, VV Mac, D Smith, I Sanz, W Wharton, FE Lee, RF Schinazi	12/01/2020
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19. Nature immunology	MC Woodruff, RP Ramonell, DC Nguyen, KS Cashman, AS Saini, NS Haddad, AM Ley, S Kyu, JC Howell, T Ozturk, S Lee, N Suryadevara, JB Case, R Bugrovsky, W Chen, J Estrada, A Morrison-Porter, A Derrico, FA Anam, M Sharma, HM Wu, SN Le, SA Jenks, CM Tipton, B Staitieh, JL Daiss, E Ghosn, MS Diamond, RH Carnahan, JE Crowe, WT Hu, FE Lee, I Sanz	12/01/2020
Methrotexate Treatment Inmunomodulates Abnormal Cytokine Expression by T CD4 Lymphocytes Present in DMARD-Naïve Rheumatoid Arthritis Patients. International journal of molecular sciences	J Monserrat Sanz, C Bohórquez, AM Gómez, A Movasat, A Pérez, L Ruíz, D Diaz, AI Sánchez, F Albarrán, I Sanz, M Álvarez-Mon	09/18/2020
GLaMST: grow lineages along minimum spanning tree for b cell receptor sequencing data. BMC genomics	X Yang, CM Tipton, MC Woodruff, E Zhou, FE Lee, I Sanz, P Qiu	09/09/2020
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein. Nature medicine	SJ Zost, P Gilchuk, RE Chen, JB Case, JX Reidy, A Trivette, RS Nargi, RE Sutton, N Suryadevara, EC Chen, E Binshtein, S Shrihari, M Ostrowski, HY Chu, JE Didier, KW MacRenaris, T Jones, S Day, L Myers, F Eun-Hyung Lee, DC Nguyen, I Sanz, DR Martinez, PW Rothlauf, LM Bloyet, SPJ Whelan, RS Baric, LB Thackray, MS Diamond, RH Carnahan, JE Crowe	09/01/2020
Dominant extrafollicular B cell responses in severe COVID-19 disease correlate with robust viral-specific antibody production but poor clinical outcomes. medRxiv : the preprint server for health sciences	M Woodruff, R Ramonell, K Cashman, D Nguyen, A Saini, N Haddad, A Ley, S Kyu, JC Howell, T Ozturk, S Lee, W Chen, J Estrada, A Morrison-Porter, A Derrico, F Anam, M Sharma, H Wu, S Le, S Jenks, CM Tipton, W Hu, FE Lee, I Sanz	06/22/2020
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein. bioRxiv : the preprint server for biology	SJ Zost, P Gilchuk, RE Chen, JB Case, JX Reidy, A Trivette, RS Nargi, RE Sutton, N Suryadevara, EC Chen, E Binshtein, S Shrihari, M Ostrowski, HY Chu, JE Didier, KW MacRenaris, T Jones, S Day, L Myers, FE Lee, DC Nguyen, I Sanz, DR Martinez, RS Baric, LB Thackray, MS Diamond, RH Carnahan, JE Crowe	05/13/2020
Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus. Immunity	SA Jenks, KS Cashman, E Zumaquero, UM Marigorta, AV Patel, X Wang, D Tomar, MC Woodruff, Z Simon, R Bugrovsky, EL Blalock, CD Scharer, CM Tipton, C Wei, SS Lim, M Petri, TB Niewold, JH Anolik, G Gibson, F Eun-Hyung Lee, JM Boss, FE Lund, I Sanz	01/14/2020
Complexity and heterogeneity - the defining features of autoimmune disease. Current opinion in immunology	I Sanz, F Lund	12/01/2019
Regulation of T and B cell responses to chronic antigenic stimulation during Infection, autoimmunity and transplantation. Immunological reviews	R Ahmed, ML Ford, I Sanz	11/01/2019
Understanding and measuring human B-cell tolerance and its breakdown in autoimmune disease. Immunological reviews	KS Cashman, SA Jenks, MC Woodruff, D Tomar, CM Tipton, CD Scharer, F Eun-Hyung Lee, JM Boss, I Sanz	11/01/2019
Clustered Mutations at the Murine and Human IgH Locus Exhibit Significant Linkage Consistent with Templated Mutagenesis. Journal of immunology (Baltimore, Md. : 1950)	GA Dale, DJ Wilkins, CD Bohannon, D Dilernia, E Hunter, T Bedford, R Antia, I Sanz, J Jacob	09/01/2019
The Abnormal CD4+T Lymphocyte Subset Distribution and Vbeta Repertoire in New-onset Rheumatoid Arthritis Can Be Modulated by Methotrexate Treament. Cells	J Monserrat, C Bohórquez, AM Gómez Lahoz, A Movasat, A Pérez, L Ruíz, D Díaz, L Chara, AI Sánchez, F Albarrán, I Sanz, M Álvarez-Mon	08/10/2019
Epigenetic programming underpins B cell dysfunction in human SLE. Nature immunology	CD Scharer, EL Blalock, T Mi, BG Barwick, SA Jenks, T Deguchi, KS Cashman, BE Neary, DG Patterson, SL Hicks, A Khosroshahi, F Eun-Hyung Lee, C Wei, I Sanz, JM Boss	08/01/2019
IFNγ induces epigenetic programming of human T-bet^hi B cells and promotes TLR7/8 and IL-21 induced differentiation. eLife	E Zumaquero, SL Stone, CD Scharer, SA Jenks, A Nellore, B Mousseau, A Rosal-Vela, D Botta, JE Bradley, W Wojciechowski, T Ptacek, MI Danila, JC Edberg, SL Bridges, RP Kimberly, WW Chatham, TR Schoeb, AF Rosenberg, JM Boss, I Sanz, FE Lund	05/15/2019
T-bet⁺ B cells: A common denominator in protective and autoreactive antibody responses? Current opinion in immunology	A Myles, I Sanz, MP Cancro	04/01/2019
Extrafollicular responses in humans and SLE. Immunological reviews	SA Jenks, KS Cashman, MC Woodruff, FE Lee, I Sanz	03/01/2019
PD-1 immunobiology in systemic lupus erythematosus. Journal of autoimmunity	CS Curran, S Gupta, I Sanz, E Sharon	02/01/2019
Author Correction: Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion. Nature communications	DC Nguyen, S Garimalla, H Xiao, S Kyu, I Albizua, J Galipeau, KY Chiang, EK Waller, R Wu, G Gibson, J Roberson, FE Lund, TD Randall, I Sanz, FE Lee	01/17/2019
Challenges and Opportunities for Consistent Classification of Human B Cell and Plasma Cell Populations. Frontiers in immunology	I Sanz, C Wei, SA Jenks, KS Cashman, C Tipton, MC Woodruff, J Hom, FE Lee	01/01/2019
Failure of B Cell Tolerance in CVID. Frontiers in immunology	CT Richardson, MA Slack, G Dhillon, CZ Marcus, J Barnard, A Palanichamy, I Sanz, RJ Looney, JH Anolik	01/01/2019
Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus. Immunity	SA Jenks, KS Cashman, E Zumaquero, UM Marigorta, AV Patel, X Wang, D Tomar, MC Woodruff, Z Simon, R Bugrovsky, EL Blalock, CD Scharer, CM Tipton, C Wei, SS Lim, M Petri, TB Niewold, JH Anolik, G Gibson, FE Lee, JM Boss, FE Lund, I Sanz	10/16/2018
Cutting Edge: Intracellular IFN-β and Distinct Type I IFN Expression Patterns in Circulating Systemic Lupus Erythematosus B Cells. Journal of immunology (Baltimore, Md. : 1950)	JA Hamilton, Q Wu, P Yang, B Luo, S Liu, J Li, A L Mattheyses, I Sanz, WW Chatham, HC Hsu, JD Mountz	10/15/2018
Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion. Nature communications	DC Nguyen, S Garimalla, H Xiao, S Kyu, I Albizua, J Galipeau, KY Chiang, EK Waller, R Wu, G Gibson, J Roberson, FE Lund, TD Randall, I Sanz, FE Lee	09/12/2018
Clinical Efficacy and Safety of Baminercept, a Lymphotoxin β Receptor Fusion Protein, in Primary Sjögren's Syndrome: Results From a Phase II Randomized, Double-Blind, Placebo-Controlled Trial. Arthritis & rheumatology (Hoboken, N.J.)	EW St Clair, AN Baer, C Wei, G Noaiseh, A Parke, A Coca, TO Utset, MC Genovese, DJ Wallace, J McNamara, K Boyle, L Keyes-Elstein, JL Browning, N Franchimont, K Smith, JM Guthridge, I Sanz, JA James	09/01/2018
The SLE-key test serological signature: new insights into the course of lupus. Rheumatology (Oxford, England)	C Putterman, DS Pisetsky, M Petri, R Caricchio, AHB Wu, I Sanz, JC Oates, S Wallace, R Sorek, R Gerwien, P Safer, K Jakobi-Brook, IR Cohen	09/01/2018
Understanding B-cell activation and autoantibody repertoire selection in systemic lupus erythematosus: A B-cell immunomics approach. Immunological reviews	CM Tipton, JR Hom, CF Fucile, AF Rosenberg, I Sanz	07/01/2018
Autoreactive monoclonal antibodies from patients with primary biliary cholangitis recognize environmental xenobiotics. Hepatology (Baltimore, Md.)	T Tanaka, W Zhang, Y Sun, Z Shuai, AS Chida, TP Kenny, GX Yang, I Sanz, A Ansari, CL Bowlus, GC Ippolito, RL Coppel, K Okazaki, XS He, PSC Leung, ME Gershwin	09/01/2017