Cancer Animal Models

The function of the Cancer Animal Models Shared Resource is to assist investigators in the development, characterization and analysis of appropriate animal models for cancer research.

The Cancer Animal Models facility assists investigators in developing and analyzing appropriate animal models for cancer research, and as such it plays an important role in translating research discoveries into potential treatments.  Currently, the major emphasis and expertise of the facility lies in genetically engineered mouse models.

IVIS Spectrum: pre-clinical optical imaging system

The IVIS® Spectrum Series imaging system is PerkinElmer's leading pre-clinical optical imaging system combining high throughput and full tomographic optical imaging in one. The platform harnesses a novel patented optical imaging technology to facilitate non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals. The combination of exquisitely sensitive bioluminescence detection and fluorescence tunability combined with near infrared (NIR) optimized illumination offers the industry's most proficient system to detect small sources deep in the animal.

Service Highlights

Services include:

  • Full-service colony management, genotyping and database updates
  • In vivo optical bioluminescent and fluorescent imaging
  • Delivery of therapeutics to experimental animals (ip, iv, oral gavage, dietary)
  • Monitoring and analysis for tumor development including weekly body weight measurements, tumor burden scoring and general health status monitoring
  • Complete necropsy and tissue collection for histology (OCT, formalin fixed), as well as biochemical analysis (RNA, DNA, whole tissue)
  • Surgical cranial window placement
  • Subcutaneous and orthotopic xenograft procedures
  • Establishment of syngeneic mouse models
  • In vivo delivery of viral-Cre (intranasal, intratracheal, or custom design)
  • Assistance with IACUC applications and protocol writing

Request Service

The Emory University School of Medicine adopted the PPMS core management system to allow investigators to access core services, while streamlining administration and billing. We use the PPMS for managing all Cancer Animal Models services. For new service requests, please log in to PPMS and submit your project.

Publication Acknowledgement Policy

The National Cancer Institute requires that publications acknowledge the Winship Cancer Institute Cancer Center Support Grant (CCSG), and it is tracking compliance. If a Winship Cancer Institute CCSG-supported Shared Resource provided data, designed the study, performed analyses, provided results used in your publication, and/or provided any systems or services that were used for the work that resulted in your publication, please include the following statement in the acknowledgment section of your publication(s):

Research reported in this publication was supported in part by the Cancer Animal Models shared resource of Winship Cancer Institute of Emory University and NIH/NCI under award number P30CA138292. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Contact Information

Laboratory Staff:
B. R. Achyut, PhD
Associate Scientist
Phone: (404) 712-8371
Fax: (404) 712-8373
Email: bhagelu.r.achyut@emory.edu

Chunzi Huang
Sr. Research Specialist
Phone: (404) 778-4640
Email: chuang4@emory.edu

Address:
The Emory Clinic
1365B Clifton Road, Suite 3200
Atlanta, GA 30322

Please acknowledge the Core Facility in all publications as follows:
Research reported in this publication was supported in part by the Cancer Animal Models Shared Resource, a core supported by the Winship Cancer Institute of Emory University.

Photo of  Melissa Gilbert-Ross, PhD
Melissa Gilbert-Ross, PhD

Melissa Gilbert-Ross, PhD

Director, Cancer Animal Models Shared Resource
Winship Cancer Institute of Emory University

Dr. Gilbert-Ross is Director of the Cancer Animal Models Shared Resource, which assists Winship Cancer Institute members in the development, characterization and analysis of animal models for cancer research.

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