Kenneth Moberg, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-727-3733
Email Address

kmoberg@emory.edu

Biography

Kenneth H. Moberg, PhD, is a professor in the Department of Cell Biology at Emory University School of Medicine. Dr. Moberg is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute of Emory University.

Education

Dr. Moberg earned his PhD from Massachusetts Institute of Technology. He completed his postdoctoral training at Massachusetts General Hospital Cancer Center.

Titles & Roles

Professor, Department of Cell Biology

Emory University School of Medicine

Research

Dr. Moberg's laboratory uses the fruit fly Drosophila melanogaster to model fundamental aspects of metazoan development and disease, with a main focus on cancer cell biology and an emerging interest in development of the central nervous system. His lab team study (i) the roles of conserved growth regulatory proteins Archipelago/Fbw7, Crumbs/Crb3 and Taiman/AIB1 in the growth, morphogenesis, and motility of epithelial cells and (ii) the neurological role of the conserved poly(A) RNA binding protein dNab2/ZC3H14, which is mutated in a heritable form of autosomal recessive intellectual disability in humans.

Publications

Title/Journal	Authors	Publication Date
The Drosophila EcR-Hippo component Taiman promotes epithelial cell fitness by control of the Dally-like glypican and Wg gradient. bioRxiv : the preprint server for biology	CK Schweibenz, VC Placentra, KH Moberg	10/13/2024
Adverse impact of female reproductive signaling on age-dependent neurodegeneration after mild head trauma in Drosophila. eLife	C Ye, R Ho, KH Moberg, JQ Zheng	08/30/2024
The RNA-binding protein Nab2 regulates levels of the RhoGEF Trio to govern axon and dendrite morphology. Molecular biology of the cell	CL Lancaster, PS Yalamanchili, JN Goldy, SW Leung, AH Corbett, KH Moberg	08/01/2024
Sexual Dimorphism in Age-Dependent Neurodegeneration After Mild Head Trauma in Drosophila : Unveiling the Adverse Impact of Female Reproductive Signaling. bioRxiv : the preprint server for biology	C Ye, R Ho, KH Moberg, JQ Zheng	06/25/2024
Local Ecdysone synthesis in a wounded epithelium sustains developmental delay and promotes regeneration in Drosophila. Development (Cambridge, England)	D Terry, C Schweibenz, K Moberg	06/15/2024
Local ecdysone synthesis in a wounded epithelium sustains developmental delay and promotes regeneration in Drosophila. bioRxiv : the preprint server for biology	D Terry, C Schweibenz, K Moberg	02/26/2024
Colorimetric Synchronization of Drosophila Larvae. Current protocols	T Hailstock, D Terry, J Wardwell-Ozgo, BV Robinson, KH Moberg, DA Lerit	10/01/2023
The Drosophila Nab2 RNA binding protein inhibits m⁶A methylation and male-specific splicing of Sex lethal transcript in female neuronal tissue. eLife	B Jalloh, CL Lancaster, JC Rounds, BE Brown, SW Leung, A Banerjee, DJ Morton, RS Bienkowski, MB Fasken, IJ Kremsky, M Tegowski, K Meyer, A Corbett, K Moberg	07/17/2023
Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye. Developmental cell	H Zhao, KH Moberg, A Veraksa	03/13/2023
The Nab2 RNA-binding protein patterns dendritic and axonal projections through a planar cell polarity-sensitive mechanism. G3 (Bethesda, Md.)	EB Corgiat, SM List, JC Rounds, D Yu, P Chen, AH Corbett, KH Moberg	05/30/2022
The disease-associated proteins Drosophila Nab2 and Ataxin-2 interact with shared RNAs and coregulate neuronal morphology. Genetics	JC Rounds, EB Corgiat, C Ye, JA Behnke, SM Kelly, AH Corbett, KH Moberg	01/04/2022
A protocol to detect neurodegeneration in Drosophila melanogaster whole-brain mounts using advanced microscopy. STAR protocols	JA Behnke, C Ye, KH Moberg, JQ Zheng	09/17/2021
The RNA-binding protein Nab2 regulates the proteome of the developing Drosophila brain. The Journal of biological chemistry	EB Corgiat, SM List, JC Rounds, AH Corbett, KH Moberg	07/01/2021
Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model. Scientific reports	JA Behnke, C Ye, A Setty, KH Moberg, JQ Zheng	05/06/2021
A Genetic Screen Links the Disease-Associated Nab2 RNA-Binding Protein to the Planar Cell Polarity Pathway in Drosophila melanogaster. G3 (Bethesda, Md.)	WH Lee, E Corgiat, JC Rounds, Z Shepherd, AH Corbett, KH Moberg	10/05/2020
A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons. PLoS genetics	DJ Morton, B Jalloh, L Kim, I Kremsky, RJ Nair, KB Nguyen, JC Rounds, MC Sterrett, B Brown, T Le, MC Karkare, KD McGaughey, S Sheng, SW Leung, MB Fasken, KH Moberg, AH Corbett	07/01/2020
Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism. eLife	Y Kuang, O Golan, K Preusse, B Cain, CJ Christensen, J Salomone, I Campbell, FV Okwubido-Williams, MR Hass, Z Yuan, N Eafergan, KH Moberg, RA Kovall, R Kopan, D Sprinzak, B Gebelein	04/16/2020
One repressor to rule them all: ANCO1 links YAP and AIB1. EMBO reports	C Zhang, K Moberg	01/07/2020
The Taiman Transcriptional Coactivator Engages Toll Signals to Promote Apoptosis and Intertissue Invasion in Drosophila. Current biology : CB	PK Byun, C Zhang, B Yao, J Wardwell-Ozgo, D Terry, P Jin, K Moberg	09/09/2019
Rare variants in MYH15 modify amyotrophic lateral sclerosis risk. Human molecular genetics	H Kim, J Lim, H Bao, B Jiao, SM Canon, MP Epstein, K Xu, J Jiang, J Parameswaran, Y Li, KH Moberg, JE Landers, C Fournier, EG Allen, JD Glass, TS Wingo, P Jin	07/15/2019
Active N⁶-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons. Molecular cell	B Yao, Y Li, Z Wang, L Chen, M Poidevin, C Zhang, L Lin, F Wang, H Bao, B Jiao, J Lim, Y Cheng, L Huang, BL Phillips, T Xu, R Duan, KH Moberg, H Wu, P Jin	09/06/2018
The domino SWI2/SNF2 Gene Product Represses Cell Death in Drosophila melanogaster. G3 (Bethesda, Md.)	K Ellis, J Wardwell-Ozgo, KH Moberg, B Yedvobnick	07/02/2018
The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice. Human molecular genetics	J Rha, SK Jones, J Fidler, A Banerjee, SW Leung, KJ Morris, JC Wong, GAS Inglis, L Shapiro, Q Deng, AA Cutler, AM Hanif, MT Pardue, A Schaffer, NT Seyfried, KH Moberg, GJ Bassell, A Escayg, PS García, AH Corbett	10/01/2017
The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons. Cell reports	RS Bienkowski, A Banerjee, JC Rounds, J Rha, OF Omotade, C Gross, KJ Morris, SW Leung, C Pak, SK Jones, MR Santoro, ST Warren, JQ Zheng, GJ Bassell, AH Corbett, KH Moberg	08/08/2017
Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport. Cancer research	S Mukherjee, C Tucker-Burden, C Zhang, K Moberg, R Read, C Hadjipanayis, DJ Brat	04/15/2016
Inverse regulation of two classic Hippo pathway target genes in Drosophila by the dimerization hub protein Ctp. Scientific reports	DA Barron, K Moberg	03/14/2016
The ecdysone receptor coactivator Taiman links Yorkie to transcriptional control of germline stem cell factors in somatic tissue. Developmental cell	C Zhang, BS Robinson, W Xu, L Yang, B Yao, H Zhao, PK Byun, P Jin, A Veraksa, KH Moberg	07/27/2015
Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome. Cell reports	C Gross, CW Chang, SM Kelly, A Bhattacharya, SM McBride, SW Danielson, MQ Jiang, CB Chan, K Ye, JR Gibson, E Klann, TA Jongens, KH Moberg, KM Huber, GJ Bassell	05/05/2015
An intergenic regulatory region mediates Drosophila Myc-induced apoptosis and blocks tissue hyperplasia. Oncogene	C Zhang, S Casas-Tintó, G Li, N Lin, M Chung, E Moreno, KH Moberg, L Zhou	04/30/2015
An intergenic regulatory region mediates Drosophila Myc-induced apoptosis and blocks tissue hyperplasia. Oncogene	C Zhang, S Casas-Tintó, G Li, N Lin, M Chung, E Moreno, KH Moberg, L Zhou	04/30/2015
A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length. RNA (New York, N.Y.)	SM Kelly, SW Leung, C Pak, A Banerjee, KH Moberg, AH Corbett	05/01/2014
The archipelago ubiquitin ligase subunit acts in target tissue to restrict tracheal terminal cell branching and hypoxic-induced gene expression. PLoS genetics	NT Mortimer, KH Moberg	01/01/2013
Stable isotope labeling with amino acids in Drosophila for quantifying proteins and modifications. Journal of proteome research	P Xu, H Tan, DM Duong, Y Yang, J Kupsco, KH Moberg, H Li, P Jin, J Peng	09/07/2012
New kid on the ID block: neural functions of the Nab2/ZC3H14 class of Cys₃His tandem zinc-finger polyadenosine RNA binding proteins. RNA biology	S Kelly, C Pak, M Garshasbi, A Kuss, AH Corbett, K Moberg	05/01/2012
Aeromonas salmonicida-secreted protein AopP is a potent inducer of apoptosis in a mammalian and a Drosophila model. Cellular microbiology	RM Jones, L Luo, KH Moberg	02/01/2012
Regulation of Yorkie activity in Drosophila imaginal discs by the Hedgehog receptor gene patched. Mechanisms of development	JD Kagey, JA Brown, KH Moberg	01/01/2012
Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway. Cell cycle (Georgetown, Tex.)	BS Robinson, KH Moberg	12/01/2011
Cell-cell junctions: α-catenin and E-cadherin help fence in Yap1. Current biology : CB	BS Robinson, KH Moberg	11/08/2011
Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans. Proceedings of the National Academy of Sciences of the United States of America	C Pak, M Garshasbi, K Kahrizi, C Gross, LH Apponi, JJ Noto, SM Kelly, SW Leung, A Tzschach, F Behjati, SS Abedini, M Mohseni, LR Jensen, H Hu, B Huang, SN Stahley, G Liu, KR Williams, S Burdick, Y Feng, S Sanyal, GJ Bassell, HH Ropers, H Najmabadi, AH Corbett, KH Moberg, AW Kuss	07/26/2011
A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie. Developmental cell	MM Gilbert, M Tipping, A Veraksa, KH Moberg	05/17/2011
Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. Development (Cambridge, England)	SC Nicholson, BN Nicolay, MV Frolov, KH Moberg	01/01/2011
Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Current biology : CB	BS Robinson, J Huang, Y Hong, KH Moberg	04/13/2010
A Drosophila melanogaster model of classic galactosemia. Disease models & mechanisms	RF Kushner, EL Ryan, JM Sefton, RD Sanders, PJ Lucioni, KH Moberg, JL Fridovich-Keil	01/01/2010
Linking model systems to cancer therapeutics: the case of Mastermind. Disease models & mechanisms	B Yedvobnick, K Moberg	01/01/2010
UDP-galactose 4' epimerase (GALE) is essential for development of Drosophila melanogaster. Disease models & mechanisms	RD Sanders, JM Sefton, KH Moberg, JL Fridovich-Keil	01/01/2010
The gang of four gene regulates growth and patterning of the developing Drosophila eye. Fly	CK Beam, K Moberg	01/01/2010
The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues. Current biology : CB	SC Nicholson, MM Gilbert, BN Nicolay, MV Frolov, KH Moberg	09/29/2009
Functional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in Drosophila imaginal disc tumors. PloS one	MM Gilbert, BS Robinson, KH Moberg	09/29/2009
Genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor. PloS one	MM Gilbert, CK Beam, BS Robinson, KH Moberg	09/29/2009
Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia. Developmental biology	NT Mortimer, KH Moberg	05/15/2009

Awards

In 2017, Dr. Molberg was recognized with the Dean Teaching Award by Emory University School of Medicine. Awardees are nominated by colleagues and students and chosen by the Teaching Awards Committee for their dedication to medical student education and their contributions as course directors and mentors.