Edward Mocarski, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-727-9442
Email Address

mocarski@emory.edu

Biography

Edward S. Mocarski, Jr., PhD, is professor emeritus in the Department of Microbiology and Immunology of Emory University School of Medicine. Prior to joining Emory, Dr. Mocarski was a Professor of Microbiology and Immunology and Associate Dean of Research at Stanford University. Dr. Mocarski is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute of Emory University.

Education

Dr. Mocarski obtained his PhD in Microbiology from the University of Iowa. He then completed a postdoctoral fellowship in Virology at The University of Chicago.

Titles & Roles

Professor Emeritus, Department of Microbiology and Immunology

Emory University School of Medicine

Research

Dr. Mocarski’s research over the past decade has focused on the infected cell response to infection, mainly the contribution of regulated cell death pathways to host defense.

Grants

View Grants

Grant Number	Title
2T32GM095442-11	Critical Care Training Program

Publications

Title/Journal	Authors	Publication Date
Perspective on the 65-Year Anniversary of the Discovery of Cytomegalovirus. Viruses	ES Mocarski	01/09/2025
Cytomegalovirus Biology Viewed Through a Cell Death Suppression Lens. Viruses	ES Mocarski	11/23/2024
The host-directed therapeutic imatinib mesylate accelerates immune responses to Mycobacterium marinum infection and limits pathology associated with granulomas. PLoS pathogens	TL Cleverley, S Peddineni, J Guarner, F Cingolani, PK Garcia, H Koehler, ES Mocarski, D Kalman	05/01/2023
A microbiota and dietary metabolite integrates DNA repair and cell death to regulate embryo viability and aneuploidy during aging. Science advances	R Sonowal, AI Swimm, F Cingolani, N Parulekar, TL Cleverley, A Sahoo, A Ranawade, D Chaudhuri, ES Mocarski, H Koehler, K Nitsche, S Mesiano, D Kalman	02/24/2023
p38MAPK guards the integrity of endosomal compartments through regulating necrotic death. Scientific reports	J Yao, S Atasheva, R Toy, EL Blanchard, PJ Santangelo, K Roy, ES Mocarski, DM Shayakhmetov	09/29/2022
Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis. Cell host & microbe	H Koehler, S Cotsmire, T Zhang, S Balachandran, JW Upton, J Langland, D Kalman, BL Jacobs, ES Mocarski	08/11/2021
Remarkably Robust Antiviral Immune Response despite Combined Deficiency in Caspase-8 and RIPK3. Journal of immunology (Baltimore, Md. : 1950)	Y Feng, D Livingston-Rosanoff, L Roback, A Sundararajan, SH Speck, ES Mocarski, LP Daley-Bauer	10/15/2018
Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock. Immunity	P Mandal, Y Feng, JD Lyons, SB Berger, S Otani, A DeLaney, GK Tharp, K Maner-Smith, EM Burd, M Schaeffer, S Hoffman, C Capriotti, L Roback, CB Young, Z Liang, EA Ortlund, NC DiPaolo, S Bosinger, J Bertin, PJ Gough, IE Brodsky, CM Coopersmith, DM Shayakhmetov, ES Mocarski	07/17/2018
RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus. Cell host & microbe	S Nogusa, RJ Thapa, CP Dillon, S Liedmann, TH Oguin, JP Ingram, DA Rodriguez, R Kosoff, S Sharma, O Sturm, K Verbist, PJ Gough, J Bertin, BM Hartmann, SC Sealfon, WJ Kaiser, ES Mocarski, CB López, PG Thomas, A Oberst, DR Green, S Balachandran	07/13/2016
T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis. Nature immunology	BN Martin, C Wang, CJ Zhang, Z Kang, MF Gulen, JA Zepp, J Zhao, G Bian, JS Do, B Min, PG Pavicic, C El-Sanadi, PL Fox, A Akitsu, Y Iwakura, A Sarkar, MD Wewers, WJ Kaiser, ES Mocarski, ME Rothenberg, AG Hise, GR Dubyak, RM Ransohoff, X Li	05/01/2016
Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling. The Journal of biological chemistry	C Antonopoulos, HM Russo, C El Sanadi, BN Martin, X Li, WJ Kaiser, ES Mocarski, GR Dubyak	08/14/2015
Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nature communications	S Kang, T Fernandes-Alnemri, C Rogers, L Mayes, Y Wang, C Dillon, L Roback, W Kaiser, A Oberst, J Sagara, KA Fitzgerald, DR Green, J Zhang, ES Mocarski, ES Alnemri	06/24/2015
Manipulation of apoptosis and necroptosis signaling by herpesviruses. Medical microbiology and immunology	H Guo, WJ Kaiser, ES Mocarski	06/01/2015
Stanley Plotkin: the bright spark of cytomegalovirus vaccines. Medical microbiology and immunology	ES Mocarski	06/01/2015
Necroptosis: The Trojan horse in cell autonomous antiviral host defense. Virology	ES Mocarski, H Guo, WJ Kaiser	05/01/2015
The immunological underpinnings of vaccinations to prevent cytomegalovirus disease. Cellular & molecular immunology	AL McCormick, ES Mocarski	03/01/2015
The A, B, Cs of herpesvirus capsids. Viruses	R Tandon, ES Mocarski, JF Conway	02/26/2015
Herpes simplex virus suppresses necroptosis in human cells. Cell host & microbe	H Guo, S Omoto, PA Harris, JN Finger, J Bertin, PJ Gough, WJ Kaiser, ES Mocarski	02/11/2015
MicroRNA miR-21 attenuates human cytomegalovirus replication in neural cells by targeting Cdc25a. Journal of virology	YR Fu, XJ Liu, XJ Li, ZZ Shen, B Yang, CC Wu, JF Li, LF Miao, HQ Ye, GH Qiao, S Rayner, S Chavanas, C Davrinche, WJ Britt, Q Tang, M McVoy, E Mocarski, MH Luo	01/15/2015
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice. eLife	JA Rickard, H Anderton, N Etemadi, U Nachbur, M Darding, N Peltzer, N Lalaoui, KE Lawlor, H Vanyai, C Hall, A Bankovacki, L Gangoda, WW Wong, J Corbin, C Huang, ES Mocarski, JM Murphy, WS Alexander, AK Voss, DL Vaux, WJ Kaiser, H Walczak, J Silke	12/02/2014
RIP3 induces apoptosis independent of pronecrotic kinase activity. Molecular cell	P Mandal, SB Berger, S Pillay, K Moriwaki, C Huang, H Guo, JD Lich, J Finger, V Kasparcova, B Votta, M Ouellette, BW King, D Wisnoski, AS Lakdawala, MP DeMartino, LN Casillas, PA Haile, CA Sehon, RW Marquis, J Upton, LP Daley-Bauer, L Roback, N Ramia, CM Dovey, JE Carette, FK Chan, J Bertin, PJ Gough, ES Mocarski, WJ Kaiser	11/20/2014
Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans. Journal of immunology (Baltimore, Md. : 1950)	S Ganesan, VAK Rathinam, L Bossaller, K Army, WJ Kaiser, ES Mocarski, CP Dillon, DR Green, TN Mayadas, SM Levitz, AG Hise, N Silverman, KA Fitzgerald	09/01/2014
Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice. Journal of immunology (Baltimore, Md. : 1950)	SB Berger, V Kasparcova, S Hoffman, B Swift, L Dare, M Schaeffer, C Capriotti, M Cook, J Finger, A Hughes-Earle, PA Harris, WJ Kaiser, ES Mocarski, J Bertin, PJ Gough	06/15/2014
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition. Proceedings of the National Academy of Sciences of the United States of America	WJ Kaiser, LP Daley-Bauer, RJ Thapa, P Mandal, SB Berger, C Huang, A Sundararajan, H Guo, L Roback, SH Speck, J Bertin, PJ Gough, S Balachandran, ES Mocarski	05/27/2014
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proceedings of the National Academy of Sciences of the United States of America	D Weng, R Marty-Roix, S Ganesan, MK Proulx, GI Vladimer, WJ Kaiser, ES Mocarski, K Pouliot, FK Chan, MA Kelliher, PA Harris, J Bertin, PJ Gough, DM Shayakhmetov, JD Goguen, KA Fitzgerald, N Silverman, E Lien	05/20/2014
Cytomegalovirus hijacks CX3CR1(hi) patrolling monocytes as immune-privileged vehicles for dissemination in mice. Cell host & microbe	LP Daley-Bauer, LJ Roback, GM Wynn, ES Mocarski	03/12/2014
True grit: programmed necrosis in antiviral host defense, inflammation, and immunogenicity. Journal of immunology (Baltimore, Md. : 1950)	ES Mocarski, WJ Kaiser, D Livingston-Rosanoff, JW Upton, LP Daley-Bauer	03/01/2014
Transcription of true late (γ2) cytomegalovirus genes requires UL92 function that is conserved among beta- and gammaherpesviruses. Journal of virology	S Omoto, ES Mocarski	01/01/2014
Priorities for CMV vaccine development. Vaccine	PR Krause, SR Bialek, SB Boppana, PD Griffiths, CA Laughlin, P Ljungman, ES Mocarski, RF Pass, JS Read, MR Schleiss, SA Plotkin	12/17/2013
Apaf1 apoptotic function critically limits Sonic hedgehog signaling during craniofacial development. Cell death and differentiation	AB Long, WJ Kaiser, ES Mocarski, T Caspary	11/01/2013
Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. The Journal of biological chemistry	WJ Kaiser, H Sridharan, C Huang, P Mandal, JW Upton, PJ Gough, CA Sehon, RW Marquis, J Bertin, ES Mocarski	10/25/2013
Cytomegalovirus UL91 is essential for transcription of viral true late (γ2) genes. Journal of virology	S Omoto, ES Mocarski	08/01/2013
Viral modulation of programmed necrosis. Current opinion in virology	WJ Kaiser, JW Upton, ES Mocarski	06/01/2013
Gene products of the embedded m41/m41.1 locus of murine cytomegalovirus differentially influence replication and pathogenesis. Virology	LN Crosby, AL McCormick, ES Mocarski	02/20/2013
Multiplicity-dependent activation of a serine protease-dependent cytomegalovirus-associated programmed cell death pathway. Virology	AL McCormick, L Roback, G Wynn, ES Mocarski	01/20/2013
Antiviral T cell response triggers cytomegalovirus hepatitis in mice. Journal of virology	D Livingston-Rosanoff, LP Daley-Bauer, A Garcia, AL McCormick, J Huang, ES Mocarski	12/01/2012
Viral and host control of cytomegalovirus maturation. Trends in microbiology	R Tandon, ES Mocarski	08/01/2012
Cytomegalovirus impairs antiviral CD8+ T cell immunity by recruiting inflammatory monocytes. Immunity	LP Daley-Bauer, GM Wynn, ES Mocarski	07/27/2012
DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell host & microbe	JW Upton, WJ Kaiser, ES Mocarski	03/15/2012
Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways. Nature reviews. Immunology	ES Mocarski, JW Upton, WJ Kaiser	12/23/2011
Cytomegalovirus UL103 controls virion and dense body egress. Journal of virology	J Ahlqvist, E Mocarski	05/01/2011
RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature	WJ Kaiser, JW Upton, AB Long, D Livingston-Rosanoff, LP Daley-Bauer, R Hakem, T Caspary, ES Mocarski	03/17/2011
Virus inhibition of RIP3-dependent necrosis. Cell host & microbe	JW Upton, WJ Kaiser, ES Mocarski	04/22/2010
Human cytomegalovirus exploits ESCRT machinery in the process of virion maturation. Journal of virology	R Tandon, DP AuCoin, ES Mocarski	10/01/2009
The spleen plays a central role in primary humoral alloimmunization to transfused mHEL red blood cells. Transfusion	JE Hendrickson, N Saakadze, CM Cadwell, JW Upton, ES Mocarski, CD Hillyer, JC Zimring	08/01/2009
Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors. Journal of immunology (Baltimore, Md. : 1950)	WJ Kaiser, JW Upton, ES Mocarski	11/01/2008
Control of cytoplasmic maturation events by cytomegalovirus tegument protein pp150. Journal of virology	R Tandon, ES Mocarski	10/01/2008
Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1. The Journal of biological chemistry	JW Upton, WJ Kaiser, ES Mocarski	06/20/2008
HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA). PLoS pathogens	AL McCormick, L Roback, ES Mocarski	05/09/2008