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Chrystal M. Paulos, PhD

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Biography

Chrystal M. Paulos, PhD, is a professor in the Department of Surgery at Emory University School of Medicine, with a joint appointment in the Department of Microbiology and Immunology. She holds the David H. Lawson Professorship in Cancer Research and serves as director of translational research for cutaneous malignancies and as co-leader of the Cancer Immunology Research Program at Winship Cancer Institute of Emory University.

Prior to joining Emory, Dr. Paulos was the Cecilia and Vincent Peng Endowed Chair in Melanoma at Medical University of South Carolina. She also served as co-leader of the Cancer Immunology Research Program and director of the Adoptive Cancer Immunotherapy Program at Hollings Cancer Center in Charleston, South Carolina.

Education

Dr. Paulos received her PhD in Biochemistry from Purdue University in West Lafayette, Indiana. She completed her post-doctoral training in genetherapy at University of Pennsylvania in Philadelphia, Pennsylvania, and in tumor immunology at the National Institutes of Health in Bethesda, Maryland.

Titles & Roles

  • David H. Lawson Professorship in Cancer Research
    Emory University School of Medicine
  • Professor, Department of Surgery, Department of Microbiology and Immunology
    Emory University School of Medicine
  • Co-Leader, Cancer Immunology Research Program
    Winship Cancer Institute of Emory University
  • Director, Translational Research for Cutaneous Malignancies
    Winship Cancer Institute of Emory University

Professional Memberships

Dr. Paulos holds professional memberships with American Association of Immunologists, International Society for Biological Therapy of Cancer and Society for Immunotherapy of Cancer.

Research

The objective of Dr. Paulos' research is to develop novel T cell-based therapies for patients with melanoma. Her laboratory seeks to identify mechanisms underlying protective immunity in solid tumors, with an emphasis on adoptive T cell transfer (ACT) therapy. By combining basic and translational understanding of human T cells in clinical studies with mechanistic studies in relevant mouse models and in investigator initiated clinical trials in patients, her research team has contributed significant insight into the various roles of how to mount T cell memory responses to tumors.

Grants

Publications

Dr. Paulos has published numerous articles in peer-reviewed journals including Nature, Science Immunology, and Journal of Clinical Investigation.