Jennifer M. Spangle, PhD


Titles and Roles

Assistant Professor, Department of Radiation Oncology
Emory University School of Medicine
Research Program
Cell and Molecular Biology


Jennifer M. Spangle, PhD, is Assistant Professor in the Department of Radiation Oncology at Emory University School of Medicine. Prior to joining Emory, Dr. Spangle was Instructor of Pathology at Dana-Farber Cancer Institute and Harvard Medical School.


Dr. Spangle graduated with honors from the University of Arizona with a BS in Molecular and Cellular Biology. She earned her PhD in Virology from Harvard Medical School in Boston, Massachusetts. She completed her postdoctoral training at Dana-Farber Cancer Institute and Harvard Medical School in Boston, Massachusetts, where she was the American Cancer Society Lee Denim Postdoctoral Fellow.


The Spangle laboratory is committed to understanding how PI3K-mediated regulation of the epigenome contributes to cancer development and modulates treatment response. The PI3K signaling pathways is aberrantly activated in more than 40% of breast and other cancers, and yet mono- and combination therapies resulting in durable PI3K inhibition are still in development. Her research program hopes to utilize PI3K-mediated epigenetic rewiring to identify actionable targets and durable and efficacious combination therapies for the treatment of PI3K-activated cancers. The Spangle lab is specifically focusing on the mechanisms by which H3K4-directed demethylases and methyltransferases mediate resistance to PI3K inhibitors in cancer and how AKT regulates histone phosphorylation and transcriptional competence in normal tissue and how this process is deregulated in cancer.


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