Sumin Kang, PhD
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Research Program
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Phone Number
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Email Address
Biography
Education
Dr. Kang obtained her PhD from Yonsei University in Seoul, Korea. She completed her postdoctoral training at Emory University School of Medicine before joining the faculty in 2009.
Titles & Roles
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Professor, Department of Hematology and Medical OncologyEmory University School of Medicine
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Division Director of Basic and Translational Science, Department of Hematology and Medical OncologyEmory University School of Medicine
Research
Dr. Kang's laboratory focuses on phosphor-proteomics based studies to elucidate signaling mechanisms underlying protein kinase or metabolic enzyme-dependent oncogenesis and tumor metastasis; translational and preclinical studies using in vitro cell assays and in vivo mouse models of tumors and metastases to evaluate small molecule inhibitors to treat human cancers; and studies to elucidate the role of post-translational modifications of protein kinases and metabolic enzymes in pathogenesis and disease progression of human cancers including leukemia and solid tumors.
Grants
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Grant Number Title 5R01CA175316-10 Transcription-dependent and -independent signaling of RSK2 in cancer metastasis Publications
Dr. Kang has extensive publications in major peer-reviewed journals such as Cancer Cell, Molecular Cell, Journal of Clinical Investigation, Molecular and Cellular Biology, Journal of Biological Chemistry and Blood.
Title/Journal Authors Publication Date Proceedings of the National Academy of Sciences of the United States of America
AC Boese, J Kang, JS Hwang, J Kim, K Eun, CM Malin, KR Magliocca, C Pan, L Jin, S Kang 06/06/2023 Cell reports
J Kang, J Chun, JS Hwang, C Pan, J Li, AC Boese, I Young, CM Malin, Y Kang, DL Gibbons, G Sica, H Fu, SS Ramalingam, L Jin, S Kang 12/13/2022 Immunomedicine
AC Boese, JS Hwang, I Young, CM Malin, V Avalos, J Kang, S Kang 12/01/2022 Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1.
Nature communications
C Pan, J Kang, JS Hwang, J Li, AC Boese, X Wang, L Yang, TJ Boggon, GZ Chen, NF Saba, DM Shin, KR Magliocca, L Jin, S Kang 08/16/2021 Mitochondrial metabolism-mediated redox regulation in cancer progression.
Redox biology
AC Boese, S Kang 06/01/2021 DGKA Provides Platinum Resistance in Ovarian Cancer Through Activation of c-JUN-WEE1 Signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research
J Li, C Pan, AC Boese, J Kang, AD Umano, KR Magliocca, W Yang, Y Zhang, S Lonial, L Jin, S Kang 07/15/2020 New Approaches to SCLC Therapy: From the Laboratory to the Clinic.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
JT Poirier, J George, TK Owonikoko, A Berns, E Brambilla, LA Byers, D Carbone, HJ Chen, CL Christensen, C Dive, AF Farago, R Govindan, C Hann, MD Hellmann, L Horn, JE Johnson, YS Ju, S Kang, M Krasnow, J Lee, SH Lee, J Lehman, B Lok, C Lovly, D MacPherson, D McFadden, J Minna, M Oser, K Park, KS Park, Y Pommier, V Quaranta, N Ready, J Sage, G Scagliotti, ML Sos, KD Sutherland, WD Travis, CR Vakoc, SJ Wait, I Wistuba, KK Wong, H Zhang, J Daigneault, J Wiens, CM Rudin, TG Oliver 04/01/2020 Tumor Progression of Breast Cancer during Hyperinsulinemic Obesity.
Trends in molecular medicine
AC Boese, S Kang 04/01/2020 The Journal of clinical investigation
C Pan, J Chun, D Li, AC Boese, J Li, J Kang, A Umano, Y Jiang, L Song, KR Magliocca, ZG Chen, NF Saba, DM Shin, TK Owonikoko, S Lonial, L Jin, S Kang 10/01/2019 The Journal of clinical investigation
C Pan, L Jin, X Wang, Y Li, J Chun, AC Boese, D Li, HB Kang, G Zhang, L Zhou, GZ Chen, NF Saba, DM Shin, KR Magliocca, TK Owonikoko, H Mao, S Lonial, S Kang 05/13/2019 Nature metabolism
F Ni, WM Yu, Z Li, DK Graham, L Jin, S Kang, MR Rossi, S Li, HE Broxmeyer, CK Qu 03/01/2019 Science advances
H Zheng, WM Yu, J Shen, S Kang, D Hambardzumyan, JY Li, Y Shen, AM Kenney, J Chen, CK Qu 10/01/2018 MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation.
Cancer cell
L Jin, J Chun, C Pan, D Li, R Lin, GN Alesi, X Wang, HB Kang, L Song, D Wang, G Zhang, J Fan, TJ Boggon, L Zhou, J Kowalski, CK Qu, CE Steuer, GZ Chen, NF Saba, LH Boise, TK Owonikoko, FR Khuri, KR Magliocca, DM Shin, S Lonial, S Kang 08/13/2018 A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
L Wang, C Iorio, K Yan, H Yang, S Takeshita, S Kang, BG Neel, W Yang 02/01/2018 Molecular cell
L Jin, J Chun, C Pan, A Kumar, G Zhang, Y Ha, D Li, GN Alesi, Y Kang, L Zhou, WM Yu, KR Magliocca, FR Khuri, CK Qu, C Metallo, TK Owonikoko, S Kang 01/04/2018 Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis.
Oncogene
L Jin, J Chun, C Pan, GN Alesi, D Li, KR Magliocca, Y Kang, ZG Chen, DM Shin, FR Khuri, J Fan, S Kang 07/06/2017 Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nature communications
Z Zhang, O Obianyo, E Dall, Y Du, H Fu, X Liu, SS Kang, M Song, SP Yu, C Cabrele, M Schubert, X Li, JZ Wang, H Brandstetter, K Ye 03/27/2017 Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.
Molecular cell
J Fan, R Lin, S Xia, D Chen, SE Elf, S Liu, Y Pan, H Xu, Z Qian, M Wang, C Shan, L Zhou, QY Lei, Y Li, H Mao, BH Lee, J Sudderth, RJ DeBerardinis, G Zhang, T Owonikoko, M Gaddh, ML Arellano, HJ Khoury, FR Khuri, S Kang, PW Doetsch, S Lonial, TJ Boggon, WJ Curran, J Chen 12/01/2016 RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis.
Oncogene
GN Alesi, L Jin, D Li, KR Magliocca, Y Kang, ZG Chen, DM Shin, FR Khuri, S Kang 10/13/2016 Nature cell biology
R Lin, S Elf, C Shan, HB Kang, Q Ji, L Zhou, T Hitosugi, L Zhang, S Zhang, JH Seo, J Xie, M Tucker, TL Gu, J Sudderth, L Jiang, M Mitsche, RJ DeBerardinis, S Wu, Y Li, H Mao, PR Chen, D Wang, GZ Chen, SJ Hurwitz, S Lonial, ML Arellano, HJ Khoury, FR Khuri, BH Lee, Q Lei, DJ Brat, K Ye, TJ Boggon, C He, S Kang, J Fan, J Chen 11/01/2015 Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.
Molecular cell
HB Kang, J Fan, R Lin, S Elf, Q Ji, L Zhao, L Jin, JH Seo, C Shan, JL Arbiser, C Cohen, D Brat, HM Miziorko, E Kim, O Abdel-Wahab, T Merghoub, S Fröhling, C Scholl, P Tamayo, DA Barbie, L Zhou, BP Pollack, K Fisher, RR Kudchadkar, DH Lawson, G Sica, M Rossi, S Lonial, HJ Khoury, FR Khuri, BH Lee, TJ Boggon, C He, S Kang, J Chen 08/06/2015 Cancer cell
L Jin, D Li, GN Alesi, J Fan, HB Kang, Z Lu, TJ Boggon, P Jin, H Yi, ER Wright, D Duong, NT Seyfried, R Egnatchik, RJ DeBerardinis, KR Magliocca, C He, ML Arellano, HJ Khoury, DM Shin, FR Khuri, S Kang 02/09/2015 The Journal of biological chemistry
J Fan, HB Kang, C Shan, S Elf, R Lin, J Xie, TL Gu, M Aguiar, S Lonning, TW Chung, M Arellano, HJ Khoury, DM Shin, FR Khuri, TJ Boggon, S Kang, J Chen 09/19/2014 Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.
Molecular cell
C Shan, S Elf, Q Ji, HB Kang, L Zhou, T Hitosugi, L Jin, R Lin, L Zhang, JH Seo, J Xie, M Tucker, TL Gu, J Sudderth, L Jiang, RJ DeBerardinis, S Wu, Y Li, H Mao, PR Chen, D Wang, GZ Chen, S Lonial, ML Arellano, HJ Khoury, FR Khuri, BH Lee, DJ Brat, K Ye, TJ Boggon, C He, S Kang, J Fan, J Chen 08/21/2014 Molecular cell
J Fan, C Shan, HB Kang, S Elf, J Xie, M Tucker, TL Gu, M Aguiar, S Lonning, H Chen, M Mohammadi, LM Britton, BA Garcia, M Alečković, Y Kang, S Kaluz, N Devi, EG Van Meir, T Hitosugi, JH Seo, S Lonial, M Gaddh, M Arellano, HJ Khoury, FR Khuri, TJ Boggon, S Kang, J Chen 02/20/2014 The Journal of biological chemistry
D Li, L Jin, GN Alesi, YM Kim, J Fan, JH Seo, D Wang, M Tucker, TL Gu, BH Lee, J Taunton, KR Magliocca, ZG Chen, DM Shin, FR Khuri, S Kang 11/08/2013 p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms.
Molecular and cellular biology
L Jin, D Li, JS Lee, S Elf, GN Alesi, J Fan, HB Kang, D Wang, H Fu, J Taunton, TJ Boggon, M Tucker, TL Gu, ZG Chen, DM Shin, FR Khuri, S Kang 07/01/2013 Nature communications
T Hitosugi, L Zhou, J Fan, S Elf, L Zhang, J Xie, Y Wang, TL Gu, M Alečković, G LeRoy, Y Kang, HB Kang, JH Seo, C Shan, P Jin, W Gong, S Lonial, ML Arellano, HJ Khoury, GZ Chen, DM Shin, FR Khuri, TJ Boggon, S Kang, C He, J Chen 01/01/2013 Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Cancer cell
T Hitosugi, L Zhou, S Elf, J Fan, HB Kang, JH Seo, C Shan, Q Dai, L Zhang, J Xie, TL Gu, P Jin, M Alečković, G LeRoy, Y Kang, JA Sudderth, RJ DeBerardinis, CH Luan, GZ Chen, S Muller, DM Shin, TK Owonikoko, S Lonial, ML Arellano, HJ Khoury, FR Khuri, BH Lee, K Ye, TJ Boggon, S Kang, C He, J Chen 11/13/2012 Molecular cell
T Hitosugi, J Fan, TW Chung, K Lythgoe, X Wang, J Xie, Q Ge, TL Gu, RD Polakiewicz, JL Roesel, GZ Chen, TJ Boggon, S Lonial, H Fu, FR Khuri, S Kang, J Chen 12/23/2011 Molecular and cellular biology
J Fan, T Hitosugi, TW Chung, J Xie, Q Ge, TL Gu, RD Polakiewicz, GZ Chen, TJ Boggon, S Lonial, FR Khuri, S Kang, J Chen 12/01/2011 Targeting RSK2 in myeloid leukemia: right for FLT3 but wrong for BCR-ABL.
Cell cycle (Georgetown, Tex.)
BH Lee, S Kang 11/01/2011 p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.
Blood
S Elf, D Blevins, L Jin, TW Chung, IR Williams, BH Lee, JX Lin, WJ Leonard, J Taunton, HJ Khoury, S Kang 06/23/2011 Anticancer research
M Otsuka, M Mizuki, J Fujita, S Kang, Y Kanakura 01/01/2011 Targeting RSK2 in human malignancies.
Expert opinion on therapeutic targets
S Kang, J Chen 01/01/2011 The Journal of biological chemistry
YT Oh, X Liu, P Yue, S Kang, J Chen, J Taunton, FR Khuri, SY Sun 12/31/2010 The Journal of clinical investigation
S Kang, S Elf, K Lythgoe, T Hitosugi, J Taunton, W Zhou, L Xiong, D Wang, S Muller, S Fan, SY Sun, AI Marcus, TL Gu, RD Polakiewicz, ZG Chen, FR Khuri, DM Shin, J Chen 04/01/2010 Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
Science signaling
T Hitosugi, S Kang, MG Vander Heiden, TW Chung, S Elf, K Lythgoe, S Dong, S Lonial, X Wang, GZ Chen, J Xie, TL Gu, RD Polakiewicz, JL Roesel, TJ Boggon, FR Khuri, DG Gilliland, LC Cantley, J Kaufman, J Chen 11/17/2009 Oncogene
CB Chan, X Liu, SW Jang, SI Hsu, I Williams, S Kang, J Chen, K Ye 10/29/2009 Leukemia
S Dong, S Kang, S Lonial, HJ Khoury, J Viallet, J Chen 03/01/2008 The Journal of biological chemistry
S Kang, S Dong, A Guo, H Ruan, S Lonial, HJ Khoury, TL Gu, J Chen 02/22/2008 Cornea
TI Kim, MI Roh, HE Grossniklaus, SJ Kang, SM Hamilton, DF Schorderet, WB Lee, EK Kim 01/01/2008 Cancer cell
S Kang, S Dong, TL Gu, A Guo, MS Cohen, S Lonial, HJ Khoury, D Fabbro, DG Gilliland, PL Bergsagel, J Taunton, RD Polakiewicz, J Chen 09/01/2007 Blood
S Dong, S Kang, TL Gu, S Kardar, H Fu, S Lonial, HJ Khoury, F Khuri, J Chen 07/01/2007 Awards
Dr. Kang is supported with competitive peer-reviewed federal grants including NIH R01 for transcription-dependent and independent signaling of RSK2 in cancer. She has received various prestigious awards including American Cancer Society Basic Research Scholar Award, The Leukemia & Lymphoma Society Special Fellow Award, Georgia Cancer Coalition Cancer Research Award and Robbins Scholar Award.