Dr. Yu's specialties are treating head and neck, breast and lung cancers.
Titles and Roles
- Assistant Professor, Department of Radiation Oncology
- Emory University School of Medicine
- Research Program
- Cancer Genetics and Epigenetics
Dr. Yu is an Assistant Professor in the Department of Radiation Oncology at Emory University School of Medicine. The goal of his work is to translate insights gained from interactions with his patients and his research in the laboratory to innovative therapies to improve the quality of care for patients with cancer.
Dr. Yu is a member of the ASTRO Radiation and Cancer Biology Committee Research Council, ASTRO Research Evaluation Committee Research Council, American Society of Clinical Oncology, American Association for Cancer Research, Radiation Research Society and RSNA, among others. He is also a member of the Winship Cancer Institute Cancer Genetics and Epigenetics Progam, Emory Graduate Program in Cancer Biology and Graduate Program in Genetics and Molecular Biology.
Dr. Yu is actively engaged in both clinical and science research, including, understanding how cells respond to replication stress and how to utilize this knowledge for improvements in cancer diagnosis and treatment.
In his laboratory at Emory, Dr. Yu is examining the role of sirtuin deacetylases, and more generally the acetylome, in orchestrating the replication stress response. He is working to identify novel components of the replication stress response, which mediate sensitivity of cancer cells to DNA damaging agents, utilizing high throughput loss of function genetic screens. His lab is also focused on understanding mechanistically how novel replication stress response proteins function using cell biological, genetic, and biochemical approaches to define the functions of these proteins. He hopes to translate insights gained from mechanistic analyses to improvements in the clinic. By exploiting defects in the replication stress response, he hopes to utilize novel replication stress response proteins as biomarkers for clinical response and outcome to specific cancer treatments and as novel therapeutic targets to personalize cancer therapy.
Dr. Yu has authored many publications in high impact journals, including Nature, Cell, Molecular Cell, EMBO, and PNAS.