Cancer Cell Biology

The Cancer Cell Biology research program at Winship Cancer Institute of Emory University studies the changes in biological function of human cells as a result of cell transformation.

The program focuses on inter- and intra-cellular signaling modulated by the tumor microenvironment, and its ramifications for the development of prevention, prediction, biomarker and therapeutic target discovery and drug development. It is a program centered on cancer biology, with broad-based applications to many forms of solid and liquid tumors.

The primary themes of the Cancer Cell Biology program are (1) cell metabolism and survival, (2) tumor-stromal interactions and (3) oncoengineering. The themes reflect a major emphasis on translating novel basic science investigations to clinical applications. The program discovers novel intra-tumoral signaling pathway components, deciphers cross-talk between the tumor and stromal cells, evaluates their impact on cancer cell behavior, and identifies potential new targets and biomarkers that can be exploited for tumor detection through imaging. Discoveries are prioritized for further development as novel clinically validated biomarkers, therapeutic agents or clinical imaging modalities in conjunction with the other cancer center programs.

Led by Jing Chen, PhD the Cancer Cell Biology program includes seventy-eight members from thirty academic departments from the Emory University School of Medicine.

The overall goal of the Cancer Cell Biology program is to understand the cancer signalosome and how it directs the abnormal cell biology that leads to cancer formation.

The program expands on our knowledge of existing cancer signaling pathways and identifies new signaling pathways. Critical nodes and junction points contained in these signaling pathways can lead to the development of novel targets, targeting agents, biomarkers and imaging modalities for cancer prevention, detection, diagnosis and follow-up.

The objectives of the Cancer Cell Biology program are:

  • To understand the mechanism by which cancer cells escape physiological signals leading to cell death and to understand the vulnerabilities of cancer cells to death induction by therapeutic agents.
  • To decipher the metabolic and signaling mechanism underlying pathogenic links between nutrition and cancer, and identify tumor cell-specific metabolic “rewiring” that cannot be found in normal cells as novel anti-cancer targets.
  • To identify key mediators of tumor-stromal interactions that permit primary tumor growth and metastasis at distant sites.
  • To decipher cross-talk between tumors cells and stromal cells.
  • To discover novel tumoral signaling pathway components that impact tumor adhesion, communication, invasion and metastasis.
  • To use engineering tools to quantitatively measure tumor cell properties including cell-cell and cell-matrix interactions, receptor-ligand forces and cancer cell-immune cell activation.
  • To translate basic science discoveries to reduce the burden of cancer in the clinic.

Cancer Cell Biology program members continuously publish high-quality research in premier scientific journals.

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PublicationsPublication Date

To learn more about the Cancer Cell Biology research program at Winship Cancer Institute, please contact Jing Chen, PhD at (404) 778-5274

Visit the Emory University's Cancer Biology Graduate Program website to learn about outstanding training opportunities in every aspect of cancer research, from basic to translational.

Photo of  Jing  Chen, PhD
Jing Chen, PhD

Jing Chen, PhD

Interim Leader, Cancer Cell Biology Research Program
Winship Cancer Institute of Emory University

Dr. Chen's research focuses on metabolic reprogramming and rewiring in cancer cells, and the pathogenic link between diet and cancer.

Cascade Link
David Adamson, MD, PhD, MPH, MHSc
Associate Professor, Department of Neurosurgery, Emory University School of Medicine
    Leon Bernal-Mizrachi, MD
    Associate Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine
      Lawrence Boise, PhD
      Professor and Vice Chair for Basic Research, Department of Hematology and Medical Oncology, Emory University School of Medicine
        Kevin Bunting, PhD
        Professor, Department of Pediatrics, Division of Hematology and Oncology, Emory University School of Medicine
          Robert Craig Castellino, MD
          Associate Professor, Department of Pediatrics, Emory University School of Medicine
            Jaideep Chaudhary, PhD
            Professor, Department of Biological Sciences, Clark Atlanta University
              Jing Chen, PhD
              Interim Leader, Cancer Cell Biology Research Program, Winship Cancer Institute of Emory University
                Inyeong Choi, PHD
                Associate Professor, Department of Physiology, Emory University School of Medicine
                  Max D. Cooper, MD
                  Professor, Department of Pathology & Laboratory Medicine, Emory University School of Medicine
                    Kavita Dhodapkar, MBBS
                    Associate Professor, Department of Pediatrics, Emory University School of Medicine
                      Yue Feng, MD, PhD
                      Professor, Department of Pharmacology and Chemical Biology, Emory University School of Medicine
                        Melissa Gilbert-Ross, PhD
                        Director, Cancer Animal Models Shared Resource, Winship Cancer Institute of Emory University
                          Kelly C. Goldsmith, MD
                          Associate Professor, Department of Pediatrics, Emory University School of Medicine
                            Arash Grakoui, PhD
                            Professor, Department of Medicine, Division of Infectious , Emory University School of Medicine
                              Hans E. Grossniklaus, MD, MBA
                              Director, Section of Ocular Oncology and Pathology, Winship Cancer Institute of Emory University
                                Vikas A. Gupta, MD, PhD
                                Instructor, Department of Hematology and Medical Oncology, Emory University School of Medicine
                                  David Gutman, MD, PhD
                                  Associate Professor, Department of Biomedical Informatics, Emory University School of Medicine
                                    Dolores Hambardzumyan, PhD
                                    Associate Professor, Department of Pediatrics, Emory University School of Medicine
                                      Curtis Henry, PhD
                                      Assistant Professor, Department of Pediatrics, Emory University School of Medicine
                                        Cimona V. Hinton, PhD
                                        Associate Professor, Department of Biological Sciences, Clark Atlanta University
                                          Takahiro Ito, PhD
                                          Assistant Professor, Department of Biochemistry and Molecular Biology, University of Georgia
                                            David L. Jaye, MD
                                            Assistant Professor, Department of Pathology & Laboratory Medicine, Emory University School of Medicine
                                              Shu Jia, PhD
                                              Assistant Professor, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
                                                Yi Jiang, PhD
                                                Adjunct Associate Professor, Department of Physics, Emory University
                                                  Dean Jones, PhD
                                                  Professor, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine , Emory University School of Medicine
                                                    Tongzhong Ju, MD, PhD
                                                    Associate Professor, Department of Biochemistry , Emory University School of Medicine
                                                      Richard A. Kahn, PhD, MS
                                                      Professor, Department of Biochemistry, Emory University School of Medicine
                                                        Daniel Kalman, PhD
                                                        Associate Professor, Department of Pathology, Emory University School of Medicine
                                                          Stefan Kaluz, PhD
                                                          Instructor, Department of Neurosurgery, Emory University School of Medicine
                                                            Sumin Kang, PhD
                                                            Associate Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine
                                                              Melissa Kemp, PhD
                                                              Associate Professor, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
                                                                Anna M. Kenney, PhD
                                                                Associate Professor, Department of Pediatrics, Emory University School of Medicine
                                                                  Shafiq Khan, PhD
                                                                  Professor, Department of Biological Sciences, Clark Atlanta University
                                                                    Jun Kong, PhD, MS
                                                                    Assistant Professor, Department of Biomedical Informatics , Emory University
                                                                      Andrew P. Kowalczyk, PhD
                                                                      Professor, Departments of Cell Biology and Dermatology, Emory University School of Medicine
                                                                        Sandeep Kumar, PhD
                                                                        Assistant Professor, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
                                                                          Wilbur Lam, MD, PhD
                                                                          Associate Professor, Division of Hematology/Oncology, Department of Pediatrics, Emory University School of Medicine
                                                                            J. David Lambeth, MD, PhD
                                                                            Professor, Department of Pathology, Emory University School of Medicine
                                                                              Soojung Lee, PhD
                                                                              Research Scientist II, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine
                                                                                Dorothy A. Lerit, PhD
                                                                                Assistant Professor, Department of Cell Biology, Emory University School of Medicine
                                                                                  Tobey J. MacDonald, MD
                                                                                  Director, Pediatric Neuro-Oncology Program, Aflac Cancer and Blood Disorders Center
                                                                                    Bernardo Mainou, PhD
                                                                                    Associate Professor, Department of Pediatrics, Emory University
                                                                                      Adam Marcus, PhD
                                                                                      Associate Director for Basic Research and Shared Resources, Winship Cancer Institute of Emory University
                                                                                        Katherine A. Minson, MD
                                                                                        Assistant Professor, Department of Pediatrics, Emory University School of Medicine
                                                                                          Kenneth H. Moberg, PhD
                                                                                          Professor, Department of Cell Biology, Emory University School of Medicine
                                                                                            Edward S. Mocarski, PhD
                                                                                            Robert W. Woodruff Professor, Department of Microbiology and Immunology, Emory University School of Medicine
                                                                                              Rita Nahta, PhD
                                                                                              Assistant Professor, Department of Pharmacology and Chemical Biology, Emory University School of Medicine
                                                                                                Nawazish Naqvi, PhD
                                                                                                Associate Professor, Department of Medicine, Emory University School of Medicine
                                                                                                  Shoichiro Ono, PhD
                                                                                                  Associate Professor, Department of Pathology & Laboratory Medicine, Emory University School of Medicine
                                                                                                    David C. Pallas, PhD
                                                                                                    Associate Professor, Department of Biochemistry, Emory University School of Medicine
                                                                                                      Peng Qiu, PhD
                                                                                                      Associate Professor, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
                                                                                                        Cheng-Kui Qu, MD, PhD
                                                                                                        Professor, Department of Pediatrics, Emory University School of Medicine
                                                                                                          Renee Read, PhD
                                                                                                          Assistant Professor, Department of Pharmacology and Chemical Biology, Emory University School of Medicine
                                                                                                            Francisco Robles, PhD
                                                                                                            Assistant Professor, Department of Biomedical Engineering, Georgia Tech School of Engineering and Emory University School of Medicine
                                                                                                              Khalid Salaita, PhD
                                                                                                              Associate Professor, Department of Chemistry, Emory University
                                                                                                                A. Fatih Sarioglu, PhD, MS
                                                                                                                Assistant Professor, School of Electrical and Computer Engineering, Georgia Institute of Technology
                                                                                                                  Alessandra C. Schmitt, MD
                                                                                                                  Assistant Professor, Department of Pathology & Laboratory Medicine, Emory University School of Medicine
                                                                                                                    Robert Schnepp, MD, PhD
                                                                                                                    William G. Woods, MD, Aflac Clinical Investigator Chair, Aflac Cancer and Blood Disorders Center
                                                                                                                      Vahid Serpooshan, PhD
                                                                                                                      Assistant Professor, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
                                                                                                                        Nicholas T. Seyfried, PhD
                                                                                                                        Director, Emory Integrated Proteomics Core, Emory University School of Medicine
                                                                                                                          Malathy Shanmugam, PhD, MS
                                                                                                                          Associate Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine
                                                                                                                            Hyunsuk Shim, PhD
                                                                                                                            Professor and Crocker Family Chair in Cancer Innovation, Department of Radiation Oncology, Emory University School of Medicine
                                                                                                                              Hui-Kuo Shu, MD, PhD, FASTRO
                                                                                                                              Professor, Department of Radiation Oncology, Emory University School of Medicine
                                                                                                                                Shi-Yong Sun, PhD
                                                                                                                                Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine
                                                                                                                                  Denis Tsygankov, PhD
                                                                                                                                  Assistant Professor, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
                                                                                                                                    Zhengqi Wang, PhD
                                                                                                                                    Assistant Professor, Department of Pediatrics, Emory University School of Medicine
                                                                                                                                      Daniel S. Wechsler, MD, PhD
                                                                                                                                      Director of Pediatric Oncology, Aflac Cancer and Blood Disorders Center
                                                                                                                                        Daqing Wu, PhD
                                                                                                                                        Assistant Professor, Department of Urology, Emory University School of Medicine
                                                                                                                                          Lily Yang, MD, PhD
                                                                                                                                          Professor, Surgery, and Radiology and Imaging Sciences, Emory University School of Medicine
                                                                                                                                            Chang-Hyon Chris Yun, PhD
                                                                                                                                            Professor, Department of Medicine, Division of Digestive Diseases , Emory University School of Medicine
                                                                                                                                              Muxiang Zhou , MD
                                                                                                                                              Professor, Division of Hematology/Oncology, Department of Pediatrics, Emory University School of Medicine
                                                                                                                                                Cheng Zhu, PhD, MS
                                                                                                                                                J. Erskine Love Jr. Endowed Chair in Engineering Regents' Professor, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
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