Cancer Genetics and Epigenetics

The goal of the Cancer Genetics and Epigenetics research program at Winship Cancer Institute of Emory University is to better understand the fundamental mechanisms underlying genetic and epigenetic instability and its contribution to the initiation and progression of human tumors and to exploit these mechanisms to reduce cancer mortality.

A key long-term goal of the Cancer Genetics and Epigenetics research program is to interface with other components of the Winship Cancer Institute and its membership to define the genetic and epigenetic determinants of therapeutic response and clinical outcome, and to identify novel targets for therapeutic intervention.

The Cancer Genetics and Epigenetics research program accomplishes its goal through studies revolving around three inter-related and complementary thematic areas:

  • DNA damage and repair and genome instability;
  • epigenetics and gene regulation;
  • cancer genetics/genomics.

Discovery efforts have led to the identification of key genes whose mutation or altered expression contributes to cancer initiation and progression. Basic discoveries in the area of cancer epigenetics have prompted early small molecule screening efforts to identify novel targeted agents.

Led by Paula Vertino, PhD, and Jin-Tang Dong, PhD, the program comprises twenty-eight core members from thirteen academic departments and three schools at Emory University, including Emory College, the School of Medicine, and the School of Public Health, with coalition investigators from the Georgia Institute of Technology.

Cancer Genetics and Epigenetics program members continuously publish high-quality research in premier scientific journals.

View Publications by Program Members

To learn more about the Cancer Genetics and Epigenetics research program at Winship Cancer Institute, please contact Stephanie Gitukui at (404) 778-6143.

Visit the Emory University's Cancer Biology Graduate Program website to learn about outstanding training opportunities in every aspect of cancer research, from basic to translational.

Photo of  Paula M. Vertino, PhD
Paula M. Vertino, PhD

Paula M. Vertino, PhD

Leader, Cancer Genetics and Epigenetics Research Program
Winship Cancer Institute of Emory University

Dr. Vertino leads a research team focused in the area of cancer epigenetics. Their work seeks to better understand the fundamental mechanisms by which altered DNA methylation and chromatin dynamics contribute to human tumorigenesis.

Photo of  Jin-Tang Dong, PhD
Jin-Tang Dong, PhD

Jin-Tang Dong, PhD

Co-Leader, Cancer Genetics and Epigenetics Research Program
Winship Cancer Institute of Emory University

Dr. Dong's research interest is in the molecular pathogenesis of human cancer, with a focus on the identification of novel tumor suppressors and the discovery of novel molecular pathways.

Cascade Link
Jeremy M. Boss, PhD
Professor and Chair, Department of Microbiology and Immunology, Emory University School of Medicine
Xiaodong Cheng, PhD
Professor, Department of Biochemistry, Emory University School of Medicine
Anita H. Corbett, PhD
Professor, Department of Biochemistry, Emory University School of Medicine
Gray Crouse, PhD
Professor, Department of Biology, Emory University
Natalya P. Degtyareva, PhD
Assistant Professor, Department of Biochemistry, Emory University School of Medicine
Paul W. Doetsch, PhD
Associate Director for Basic Research, Winship Cancer Institute of Emory University
Jin-Tang Dong, PhD
Co-Leader, Cancer Genetics and Epigenetics Research Program, Winship Cancer Institute of Emory University
William S. Dynan, PhD
Professor, Department of Radiation Oncology, Emory University School of Medicine
Peng Jin, PhD
Professor, Department of Human Genetics, Emory University School of Medicine
David J. Katz, PhD
Assistant Professor, Department of Cell Biology, Emory University School of Medicine
Yonggang Ke, PhD
Assistant Professor, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
William G. Kelly, PhD
Professor, Department of Biology, Emory University
Haydn T. Kissick, PhD
Senior Research Associate, Division of Translational Research, Department of Urology, Emory University School of Medicine
Alyssa Krasinskas, MD
Professor, Department of Pathology & Laboratory Medicine, Emory University School of Medicine
Xiaoxian (Bill) Li, MD, PhD
Assistant Professor, Department of Pathology & Laboratory Medicine, Emory University School of Medicine
Kirill S. Lobachev, PhD, MS
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Zixu Mao, MD, PhD
Professor, Department of Pharmacology, Emory University School of Medicine
Morgan L. McLemore, MD
Assistant Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine
Carlos S. Moreno, PhD
Associate Professor, Department of Pathology and Laboratory Medicine, Emory University School of Medicine
Ilya Nemenman, PhD, MS
Associate Professor, Department of Biology, Emory University
John A. Petros, MD
Professor and Associate Chair of Research, Department of Urology, Emory University School of Medicine
Brian P. Pollack, MD, PhD
Assistant Professor, Departments of Dermatology and Pathology, Emory University School of Medicine
Maureen A. Powers, PhD
Associate Professor, Department of Cell Biology, Emory University School of Medicine
Zhaohui "Steve" Qin, PhD, MS
Associate Professor, Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University
Timothy D. Read, PhD
Associate Professor, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine
Michael Rossi, PhD
Assistant Professor, Department of Radiation Oncology, Emory University School of Medicine
Harold Saavedra, PhD
Assistant Professor, Department of Radiation Oncology, Emory University School of Medicine
Samuel Speck, PhD
Professor, Department of Microbiology and Immunology, Emory University School of Medicine
Xiaodong Sun, PhD
Instructor, Department of Biochemistry, Emory University School of Medicine
Paula M. Vertino, PhD
Leader, Cancer Genetics and Epigenetics Research Program, Winship Cancer Institute of Emory University
Ya Wang, PhD
Director, Division of Experimental Radiation Oncology, Dept. of Radiation Oncology, Emory University School of Medicine
William R. Wilcox, MD, PhD
Professor, Department of Human Genetics, Emory University School of Medicine
Keith D. Wilkinson, PhD
Professor and Vice-Chair, Department of Biochemistry, Emory University School of Medicine
Hao Wu, PhD, MHS, MS
Assistant Professor, Department of Biostatistics and Bioinformatics, Emory University School of Medicine
David Yu, MD, PhD
Assistant Professor, Department of Radiation Oncology, Emory University School of Medicine
Linsheng Zhang, MD, PhD
Assistant Professor, Department of Pathology & Laboratory Medicine, Emory University School of Medicine
Wei Zhou, PhD
Assistant Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine
Michael E. Zwick, PhD
Director, Emory Integrated Genomics Core, Emory University School of Medicine