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September 7, 2021

Immunotherapy for HPV+ head and neck cancer: Awakening the force within

A new study from scientists at Emory Vaccine Center and Winship Cancer Institute finds that the immune cells that are the major targets of immune checkpoint inhibitors are present in tumors from patients with HPV-associated head and neck cancer. The results were published on Sept. 1 in Nature. Pictured: T cells positive for PD-1 and CD8 can be found in head and neck tumor samples. They are located in the tumor stroma (inside the orange lines). From Eberhardt et al., Nature (2021).
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New therapies possible after finding immune cell changes in WM
Researchers at Winship have found that cancer-associated mutations originate in blood progenitor cells, leading to distinct changes in both cancer and non-cancer immune cells in Waldenstrom macroglobulinemia (WM). The study, led by Madhav Dhodapkar, MBBS, Kavita Dhodapkar, MD, was published on Sept. 1 in Blood Cancer Discovery.
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Higgins to co-chair World Conference on Lung Cancer
Co-Chaired by Kristin Higgins, MD, the 2021 World Conference on Lung Cancer will take place Sept. 8-14, offering virtual access to the world's largest meeting dedicated to lung cancer and other thoracic malignancies. The conference will feature Winship advances and expertise in several oral and poster sessions.
Conference Website
Ramalingam to keynote Georgia Bio Patient Advocacy Summit
Suresh Ramalingam, MD, will deliver the keynote address second annual Georgia Bio Patient Advocacy Summit on Sept. 21. The event will bring together the patient advocacy community, industry, and legislators to explore ways to partner to advance new treatments and cures.
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Pilot grant supports new discoveries in cell signaling
With new pilot funding from the Winship Lung Cancer SPORE Grant, Ahmet Coskun, PhD, and colleagues from the Department of Biomedical Engineering are working to develop automated, multiplexed platforms to more precisely diagnose patients and predict their response to therapies.
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Learn and Live: Leukemia and Lymphoma
Join David Frank, MD, PhD, and Kristie Blum, MD, on Sept. 22 for a Friends of Winship's Learn and Live virtual event covering research and treatment advances in leukemia and lymphoma.
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Kucuk presents at Eurasian Uro-Oncology Congress
Omer Kucuk, MD, presented “Integrative Oncology in Prostate Cancer” at the 11th Eurasian Uro-oncology Congress, which took place Sept. 3-5.
Conference Website
Video: Behind the scenes of Winship Emory Midtown
Winship leaders and staff recently toured the inside of Winship Emory Midtown. Project architects led the group and described the vision behind each space.
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Webinar: Winship 5K Kickoff
Join us on Sep. 8 for the Winship 5K kickoff webinar. With less than a month to go before the Oct. 2 run/walk, learn everything you need to know about this year's event including details for in-person and virtual participants.
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Below are four selected Winship publications out of 95 published over the past week:

Chen Z, Zhang C, Chen J, Wang D, Tu J, Van Waes C, Saba NF, Chen ZG, Chen Z. The Proteomic Landscape of Growth Factor Signaling Networks Associated with Mutations in Head and Neck Cancers. Cancer Research. 2021; 81(17):4402-4416. PubMed PMID: 34167951.
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Massey PR, Schmults CD, Li SJ, Arron ST, Asgari MM, Bouwes Bavinck JN, Billingsley E, Blalock TW, Blasdale K, Carroll BT, Carucci JA, Chong AH, Christensen SR, Chung CL, DeSimone JA, Ducroux E, Escutia-Muñoz B, Ferrándiz-Pulido C, Fox MC, Genders RE, Geusau A, Gjersvik P, Hanlon AM, Olasz Harken EB, Hofbauer GFL, Hopkins RS, Leitenberger JJ, Loss MJ, Del Marmol V, Mascaró JM, Myers SA, Nguyen BT, Oliveira WRP, Otley CC, Proby CM, Rácz E, Ruiz-Salas V, Samie FH, Seçkin D, Shah SN, Shin TM, Shumack SP, Soon SL, Stasko T, Zavattaro E, Zeitouni NC, Zwald FO, Harwood CA, Jambusaria-Pahlajani A. Consensus-Based Recommendations on the Prevention of Squamous Cell Carcinoma in Solid Organ Transplant Recipients: A Delphi Consensus Statement. JAMA Dermatology. 2021; PubMed PMID: 34468690.
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Zhao W, Yu D, Chen Z, Yao W, Yang J, Ramalingam SS, Sun SY. Inhibition of MEK5/ERK5 signaling overcomes acquired resistance to the third generation EGFR inhibitor, osimertinib, via enhancing Bim-dependent apoptosis. Cancer Letters. 2021; 519:141-149. PubMed PMID: 34245854.
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Gullickson C, Goodman M, Joko-Fru YW, Gnangnon FHR, N'Da G, Woldegeorgis MA, Buziba NG, Karugu C, Manraj SS, Lorenzoni CF, Hansen R, Finesse A, Somdyala NIM, Bukirwa P, Chingonzoh T, Chokunonga E, Liu B, Kantelhardt E, Parkin DM, Jemal A. Colorectal cancer survival in sub-Saharan Africa by age, stage at diagnosis and Human Development Index: A population-based registry study. International Journal of Cancer. 2021; 149(8):1553-1563. PubMed PMID: 34164808.
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September 7 - Cell and Molecular Biology (CMB) Program Meeting (virtual)
Theresa W. Gillespie, PhD, MA, BSN, FAAN - "Catchment Area Relevant Research and the CMB Program"

September 8 - Critical Updates for Clinical Research (virtual)
"Update on OnCore Enterprise, Adverse Event Reporting, Deviation Reporting, and Eligibility"

September 8 - Integrated Cellular Imaging Seminar (virtual)
µCourse on BioImage Analysis - Beth Cimini, PhD - "Making the most of your microscopy data with high content analysis"

September 8 - Cancer Network's Around the Practice Webinar (virtual)
"Optimizing First-Line Therapy in Transplant-Ineligible Multiple Myeloma" with Craig Hofmeister, MD, MPH and colleagues

September 9 - Surgical Grand Rounds (virtual option)
Subhadra Shashidharan, MD - "Living With One Ventricle"

September 10 - Elkin Lecture (virtual)
John Roeske, PhD - "Dual Energy for Markerless Lung Tumor Tracking"John Roeske, PhD - "Dual Energy for Markerless Lung Tumor Tracking"

Winship Federal Grant Stream
Winship's Federal Grant Stream provides a daily updated list of cancer-related funding from the National Institutes of Health and other agencies.
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Non-Federal Funding Opportunities
View a selection of Winship pilot grants, institutional awards, and external funding sources and learn how to apply.
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A selection of media stories and news coverage for Winship Cancer Institute.

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