Muxiang Zhou, MD

Research Program

Cell and Molecular Biology
Phone Number

404-727-1426
Email Address

mzhou@emory.edu

Biography

Muxiang Zhou, MD, is a professor in the Division of Hematology/Oncology of the Department of Pediatrics at Emory University School of Medicine. Dr. Zhou is a member of the Cell and Molecular Biology Research Program at Winship.

Education

Dr. Zhou earned his medical and doctoral degrees from Tongji Medical University. He completed postdoctoral fellowships in Pediatric Hematology/Oncology at Tongji Medical University and Emory University School of Medicine.

Titles & Roles

Professor, Department of Pediatrics, Division of Hematology and Oncology

Emory University School of Medicine

Research

Dr. Zhou's research interests focus on cell and molecular biology of childhood acute lymphoblastic leukemia.

Grants

View Grants

Grant Number	Title
1R01CA240447-01A1	Dual inhibition of MDM2 and XIAP as a therapeutic strategy in cancer
5R01CA240447-02	Dual inhibition of MDM2 and XIAP as a therapeutic strategy in cancer
5R01CA240447-03	Dual inhibition of MDM2 and XIAP as a therapeutic strategy in cancer
5R01CA240447-04	Dual inhibition of MDM2 and XIAP as a therapeutic strategy in cancer
5R01CA240447-05	Dual inhibition of MDM2 and XIAP as a therapeutic strategy in cancer

Publications

Title/Journal	Authors	Publication Date
An MDM2 degrader shows potent cytotoxicity to MDM2-overexpressing acute lymphoblastic leukemia cells with minimal toxicity to normal cells/tissues. Cancer letters	T Liu, L Gu, A Mui, Z Wu, N Albadari, W Li, M Zhou	08/28/2024
Synthesis and biological evaluation of dual MDM2/XIAP inhibitors based on the tetrahydroquinoline scaffold. European journal of medicinal chemistry	N Albadari, Y Xie, T Liu, R Wang, L Gu, M Zhou, Z Wu, W Li	07/05/2023
MYCN mRNA degradation and cancer suppression by a selective small-molecule inhibitor in MYCN-amplified neuroblastoma. Frontiers in oncology	T Liu, L Gu, Z Wu, N Albadari, W Li, M Zhou	01/01/2022
Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue. Nature communications	Y Ma, EB Dammer, D Felsky, DM Duong, HU Klein, CC White, M Zhou, BA Logsdon, C McCabe, J Xu, M Wang, TS Wingo, JJ Lah, B Zhang, J Schneider, M Allen, X Wang, N Ertekin-Taner, NT Seyfried, AI Levey, DA Bennett, PL De Jager	12/02/2021
The Genitourinary Pathology Society Update on Classification and Grading of Flat and Papillary Urothelial Neoplasia With New Reporting Recommendations and Approach to Lesions With Mixed and Early Patterns of Neoplasia. Advances in anatomic pathology	MB Amin, E Comperat, JI Epstein, LD True, D Hansel, GP Paner, H Al-Ahmadie, D Baydar, T Bivalacqua, F Brimo, L Cheng, J Cheville, G Dalbagni, S Falzarano, J Gordetsky, CC Guo, S Gupta, O Hes, G Iyer, S Kaushal, L Kunju, C Magi-Galluzzi, A Matoso, G Netto, AO Osunkoya, CC Pan, K Pivovarcikova, MR Raspollini, H Reis, J Rosenberg, M Roupret, RB Shah, S Shariat, K Trpkov, V Weyerer, M Zhou, J McKenney, VE Reuter	07/01/2021
Discovery of N-(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor. Journal of medicinal chemistry	Z Wu, L Gu, S Zhang, T Liu, PB Lukka, B Meibohm, JC Bollinger, M Zhou, W Li	02/25/2021
Upregulation of p53 through induction of MDM2 degradation: Anthraquinone analogs. Bioorganic & medicinal chemistry	AB Draganov, X Yang, A Anifowose, LKC De La Cruz, C Dai, N Ni, W Chen, Z De Los Santos, L Gu, M Zhou, B Wang	09/01/2019
Mutual regulation of MDM4 and TOP2A in cancer cell proliferation. Molecular oncology	T Liu, H Zhang, S Yi, L Gu, M Zhou	05/01/2019
Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice. Molecular cancer therapeutics	L Gu, H Zhang, T Liu, A Draganov, S Yi, B Wang, M Zhou	02/01/2018
Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment. Nature	L Dong, WM Yu, H Zheng, ML Loh, ST Bunting, M Pauly, G Huang, M Zhou, HE Broxmeyer, DT Scadden, CK Qu	11/10/2016
Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer cell	L Gu, H Zhang, T Liu, S Zhou, Y Du, J Xiong, S Yi, CK Qu, H Fu, M Zhou	10/10/2016
Targeting MYCN IRES in MYCN-amplified neuroblastoma with miR-375 inhibits tumor growth and sensitizes tumor cells to radiation. Molecular oncology	H Zhang, T Liu, S Yi, L Gu, M Zhou	08/01/2015
Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival. Molecular cancer	T Liu, H Zhang, J Xiong, S Yi, L Gu, M Zhou	03/26/2015
Inhibition of MDM2 by nilotinib contributes to cytotoxicity in both Philadelphia-positive and negative acute lymphoblastic leukemia. PloS one	H Zhang, L Gu, T Liu, KY Chiang, M Zhou	01/01/2014
Berberine represses DAXX gene transcription and induces cancer cell apoptosis. Laboratory investigation; a journal of technical methods and pathology	J Li, L Gu, H Zhang, T Liu, D Tian, M Zhou, S Zhou	03/01/2013
Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway. Molecular cancer therapeutics	M Huang, H Zhang, T Liu, D Tian, L Gu, M Zhou	02/01/2013
Methylation of RASSF1A gene promoter is regulated by p53 and DAXX. FASEB journal : official publication of the Federation of American Societies for Experimental Biology	H Zhang, J He, J Li, D Tian, L Gu, M Zhou	01/01/2013
Polysome Preparation, RNA Isolation and Analysis. Bio-protocol	H Zhang, M Zhou	10/05/2012
MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells. Oncogene	L Gu, H Zhang, J He, J Li, M Huang, M Zhou	03/15/2012
Crosstalk between MYCN and MDM2-p53 signal pathways regulates tumor cell growth and apoptosis in neuroblastoma. Cell cycle (Georgetown, Tex.)	J He, L Gu, H Zhang, M Zhou	09/01/2011
Degradation of MDM2 by the interaction between berberine and DAXX leads to potent apoptosis in MDM2-overexpressing cancer cells. Cancer research	X Zhang, L Gu, J Li, N Shah, J He, L Yang, Q Hu, M Zhou	12/01/2010
Translation of TRAF1 is regulated by IRES-dependent mechanism and stimulated by vincristine. Nucleic acids research	L Yang, L Gu, Z Li, M Zhou	07/01/2010
Cancer cell sensitivity to bortezomib is associated with survivin expression and p53 status but not cancer cell types. Journal of experimental & clinical cancer research : CR	X Ling, D Calinski, AA Chanan-Khan, M Zhou, F Li	01/22/2010
Expression of TNF-alpha leader sequence renders MCF-7 tumor cells resistant to the cytotoxicity of soluble TNF-alpha. Breast cancer research and treatment	D Yan, N Qin, H Zhang, T Liu, M Yu, X Jiang, W Feng, J Wang, B Yin, T Zhang, M Zhou, Z Li	07/01/2009
Regulation of XIAP translation and induction by MDM2 following irradiation. Cancer cell	L Gu, N Zhu, H Zhang, DL Durden, Y Feng, M Zhou	05/05/2009
Glycogen synthase kinase 3beta induces apoptosis in cancer cells through increase of survivin nuclear localization. Cancer letters	J Li, M Xing, M Zhu, X Wang, M Wang, S Zhou, N Li, R Wu, M Zhou	12/08/2008
Transmembrane TNF-alpha mediates "forward" and "reverse" signaling, inducing cell death or survival via the NF-kappaB pathway in Raji Burkitt lymphoma cells. Journal of leukocyte biology	H Zhang, D Yan, X Shi, H Liang, Y Pang, N Qin, H Chen, J Wang, B Yin, X Jiang, W Feng, W Zhang, M Zhou, Z Li	09/01/2008
Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells. Molecular cancer therapeutics	N Zhu, L Gu, F Li, M Zhou	05/01/2008
MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2. Leukemia	L Gu, N Zhu, HW Findley, M Zhou	04/01/2008
Tissue factor/FVIIa activates Bcl-2 and prevents doxorubicin-induced apoptosis in neuroblastoma cells. BMC cancer	J Fang, L Gu, N Zhu, H Tang, CS Alvarado, M Zhou	03/06/2008
Down-regulation of tissue factor by siRNA increased doxorubicin-induced apoptosis in human neuroblastoma. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban	J Fang, H Tang, L Xia, M Zhou, Y Chen, W Wei, Y Hu, S Song, M Hong	02/01/2008