Erica Werner, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-778-2193
Email Address

ewerner@emory.edu

Biography

Erica Werner, PhD, is an assistant research Pprofessor in the Department of Cell Biology at Emory University School of Medicine. Dr. Werner is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute.

Dr. Werner arrived at Emory in 2000 to work in cell adhesion, vesicular traffic and signal transduction related projects in the Department of Cell Biology. In 2011, she joined the Doetsch Lab to work on the stress response induced by DNA damage in mammalian cells. She is also involved in studies related to transcriptional mutagenesis in mammalian cells. In 2017, she joined the Yu Lab.

Education

Dr. Werner received her PhD in Cell and Molecular Biology from the Catholic University in Santiago, Chile. She pursued her postdoctoral training in the laboratory of Zena Werb, PhD at University of California, San Francisco, where she worked on integrin signaling, matrix metalloproteases and inflammation.

Titles & Roles

Assistant Research Professor, Department of Cell Biology

Emory University School of Medicine

Research

Dr. Werner's research works on the stress response and genomic instability induced by DNA damage that persist over time in radiation exposed mammalian cells. She is also involved in studies related to Sirtuin 2 regulation during the DNA Damage Response.

Publications

Title/Journal	Authors	Publication Date
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration. Molecular biology of the cell	AR Lane, NE Scher, S Bhattacharjee, SA Zlatic, AM Roberts, A Gokhale, KS Singleton, DM Duong, M McKenna, WL Liu, A Baiju, FGR Moctezuma, T Tran, AA Patel, LB Clayton, MJ Petris, LB Wood, A Patgiri, AD Vrailas-Mortimer, DN Cox, BR Roberts, E Werner, V Faundez	03/01/2025
Mitochondrially Transcribed dsRNA Mediates Manganese-induced Neuroinflammation. bioRxiv : the preprint server for biology	A Gokhale, H Mendez-Vazquez, MM Sampson, FGR Moctezuma, A Harbuzariu, A Sing, SA Zlatic, AM Roberts, M Prajapati, BR Roberts, TB Bartnikas, LB Wood, SA Sloan, V Faundez, E Werner	02/20/2025
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration. bioRxiv : the preprint server for biology	AR Lane, NE Scher, S Bhattacharjee, SA Zlatic, AM Roberts, A Gokhale, KS Singleton, DM Duong, M McKenna, WL Liu, A Baiju, FGR Moctezuma, T Tran, AA Patel, LB Clayton, MJ Petris, LB Wood, A Patgiri, AD Vrailas-Mortimer, DN Cox, BR Roberts, E Werner, V Faundez	11/18/2024
Proximity Labeling Proteomics Reveals Kv1.3 Potassium Channel Immune Interactors in Microglia. Molecular & cellular proteomics : MCP	CA Bowen, HM Nguyen, Y Lin, P Bagchi, A Natu, C Espinosa-Garcia, E Werner, R Kumari, AD Brandelli, P Kumar, BR Tobin, L Wood, V Faundez, H Wulff, NT Seyfried, S Rangaraju	08/01/2024
Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants. Human molecular genetics	SA Zlatic, E Werner, V Surapaneni, CE Lee, A Gokhale, K Singleton, D Duong, A Crocker, K Gentile, F Middleton, JM Dalloul, WL Liu, A Patgiri, D Tarquinio, R Carpenter, V Faundez	12/12/2023
Systemic Proteome Phenotypes Reveal Defective Metabolic Flexibility in Mecp2 Mutants. bioRxiv : the preprint server for biology	SA Zlatic, E Werner, V Surapaneni, CE Lee, A Gokhale, K Singleton, D Duong, A Crocker, K Gentile, F Middleton, JM Dalloul, WL Liu, A Patgiri, D Tarquinio, R Carpenter, V Faundez	09/01/2023
Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion. Science advances	RH Purcell, E Sefik, E Werner, AT King, TJ Mosley, ME Merritt-Garza, P Chopra, ZT McEachin, S Karne, N Raj, BJ Vaglio, D Sullivan, BL Firestein, K Tilahun, MI Robinette, ST Warren, Z Wen, V Faundez, SA Sloan, GJ Bassell, JG Mulle	08/18/2023
APOE expression and secretion are modulated by mitochondrial dysfunction. eLife	ME Wynne, O Ogunbona, AR Lane, A Gokhale, SA Zlatic, C Xu, Z Wen, DM Duong, S Rayaprolu, A Ivanova, EA Ortlund, EB Dammer, NT Seyfried, BR Roberts, A Crocker, V Shanbhag, M Petris, N Senoo, S Kandasamy, SM Claypool, A Barrientos, A Wingo, TS Wingo, S Rangaraju, AI Levey, E Werner, V Faundez	05/12/2023
Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus. The Journal of neuroscience : the official journal of the Society for Neuroscience	A Gokhale, CE Lee, SA Zlatic, AAH Freeman, N Shearing, C Hartwig, O Ogunbona, JL Bassell, ME Wynne, E Werner, C Xu, Z Wen, D Duong, NT Seyfried, CE Bearden, VJ Oláh, MJM Rowan, JR Glausier, DA Lewis, V Faundez	08/04/2021
EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair. Oncogene	AE Koyen, MZ Madden, D Park, EV Minten, P Kapoor-Vazirani, E Werner, NT Pfister, R Haji-Seyed-Javadi, H Zhang, J Xu, N Deng, DM Duong, TJ Pecen, Z Frazier, ZD Nagel, JB Lazaro, KW Mouw, NT Seyfried, CS Moreno, TK Owonikoko, X Deng, DS Yu	06/01/2020
Replication stress and FOXM1 drive radiation induced genomic instability and cell transformation. PloS one	Z Li, DS Yu, PW Doetsch, E Werner	01/01/2020
Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue. Scientific reports	E Werner, A Alter, Q Deng, EB Dammer, Y Wang, DS Yu, DM Duong, NT Seyfried, PW Doetsch	08/29/2019
Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience	A Gokhale, C Hartwig, AAH Freeman, JL Bassell, SA Zlatic, C Sapp Savas, T Vadlamudi, F Abudulai, TT Pham, A Crocker, E Werner, Z Wen, GM Repetto, JA Gogos, SM Claypool, JK Forsyth, CE Bearden, J Glausier, DA Lewis, NT Seyfried, JQ Kwong, V Faundez	05/01/2019
Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer. Nucleic acids research	KL Limpose, KS Trego, Z Li, SW Leung, AH Sarker, JA Shah, SS Ramalingam, EM Werner, WS Dynan, PK Cooper, AH Corbett, PW Doetsch	05/18/2018
Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees. Cell systems	SA Zlatic, A Vrailas-Mortimer, A Gokhale, LJ Carey, E Scott, R Burch, MM McCall, S Rudin-Rush, JB Davis, C Hartwig, E Werner, L Li, M Petris, V Faundez	03/28/2018
A Single Exposure to Low- or High-LET Radiation Induces Persistent Genomic Damage in Mouse Epithelial Cells In Vitro and in Lung Tissue. Radiation research	E Werner, Y Wang, PW Doetsch	10/01/2017
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination. Cell reports	W Daddacha, AE Koyen, AJ Bastien, PE Head, VR Dhere, GN Nabeta, EC Connolly, E Werner, MZ Madden, MB Daly, EV Minten, DR Whelan, AJ Schlafstein, H Zhang, R Anand, C Doronio, AE Withers, C Shepard, RK Sundaram, X Deng, WS Dynan, Y Wang, RS Bindra, P Cejka, E Rothenberg, PW Doetsch, B Kim, DS Yu	08/22/2017
The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors. eLife	HS Comstra, J McArthy, S Rudin-Rush, C Hartwig, A Gokhale, SA Zlatic, JB Blackburn, E Werner, M Petris, P D'Souza, P Panuwet, DB Barr, V Lupashin, A Vrailas-Mortimer, V Faundez	03/29/2017
Evaluating biomarkers to model cancer risk post cosmic ray exposure. Life sciences in space research	DM Sridharan, A Asaithamby, SR Blattnig, SV Costes, PW Doetsch, WS Dynan, P Hahnfeldt, L Hlatky, Y Kidane, A Kronenberg, MD Naidu, LE Peterson, I Plante, AL Ponomarev, J Saha, AM Snijders, K Srinivasan, J Tang, E Werner, JM Pluth	06/01/2016
Role of Pro-inflammatory Cytokines in Radiation-Induced Genomic Instability in Human Bronchial Epithelial Cells. Radiation research	E Werner, H Wang, PW Doetsch	12/01/2015
HPV16 E6 and E7 proteins induce a chronic oxidative stress response via NOX2 that causes genomic instability and increased susceptibility to DNA damage in head and neck cancer cells. Carcinogenesis	R Marullo, E Werner, H Zhang, GZ Chen, DM Shin, PW Doetsch	11/01/2015
Neuronal copper homeostasis susceptibility by genetic defects in dysbindin, a schizophrenia susceptibility factor. Human molecular genetics	A Gokhale, A Vrailas-Mortimer, J Larimore, HS Comstra, SA Zlatic, E Werner, DF Manvich, PM Iuvone, D Weinshenker, V Faundez	10/01/2015
Inactivation of a common OGG1 variant by TNF-alpha in mammalian cells. DNA repair	J Morreall, K Limpose, C Sheppard, YW Kow, E Werner, PW Doetsch	02/01/2015
Understanding cancer development processes after HZE-particle exposure: roles of ROS, DNA damage repair and inflammation. Radiation research	DM Sridharan, A Asaithamby, SM Bailey, SV Costes, PW Doetsch, WS Dynan, A Kronenberg, KN Rithidech, J Saha, AM Snijders, E Werner, C Wiese, FA Cucinotta, JM Pluth	01/01/2015
Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability. PloS one	E Werner, H Wang, PW Doetsch	01/01/2014
Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions. PloS one	R Marullo, E Werner, N Degtyareva, B Moore, G Altavilla, SS Ramalingam, PW Doetsch	01/01/2013
MicroRNA-21 modulates the levels of reactive oxygen species by targeting SOD3 and TNFα. Cancer research	X Zhang, WL Ng, P Wang, L Tian, E Werner, H Wang, P Doetsch, Y Wang	09/15/2012
A novel microtubule-modulating agent EM011 inhibits angiogenesis by repressing the HIF-1α axis and disrupting cell polarity and migration. Carcinogenesis	P Karna, PC Rida, RC Turaga, J Gao, M Gupta, A Fritz, E Werner, C Yates, J Zhou, R Aneja	09/01/2012
Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1. The Journal of neuroscience : the official journal of the Society for Neuroscience	A Gokhale, J Larimore, E Werner, L So, A Moreno-De-Luca, C Lese-Martin, VV Lupashin, Y Smith, V Faundez	03/14/2012
Tumor endothelial marker 8 amplifies canonical Wnt signaling in blood vessels. PloS one	K Verma, J Gu, E Werner	01/01/2011
Endosomal recycling regulates Anthrax Toxin Receptor 1/Tumor Endothelial Marker 8-dependent cell spreading. Experimental cell research	J Gu, V Faundez, E Werner	07/15/2010