Please Join Emory’s Center for Comprehensive Informatics & Department of Biomedical Informatics and Winship Cancer Institute for this Special Presentation
Speaker: Michael Krauthammer, MD, PhD
Associate Professor of Pathology
Yale University School of Medicine
11:00 AM -12:00 PM
C5012, 5th Floor Conference Room
Winship Cancer Institute of Emory University
This talk will discuss results from a large-scale exome sequencing screen of 147 melanoma patients at Yale University. The screen was instrumental in the discovery of a frequent activating mutation in RAC1 P29S, the most commonly found recurrent mutation in a Rho family GTPase, and significant mutations in PPP6C, a serine/threonine phosphatase, which were exclusively found in BRAF and NRAS mutant melanomas. The talk will also describe a “third generation” algorithm for assessing gene mutation burden that was specifically designed for identifying melanoma driver genes on a background of UV-induced passenger mutations.
About the Speaker:
Dr. Krauthammer holds the position of Associate Professor in Pathology at the Yale University School of Medicine. After board certification as general practitioner in Switzerland, he obtained a Ph.D. in biomedical informatics at Columbia University in New York and joined the Yale Pathology Informatics program in July 2004. His main research interests include the design of large-scale text and image mining systems and research in translational informatics, specifically as it relates to analysis of high-throughput sequencing data. His work is mainly supported by grants from the National Library of Medicine (R01 on text and image mining, PI), and the National Cancer Institute (Yale SPORE in skin cancer, bioinformatics/biostatistics Core co-director, project co-PI).