Karen Conneely, PhD

Research Program

Cancer Immunology
Phone Number

404-727-2986
Email Address

kconnee@emory.edu

Biography

Karen Conneely, PhD, is an associate professor in the Department of Human Genetics at Emory University School of Medicine. Dr. Conneely is a member of the Cancer Immunology Research Program at Winship Cancer Institute of Emory University in Atlanta, Georgia.

Education

Dr. Conneely received her PhD in Biostatistics from the University of Michigan in Ann Arbor, Michigan.

Titles & Roles

Associate Professor, Department of Human Genetics

Emory University School of Medicine

Research

Dr. Conneely's research focuses on statistical methods for genetic association studies and large-scale studies of DNA methylation. She is currently involved in GWAS, candidate gene studies and methylation studies involving psychiatric outcomes, environmental stressors and aging. Through the development of novel techniques and adaptation of existing ones, her work seeks to identify biomarkers and variants involved in disease, and to explore the role of DNA methylation as a mediator between environment and phenotype.

Publications

Title/Journal	Authors	Publication Date
DNA methylation profiles of cancer-related fatigue associated with markers of inflammation and immunometabolism. Molecular psychiatry	C Xiao, G Peng, KN Conneely, H Zhao, JC Felger, EC Wommack, KA Higgins, DM Shin, NF Saba, DW Bruner, AH Miller	01/01/2025
Epigenetic associations with neonatal age in infants born very preterm, particularly among genes involved in neurodevelopment. Scientific reports	KM Hodge, AA Burt, M Camerota, BS Carter, J Check, KN Conneely, J Helderman, JA Hofheimer, A Hüls, EC McGowan, CR Neal, SL Pastyrnak, LM Smith, SA DellaGrotta, LM Dansereau, TM O'Shea, CJ Marsit, BM Lester, TM Everson	08/05/2024
Epigenome-wide DNA Methylation Association Study of CHIP Provides Insight into Perturbed Gene Regulation. Research square	D Levy, S Kirmani, T Huan, J Van Amburg, R Joehanes, MM Uddin, NQ Nguyen, B Yu, J Brody, M Fornage, J Bressler, N Sotoodehnia, D Ong, F Puddu, J Floyd, C Ballantyne, B Psaty, L Raffield, P Natarajan, K Conneely, A Carson, L Lange, K Ferrier, N Heard-Costa, J Murabito, A Bick	07/16/2024
Associations of childhood, adolescence, and midlife cognitive function with DNA methylation age acceleration in midlife. Aging	J Chen, L Moubadder, ES Clausing, KL Kezios, KN Conneely, A Hüls, A Baccarelli, P Factor-Litvak, P Cirrillo, RC Shelton, BG Link, SF Suglia	06/13/2024
Investigating the potential of single-cell DNA methylation data to detect allele-specific methylation and imprinting. American journal of human genetics	ND Johnson, DJ Cutler, KN Conneely	04/04/2024
Cumulative Stress Across the Life Course and Biological Aging in Adulthood. Psychosomatic medicine	SF Suglia, ES Clausing, RC Shelton, K Conneely, D Prada-Ortega, I DeVivo, P Factor-Litvak, P Cirillo, AA Baccarelli, B Cohn, BG Link	04/01/2024
Pruning and thresholding approach for methylation risk scores in multi-ancestry populations. Epigenetics	J Chen, E Gatev, T Everson, KN Conneely, N Koen, MP Epstein, MS Kobor, HJ Zar, DJ Stein, A Hüls	12/01/2023
Outcomes Stratification of Head and Neck Cancer Using Pre- and Post-treatment DNA Methylation From Peripheral Blood. International journal of radiation oncology, biology, physics	DC Qian, BC Ulrich, G Peng, H Zhao, KN Conneely, AH Miller, DW Bruner, RC Eldridge, EC Wommack, KA Higgins, DM Shin, NF Saba, AK Smith, B Burtness, HS Park, WA Stokes, JJ Beitler, C Xiao	04/01/2023
Longitudinal DNA methylation profiling of the rectal mucosa identifies cell-specific signatures of disease status, severity and clinical outcomes in ulcerative colitis cell-specific DNA methylation signatures of UC. Clinical epigenetics	S Venkateswaran, HK Somineni, JD Matthews, V Kilaru, JS Hyams, LA Denson, R Kellamayer, G Gibson, DJ Cutler, KN Conneely, AK Smith, S Kugathasan	03/24/2023
Elimination of PBB-153; findings from a cohort of Michigan adults. Environmental research	RB Hood, ML Terrell, AK Smith, S Curtis, K Conneely, M Pearson, H Barton, DB Barr, EM Marder, M Marcus	03/01/2023
Epigenome-wide meta-analysis of BMI in nine cohorts: Examining the utility of epigenetically predicted BMI. American journal of human genetics	WL Do, D Sun, K Meeks, PA Dugué, E Demerath, W Guan, S Li, W Chen, R Milne, A Adeyemo, C Agyemang, R Nassir, JE Manson, AH Shadyab, L Hou, S Horvath, TL Assimes, P Bhatti, KM Jordahl, AA Baccarelli, AK Smith, LR Staimez, AD Stein, EA Whitsel, KMV Narayan, KN Conneely	02/02/2023
Redlining-associated methylation in breast tumors: the impact of contemporary structural racism on the tumor epigenome. Frontiers in oncology	JM Miller-Kleinhenz, L Moubadder, KM Beyer, Y Zhou, AH Gaglioti, LJ Collin, J Gohar, W Do, K Conneely, U Krishnamurti, K Gogineni, S Gabram-Mendola, O D'Angelo, K Henry, M Torres, LE McCullough	01/01/2023
Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease. Nature communications	MDM Uddin, NQH Nguyen, B Yu, JA Brody, A Pampana, T Nakao, M Fornage, J Bressler, N Sotoodehnia, JS Weinstock, MC Honigberg, D Nachun, R Bhattacharya, GK Griffin, V Chander, RA Gibbs, JI Rotter, C Liu, AA Baccarelli, DI Chasman, EA Whitsel, DP Kiel, JM Murabito, E Boerwinkle, BL Ebert, S Jaiswal, JS Floyd, AG Bick, CM Ballantyne, BM Psaty, P Natarajan, KN Conneely	09/12/2022
Gaseous air pollutants and DNA methylation in a methylome-wide association study of an ethnically and environmentally diverse population of U.S. adults. Environmental research	KM Holliday, R Gondalia, A Baldassari, AE Justice, JD Stewart, D Liao, JD Yanosky, KM Jordahl, P Bhatti, TL Assimes, JS Pankow, W Guan, M Fornage, J Bressler, KE North, KN Conneely, Y Li, L Hou, PS Vokonas, CK Ward-Caviness, R Wilson, K Wolf, M Waldenberger, J Cyrys, A Peters, HM Boezen, JM Vonk, S Sayols-Baixeras, M Lee, AA Baccarelli, EA Whitsel	09/01/2022
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases. Nature communications	M Wielscher, PR Mandaviya, B Kuehnel, R Joehanes, R Mustafa, O Robinson, Y Zhang, B Bodinier, E Walton, PP Mishra, P Schlosser, R Wilson, PC Tsai, S Palaniswamy, RE Marioni, G Fiorito, G Cugliari, V Karhunen, M Ghanbari, BM Psaty, M Loh, JC Bis, B Lehne, N Sotoodehnia, IJ Deary, M Chadeau-Hyam, JA Brody, A Cardona, E Selvin, AK Smith, AH Miller, MA Torres, E Marouli, X Gào, JBJ van Meurs, J Graf-Schindler, W Rathmann, W Koenig, A Peters, W Weninger, M Farlik, T Zhang, W Chen, Y Xia, A Teumer, M Nauck, HJ Grabe, M Doerr, T Lehtimäki, W Guan, L Milani, T Tanaka, K Fisher, LL Waite, S Kasela, P Vineis, N Verweij, P van der Harst, L Iacoviello, C Sacerdote, S Panico, V Krogh, R Tumino, E Tzala, G Matullo, MA Hurme, OT Raitakari, E Colicino, AA Baccarelli, M Kähönen, KH Herzig, S Li, KN Conneely, JS Kooner, A Köttgen, BT Heijmans, P Deloukas, C Relton, KK Ong, JT Bell, E Boerwinkle, P Elliott, H Brenner, M Beekman, D Levy, M Waldenberger, JC Chambers, A Dehghan, MR Järvelin	05/03/2022
Methylation quantitative trait loci are largely consistent across disease states in Crohn's disease. G3 (Bethesda, Md.)	S Venkateswaran, HK Somineni, V Kilaru, S Katrinli, J Prince, DT Okou, JS Hyams, LA Denson, R Kellermayer, G Gibson, DJ Cutler, AK Smith, S Kugathasan, KN Conneely	04/04/2022
Brain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline. Biological psychiatry	A Hüls, C Robins, KN Conneely, R Edgar, PL De Jager, DA Bennett, AP Wingo, MP Epstein, TS Wingo	02/15/2022
Neighborhood characteristics and breast tumor methylation: using epigenomics to explore cancer outcome disparities. Breast cancer research and treatment	J Gohar, WL Do, J Miller-Kleinhenz, K Conneely, U Krishnamurti, O D'Angelo, K Gogineni, M Torres, S Gabram-Mendola, LE McCullough	02/01/2022
Differential Methylation Analysis for Bisulfite Sequencing (BS-Seq) Data. Methods in molecular biology (Clifton, N.J.)	H Feng, K Conneely, H Wu	01/01/2022
Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes. Clinical epigenetics	WL Do, S Nguyen, J Yao, X Guo, EA Whitsel, E Demerath, JI Rotter, SS Rich, L Lange, J Ding, D Van Den Berg, Y Liu, AE Justice, W Guan, S Horvath, TL Assimes, P Bhatti, K Jordahl, A Shadyab, CI Valencia, AD Stein, A Smith, LR Staimez, K Conneely, KMV Narayan	12/22/2021
Examining the association between adiposity and DNA methylation: A systematic review and meta-analysis. Obesity reviews : an official journal of the International Association for the Study of Obesity	WL Do, J Gohar, LE McCullough, KI Galaviz, KN Conneely, KMV Narayan	10/01/2021
Epigenetic age acceleration, fatigue, and inflammation in patients undergoing radiation therapy for head and neck cancer: A longitudinal study. Cancer	C Xiao, JJ Beitler, G Peng, ME Levine, KN Conneely, H Zhao, JC Felger, EC Wommack, CE Chico, S Jeon, KA Higgins, DM Shin, NF Saba, BA Burtness, DW Bruner, AH Miller	09/15/2021
Association of Epigenetic Age Acceleration With Risk Factors, Survival, and Quality of Life in Patients With Head and Neck Cancer. International journal of radiation oncology, biology, physics	C Xiao, AH Miller, G Peng, ME Levine, KN Conneely, H Zhao, RC Eldridge, EC Wommack, S Jeon, KA Higgins, DM Shin, NF Saba, AK Smith, B Burtness, HS Park, ML Irwin, LM Ferrucci, B Ulrich, DC Qian, JJ Beitler, DW Bruner	09/01/2021
Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD. Clinical epigenetics	ND Johnson, X Wu, CD Still, X Chu, AT Petrick, GS Gerhard, KN Conneely, JK DiStefano	08/05/2021
Epigenetically mediated electrocardiographic manifestations of sub-chronic exposures to ambient particulate matter air pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study. Environmental research	R Gondalia, A Baldassari, KM Holliday, AE Justice, JD Stewart, D Liao, JD Yanosky, SM Engel, D Sheps, KM Jordahl, P Bhatti, S Horvath, TL Assimes, EW Demerath, W Guan, M Fornage, J Bressler, KE North, KN Conneely, Y Li, L Hou, AA Baccarelli, EA Whitsel	07/01/2021
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging. Genome biology	DL McCartney, JL Min, RC Richmond, AT Lu, MK Sobczyk, G Davies, L Broer, X Guo, A Jeong, J Jung, S Kasela, S Katrinli, PL Kuo, PR Matias-Garcia, PP Mishra, M Nygaard, T Palviainen, A Patki, LM Raffield, SM Ratliff, TG Richardson, O Robinson, M Soerensen, D Sun, PC Tsai, MD van der Zee, RM Walker, X Wang, Y Wang, R Xia, Z Xu, J Yao, W Zhao, A Correa, E Boerwinkle, PA Dugué, P Durda, HR Elliott, C Gieger, EJC de Geus, SE Harris, G Hemani, M Imboden, M Kähönen, SLR Kardia, JK Kresovich, S Li, KL Lunetta, M Mangino, D Mason, AM McIntosh, J Mengel-From, AZ Moore, JM Murabito, M Ollikainen, JS Pankow, NL Pedersen, A Peters, S Polidoro, DJ Porteous, O Raitakari, SS Rich, DP Sandler, E Sillanpää, AK Smith, MC Southey, K Strauch, H Tiwari, T Tanaka, T Tillin, AG Uitterlinden, DJ Van Den Berg, J van Dongen, JG Wilson, J Wright, I Yet, D Arnett, S Bandinelli, JT Bell, AM Binder, DI Boomsma, W Chen, K Christensen, KN Conneely, P Elliott, L Ferrucci, M Fornage, S Hägg, C Hayward, M Irvin, J Kaprio, DA Lawlor, T Lehtimäki, FW Lohoff, L Milani, RL Milne, N Probst-Hensch, AP Reiner, B Ritz, JI Rotter, JA Smith, JA Taylor, JBJ van Meurs, P Vineis, M Waldenberger, IJ Deary, CL Relton, S Horvath, RE Marioni	06/29/2021
Chromatin Accessibility Identifies Regulatory Elements Predictive of Gene Expression and Disease Outcome in Multiple Myeloma. Clinical cancer research : an official journal of the American Association for Cancer Research	BG Barwick, VA Gupta, SM Matulis, JC Patton, DR Powell, Y Gu, DL Jaye, KN Conneely, YC Lin, CC Hofmeister, AK Nooka, JJ Keats, S Lonial, PM Vertino, LH Boise	06/01/2021
The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer	C Xiao, V Fedirko, J Beitler, J Bai, G Peng, C Zhou, J Gu, H Zhao, IH Lin, CE Chico, S Jeon, TM Knobf, KN Conneely, K Higgins, DM Shin, N Saba, A Miller, D Bruner	06/01/2021
Epigenome-wide association study of diet quality in the Women's Health Initiative and TwinsUK cohort. International journal of epidemiology	WL Do, EA Whitsel, R Costeira, OM Masachs, CI Le Roy, JT Bell, LR Staimez, AD Stein, AK Smith, S Horvath, TL Assimes, S Liu, JE Manson, AH Shadyab, Y Li, L Hou, P Bhatti, K Jordahl, KMV Narayan, KN Conneely	05/17/2021
Polygenic risk scores differentiate schizophrenia patients with toxoplasma gondii compared to toxoplasma seronegative patients. Comprehensive psychiatry	A Lori, D Avramopoulos, AW Wang, J Mulle, N Massa, EJ Duncan, A Powers, K Conneely, CF Gillespie, T Jovanovic, KJ Ressler, BD Pearce	05/01/2021
Ten-eleven translocation protein 1 modulates medulloblastoma progression. Genome biology	H Kim, Y Kang, Y Li, L Chen, L Lin, ND Johnson, D Zhu, MH Robinson, L McSwain, BG Barwick, X Yuan, X Liao, J Zhao, Z Zhang, Q Shu, J Chen, EG Allen, AM Kenney, RC Castellino, EG Van Meir, KN Conneely, PM Vertino, P Jin, J Li	04/29/2021
Genome-wide DNA methylation differences and polychlorinated biphenyl (PCB) exposure in a US population. Epigenetics	SW Curtis, DO Cobb, V Kilaru, ML Terrell, ME Marder, DB Barr, CJ Marsit, M Marcus, KN Conneely, AK Smith	03/01/2021
Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems. Epigenomics	AE Justice, G Chittoor, R Gondalia, PE Melton, E Lim, ML Grove, EA Whitsel, CT Liu, LA Cupples, L Fernandez-Rhodes, W Guan, J Bressler, M Fornage, E Boerwinkle, Y Li, E Demerath, N Heard-Costa, D Levy, JD Stewart, A Baccarelli, L Hou, K Conneely, TA Mori, LJ Beilin, RC Huang, P Gordon-Larsen, AG Howard, KE North	09/01/2020
Association between DNA methylation levels in brain tissue and late-life depression in community-based participants. Translational psychiatry	A Hüls, C Robins, KN Conneely, PL De Jager, DA Bennett, MP Epstein, TS Wingo, AP Wingo	07/30/2020
Obesity-associated methylation in breast tumors: a possible link to disparate outcomes? Breast cancer research and treatment	WL Do, K Conneely, S Gabram-Mendola, U Krishnamurti, O D'Angelo, J Miller-Kleinhenz, K Gogineni, M Torres, LE McCullough	05/01/2020
Sex-specific DNA methylation differences in people exposed to polybrominated biphenyl. Epigenomics	SW Curtis, SA Gerkowicz, DO Cobb, V Kilaru, ML Terrell, ME Marder, DB Barr, CJ Marsit, M Marcus, KN Conneely, AK Smith	05/01/2020
Age-related DNA hydroxymethylation is enriched for gene expression and immune system processes in human peripheral blood. Epigenetics	ND Johnson, L Huang, R Li, Y Li, Y Yang, HR Kim, C Grant, H Wu, EA Whitsel, DP Kiel, AA Baccarelli, P Jin, JM Murabito, KN Conneely	03/01/2020
Critical evaluation of copy number variant calling methods using DNA methylation. Genetic epidemiology	V Kilaru, AK Knight, S Katrinli, D Cobb, A Lori, CF Gillespie, AX Maihofer, CM Nievergelt, AL Dunlop, KN Conneely, AK Smith	03/01/2020
Endometriosis, endocrine disrupters, and epigenetics: an investigation into the complex interplay in women with polybrominated biphenyl exposure and endometriosis. Journal of assisted reproduction and genetics	SA Gerkowicz, SW Curtis, AK Knight, DO Cobb, JB Spencer, KN Conneely, ML Terrell, M Marcus, AK Smith	02/01/2020
Leukocyte Traits and Exposure to Ambient Particulate Matter Air Pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study. Environmental health perspectives	R Gondalia, KM Holliday, A Baldassari, AE Justice, JD Stewart, D Liao, JD Yanosky, SM Engel, KM Jordahl, P Bhatti, S Horvath, TL Assimes, JS Pankow, EW Demerath, W Guan, M Fornage, J Bressler, KE North, KN Conneely, Y Li, L Hou, AA Baccarelli, EA Whitsel	01/01/2020
Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation. Environment international	R Gondalia, A Baldassari, KM Holliday, AE Justice, R Méndez-Giráldez, JD Stewart, D Liao, JD Yanosky, KJM Brennan, SM Engel, KM Jordahl, E Kennedy, CK Ward-Caviness, K Wolf, M Waldenberger, J Cyrys, A Peters, P Bhatti, S Horvath, TL Assimes, JS Pankow, EW Demerath, W Guan, M Fornage, J Bressler, KE North, KN Conneely, Y Li, L Hou, AA Baccarelli, EA Whitsel	11/01/2019
Exposure to polybrominated biphenyl and stochastic epigenetic mutations: application of a novel epigenetic approach to environmental exposure in the Michigan polybrominated biphenyl registry. Epigenetics	SW Curtis, DO Cobb, V Kilaru, ML Terrell, ME Marder, DB Barr, CJ Marsit, M Marcus, KN Conneely, AK Smith	10/01/2019
Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics	S Sikdar, R Joehanes, BR Joubert, CJ Xu, M Vives-Usano, FI Rezwan, JF Felix, JM Ward, W Guan, RC Richmond, JA Brody, LK Küpers, N Baïz, SE Håberg, JA Smith, SE Reese, S Aslibekyan, C Hoyo, R Dhingra, CA Markunas, T Xu, LM Reynolds, AC Just, PR Mandaviya, A Ghantous, BD Bennett, T Wang, TB Consortium, KM Bakulski, E Melen, S Zhao, J Jin, Z Herceg, JV Meurs, JA Taylor, AA Baccarelli, SK Murphy, Y Liu, MC Munthe-Kaas, IJ Deary, W Nystad, M Waldenberger, I Annesi-Maesano, K Conneely, VW Jaddoe, D Arnett, H Snieder, SL Kardia, CL Relton, KK Ong, S Ewart, H Moreno-Macias, I Romieu, N Sotoodehnia, M Fornage, A Motsinger-Reif, GH Koppelman, M Bustamante, D Levy, SJ London	10/01/2019
Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease. Nature communications	T Huan, R Joehanes, C Song, F Peng, Y Guo, M Mendelson, C Yao, C Liu, J Ma, M Richard, G Agha, W Guan, LM Almli, KN Conneely, J Keefe, SJ Hwang, AD Johnson, M Fornage, L Liang, D Levy	09/19/2019
Thyroid hormone levels associate with exposure to polychlorinated biphenyls and polybrominated biphenyls in adults exposed as children. Environmental health : a global access science source	SW Curtis, ML Terrell, MH Jacobson, DO Cobb, VS Jiang, MF Neblett, SA Gerkowicz, JB Spencer, ME Marder, DB Barr, KN Conneely, AK Smith, M Marcus	08/23/2019
Environmental exposure to polybrominated biphenyl (PBB) associates with an increased rate of biological aging. Aging	SW Curtis, DO Cobb, V Kilaru, ML Terrell, ME Marder, DB Barr, CJ Marsit, M Marcus, KN Conneely, AK Smith	08/02/2019
The differential effects of PTSD, MDD, and dissociation on CRP in trauma-exposed women. Comprehensive psychiatry	A Powers, HD Dixon, K Conneely, R Gluck, A Munoz, C Rochat, H Mendoza, G Hartzell, KJ Ressler, B Bradley, TWW Pace, GE Umpierrez, AC Schwartz, V Michopoulos, CF Gillespie	08/01/2019
Genome-wide association study in two populations to determine genetic variants associated with Toxoplasma gondii infection and relationship to schizophrenia risk. Progress in neuro-psychopharmacology & biological psychiatry	AW Wang, D Avramopoulos, A Lori, J Mulle, K Conneely, A Powers, E Duncan, L Almli, N Massa, J McGrath, AC Schwartz, FS Goes, L Weng, R Wang, R Yolken, I Ruczinski, CF Gillespie, T Jovanovic, K Ressler, AE Pulver, BD Pearce	06/08/2019
Blood-Derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation. Gastroenterology	HK Somineni, S Venkateswaran, V Kilaru, UM Marigorta, A Mo, DT Okou, R Kellermayer, K Mondal, D Cobb, TD Walters, A Griffiths, JD Noe, WV Crandall, JR Rosh, DR Mack, MB Heyman, SS Baker, MC Stephens, RN Baldassano, JF Markowitz, MC Dubinsky, J Cho, JS Hyams, LA Denson, G Gibson, DJ Cutler, KN Conneely, AK Smith, S Kugathasan	06/01/2019
The role of DNA methylation and hydroxymethylation in immunosenescence. Ageing research reviews	ND Johnson, KN Conneely	05/01/2019
Exposure to polybrominated biphenyl (PBB) associates with genome-wide DNA methylation differences in peripheral blood. Epigenetics	SW Curtis, DO Cobb, V Kilaru, ML Terrell, EM Kennedy, ME Marder, DB Barr, CJ Marsit, M Marcus, KN Conneely, AK Smith	01/01/2019
Robust Rare-Variant Association Tests For Quantitative Traits in General Pedigrees. Statistics in biosciences	Y Jiang, KN Conneely, MP Epstein	12/01/2018
Identification of the Transcription Factor Relationships Associated with Androgen Deprivation Therapy Response and Metastatic Progression in Prostate Cancer. Cancers	NV Sharma, KL Pellegrini, V Ouellet, FO Giuste, S Ramalingam, K Watanabe, E Adam-Granger, L Fossouo, S You, MR Freeman, P Vertino, K Conneely, AO Osunkoya, D Trudel, AM Mes-Masson, JA Petros, F Saad, CS Moreno	10/11/2018
Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations. Addiction biology	LM Almli, A Lori, JL Meyers, J Shin, N Fani, AX Maihofer, CM Nievergelt, AK Smith, KB Mercer, K Kerley, JM Leveille, H Feng, D Abu-Amara, JD Flory, R Yehuda, CR Marmar, DG Baker, B Bradley, KC Koenen, KN Conneely, KJ Ressler	09/01/2018
Presentation, progression, and predictors of ovarian insufficiency in classic galactosemia. Journal of inherited metabolic disease	AB Frederick, AM Zinsli, G Carlock, K Conneely, JL Fridovich-Keil	09/01/2018
Powerful and robust cross-phenotype association test for case-parent trios. Genetic epidemiology	ST Fischer, Y Jiang, KA Broadaway, KN Conneely, MP Epstein	07/01/2018
Relationship between Epigenetic Maturity and Respiratory Morbidity in Preterm Infants. The Journal of pediatrics	AK Knight, AK Smith, KN Conneely, P Dalach, YJ Loke, JL Cheong, PG Davis, JM Craig, LW Doyle, C Theda	07/01/2018
An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells. BMC genomics	EM Kennedy, GN Goehring, MH Nichols, C Robins, D Mehta, T Klengel, E Eskin, AK Smith, KN Conneely	06/19/2018
Intergenerational effects of endocrine-disrupting compounds: a review of the Michigan polybrominated biphenyl registry. Epigenomics	SW Curtis, KN Conneely, ME Marder, ML Terrell, M Marcus, AK Smith	06/01/2018
HLA typing using genome wide data reveals susceptibility types for infections in a psychiatric disease enriched sample. Brain, behavior, and immunity	S Parks, D Avramopoulos, J Mulle, J McGrath, R Wang, FS Goes, K Conneely, I Ruczinski, R Yolken, AE Pulver, BD Pearce	05/01/2018
Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer. Scientific reports	EM Kennedy, DR Powell, Z Li, JSK Bell, BG Barwick, H Feng, MR McCrary, B Dwivedi, J Kowalski, WS Dynan, KN Conneely, PM Vertino	04/30/2018
Kernel machine methods for integrative analysis of genome-wide methylation and genotyping studies. Genetic epidemiology	N Zhao, X Zhan, YT Huang, LM Almli, A Smith, MP Epstein, K Conneely, MC Wu	03/01/2018
Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD. Molecular psychiatry	SA Maddox, V Kilaru, J Shin, T Jovanovic, LM Almli, BG Dias, SD Norrholm, N Fani, V Michopoulos, Z Ding, KN Conneely, EB Binder, KJ Ressler, AK Smith	03/01/2018
A DNA methylation biomarker of alcohol consumption. Molecular psychiatry	C Liu, RE Marioni, ÅK Hedman, L Pfeiffer, PC Tsai, LM Reynolds, AC Just, Q Duan, CG Boer, T Tanaka, CE Elks, S Aslibekyan, JA Brody, B Kühnel, C Herder, LM Almli, D Zhi, Y Wang, T Huan, C Yao, MM Mendelson, R Joehanes, L Liang, SA Love, W Guan, S Shah, AF McRae, A Kretschmer, H Prokisch, K Strauch, A Peters, PM Visscher, NR Wray, X Guo, KL Wiggins, AK Smith, EB Binder, KJ Ressler, MR Irvin, DM Absher, D Hernandez, L Ferrucci, S Bandinelli, K Lohman, J Ding, L Trevisi, S Gustafsson, JH Sandling, L Stolk, AG Uitterlinden, I Yet, JE Castillo-Fernandez, TD Spector, JD Schwartz, P Vokonas, L Lind, Y Li, M Fornage, DK Arnett, NJ Wareham, N Sotoodehnia, KK Ong, JBJ van Meurs, KN Conneely, AA Baccarelli, IJ Deary, JT Bell, KE North, Y Liu, M Waldenberger, SJ London, E Ingelsson, D Levy	02/01/2018
SLC9B1 methylation predicts fetal intolerance of labor. Epigenetics	AK Knight, KN Conneely, V Kilaru, D Cobb, JL Payne, S Meilman, EJ Corwin, ZA Kaminsky, AL Dunlop, AK Smith	01/01/2018
Characterization of gene expression changes over healthy term pregnancies. PloS one	AK Knight, AL Dunlop, V Kilaru, D Cobb, EJ Corwin, KN Conneely, AK Smith	01/01/2018
Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data. Genetics	C Robins, AF McRae, JE Powell, HW Wiener, S Aslibekyan, EM Kennedy, DM Absher, DK Arnett, GW Montgomery, PM Visscher, DJ Cutler, KN Conneely	12/01/2017
A longitudinal study of DNA methylation as a potential mediator of age-related diabetes risk. GeroScience	CD Grant, N Jafari, L Hou, Y Li, JD Stewart, G Zhang, A Lamichhane, JE Manson, AA Baccarelli, EA Whitsel, KN Conneely	12/01/2017
Serum Polybrominated Biphenyls (PBBs) and Polychlorinated Biphenyls (PCBs) and Thyroid Function among Michigan Adults Several Decades after the 1973-1974 PBB Contamination of Livestock Feed. Environmental health perspectives	MH Jacobson, LA Darrow, DB Barr, PP Howards, RH Lyles, ML Terrell, AK Smith, KN Conneely, ME Marder, M Marcus	09/26/2017
Powerful Genetic Association Analysis for Common or Rare Variants with High-Dimensional Structured Traits. Genetics	X Zhan, N Zhao, A Plantinga, TA Thornton, KN Conneely, MP Epstein, MC Wu	08/01/2017
Non-linear patterns in age-related DNA methylation may reflect CD4⁺ T cell differentiation. Epigenetics	ND Johnson, HW Wiener, AK Smith, S Nishitani, DM Absher, DK Arnett, S Aslibekyan, KN Conneely	06/03/2017
Gestational age predicted by DNA methylation: potential clinical and research utility. Epigenomics	AK Knight, KN Conneely, AK Smith	01/23/2017
Case-control Association Study of Autoimmunity Associated Variants in PDCD1 and Juvenile Idiopathic Arthritis. Current rheumatology reviews	C Tejeda, AK Broadaway, MJ Ombrello, MR Brown, LA Ponder, MR Pichavant, G Wang, S Angeles-Han, A Hersh, J Bohnsack, KN Conneely, M Epstein, S Prahalad	01/01/2017
DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome biology	S Ligthart, C Marzi, S Aslibekyan, MM Mendelson, KN Conneely, T Tanaka, E Colicino, LL Waite, R Joehanes, W Guan, JA Brody, C Elks, R Marioni, MA Jhun, G Agha, J Bressler, CK Ward-Caviness, BH Chen, T Huan, K Bakulski, EL Salfati, G Fiorito, S Wahl, K Schramm, J Sha, DG Hernandez, AC Just, JA Smith, N Sotoodehnia, LC Pilling, JS Pankow, PS Tsao, C Liu, W Zhao, S Guarrera, VJ Michopoulos, AK Smith, MJ Peters, D Melzer, P Vokonas, M Fornage, H Prokisch, JC Bis, AY Chu, C Herder, H Grallert, C Yao, S Shah, AF McRae, H Lin, S Horvath, D Fallin, A Hofman, NJ Wareham, KL Wiggins, AP Feinberg, JM Starr, PM Visscher, JM Murabito, SL Kardia, DM Absher, EB Binder, AB Singleton, S Bandinelli, A Peters, M Waldenberger, G Matullo, JD Schwartz, EW Demerath, AG Uitterlinden, JB van Meurs, OH Franco, YI Chen, D Levy, ST Turner, IJ Deary, KJ Ressler, J Dupuis, L Ferrucci, KK Ong, TL Assimes, E Boerwinkle, W Koenig, DK Arnett, AA Baccarelli, EJ Benjamin, A Dehghan	12/12/2016
Prioritizing individual genetic variants after kernel machine testing using variable selection. Genetic epidemiology	Q He, T Cai, Y Liu, N Zhao, QE Harmon, LM Almli, EB Binder, SM Engel, KJ Ressler, KN Conneely, X Lin, MC Wu	12/01/2016
An epigenetic clock for gestational age at birth based on blood methylation data. Genome biology	AK Knight, JM Craig, C Theda, M Bækvad-Hansen, J Bybjerg-Grauholm, CS Hansen, MV Hollegaard, DM Hougaard, PB Mortensen, SM Weinsheimer, TM Werge, PA Brennan, JF Cubells, DJ Newport, ZN Stowe, JL Cheong, P Dalach, LW Doyle, YJ Loke, AA Baccarelli, AC Just, RO Wright, MM Téllez-Rojo, K Svensson, L Trevisi, EM Kennedy, EB Binder, S Iurato, D Czamara, K Räikkönen, JM Lahti, AK Pesonen, E Kajantie, PM Villa, H Laivuori, E Hämäläinen, HJ Park, LB Bailey, SE Parets, V Kilaru, R Menon, S Horvath, NR Bush, KZ LeWinn, FA Tylavsky, KN Conneely, AK Smith	10/07/2016
Epigenetic Signatures of Cigarette Smoking. Circulation. Cardiovascular genetics	R Joehanes, AC Just, RE Marioni, LC Pilling, LM Reynolds, PR Mandaviya, W Guan, T Xu, CE Elks, S Aslibekyan, H Moreno-Macias, JA Smith, JA Brody, R Dhingra, P Yousefi, JS Pankow, S Kunze, SH Shah, AF McRae, K Lohman, J Sha, DM Absher, L Ferrucci, W Zhao, EW Demerath, J Bressler, ML Grove, T Huan, C Liu, MM Mendelson, C Yao, DP Kiel, A Peters, R Wang-Sattler, PM Visscher, NR Wray, JM Starr, J Ding, CJ Rodriguez, NJ Wareham, MR Irvin, D Zhi, M Barrdahl, P Vineis, S Ambatipudi, AG Uitterlinden, A Hofman, J Schwartz, E Colicino, L Hou, PS Vokonas, DG Hernandez, AB Singleton, S Bandinelli, ST Turner, EB Ware, AK Smith, T Klengel, EB Binder, BM Psaty, KD Taylor, SA Gharib, BR Swenson, L Liang, DL DeMeo, GT O'Connor, Z Herceg, KJ Ressler, KN Conneely, N Sotoodehnia, SL Kardia, D Melzer, AA Baccarelli, JB van Meurs, I Romieu, DK Arnett, KK Ong, Y Liu, M Waldenberger, IJ Deary, M Fornage, D Levy, SJ London	10/01/2016
Statistical challenges in analyzing methylation and long-range chromosomal interaction data. Statistics in biosciences	Z Qin, B Li, KN Conneely, H Wu, M Hu, D Ayyala, Y Park, VX Jin, F Zhang, H Zhang, L Li, S Lin	10/01/2016
Genome-wide gene-based analysis suggests an association between Neuroligin 1 (NLGN1) and post-traumatic stress disorder. Translational psychiatry	V Kilaru, SV Iyer, LM Almli, JS Stevens, A Lori, T Jovanovic, TD Ely, B Bradley, EB Binder, N Koen, DJ Stein, KN Conneely, AP Wingo, AK Smith, KJ Ressler	05/24/2016
Across-Platform Imputation of DNA Methylation Levels Incorporating Nonlocal Information Using Penalized Functional Regression. Genetic epidemiology	G Zhang, KC Huang, Z Xu, JY Tzeng, KN Conneely, W Guan, J Kang, Y Li	05/01/2016
Phenotypic Characterization of Juvenile Idiopathic Arthritis in African American Children. The Journal of rheumatology	L Fitzpatrick, KA Broadaway, L Ponder, ST Angeles-Han, K Jenkins, K Rouster-Stevens, CF Pelajo, K Conneely, MP Epstein, J Lopez-Benitez, LB Vogler, S Prahalad	04/01/2016
Autosomal Dominant Retinal Dystrophies Caused by a Founder Splice Site Mutation, c.828+3A>T, in PRPH2 and Protein Haplotypes in trans as Modifiers. Investigative ophthalmology & visual science	SP Shankar, DK Hughbanks-Wheaton, DG Birch, LS Sullivan, KN Conneely, SJ Bowne, EM Stone, SP Daiger	02/01/2016
Oxytocin Receptor Genetic and Epigenetic Variations: Association With Child Abuse and Adult Psychiatric Symptoms. Child development	EL Smearman, LM Almli, KN Conneely, GH Brody, JM Sales, B Bradley, KJ Ressler, AK Smith	01/01/2016
Emotion Dysregulation and Inflammation in African-American Women with Type 2 Diabetes. Neural plasticity	A Powers, V Michopoulos, K Conneely, R Gluck, H Dixon, J Wilson, T Jovanovic, TW Pace, GE Umpierrez, KJ Ressler, B Bradley, CF Gillespie	01/01/2016
Detection of differentially methylated regions from whole-genome bisulfite sequencing data without replicates. Nucleic acids research	H Wu, T Xu, H Feng, L Chen, B Li, B Yao, Z Qin, P Jin, KN Conneely	12/02/2015
The transcriptional landscape of age in human peripheral blood. Nature communications	MJ Peters, R Joehanes, LC Pilling, C Schurmann, KN Conneely, J Powell, E Reinmaa, GL Sutphin, A Zhernakova, K Schramm, YA Wilson, S Kobes, T Tukiainen, YF Ramos, HH Göring, M Fornage, Y Liu, SA Gharib, BE Stranger, PL De Jager, A Aviv, D Levy, JM Murabito, PJ Munson, T Huan, A Hofman, AG Uitterlinden, F Rivadeneira, J van Rooij, L Stolk, L Broer, MM Verbiest, M Jhamai, P Arp, A Metspalu, L Tserel, L Milani, NJ Samani, P Peterson, S Kasela, V Codd, A Peters, CK Ward-Caviness, C Herder, M Waldenberger, M Roden, P Singmann, S Zeilinger, T Illig, G Homuth, HJ Grabe, H Völzke, L Steil, T Kocher, A Murray, D Melzer, H Yaghootkar, S Bandinelli, EK Moses, JW Kent, JE Curran, MP Johnson, S Williams-Blangero, HJ Westra, AF McRae, JA Smith, SL Kardia, I Hovatta, M Perola, S Ripatti, V Salomaa, AK Henders, NG Martin, AK Smith, D Mehta, EB Binder, KM Nylocks, EM Kennedy, T Klengel, J Ding, AM Suchy-Dicey, DA Enquobahrie, J Brody, JI Rotter, YD Chen, J Houwing-Duistermaat, M Kloppenburg, PE Slagboom, Q Helmer, W den Hollander, S Bean, T Raj, N Bakhshi, QP Wang, LJ Oyston, BM Psaty, RP Tracy, GW Montgomery, ST Turner, J Blangero, I Meulenbelt, KJ Ressler, J Yang, L Franke, J Kettunen, PM Visscher, GG Neely, R Korstanje, RL Hanson, H Prokisch, L Ferrucci, T Esko, A Teumer, JB van Meurs, AD Johnson	10/22/2015
Kernel Approach for Modeling Interaction Effects in Genetic Association Studies of Complex Quantitative Traits. Genetic epidemiology	KA Broadaway, R Duncan, KN Conneely, LM Almli, B Bradley, KJ Ressler, MP Epstein	07/01/2015
DNA methylation provides insight into intergenerational risk for preterm birth in African Americans. Epigenetics	SE Parets, KN Conneely, V Kilaru, R Menon, AK Smith	01/01/2015
Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption. PloS one	AW Bergen, M Michel, D Nishita, R Krasnow, HS Javitz, KN Conneely, CN Lessov-Schlaggar, H Hops, AZ Zhu, JW Baurley, JB McClure, SM Hall, TB Baker, DV Conti, NL Benowitz, C Lerman, RF Tyndale, GE Swan	01/01/2015
Testing evolutionary models of senescence: traditional approaches and future directions. Human genetics	C Robins, KN Conneely	12/01/2014
Correcting systematic inflation in genetic association tests that consider interaction effects: application to a genome-wide association study of posttraumatic stress disorder. JAMA psychiatry	LM Almli, R Duncan, H Feng, D Ghosh, EB Binder, B Bradley, KJ Ressler, KN Conneely, MP Epstein	12/01/2014
Flexible and robust methods for rare-variant testing of quantitative traits in trios and nuclear families. Genetic epidemiology	Y Jiang, KN Conneely, MP Epstein	09/01/2014
Epigenetic changes associated with inflammation in breast cancer patients treated with chemotherapy. Brain, behavior, and immunity	AK Smith, KN Conneely, TW Pace, D Mister, JC Felger, V Kilaru, MJ Akel, PM Vertino, AH Miller, MA Torres	05/01/2014
Accounting for population stratification in DNA methylation studies. Genetic epidemiology	RT Barfield, LM Almli, V Kilaru, AK Smith, KB Mercer, R Duncan, T Klengel, D Mehta, EB Binder, MP Epstein, KJ Ressler, KN Conneely	04/01/2014
A Bayesian hierarchical model to detect differentially methylated loci from single nucleotide resolution sequencing data. Nucleic acids research	H Feng, KN Conneely, H Wu	04/01/2014
Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type. BMC genomics	AK Smith, V Kilaru, M Kocak, LM Almli, KB Mercer, KJ Ressler, FA Tylavsky, KN Conneely	02/21/2014
Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills. Proceedings of the National Academy of Sciences of the United States of America	DH Skuse, A Lori, JF Cubells, I Lee, KN Conneely, K Puura, T Lehtimäki, EB Binder, LJ Young	02/04/2014
Meta-analysis confirms association between TNFA-G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA. Pediatric rheumatology online journal	MJ Kaalla, KA Broadaway, M Rohani-Pichavant, KN Conneely, A Whiting, L Ponder, DT Okou, S Angeles-Han, K Rouster-Stevens, MR Brown, LB Vogler, LB Jorde, JF Bohnsack, MP Epstein, S Prahalad	10/25/2013
Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans. Human genetics	YV Sun, AK Smith, KN Conneely, Q Chang, W Li, A Lazarus, JA Smith, LM Almli, EB Binder, T Klengel, D Cross, ST Turner, KJ Ressler, SL Kardia	09/01/2013
Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Proceedings of the National Academy of Sciences of the United States of America	D Mehta, T Klengel, KN Conneely, AK Smith, A Altmann, TW Pace, M Rex-Haffner, A Loeschner, M Gonik, KB Mercer, B Bradley, B Müller-Myhsok, KJ Ressler, EB Binder	05/14/2013
ADCYAP1R1 genotype associates with post-traumatic stress symptoms in highly traumatized African-American females. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics	LM Almli, KB Mercer, K Kerley, H Feng, B Bradley, KN Conneely, KJ Ressler	04/01/2013
Genome-wide analysis validates aberrant methylation in fragile X syndrome is specific to the FMR1 locus. BMC medical genetics	RS Alisch, T Wang, P Chopra, J Visootsak, KN Conneely, ST Warren	01/29/2013
Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder. Frontiers in behavioral neuroscience	SD Norrholm, T Jovanovic, AK Smith, E Binder, T Klengel, K Conneely, KB Mercer, JS Davis, K Kerley, J Winkler, CF Gillespie, B Bradley, KJ Ressler	01/01/2013
Assessing the impact of population stratification on association studies of rare variation. Human heredity	Y Jiang, MP Epstein, KN Conneely	01/01/2013
Mutations in FKBP10, which result in Bruck syndrome and recessive forms of osteogenesis imperfecta, inhibit the hydroxylation of telopeptide lysines in bone collagen. Human molecular genetics	U Schwarze, T Cundy, SM Pyott, HE Christiansen, MR Hegde, RA Bank, G Pals, A Ankala, K Conneely, L Seaver, SM Yandow, E Raney, D Babovic-Vuksanovic, J Stoler, Z Ben-Neriah, R Segel, S Lieberman, L Siderius, A Al-Aqeel, M Hannibal, L Hudgins, E McPherson, M Clemens, MD Sussman, RD Steiner, J Mahan, R Smith, K Anyane-Yeboa, J Wynn, K Chong, T Uster, S Aftimos, VR Sutton, EC Davis, LS Kim, MA Weis, D Eyre, PH Byers	01/01/2013
CpGassoc: an R function for analysis of DNA methylation microarray data. Bioinformatics (Oxford, England)	RT Barfield, V Kilaru, AK Smith, KN Conneely	05/01/2012