Robert Craig Castellino, MD
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![Robert Craig Castellino, MD](_images/castellino-r-headshot.png)
Robert Craig Castellino, MD, is an associate professor in the Department of Pediatrics at Emory University School of Medicine. He is a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute.
Education
Dr. Castellino received his medical degree from Duke University, Durham, North Carolina. He completed his residency in pediatrics at Harvard Medical School and Massachusetts General Hospital in Boston, Massachussetts. He completed his fellowship in pediatric hematology and oncology at Texas Children's Cancer Center at Baylor College of Medicine in Houston.
Dr. Castellino is a member of the American Association for Cancer Research.
Dr. Castellino's research focuses on PPM1D-mediated signaling pathways that divert normal brain development toward growth and dissemination of medulloblastoma or DIPG. His team uses in vitro assays, mouse models, and patient-derived tissues to understand signaling in growth, treatment resistance, and response to novel PPM1D-targeted therapies to improve survival and outcome in children.
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Title/Journal | Authors | Publication Date |
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Indoximod-based chemo-immunotherapy for pediatric brain tumors: A first-in-children phase I trial. Neuro-oncology |
TS Johnson, TJ MacDonald, R Pacholczyk, D Aguilera, A Al-Basheer, M Bajaj, P Bandopadhayay, Z Berrong, E Bouffet, RC Castellino, K Dorris, BR Eaton, N Esiashvili, JR Fangusaro, N Foreman, D Fridlyand, C Giller, IM Heger, C Huang, N Kadom, EP Kennedy, N Manoharan, W Martin, C McDonough, RS Parker, V Ramaswamy, E Ring, A Rojiani, RF Sadek, S Satpathy, M Schniederjan, A Smith, C Smith, BE Thomas, R Vaizer, KK Yeo, MK Bhasin, DH Munn | 02/02/2024 |
Clinical cancer research : an official journal of the American Association for Cancer Research |
KJ Cohen, V Munjapara, D Aguilera, RC Castellino, SL Stapleton, D Landi, DM Ashley, FJ Rodriguez, C Hawkins, E Yang, W London, S Chi, P Bandopadhayay | 12/15/2023 |
JCO precision oncology |
RJ Summers, SM Castellino, CC Porter, TJ MacDonald, GD Basu, S Szelinger, MK Bhasin, T Cash, AB Carter, RC Castellino, JR Fangusaro, SG Mitchell, MG Pauly, B Pencheva, DS Wechsler, DK Graham, KC Goldsmith | 04/01/2022 |
Neuro-oncology advances |
CM Rota, AT Brown, E Addleson, C Ives, E Trumper, K Pelton, WP Teh, MJ Schniederjan, RC Castellino, S Buhrlage, DA Lauffenburger, KL Ligon, LG Griffith, RA Segal | 01/01/2022 |
Ten-eleven translocation protein 1 modulates medulloblastoma progression. Genome biology |
H Kim, Y Kang, Y Li, L Chen, L Lin, ND Johnson, D Zhu, MH Robinson, L McSwain, BG Barwick, X Yuan, X Liao, J Zhao, Z Zhang, Q Shu, J Chen, EG Allen, AM Kenney, RC Castellino, EG Van Meir, KN Conneely, PM Vertino, P Jin, J Li | 04/29/2021 |
Biochemical pharmacology |
R Nahta, RC Castellino | 02/01/2021 |
Oncotarget |
BF Peake, SM Eze, L Yang, RC Castellino, R Nahta | 11/03/2020 |
Neuro-oncology |
MP Akamandisa, K Nie, R Nahta, D Hambardzumyan, RC Castellino | 06/10/2019 |
AJNR. American journal of neuroradiology |
CD Spyris, RC Castellino, MJ Schniederjan, N Kadom | 02/01/2019 |
Atoh1/MATH1 Adds Up to Ciliogenesis for Transducing SHH Signaling in the Cerebellum. Developmental cell |
RC Castellino, AM Kenney | 01/28/2019 |
Clinical responses of patients with diffuse leptomeningeal glioneuronal tumors to chemotherapy. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery |
D Aguilera, RC Castellino, A Janss, M Schniederjan, R McNall, T MacDonald, C Mazewski | 02/01/2018 |
Oncotarget |
BF Peake, SM Eze, L Yang, RC Castellino, R Nahta | 11/07/2017 |
Oncogene |
J Wen, J Lee, A Malhotra, R Nahta, AR Arnold, MC Buss, BD Brown, C Maier, AM Kenney, M Remke, V Ramaswamy, MD Taylor, RC Castellino | 10/20/2016 |
Successful Retreatment of a Child with a Refractory Brainstem Ganglioglioma with Vemurafenib. Pediatric blood & cancer |
D Aguilera, A Janss, C Mazewski, RC Castellino, M Schniederjan, L Hayes, B Brahma, L Fogelgren, TJ MacDonald | 03/01/2016 |
PPM1D/WIP1 in medulloblastoma. Oncoscience |
MP Akamandisa, R Nahta, RC Castellino | 01/01/2016 |
Carcinogenesis |
WH Goodson, L Lowe, DO Carpenter, M Gilbertson, A Manaf Ali, A Lopez de Cerain Salsamendi, A Lasfar, A Carnero, A Azqueta, A Amedei, AK Charles, AR Collins, A Ward, AC Salzberg, A Colacci, AK Olsen, A Berg, BJ Barclay, BP Zhou, C Blanco-Aparicio, CJ Baglole, C Dong, C Mondello, CW Hsu, CC Naus, C Yedjou, CS Curran, DW Laird, DC Koch, DJ Carlin, DW Felsher, D Roy, DG Brown, E Ratovitski, EP Ryan, E Corsini, E Rojas, EY Moon, E Laconi, F Marongiu, F Al-Mulla, F Chiaradonna, F Darroudi, FL Martin, FJ Van Schooten, GS Goldberg, G Wagemaker, GN Nangami, GM Calaf, G Williams, GT Wolf, G Koppen, G Brunborg, HK Lyerly, H Krishnan, H Ab Hamid, H Yasaei, H Sone, H Kondoh, HK Salem, HY Hsu, HH Park, I Koturbash, IR Miousse, AI Scovassi, JE Klaunig, J Vondráček, J Raju, J Roman, JP Wise, JR Whitfield, J Woodrick, JA Christopher, J Ochieng, JF Martinez-Leal, J Weisz, J Kravchenko, J Sun, KR Prudhomme, KB Narayanan, KA Cohen-Solal, K Moorwood, L Gonzalez, L Soucek, L Jian, LS D'Abronzo, LT Lin, L Li, L Gulliver, LJ McCawley, L Memeo, L Vermeulen, L Leyns, L Zhang, M Valverde, M Khatami, MF Romano, M Chapellier, MA Williams, M Wade, MH Manjili, ME Lleonart, M Xia, MJ Gonzalez, MV Karamouzis, M Kirsch-Volders, M Vaccari, NB Kuemmerle, N Singh, N Cruickshanks, N Kleinstreuer, N van Larebeke, N Ahmed, O Ogunkua, PK Krishnakumar, P Vadgama, PA Marignani, PM Ghosh, P Ostrosky-Wegman, PA Thompson, P Dent, P Heneberg, P Darbre, P Sing Leung, P Nangia-Makker, QS Cheng, RB Robey, R Al-Temaimi, R Roy, R Andrade-Vieira, RK Sinha, R Mehta, R Vento, R Di Fiore, R Ponce-Cusi, R Dornetshuber-Fleiss, R Nahta, RC Castellino, R Palorini, R Abd Hamid, SA Langie, SE Eltom, SA Brooks, S Ryeom, SS Wise, SN Bay, SA Harris, S Papagerakis, S Romano, S Pavanello, S Eriksson, S Forte, SC Casey, S Luanpitpong, TJ Lee, T Otsuki, T Chen, T Massfelder, T Sanderson, T Guarnieri, T Hultman, V Dormoy, V Odero-Marah, V Sabbisetti, V Maguer-Satta, WK Rathmell, W Engström, WK Decker, WH Bisson, Y Rojanasakul, Y Luqmani, Z Chen, Z Hu | 06/01/2015 |
Carcinogenesis |
R Nahta, F Al-Mulla, R Al-Temaimi, A Amedei, R Andrade-Vieira, SN Bay, DG Brown, GM Calaf, RC Castellino, KA Cohen-Solal, A Colacci, N Cruickshanks, P Dent, R Di Fiore, S Forte, GS Goldberg, RA Hamid, H Krishnan, DW Laird, A Lasfar, PA Marignani, L Memeo, C Mondello, CC Naus, R Ponce-Cusi, J Raju, D Roy, R Roy, EP Ryan, HK Salem, AI Scovassi, N Singh, M Vaccari, R Vento, J Vondráček, M Wade, J Woodrick, WH Bisson | 06/01/2015 |
The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants. Oncogene |
MC Buss, M Remke, J Lee, K Gandhi, MJ Schniederjan, M Kool, PA Northcott, SM Pfister, MD Taylor, RC Castellino | 02/26/2015 |
Molecular pharmacology |
E Sanabria-Figueroa, SM Donnelly, KC Foy, MC Buss, RC Castellino, E Paplomata, L Taliaferro-Smith, PT Kaumaya, R Nahta | 02/01/2015 |
Response of subependymal giant cell astrocytoma with spinal cord metastasis to everolimus. Journal of pediatric hematology/oncology |
D Aguilera, R Flamini, C Mazewski, M Schniederjan, L Hayes, W Boydston, RC Castellino, TJ MacDonald | 10/01/2014 |
The rationale for targeted therapies in medulloblastoma. Neuro-oncology |
TJ MacDonald, D Aguilera, RC Castellino | 01/01/2014 |
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery |
D Aguilera, C Mazewski, J Fangusaro, TJ MacDonald, RY McNall-Knapp, LL Hayes, S Kim, RC Castellino | 04/01/2013 |
MEK inhibition increases lapatinib sensitivity via modulation of FOXM1. Current medicinal chemistry |
SS Gayle, RC Castellino, MC Buss, R Nahta | 01/01/2013 |
HDM2 promotes WIP1-mediated medulloblastoma growth. Neuro-oncology |
MC Buss, TA Read, MJ Schniederjan, K Gandhi, RC Castellino | 04/01/2012 |
A MCP1 fusokine with CCR2-specific tumoricidal activity. Molecular cancer |
M Rafei, J Deng, MN Boivin, P Williams, SM Matulis, S Yuan, E Birman, K Forner, L Yuan, C Castellino, LH Boise, TJ MacDonald, J Galipeau | 09/24/2011 |
Journal of neuro-oncology |
TJ Abouantoun, RC Castellino, TJ MacDonald | 01/01/2011 |
Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma. PloS one |
RC Castellino, BG Barwick, M Schniederjan, MC Buss, O Becher, D Hambardzumyan, TJ Macdonald, DJ Brat, DL Durden | 05/26/2010 |
PI-3 kinase-PTEN signaling node: an intercept point for the control of angiogenesis. Current pharmaceutical design |
RC Castellino, CR Muh, DL Durden | 01/01/2009 |
Dr. Castellino has been the recipient of numerous awards. He was named a Duke Futures Scholar and received a North Carolina Scholars Scholarship, General Motors Full-Tuition Scholarship, Hillory M. Wilder Endowed Scholarship, and Medical School Faculty Wives Club Endowed Scholarship. He completed the Charles Stark Draper Fellowship in Aeronautics at M.I.T. in 1993 and the Medical Student Summer Fellowship at Duke University in 1998.
Dr. Castellino is or has been the recipient of the NIH T32 Pediatric Training Award, the Stephanie Kramer/American Brain Tumor Association Translational Brain Tumor Research Grant, the NIH Molecular Medicine Scholar Award, Alex's Lemonade Stand Foundation Young Investigator Award, the Bear Necessities Pediatric Cancer Foundation, Junior Investigator Award, the AACR-Aflac, Inc. Career Development Award for Pediatric Cancer Research, the CURE Childhood Cancer Foundation Research Award, the St. Baldrick's Foundation Career Development (Scholar) Award, the Emory Egleston Children's Research Center Seed Grant, Winship Cancer Institute Molecular Pathways and Biomarkers Program Seed Grant, Southeastern Brain Tumor Foundation Research Grant, the Scholar Award-Competitive Extension from St. Baldrick's Foundation, the Pediatric Research Center for Neuroscience Pilot Grant and the Alex's Lemonade Stand Foundation Springboard Grant.
Dr. Castellino was also featured on CNN Health Update as a St. Baldrick's Foundation Scholar in 2009 and received an NIH/NCI R01 for Mechanisms of PPM1D in medulloblastoma tumorigenesis and invasion at Emory University for 2013-2018.