Manoj Bhasin, PhD, MS

Research Program

Cancer Immunology
Phone Number

404-712-9849
Email Address

manoj.bhasin@emory.edu

Biography

Manoj Bhasin, PhD, MS, holds joint appointments as professor in the Department of Pediatrics and in the Department of Biomedical Informatics at Emory University School of Medicine. Dr. Bhasin serves as director of Genomics, Proteomics, Bioinformatics and Systems Biology and as the Aflac Director of the Single Cell Biology Program at Children's Healthcare of Atlanta. Prior to joining Emory, he was an assistant professor of medicine at Harvard Medical School and co-director of Genomics, Proteomics, Bioinformatics and Systems Biology Center at Beth Israel Deaconess Medical Center.

Dr. Bhasin is a member of the Cancer Immunology Research Program at Winship Cancer Institute.

Education

Dr. Bhasin received his PhD in Bioinformatics from Institute of Microbial Technology, Jawaharlal Nehru University. He obtained his Master of Science from Kurukshetra University. He completed a postdoctoral fellowship at Dana-Farber Cancer Institute and Harvard Medical School.

Titles & Roles

Professor, Department of Pediatrics

Emory University School of Medicine
Professor, Department of Biomedical Bioinformatics

Emory University School of Medicine
Director, Genomics, Proteomics, Bioinformatics and Systems Biology

Children's Healthcare of Atlanta
Director, Single Cell Biology Program at Aflac Cancer and Blood Disorders Center

Children's Healthcare of Atlanta

Research

Dr. Bhasin's laboratory has developed strategies for analysis of transcriptome, epigenome and proteomics data to perform multi-scale modeling of interaction among different cells molecular level and to identify novel biomarkers. He and his team are currently focusing on developing novel single cell omics approaches to understand disease heterogeneity and impact of treatments at single cell resolution.

Publications

Title/Journal	Authors	Publication Date
MERTK inhibition selectively activates a DC - T-cell axis to provide anti-leukemia immunity. Leukemia	JM Huelse, SS Bhasin, KM Jacobsen, J Yim, BE Thomas, GM Branella, M Bakhtiari, ML Chimenti, TA Baxter, SS Raikar, X Wang, SV Frye, CJ Henry, HS Earp, M Bhasin, D DeRyckere, DK Graham	12/01/2024
Less-deformable erythrocyte subpopulations biomechanically induce endothelial inflammation in sickle cell disease. Blood	C Caruso, X Cheng, ME Michaud, HM Szafraniec, BE Thomas, ME Fay, RG Mannino, X Zhang, Y Sakurai, W Li, DR Myers, CH Joiner, DK Wood, M Bhasin, MD Graham, WA Lam	11/07/2024
Single-cell Analysis of Debrided Diabetic Foot Ulcers Reveals Dysregulated Wound Healing Environment in non-Hispanic Blacks. The Journal of investigative dermatology	D Choi, M Bakhtiari, W Pilcher, C Huang, BE Thomas, H Mumme, G Blanco, R Rajani, MC Schechter, M Fayfman, G Santamarina, S Bhasin, M Bhasin	08/08/2024
Medulloblastoma Spatial Transcriptomics Reveals Tumor Microenvironment Heterogeneity with High-Density Progenitor Cell Regions Correlating with High-Risk Disease. bioRxiv : the preprint server for biology	F Chien, ME Michaud, M Bakhtiari, C Schroff, M Snuderl, JE Velazquez Vega, TJ MacDonald, MK Bhasin	06/28/2024
Early Injury Landscape in Vein Harvest by Single-Cell and Spatial Transcriptomics. Circulation research	ME Michaud, L Mota, M Bakhtiari, BE Thomas, J Tomeo, W Pilcher, M Contreras, C Ferran, SS Bhasin, L Pradhan-Nabzdyk, FW LoGerfo, P Liang, MK Bhasin	06/21/2024
A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma. bioRxiv : the preprint server for biology	WC Pilcher, L Yao, E Gonzalez-Kozlova, Y Pita-Juarez, D Karagkouni, CR Acharya, ME Michaud, M Hamilton, S Nanda, Y Song, K Sato, JT Wang, S Satpathy, Y Ma, J Schulman, D D'Souza, RG Jayasinghe, G Cheloni, M Bakhtiari, N Pabustan, K Nie, JA Foltz, I Saldarriaga, R Alaaeldin, E Lepisto, R Chen, MA Fiala, BE Thomas, A Cook, JV Dos Santos, IL Chiang, I Figueiredo, J Fortier, M Slade, ST Oh, MP Rettig, E Anderson, Y Li, S Dasari, MA Strausbauch, VA Simon, AH Rahman, Z Chen, A Lagana, JF DiPersio, J Rosenblatt, S Kim-Schulze, MV Dhodapkar, S Lonial, S Kumar, SS Bhasin, T Kourelis, R Vij, D Avigan, HJ Cho, G Mulligan, L Ding, S Gnjatic, IS Vlachos, M Bhasin	05/17/2024
Single-cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells. Journal of virology	KM Moore, A-N Pelletier, S Lapp, A Metz, GK Tharp, M Lee, SS Bhasin, M Bhasin, R-P Sékaly, SE Bosinger, MS Suthar	05/14/2024
Why Certain Repurposed Drugs Are Unlikely to Be Effective Antivirals to Treat SARS-CoV-2 Infections. Viruses	SJ Hurwitz, R De, JC LeCher, JA Downs-Bowen, SL Goh, K Zandi, T McBrayer, F Amblard, D Patel, JJ Kohler, M Bhasin, BS Dobosh, V Sukhatme, RM Tirouvanziam, RF Schinazi	04/22/2024
Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin. Communications biology	K Mittal, GW Cooper, BP Lee, Y Su, KT Skinner, J Shim, HC Jonus, WJ Kim, M Doshi, D Almanza, BD Kynnap, AL Christie, X Yang, GS Cowley, BA Leeper, CL Morton, B Dwivedi, T Lawrence, M Rupji, P Keskula, S Meyer, CM Clinton, M Bhasin, BD Crompton, YY Tseng, JS Boehm, KL Ligon, DE Root, AJ Murphy, DM Weinstock, PC Gokhale, JM Spangle, MN Rivera, EA Mullen, K Stegmaier, KC Goldsmith, WC Hahn, AL Hong	04/08/2024
Integrated single-nuclei and spatial transcriptomic analysis reveals propagation of early acute vein harvest and distension injury signaling pathways following arterial implantation. bioRxiv : the preprint server for biology	ME Michaud, L Mota, M Bakhtiari, BE Thomas, J Tomeo, W Pilcher, M Contreras, C Ferran, S Bhasin, L Pradhan-Nabzdyk, FW LoGerfo, P Liang, MK Bhasin	03/02/2024
Indoximod-based chemo-immunotherapy for pediatric brain tumors: A first-in-children phase I trial. Neuro-oncology	TS Johnson, TJ MacDonald, R Pacholczyk, D Aguilera, A Al-Basheer, M Bajaj, P Bandopadhayay, Z Berrong, E Bouffet, RC Castellino, K Dorris, BR Eaton, N Esiashvili, JR Fangusaro, N Foreman, D Fridlyand, C Giller, IM Heger, C Huang, N Kadom, EP Kennedy, N Manoharan, W Martin, C McDonough, RS Parker, V Ramaswamy, E Ring, A Rojiani, RF Sadek, S Satpathy, M Schniederjan, A Smith, C Smith, BE Thomas, R Vaizer, KK Yeo, MK Bhasin, DH Munn	02/02/2024
Single cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells. bioRxiv : the preprint server for biology	KM Moore, AN Pelletier, S Lapp, A Metz, GK Tharp, M Lee, SS Bhasin, M Bhasin, RP Sékaly, SE Bosinger, MS Suthar	01/21/2024
DFUCare: deep learning platform for diabetic foot ulcer detection, analysis, and monitoring. Frontiers in endocrinology	V Sendilraj, W Pilcher, D Choi, A Bhasin, A Bhadada, SK Bhadadaa, M Bhasin	01/01/2024
Single-cell RNA sequencing distinctly characterizes the wide heterogeneity in pediatric mixed phenotype acute leukemia. Genome medicine	HL Mumme, SS Raikar, SS Bhasin, BE Thomas, T Lawrence, EP Weinzierl, Y Pang, D DeRyckere, C Gawad, DS Wechsler, CC Porter, SM Castellino, DK Graham, M Bhasin	10/16/2023
Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia. Nature communications	H Mumme, BE Thomas, SS Bhasin, U Krishnan, B Dwivedi, P Perumalla, D Sarkar, GB Ulukaya, HS Sabnis, SI Park, D DeRyckere, SS Raikar, M Pauly, RJ Summers, SM Castellino, DS Wechsler, CC Porter, DK Graham, M Bhasin	10/05/2023
Taxane chemotherapy induces stromal injury that leads to breast cancer dormancy escape. PLoS biology	R Ganesan, SS Bhasin, M Bakhtiary, U Krishnan, NR Cheemarla, BE Thomas, MK Bhasin, VP Sukhatme	09/01/2023
Pediatric T-cell acute lymphoblastic leukemia blast signature and MRD associated immune environment changes defined by single cell transcriptomics analysis. Scientific reports	SS Bhasin, BE Thomas, RJ Summers, D Sarkar, H Mumme, W Pilcher, M Emam, SS Raikar, SI Park, SM Castellino, DK Graham, MK Bhasin, D DeRyckere	08/02/2023
DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation and Tumour Growth That Acts through Neddylation of Cullin 1, 3, 4A and 5 and Deregulation of Wnt/Catenin Pathway. Cells	A Vava, JD Paccez, Y Wang, X Gu, MK Bhasin, M Myers, NC Soares, TA Libermann, LF Zerbini	07/31/2023
The 'omics of obesity in B-cell acute lymphoblastic leukemia. Journal of the National Cancer Institute. Monographs	DK Geitgey, M Lee, KA Cottrill, M Jaffe, W Pilcher, S Bhasin, J Randall, AJ Ross, M Salemi, M Castillo-Castrejon, MB Kilgore, AC Brown, JM Boss, R Johnston, AM Fitzpatrick, ML Kemp, R English, E Weaver, P Bagchi, R Walsh, CD Scharer, M Bhasin, JD Chandler, KA Haynes, EA Wellberg, CJ Henry	05/04/2023
Cross center single-cell RNA sequencing study of the immune microenvironment in rapid progressing multiple myeloma. NPJ genomic medicine	W Pilcher, BE Thomas, SS Bhasin, RG Jayasinghe, L Yao, E Gonzalez-Kozlova, S Dasari, S Kim-Schulze, A Rahman, J Patton, M Fiala, G Cheloni, T Kourelis, MV Dhodapkar, R Vij, S Mehr, M Hamilton, HJ Cho, D Auclair, DE Avigan, SK Kumar, S Gnjatic, L Ding, M Bhasin	01/26/2023
The Simple prEservatioN of Single cElls method for cryopreservation enables the generation of single-cell immune profiles from whole blood. Frontiers in immunology	S Satpathy, BE Thomas, WJ Pilcher, M Bakhtiari, LA Ponder, R Pacholczyk, S Prahalad, SS Bhasin, DH Munn, MK Bhasin	01/01/2023
Comprehensive Characterization of the Multiple Myeloma Immune Microenvironment Using Integrated scRNA-seq, CyTOF, and CITE-seq Analysis. Cancer research communications	L Yao, RG Jayasinghe, BH Lee, SS Bhasin, W Pilcher, DB Doxie, E Gonzalez-Kozlova, S Dasari, MA Fiala, Y Pita-Juarez, M Strausbauch, G Kelly, BE Thomas, SK Kumar, HJ Cho, E Anderson, MC Wendl, T Dawson, D D'souza, ST Oh, G Cheloni, Y Li, JF DiPersio, AH Rahman, KM Dhodapkar, S Kim-Schulze, R Vij, IS Vlachos, S Mehr, M Hamilton, D Auclair, T Kourelis, D Avigan, MV Dhodapkar, S Gnjatic, MK Bhasin, L Ding	10/01/2022
Therapeutic implications of mitochondrial stress-induced proteasome inhibitor resistance in multiple myeloma. Science advances	A Sharma, R Nair, A Achreja, A Mittal, P Gupta, K Balakrishnan, CL Edgar, O Animasahun, B Dwivedi, BG Barwick, VA Gupta, SM Matulis, M Bhasin, S Lonial, AK Nooka, AP Wiita, LH Boise, D Nagrath, M Shanmugam	09/30/2022
Transcriptomics and systems biology identify non-antibiotic drugs for the treatment of ocular bacterial infection. iScience	S Das, S Singh, S Satpathy, M Bhasin, A Kumar	09/16/2022
Cellular and immunometabolic mechanisms of inflammation in depression: Preliminary findings from single cell RNA sequencing and a tribute to Bruce McEwen. Neurobiology of stress	M Bekhbat, GB Ulukaya, MK Bhasin, JC Felger, AH Miller	07/01/2022
Baricitinib attenuates the proinflammatory phase of COVID-19 driven by lung-infiltrating monocytes. Cell reports	B Dobosh, K Zandi, DM Giraldo, SL Goh, K Musall, M Aldeco, J LeCher, VD Giacalone, J Yang, DJ Eddins, M Bhasin, E Ghosn, V Sukhatme, RF Schinazi, R Tirouvanziam	06/14/2022
Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer. Cancer research	F Ma, S Arai, K Wang, C Calagua, AR Yuan, L Poluben, Z Gu, JW Russo, DJ Einstein, H Ye, MX He, Y Liu, E Van Allen, AG Sowalsky, MK Bhasin, X Yuan, SP Balk	04/15/2022
Comprehensive Genomic Profiling of High-Risk Pediatric Cancer Patients Has a Measurable Impact on Clinical Care. JCO precision oncology	RJ Summers, SM Castellino, CC Porter, TJ MacDonald, GD Basu, S Szelinger, MK Bhasin, T Cash, AB Carter, RC Castellino, JR Fangusaro, SG Mitchell, MG Pauly, B Pencheva, DS Wechsler, DK Graham, KC Goldsmith	04/01/2022
Survival Genie, a web platform for survival analysis across pediatric and adult cancers. Scientific reports	B Dwivedi, H Mumme, S Satpathy, SS Bhasin, M Bhasin	02/23/2022
Single cell transcriptomic landscape of diabetic foot ulcers. Nature communications	G Theocharidis, BE Thomas, D Sarkar, HL Mumme, WJR Pilcher, B Dwivedi, T Sandoval-Schaefer, RF Sîrbulescu, A Kafanas, I Mezghani, P Wang, A Lobao, IS Vlachos, B Dash, HC Hsia, V Horsley, SS Bhasin, A Veves, M Bhasin	01/10/2022
A Grammastola spatulata mechanotoxin-4 (GsMTx4)-sensitive cation channel mediates increased cation permeability in human hereditary spherocytosis of multiple genetic etiologies. Haematologica	DH Vandorpe, BE Shmukler, Y Ilboudo, S Bhasin, B Thomas, A Rivera, JG Wohlgemuth, JS Dlott, LM Snyder, C Sieff, M Bhasin, G Lettre, C Brugnara, SL Alper	10/01/2021
Leukemia vaccine overcomes limitations of checkpoint blockade by evoking clonal T cell responses in a murine acute myeloid leukemia model. Haematologica	D Stroopinsky, J Liegel, M Bhasin, G Cheloni, B Thomas, S Bhasin, R Panchal, H Ghiasuddin, M Rahimian, M Nahas, S Orr, M Capelletti, D Torres, C Tacettin, M Weinstock, L Bisharat, A Morin, KM Mahoney, B Ebert, R Stone, D Kufe, GJ Freeman, J Rosenblatt, D Avigan	05/01/2021
ACE2 abrogates tumor resistance to VEGFR inhibitors suggesting angiotensin-(1-7) as a therapy for clear cell renal cell carcinoma. Science translational medicine	P Khanna, HJ Soh, CH Chen, R Saxena, S Amin, M Naughton, PN Joslin, A Moore, Z Bakouny, C O'Callaghan, P Catalano, S Signoretti, R McKay, TK Choueiri, M Bhasin, T Walther, RS Bhatt	01/20/2021
COVID-19 and Type 2 Diabetes Mellitus: HCQ may be the Holy Grail. Infectious disorders drug targets	R Pal, MK Bhasin, SK Bhadada	01/01/2021
SARS-CoV-2 morbidity and mortality in racial/ethnic minority populations: A window into the stress related inflammatory basis of health disparities? Brain, behavior, & immunity - health	B Gelaye, S Foster, M Bhasin, A Tawakol, G Fricchione	12/01/2020
Embryonic periventricular endothelial cells demonstrate a unique pro-neurodevelopment and anti-inflammatory gene signature. Scientific reports	FC Kipper, C Angolano, R Vissapragada, MA Contreras, J Moore, M Bhasin, C Ferran, AJ Thomas	11/23/2020
Integrated Skin Transcriptomics and Serum Multiplex Assays Reveal Novel Mechanisms of Wound Healing in Diabetic Foot Ulcers. Diabetes	G Theocharidis, D Baltzis, M Roustit, A Tellechea, S Dangwal, RS Khetani, B Shu, W Zhao, J Fu, S Bhasin, A Kafanas, D Hui, SH Sui, NA Patsopoulos, M Bhasin, A Veves	10/01/2020
TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance. JCI insight	MR Lynch, MT Tran, KM Ralto, ZK Zsengeller, V Raman, SS Bhasin, N Sun, X Chen, D Brown, II Rovira, K Taguchi, CR Brooks, IE Stillman, MK Bhasin, T Finkel, SM Parikh	08/06/2020
Smad2/3-pathway ligand trap luspatercept enhances erythroid differentiation in murine β-thalassaemia by increasing GATA-1 availability. Journal of cellular and molecular medicine	PA Martinez, R Li, HN Ramanathan, M Bhasin, RS Pearsall, R Kumar, RNVS Suragani	06/01/2020
Topical Application of a Mast Cell Stabilizer Improves Impaired Diabetic Wound Healing. The Journal of investigative dermatology	A Tellechea, S Bai, S Dangwal, G Theocharidis, M Nagai, S Koerner, JE Cheong, S Bhasin, TY Shih, Y Zheng, W Zhao, C Zhang, X Li, K Kounas, S Panagiotidou, T Theoharides, D Mooney, M Bhasin, L Sun, A Veves	04/01/2020
A Transcriptomics-Based Meta-Analysis Combined With Machine Learning Identifies a Secretory Biomarker Panel for Diagnosis of Pancreatic Adenocarcinoma. Frontiers in genetics	I Khatri, MK Bhasin	01/01/2020
Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists. Science advances	J Chen, CA Haller, FE Jernigan, SK Koerner, DJ Wong, Y Wang, JE Cheong, R Kosaraju, J Kwan, DD Park, B Thomas, S Bhasin, RC De La Rosa, AM Premji, L Liu, E Park, AC Moss, A Emili, M Bhasin, L Sun, EL Chaikof	01/01/2020