Titles and Roles
- Associate Professor, Department of Medicine, Division of Digestive Diseases
- Emory University School of Medicine
- Research Program
- Cancer Cell Biology
Chang-Hyon Chris Yun, PhD, is an Associate Professor in the Department of Medicine and he joined Emory University in 2002 from Johns Hopkins University.
Dr. Yun is a member of the Cancer Cell Biology Research Program at Winship Cancer Institute. He is also a member of Biochemistry, Cell and Developmental Biology (BCDB) program and Nutrition and Health Sciences (NHS) program at Emory University. He holds professional memberships with American Physiological Society and American Gastroenterology Association.
Dr. Yun earned his BA in Chemistry from Oberlin College in Oberlin, Ohio. He then received his PhD degree in Biophysics from the University of Illinois at Urbana-Champaign and went on to do postdoctoral training at Johns Hopkins in electrolyte transport.
Dr. Yun's research is in mammalian intestine, NHE3 is a component of electroneutral NaCl absorption, which is a major constituent in basal Na+ and fluid absorption and this is a frequent target of inhibition in many diarrheal diseases. Another site of NHE3 is kidney where 70% of HCO3- reabsorption can be attributed to Na+/H+ exchanger NHE3. NHE3 is regulated by hormones, growth factor, and external stimuli that target protein kinases. The first goal is understand the mechanisms of NHE3 regulation by G protein-coupled receptors and protein kinases. The second goal is to delineate how the interaction of NHE3 with accessory proteins (NHERF1, NHERF2, and IRBIT) affects the signaling targeting NHE3. We are focusing on the cellular signaling elicited by glucocorticoids, angiotensin and lysophosphatidic acid (LPA).