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Improved survival for slow-growing brain tumor


02.03.2014

Adding chemotherapy following radiation treatment improves survival for adults with a slow-growing type of brain tumor

Adults with low-grade gliomas, a type of brain tumor, who received a chemotherapy regimen following radiation therapy, lived longer than patients who received radiation therapy alone, according to long-term follow-up results from a National Cancer Institute-supported randomized controlled clinical trial.

“This trial has the capacity to transform our approach to patients with low-grade gliomas,” said Walter J. Curran, Jr., MD, co-senior author of the trial and executive director of the Winship Cancer Institute of Emory University. “It is remarkable that the experimental arm extended the median survival time of these patients by over 5 years.”

Curran is also chair of the Radiation Therapy Oncology Group (RTOG), the clinical trials organization funded by the National Cancer Institute (NCI) which conducted this trial. RTOG and NCI are making the results of this trial public today because a long-term follow-up analysis showed significantly longer survival for those people on the trial who received chemotherapy. 

Since all three chemotherapy drugs in the regimen are commercially available, the treatment used in the clinical trial is available for use now. However, this form of chemotherapy is associated with some toxicities, such as reduced white blood cell counts leading to increased infection risk, and trial investigators recommend that it should be utilized only by physicians experienced with managing the side-effects that may occur. 

Low-grade gliomas grow more slowly and have a better outcome than the more common type of primary brain tumor in adults, which is classified as glioblastoma.

The study, RTOG 9802, enrolled 251 patients with low-grade gliomas between October 1998 and June 2002 to address the role of chemotherapy following radiation treatment. Patients enrolled were at higher risk compared to other low-grade glioma patients because they were 40 years of age or older or had a less than complete surgical removal of their tumor if they were under 40 years of age. 

All patients started treatment with surgery followed by radiation therapy. By random assignment, half of patients stopped treatment after radiation therapy and the other half received six cycles of chemotherapy after completing radiation therapy. Patients receiving chemotherapy got three drugs: procarbazine (P); CCNU (C), which generically is known as lomustine; and vincristine (V). This chemotherapy, termed PCV, was given over 21 days and repeated every eight weeks for a total of six cycles.

A significant improvement in overall survival was noted for study participants who received PCV chemotherapy plus radiation therapy (13. 3 years median survival time) compared to those receiving radiation therapy alone (7.8 years median survival time), which is a difference of 5.5 years. Median follow-up time after initial enrollment has been almost 12 years. 

Analysis of how patients are doing based upon the molecular and genetic characteristics of their tumors is ongoing. These studies will be important since molecular characteristics of related brain tumors have been able to identify patients most likely to benefit from chemotherapy.

“The results of this study are practice-changing,” said co-lead investigator Jan Buckner, MD, professor of oncology, Mayo Clinic, Rochester, Minn. “Additionally, ongoing analysis of patient tumor samples should allow us to further identify the patients who will, and who will not, benefit from chemotherapy, taking yet another step toward individualized therapy.” 

Edward Shaw, MD, co-lead investigator and radiation oncologist at Wake Forest School of Medicine, Winston-Salem, NC, noted, “Patients who are deemed appropriate candidates for radiation therapy should be encouraged to receive chemotherapy as well, understanding both the potential benefits and risks.”

RTOG 9802 was sponsored by NCI and was designed and conducted by RTOG in collaboration with three other NCI cooperative groups (SWOG, ECOG-ACRIN, and the Alliance for Clinical Trials in Oncology). RTOG will work as a component of a new network group, NRG Oncology, effective March 2014.

It is estimated that over 23,000 people will be diagnosed with primary brain tumors in the United States in 2014 and that 10 percent to 15 percent will have low-grade gliomas.

Reference: RTOG 9802: A Phase II Study of Observation in Favorable Low-Grade Glioma and A Phase III Study of Radiation with or without PCV Chemotherapy in Unfavorable Low-Grade Glioma. A description of the clinical trial can be found at http://www.clinicaltrials.gov/ct2/show/NCT00003375.
 

Winship Media Contact: Catherine Williams; Catherine.s.williams@emory.edu; 404-778-5848.



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