Chang-Hyon Chris Yun, PhD


Titles and Roles

Professor, Department of Medicine, Division of Digestive Diseases
Emory University School of Medicine
Research Program
Cell and Molecular Biology


Chang-Hyon Chris Yun, PhD, is Professor in the Department of Medicine at Emory University School of Medicine. Dr. Yun joined Emory University in 2002 from Johns Hopkins University.

Dr. Yun is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute. He is also a member of Biochemistry, Cell and Developmental Biology (BCDB) program and Nutrition and Health Sciences (NHS) program at Emory University. He holds professional memberships with American Physiological Society and American Gastroenterology Association.


Dr. Yun earned his PhD in Biophysics from University of Illinois at Urbana-Champaign, and went on to do postdoctoral training at Johns Hopkins University in electrolyte transport.


Dr. Yun's research is in mammalian intestine NHE3, a component of electroneutral NaCl absorption, which is a major constituent in basal Na+ and fluid absorption. This is a frequent target of inhibition in many diarrheal diseases. Another site of NHE3 is the kidney where 70% of HCO3- reabsorption can be attributed to Na+/H+ exchanger NHE3. NHE3 is regulated by hormones, growth factor, and external stimuli that target protein kinases. The first goal is to understand the mechanisms of NHE3 regulation by G protein-coupled receptors and protein kinases. The second goal is to delineate how the interaction of NHE3 with accessory proteins (NHERF1, NHERF2, and IRBIT) affects the signaling targeting NHE3. We are focusing on the cellular signaling elicited by glucocorticoids, angiotensin and lysophosphatidic acid (LPA).


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