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May 9, 2022

Uncovering warped protein interactions in cancer

Winship researchers led by Haian Fu, PhD, have revealed widespread distortions of a cell’s protein interaction machinery resulting from cancer-causing mutations and developed a process to map the hidden landscape of anticancer drug opportunities. Their findings were recently published in Cell. Pictured: co-first authors Xiulei Mo, PhD, Qiankun Niu, PhD, and Andrey Ivanov, PhD.

Is inflammation the link between cancer and depression—and can we screen for it?

A first-ever systematic review and meta-analysis has found that certain measurable indicators of inflammation typically found in patients with cancer may provide a useful, screenable indication as to which of them may be at risk for depression. Winship psychiatrist Andrew H. Miller, MD, is senior author of the study recently published in the journal Cancer.

Fashion a Cure event raises critical funds for women’s cancer research at Winship

The 2022 Friends of Winship Fashion a Cure Fashion Show on May 3 raised more than $280,000 to support Winship research in cancers that affect women. This year's theme was "Around the World" and featured travel-inspired fashions from local boutiques and designers. Models included cancer survivors, caregivers, Winship researchers and volunteers.

Video: Oncology Nursing Month spotlight with JB Belonio

Meet JB Belonio, BSN, RN, OCN, a shift nurse manager in ambulatory infusion at Winship. In this video, Belonio talks about Winship's uniquely knowledgeable and compassionate nurses, and how they work together to bring the best care and support to their patients.

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Winship investigators receive Georgia CORE grant for phase I trial

Jack Arbiser, MD, PhD, and Lisa Flowers, MD, MPH, have received a $100,000 Collaborative Cancer Research Seed Grant from Georgia CORE. The grant will fund a phase I trial of ACU-D1 for premalignant HPV-related anogenital disease among people living with HIV.

Gillespie will use award to unify health disparities research at Emory

Winship researchers led by Theresa W. Gillespie, PhD, MA, BSN, have received an Imagine, Innovate, and Impact (I3) WOW! Research Award from Emory School of Medicine. The research project, which includes co-investigators Randi Smith, MD, MPH, Joseph Lipscomb, PhD, and Jessica Wells, PhD, RN, will build an Emory initiative for health equity research to reduce health disparities in Georgia.

Jones honored with Albert E. Levy Award for Excellence in Scientific Research

Winship member and Emory environmental health researcher Dean P. Jones, PhD, is one of this year’s recipients of the Albert E. Levy Award for Excellence in Scientific Research. The annual award recognizes the contributions of one junior and one senior Emory faculty member to the advancement of scientific knowledge.

Flow Cytometry Core recognized for operational excellence

The Pediatrics/Winship Flow Cytometry Core has been accepted into the International Society for the Advancement of Cytometry’s SRL Recognition Program. Recognition is conferred to labs that demonstrate excellence in shared resource lab operations and adherence to flow cytometry best practices.

About the Flow Cytometry Core

McCullough leads community forum on GA breast cancer disparities

Lauren E. McCullough, PhD, MSPH, whose research has revealed pronounced race disparities in breast cancer deaths in several Georgia counties, will host a virtual forum on May 17 to share information and gather community input on the possible causes of breast cancer inequities across the state.

Video: Kalinsky gives updates on the TAILORx trial for breast cancer

In an interview with OncLive, Winship physician Kevin Kalinsky, MD, MS, discusses updates from the phase 3 TAILORx trial in patients with hormone receptor–positive or HER2-negative breast cancer with node-negative disease.

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Video: Boise discusses novel targets in multiple myeloma

Winship scientist Lawrence Boise, PhD, and the University of Calgary's Paola Neri, PhD, discuss novel targets for the treatment of multiple myeloma as co-chairs of a roundtable session recorded at the International Workshop on Myeloma 2022.

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Ford joins American Society of Transplantation Board

Winship researcher Mandy Ford, PhD, has been named to the Board of Directors of the American Society of Transplantation, dedicated to advancing the field and improving patient care through research, education, advocacy, organ donation, and service to the community.

About the Society

Winship launches new Molecular Tumor Board

Chaired by Ludimila Cavalcante, MD, Jennifer Carlisle, MD, and Linsheng Zhang, MD, PhD, Winship's new Molecular Tumor Board will take place twice a month via Zoom, with the first meeting on Monday, May 23. The deadline to submit cases is one week prior to each meeting.

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Emory University Commencement returns to the Quad on May 9

The Emory University Commencement Ceremony celebrates the Class of 2022 and will feature keynote speaker Tyler Perry. Visit Emory’s Commencement website for the full schedule of events, including diploma ceremonies for each of Emory’s nine schools.

Call for proposals: Cancer screening and early detection grants

New priority funding from the American Cancer Society is focused on innovative solutions to improve cancer screening and early detection. Learn more about the application process during an interactive webinar at noon on May 16. (The webinar will be recorded and available upon request.) Letters of intent are due June 15.

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NCI Notice of Special Interest: Addressing cancer-related financial hardship

The National Cancer Institute has published a Notice of Special Interest on addressing cancer-related financial hardship to improve patient outcomes. Applications may focus on any cancer type and may be submitted through R03, R01, P01, or R21 funding mechanisms.

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Below are four selected Winship publications out of 88 published over the past week:

Rodriguez-Calero A, Gallon J, Akhoundova D, Maletti S, Ferguson A, Cyrta J, Amstutz U, Garofoli A, Paradiso V, Tomlins SA, Hewer E, Genitsch V, Fleischmann A, Vassella E, Rushing EJ, Grobholz R, Fischer I, Jochum W, Cathomas G, Osunkoya AO, Bubendorf L, Moch H, Thalmann G, Ng CKY, Gillessen S, Piscuoglio S, Rubin MA. Alterations in homologous recombination repair genes in prostate cancer brain metastases. Nature Communications. 2022; 13(1):2400. PubMed PMID: 35504881.

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Pal S, Perrien DS, Yumoto T, Faccio R, Stoica A, Adams J, Coopersmith CM, Jones RM, Weitzmann MN, Pacifici R. The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cells homing to bone. The Journal of Clinical Investigation. 2022; PubMed PMID: 35503658.

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Peres LC, Colin-Leitzinger C, Sinha S, Marks JR, Conejo-Garcia JR, Alberg AJ, Bandera EV, Berchuck A, Bondy ML, Christensen BC, Cote ML, Doherty JA, Moorman PG, Peters ES, Moran Segura C, Nguyen JV, Schwartz AG, Terry PD, Wilson CM, Fridley BL, Schildkraut JM. Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma. Cancer Epidemiology, Biomarkers & Prevention. 2022; 31(5):1006-1016. PubMed PMID: 35244678.

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Yao W, Bai L, Wang S, Zhai Y, Sun SY. Mcl-1 levels critically impact the sensitivities of human colorectal cancer cells to APG-1252-M1, a novel Bcl-2/Bcl-X L dual inhibitor that induces Bax-dependent apoptosis. Neoplasia. 2022; 29:100798. PubMed PMID: 35462114; PubMed Central PMCID: PMC9046866.

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