Nicolas T. Seyfried, PhD
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Research Program
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Phone Number
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Email Address
Biography
Nicholas Seyfried, PhD, is a professor in the Department of Biochemistry and Neurology at Emory University School of Medicine and is a member of the Center for Neurodegenerative Diseases. As scientific director of the Emory Integrated Proteomics Core, he coordinates efforts to address the needs of investigators needing protein analytical services by cutting edge mass spectrometry.
Education
Dr. Seyfried earned his PhD in Biochemistry from the University of Oxford. He completed a postdoctoral fellowship at Emory University School of Medicine and held a postdoctoral research position in the Complex Carbohydrate Research Center at the University of Georgia.
Titles & Roles
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Professor, Department of BiochemistryEmory University School of Medicine
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Scientific DirectorEmory Integrated Proteomics Core
Professional Memberships
Dr. Seyfried holds memberships with American Society for Mass Spectrometry, Society for Neuroscience and American Society for Neurochemistry.
Research
Dr. Seyfried's research is focused on the use of quantitative proteomics to identify and characterize disease-specific proteins and their post-translational modifications (PTMs) in neurodegeneration.
Grants
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Grant Number Title 5R01AG061800-05 Identifying therapeutic targets that confer synaptic resilience to Alzheimer's disease Publications
Title/Journal Authors Publication Date Epigenetics
F Grodstein, B Lemos, J Yang, K de Paiva Lopes, RA Vialle, N Seyfried, Y Wang, G Shireby, E Hannon, A Thomas, K Brookes, J Mill, PL De Jager, DA Bennett 12/01/2024 Alzheimer's & dementia : the journal of the Alzheimer's Association
JS Reddy, L Heath, AV Linden, M Allen, KP Lopes, F Seifar, E Wang, Y Ma, WL Poehlman, ZS Quicksall, A Runnels, Y Wang, DM Duong, L Yin, K Xu, ES Modeste, A Shantaraman, EB Dammer, L Ping, SR Oatman, J Scanlan, C Ho, MM Carrasquillo, M Atik, G Yepez, AO Mitchell, TT Nguyen, X Chen, DX Marquez, H Reddy, H Xiao, S Seshadri, R Mayeux, S Prokop, EB Lee, GE Serrano, TG Beach, AF Teich, V Haroutunian, EJ Fox, M Gearing, A Wingo, T Wingo, JJ Lah, AI Levey, DW Dickson, LL Barnes, P De Jager, B Zhang, D Bennett, NT Seyfried, AK Greenwood, N Ertekin-Taner 08/30/2024 The journals of gerontology. Series A, Biological sciences and medical sciences
A Nagarajan, J Laird, O Ugochukwu, S Reppe, K Gautvik, RD Ross, DA Bennett, C Rosen, DP Kiel, LA Higginbotham, NT Seyfried, CW Lary 08/28/2024 Alzheimer's & dementia : the journal of the Alzheimer's Association
BN Lizama, C Williams, HA North, K Pandey, D Duong, V Di Caro, AP Mecca, K Blennow, H Zetterberg, AI Levey, M Grundman, CH van Dyck, AO Caggiano, NT Seyfried, ME Hamby 08/21/2024 Nature aging
EA Frick, V Emilsson, T Jonmundsson, AE Steindorsdottir, ECB Johnson, R Puerta, EB Dammer, A Shantaraman, A Cano, M Boada, S Valero, P García-González, EF Gudmundsson, A Gudjonsson, R Pitts, X Qiu, N Finkel, JJ Loureiro, AP Orth, NT Seyfried, AI Levey, A Ruiz, T Aspelund, LL Jennings, LJ Launer, V Gudmundsdottir, V Gudnason 08/21/2024 Human molecular genetics
M Pavešković, RB De-Paula, SA Ojelade, EK Tantry, MY Kochukov, S Bao, S Veeraragavan, AR Garza, S Srivastava, SY Song, M Fujita, DM Duong, DA Bennett, PL De Jager, NT Seyfried, ME Dickinson, JD Heaney, BR Arenkiel, JM Shulman 08/16/2024 Dendritic spine head diameter predicts episodic memory performance in older adults.
Science advances
CK Walker, E Liu, KM Greathouse, AB Adamson, JP Wilson, EH Poovey, KA Curtis, HM Muhammad, AJ Weber, DA Bennett, NT Seyfried, C Gaiteri, JH Herskowitz 08/09/2024 bioRxiv : the preprint server for biology
AM Goettemoeller, E Banks, P Kumar, VJ Olah, KE McCann, K South, CC Ramelow, A Eaton, DM Duong, NT Seyfried, D Weinshenker, S Rangaraju, MJ Rowan 07/05/2024 Psychosocial experiences are associated with human brain mitochondrial biology.
Proceedings of the National Academy of Sciences of the United States of America
C Trumpff, AS Monzel, C Sandi, V Menon, HU Klein, M Fujita, A Lee, VA Petyuk, C Hurst, DM Duong, NT Seyfried, AP Wingo, TS Wingo, Y Wang, M Thambisetty, L Ferrucci, DA Bennett, PL De Jager, M Picard 07/02/2024 Proteins linking APOE ɛ4 with Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association
S Oveisgharan, L Yu, K de Paiva Lopes, S Tasaki, Y Wang, V Menon, JA Schneider, NT Seyfried, DA Bennett 07/01/2024 Science translational medicine
EB Dammer, A Shantaraman, L Ping, DM Duong, ES Gerasimov, SP Ravindran, V Gudmundsdottir, EA Frick, GT Gomez, KA Walker, V Emilsson, LL Jennings, V Gudnason, D Western, C Cruchaga, JJ Lah, TS Wingo, AP Wingo, NT Seyfried, AI Levey, ECB Johnson 06/26/2024 Alzheimer's & dementia : the journal of the Alzheimer's Association
AM Wojtas, EB Dammer, Q Guo, L Ping, A Shantaraman, DM Duong, L Yin, EJ Fox, F Seifar, EB Lee, ECB Johnson, JJ Lah, AI Levey, Y Levites, S Rangaraju, TE Golde, NT Seyfried 06/01/2024 Molecular neurobiology
Z Mei, J Liu, JP Schroeder, D Weinshenker, DM Duong, NT Seyfried, Y Li, P Jin, AP Wingo, TS Wingo 06/01/2024 Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood.
Science (New York, N.Y.)
NP Daskalakis, A Iatrou, C Chatzinakos, A Jajoo, C Snijders, D Wylie, CP DiPietro, I Tsatsani, CY Chen, CD Pernia, M Soliva-Estruch, D Arasappan, RA Bharadwaj, L Collado-Torres, S Wuchty, VE Alvarez, EB Dammer, A Deep-Soboslay, DM Duong, N Eagles, BR Huber, L Huuki, VL Holstein, MW Logue, JF Lugenbühl, AX Maihofer, MW Miller, CM Nievergelt, G Pertea, D Ross, MSE Sendi, BB Sun, R Tao, J Tooke, EJ Wolf, Z Zeier, S Berretta, FA Champagne, T Hyde, NT Seyfried, JH Shin, DR Weinberger, CB Nemeroff, JE Kleinman, KJ Ressler 05/24/2024 Nature biotechnology
B Aguzzoli Heberle, JA Brandon, ML Page, KA Nations, KI Dikobe, BJ White, LA Gordon, GA Fox, ME Wadsworth, PH Doyle, BA Williams, EJ Fox, A Shantaraman, M Ryten, S Goodwin, E Ghiban, R Wappel, S Mavruk-Eskipehlivan, JB Miller, NT Seyfried, PT Nelson, JD Fryer, MTW Ebbert 05/22/2024 Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50.
bioRxiv : the preprint server for biology
E Paz, S Jain, I Gottfried, O Staretz-Chacham, M Mahajnah, P Bagchi, NT Seyfried, U Ashery, A Azem 05/20/2024 Associations of brain morphology with cortical proteins of cognitive resilience.
Neurobiology of aging
VN Poole, AR Ridwan, K Arfanakis, RJ Dawe, NT Seyfried, PL De Jager, JA Schneider, SE Leurgans, L Yu, DA Bennett 05/01/2024 bioRxiv : the preprint server for biology
H Huhe, SM Shapley, D Duong, F Wu, SK Ha, SH Choi, J Kofler, Y Mou, TR Guimaraes, A Thathiah, LKH Schaeffer, GW Carter, NT Seyfried, AC Silva, SJ Sukoff Rizzo 04/29/2024 Large-scale Deep Proteomic Analysis in Alzheimer's Disease Brain Regions Across Race and Ethnicity.
bioRxiv : the preprint server for biology
F Seifar, EJ Fox, A Shantaraman, Y Liu, EB Dammer, E Modeste, DM Duong, L Yin, AN Trautwig, Q Guo, K Xu, L Ping, JS Reddy, M Allen, Z Quicksall, L Heath, J Scanlan, E Wang, M Wang, AV Linden, W Poehlman, X Chen, S Baheti, C Ho, T Nguyen, G Yepez, AO Mitchell, SR Oatman, X Wang, MM Carrasquillo, A Runnels, T Beach, GE Serrano, DW Dickson, EB Lee, TE Golde, S Prokop, LL Barnes, B Zhang, V Haroutunian, M Gearing, JJ Lah, P Jager, DA Bennett, A Greenwood, N Ertekin-Taner, AI Levey, A Wingo, T Wingo, NT Seyfried 04/26/2024 bioRxiv : the preprint server for biology
JS Reddy, L Heath, A Vander Linden, M Allen, K de Paiva Lopes, F Seifar, E Wang, Y Ma, WL Poehlman, ZS Quicksall, A Runnels, Y Wang, DM Duong, L Yin, K Xu, ES Modeste, A Shantaraman, EB Dammer, L Ping, SR Oatman, J Scanlan, C Ho, MM Carrasquillo, M Atik, G Yepez, AO Mitchell, TT Nguyen, X Chen, DX Marquez, H Reddy, H Xiao, S Seshadri, R Mayeux, S Prokop, EB Lee, GE Serrano, TG Beach, AF Teich, V Haroutunian, EJ Fox, M Gearing, A Wingo, T Wingo, JJ Lah, AI Levey, DW Dickson, LL Barnes, P De Jager, B Zhang, D Bennett, NT Seyfried, AK Greenwood, N Ertekin-Taner 04/20/2024 Neurology
AS Buchman, L Yu, HU Klein, AR Zammit, S Oveisgharan, S Nag, N Tickotsky, H Levy, N Seyfried, D Morgenstern, Y Levin, M Schnaider Beeri, DA Bennett 04/09/2024 Person-specific differences in ubiquitin-proteasome mediated proteostasis in human neurons.
Alzheimer's & dementia : the journal of the Alzheimer's Association
YC Hsieh, ZM Augur, M Arbery, N Ashour, K Barrett, RV Pearse, ES Tio, DM Duong, D Felsky, PL De Jager, DA Bennett, NT Seyfried, TL Young-Pearse 04/01/2024 Nature communications
P Kumar, AM Goettemoeller, C Espinosa-Garcia, BR Tobin, A Tfaily, RS Nelson, A Natu, EB Dammer, JV Santiago, S Malepati, L Cheng, H Xiao, DD Duong, NT Seyfried, LB Wood, MJM Rowan, S Rangaraju 04/01/2024 Research square
R Saloner, A Staffaroni, E Dammer, ECB Johnson, E Paolillo, A Wise, H Heuer, L Forsberg, AL Lago, J Webb, J Vogel, A Santillo, O Hansson, J Kramer, B Miller, J Li, J Loureiro, R Sivasankaran, K Worringer, N Seyfried, J Yokoyama, W Seeley, S Spina, L Grinberg, L VandeVrede, P Ljubenkov, E Bayram, A Bozoki, D Brushaber, C Considine, G Day, B Dickerson, K Domoto-Reilly, K Faber, D Galasko, D Geschwind, N Ghoshal, N Graff-Radford, C Hales, L Honig, GY Hsiung, E Huey, J Kornak, W Kremers, M Lapid, S Lee, I Litvan, C McMillan, M Mendez, T Miyagawa, A Pantelyat, B Pascual, H Paulson, L Petrucelli, P Pressman, E Ramos, K Rascovsky, E Roberson, R Savica, A Snyder, AC Sullivan, C Tartaglia, M Vandebergh, B Boeve, H Rosen, J Rojas, A Boxer, K Casaletto 03/28/2024 Research square
E Ortlund, CY Chen, K Maner-Smith, M Khadka, J Ahn, X Gulbin, A Ivanova, E Dammer, N Seyfried, D Bennett, I Hajjar 02/27/2024 Heparin-enriched plasma proteome is significantly altered in Alzheimer's Disease.
Research square
Q Guo, L Ping, EB Dammer, L Yin, K Xu, A Shantaraman, EJ Fox, TE Golde, ECB Johnson, BR Roberts, JJ Lah, AI Levey, NT Seyfried 02/23/2024 Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.
Science translational medicine
S Seddighi, YA Qi, AL Brown, OG Wilkins, C Bereda, C Belair, YJ Zhang, M Prudencio, MJ Keuss, A Khandeshi, S Pickles, SE Kargbo-Hill, J Hawrot, DM Ramos, H Yuan, J Roberts, EK Sacramento, SI Shah, MA Nalls, JM Colón-Mercado, JF Reyes, VH Ryan, MP Nelson, CN Cook, Z Li, L Screven, JY Kwan, PR Mehta, M Zanovello, M Hallegger, A Shantaraman, L Ping, Y Koike, B Oskarsson, NP Staff, DM Duong, A Ahmed, M Secrier, J Ule, S Jacobson, DS Reich, JD Rohrer, A Malaspina, DW Dickson, JD Glass, A Ori, NT Seyfried, M Maragkakis, L Petrucelli, P Fratta, ME Ward 02/14/2024 Cryptic exon inclusion is a molecular signature of LATE-NC in aging brains.
Acta neuropathologica
M Chung, EK Carter, AM Veire, EB Dammer, J Chang, DM Duong, N Raj, GJ Bassell, JD Glass, TF Gendron, PT Nelson, AI Levey, NT Seyfried, ZT McEachin 02/03/2024 bioRxiv : the preprint server for biology
A Shantaraman, EB Dammer, O Ugochukwu, DM Duong, L Yin, EK Carter, M Gearing, A Chen-Plotkin, EB Lee, JQ Trojanowski, DA Bennett, JJ Lah, AI Levey, NT Seyfried, L Higginbotham 01/24/2024 Science translational medicine
JD Marks, VE Ayuso, Y Carlomagno, M Yue, TW Todd, Y Hao, Z Li, ZT McEachin, A Shantaraman, DM Duong, LM Daughrity, K Jansen-West, W Shao, A Calliari, JG Bejarano, M DeTure, B Rawlinson, MC Casey, MT Lilley, MH Donahue, VM Jawahar, BF Boeve, RC Petersen, DS Knopman, B Oskarsson, NR Graff-Radford, ZK Wszolek, DW Dickson, KA Josephs, YA Qi, NT Seyfried, ME Ward, YJ Zhang, M Prudencio, L Petrucelli, CN Cook 01/17/2024 medRxiv : the preprint server for health sciences
Y Shen, M Ali, J Timsina, C Wang, A Do, D Western, M Liu, P Gorijala, J Budde, H Liu, B Gordon, E McDade, JC Morris, JJ Llibre-Guerra, RJ Bateman, N Joseph-Mathurin, RJ Perrin, D Maschi, T Wyss-Coray, P Pastor, A Goate, AE Renton, EI Surace, ECB Johnson, AI Levey, I Alvarez, J Levin, JM Ringman, RF Allegri, N Seyfried, GS Day, Q Wu, MV Fernández, L Ibanez, YJ Sung, C Cruchaga 01/13/2024 medRxiv : the preprint server for health sciences
AM Wojtas, EB Dammer, Q Guo, L Ping, A Shantaraman, DM Duong, L Yin, EJ Fox, F Seifar, EB Lee, ECB Johnson, JJ Lah, AI Levey, Y Levites, S Rangaraju, TE Golde, NT Seyfried 01/11/2024 OXR1 maintains the retromer to delay brain aging under dietary restriction.
Nature communications
KA Wilson, S Bar, EB Dammer, EM Carrera, BA Hodge, TAU Hilsabeck, J Bons, GW Brownridge, JN Beck, J Rose, M Granath-Panelo, CS Nelson, G Qi, AA Gerencser, J Lan, A Afenjar, G Chawla, RB Brem, PM Campeau, HJ Bellen, B Schilling, NT Seyfried, LM Ellerby, P Kapahi 01/11/2024 Neurology
AR Zammit, HU Klein, L Yu, AI Levey, NT Seyfried, AP Wingo, TS Wingo, JA Schneider, DA Bennett, AS Buchman 01/09/2024 Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer's disease.
Research square
V Gudmundsdottir, E Frick, V Emilsson, T Jonmundsson, A Steindorsdottir, ECB Johnson, R Puerta, E Dammer, A Shantaraman, A Cano, M Boada, S Valero, P Garcia-Gonzalez, E Gudmundsson, A Gudjonsson, R Pitts, X Qiu, N Finkel, J Loureiro, A Orth, N Seyfried, A Levey, A Ruiz, T Aspelund, L Jennings, L Launer, V Gudnason 01/09/2024 Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in Alzheimer's Disease.
Biomolecules
E Wang, AL Pan, P Bagchi, S Rangaraju, NT Seyfried, ME Ehrlich, SR Salton, B Zhang 01/03/2024 Associations of cortical SPP1 and ITGAX with cognition and common neuropathologies in older adults.
Alzheimer's & dementia : the journal of the Alzheimer's Association
KP Lopes, L Yu, X Shen, Y Qiu, S Tasaki, A Iatrou, MS Beeri, NT Seyfried, V Menon, Y Wang, JA Schneider, H Cantor, DA Bennett 01/01/2024 bioRxiv : the preprint server for biology
BA Heberle, JA Brandon, ML Page, KA Nations, KI Dikobe, BJ White, LA Gordon, GA Fox, ME Wadsworth, PH Doyle, BA Williams, EJ Fox, A Shantaraman, M Ryten, S Goodwin, E Ghiban, R Wappel, S Mavruk-Eskipehlivan, JB Miller, NT Seyfried, PT Nelson, JD Fryer, MTW Ebbert 12/11/2023 Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease.
bioRxiv : the preprint server for biology
Y Levites, EB Dammer, Y Ran, W Tsering, D Duong, M Abreha, J Gadhavi, K Lolo, J Trejo-Lopez, JL Phillips, A Iturbe, A Erqiuzi, BD Moore, D Ryu, A Natu, KD Dillon, J Torrellas, C Moran, TB Ladd, KF Afroz, T Islam, J Jagirdar, CC Funk, M Robinson, DR Borchelt, N Ertekin-Taner, JW Kelly, FL Heppner, EC Johnson, K McFarland, AL Levey, S Prokop, NT Seyfried, TE Golde 12/07/2023 Molecular & cellular proteomics : MCP
JV Santiago, A Natu, CC Ramelow, S Rayaprolu, H Xiao, V Kumar, P Kumar, NT Seyfried, S Rangaraju 12/01/2023 INPP5D regulates inflammasome activation in human microglia.
Nature communications
V Chou, RV Pearse, AJ Aylward, N Ashour, M Taga, G Terzioglu, M Fujita, SB Fancher, A Sigalov, CR Benoit, H Lee, M Lam, NT Seyfried, DA Bennett, PL De Jager, V Menon, TL Young-Pearse 11/29/2023 Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer's disease.
medRxiv : the preprint server for health sciences
EA Frick, V Emilsson, T Jonmundsson, AE Steindorsdottir, ECB Johnson, R Puerta, EB Dammer, A Shantaraman, A Cano, M Boada, S Valero, P García-González, EF Gudmundsson, A Gudjonsson, JJ Loureiro, AP Orth, NT Seyfried, AI Levey, A Ruiz, T Aspelund, LL Jennings, LJ Launer, V Gudmundsdottir, V Gudnason 11/09/2023 Research square
S Bar, KA Wilson, TAU Hilsabeck, S Alderfer, EB Dammer, JB Burton, S Shah, A Holtz, EM Carrera, JN Beck, JH Chen, G Kauwe, TE Tracy, NT Seyfried, B Schilling, LM Ellerby, P Kapahi 11/08/2023 Research square
AM Goettemoeller, E Banks, KE McCann, P Kumar, K South, VJ Olah, CC Ramelow, DM Duong, NT Seyfried, S Rangaraju, D Weinshenker, MJ Rowan 11/06/2023 medRxiv : the preprint server for health sciences
EB Dammer, A Shantaraman, L Ping, DM Duong, ES Gerasimov, SP Ravindran, V Gudmundsdottir, EA Frick, GT Gomez, KA Walker, V Emilsson, LL Jennings, V Gudnason, D Western, C Cruchaga, JJ Lah, TS Wingo, AP Wingo, NT Seyfried, AI Levey, ECB Johnson 10/30/2023 Proteomic signaling of dual specificity phosphatase 4 (DUSP4) in Alzheimer's disease.
Research square
E Wang, AL Pan, P Bagchi, S Ranjaraju, NT Seyfried, ME Ehrlich, SR Salton, B Zhang 10/19/2023 Neurobiology of disease
L Higginbotham, EK Carter, EB Dammer, RU Haque, ECB Johnson, DM Duong, L Yin, PL De Jager, DA Bennett, D Felsky, ES Tio, JJ Lah, AI Levey, NT Seyfried 10/01/2023 Proteomic signaling of dual specificity phosphatase 4 (DUSP4) in Alzheimer's disease.
bioRxiv : the preprint server for biology
E Wang, AL Pan, P Bagchi, S Ranjaraju, NT Seyfried, ME Ehrlich, SR Salton, B Zhang 09/14/2023 Science translational medicine
R Haque, CM Watson, J Liu, EK Carter, DM Duong, JJ Lah, AP Wingo, BR Roberts, ECB Johnson, AJ Saykin, LM Shaw, NT Seyfried, TS Wingo, AI Levey 09/06/2023 Sex differences in brain protein expression and disease.
Nature medicine
AP Wingo, Y Liu, ES Gerasimov, SM Vattathil, J Liu, DJ Cutler, MP Epstein, GAM Blokland, M Thambisetty, JC Troncoso, DM Duong, DA Bennett, AI Levey, NT Seyfried, TS Wingo 09/01/2023 Cell reports
H Lee, AJ Aylward, RV Pearse, AM Lish, YC Hsieh, ZM Augur, CR Benoit, V Chou, A Knupp, C Pan, S Goberdhan, DM Duong, NT Seyfried, DA Bennett, MF Taga, K Huynh, M Arnold, PJ Meikle, PL De Jager, V Menon, JE Young, TL Young-Pearse 08/29/2023 Nucleic acids research
PE Head, P Kapoor-Vazirani, GP Nagaraju, H Zhang, SK Rath, NC Luong, R Haji-Seyed-Javadi, F Sesay, SY Wang, DM Duong, W Daddacha, EV Minten, B Song, D Danelia, X Liu, S Li, EA Ortlund, NT Seyfried, DM Smalley, Y Wang, X Deng, WS Dynan, B El-Rayes, AJ Davis, DS Yu 08/25/2023 Scientific reports
K Borkowski, NT Seyfried, M Arnold, JJ Lah, AI Levey, CM Hales, EB Dammer, C Blach, G Louie, R Kaddurah-Daouk, JW Newman 08/23/2023 Research square
Z Mei, J Liu, JP Schroeder, D Weinshenker, DM Duong, NT Seyfried, Y Li, P Jin, AP Wingo, TS Wingo 08/16/2023 Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus.
Alzheimer's & dementia : the journal of the Alzheimer's Association
M Čarna, IG Onyango, S Katina, D Holub, JS Novotny, M Nezvedova, D Jha, Z Nedelska, V Lacovich, TV Vyvere, R Houbrechts, K Garcia-Mansfield, R Sharma, V David-Dirgo, M Vyhnalek, K Texlova, H Chaves, N Bakkar, L Pertierra, M Vinkler, H Markova, J Laczo, K Sheardova, M Hortova-Kohoutkova, J Frič, G Forte, P Kaňovsky, S Belaškova, J Damborsky, J Hort, NT Seyfried, R Bowser, G Sevlever, RA Rissman, RA Smith, M Hajduch, P Pirrotte, Z Spacil, EB Dammer, C Limbäck-Stokin, GB Stokin 08/01/2023 Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease.
Nature medicine
ECB Johnson, S Bian, RU Haque, EK Carter, CM Watson, BA Gordon, L Ping, DM Duong, MP Epstein, E McDade, NR Barthélemy, CM Karch, C Xiong, C Cruchaga, RJ Perrin, AP Wingo, TS Wingo, JP Chhatwal, GS Day, JM Noble, SB Berman, R Martins, NR Graff-Radford, PR Schofield, T Ikeuchi, H Mori, J Levin, M Farlow, JJ Lah, C Haass, M Jucker, JC Morris, TLS Benzinger, BR Roberts, RJ Bateman, AM Fagan, NT Seyfried, AI Levey 08/01/2023 bioRxiv : the preprint server for biology
JV Santiago, A Natu, CC Ramelow, S Rayaprolu, H Xiao, V Kumar, NT Seyfried, S Rangaraju 07/29/2023 A Molecular Basis of Human Brain Connectivity.
bioRxiv : the preprint server for biology
B Ng, S Tasaki, KM Greathouse, CK Walker, A Zhang, S Covitz, M Cieslak, AB Adamson, JP Andrade, EH Poovey, KA Curtis, HM Muhammad, J Seidlitz, T Satterthwaite, DA Bennett, NT Seyfried, J Vogel, C Gaiteri, JH Herskowitz 07/24/2023 Molecular neurodegeneration
ES Modeste, L Ping, CM Watson, DM Duong, EB Dammer, ECB Johnson, BR Roberts, JJ Lah, AI Levey, NT Seyfried 07/19/2023 Science translational medicine
YJ Sung, C Yang, J Norton, M Johnson, A Fagan, RJ Bateman, RJ Perrin, JC Morris, MR Farlow, JP Chhatwal, PR Schofield, H Chui, F Wang, B Novotny, A Eteleeb, C Karch, SE Schindler, H Rhinn, ECB Johnson, HS Oh, JE Rutledge, EB Dammer, NT Seyfried, T Wyss-Coray, O Harari, C Cruchaga 07/05/2023 Genetic background influences the 5XFAD Alzheimer's disease mouse model brain proteome.
bioRxiv : the preprint server for biology
CD Hurst, AR Dunn, EB Dammer, DM Duong, NT Seyfried, CC Kaczorowski, ECB Johnson 06/13/2023 Molecular & cellular proteomics : MCP
S Sunna, C Bowen, H Zeng, S Rayaprolu, P Kumar, P Bagchi, EB Dammer, Q Guo, DM Duong, S Bitarafan, A Natu, L Wood, NT Seyfried, S Rangaraju 06/01/2023 Neurobiology of aging
M Seto, L Dumitrescu, ER Mahoney, AM Sclafani, PL De Jager, V Menon, MEI Koran, RA Robinson, DM Ruderfer, NJ Cox, NT Seyfried, AL Jefferson, JA Schneider, DA Bennett, VA Petyuk, TJ Hohman 06/01/2023 bioRxiv : the preprint server for biology
P Kumar, AM Goettemoeller, C Espinosa-Garcia, BR Tobin, A Tfaily, RS Nelson, A Natu, EB Dammer, JV Santiago, S Malepati, L Cheng, H Xiao, D Duong, NT Seyfried, LB Wood, MJ Rowan, S Rangaraju 05/17/2023 The Journal of neuroscience : the official journal of the Society for Neuroscience
CK Walker, KM Greathouse, JJ Tuscher, EB Dammer, AJ Weber, E Liu, KA Curtis, BD Boros, CD Freeman, JV Seo, R Ramdas, C Hurst, DM Duong, M Gearing, CF Murchison, JJ Day, NT Seyfried, JH Herskowitz 05/17/2023 APOE expression and secretion are modulated by mitochondrial dysfunction.
eLife
ME Wynne, O Ogunbona, AR Lane, A Gokhale, SA Zlatic, C Xu, Z Wen, DM Duong, S Rayaprolu, A Ivanova, EA Ortlund, EB Dammer, NT Seyfried, BR Roberts, A Crocker, V Shanbhag, M Petris, N Senoo, S Kandasamy, SM Claypool, A Barrientos, A Wingo, TS Wingo, S Rangaraju, AI Levey, E Werner, V Faundez 05/12/2023 Scientific data
CM Watson, EB Dammer, L Ping, DM Duong, E Modeste, EK Carter, ECB Johnson, AI Levey, JJ Lah, BR Roberts, NT Seyfried 05/09/2023 Molecular & cellular proteomics : MCP
C Hurst, DA Pugh, MH Abreha, DM Duong, EB Dammer, DA Bennett, JH Herskowitz, NT Seyfried 05/01/2023 PLoS genetics
M Yu, H Ye, RB De-Paula, CG Mangleburg, T Wu, TV Lee, Y Li, D Duong, B Phillips, C Cruchaga, GI Allen, NT Seyfried, I Al-Ramahi, J Botas, JM Shulman 05/01/2023 The landscape of metabolic brain alterations in Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association
R Batra, M Arnold, MA Wörheide, M Allen, X Wang, C Blach, AI Levey, NT Seyfried, N Ertekin-Taner, DA Bennett, G Kastenmüller, RF Kaddurah-Daouk, J Krumsiek 03/01/2023 The journals of gerontology. Series A, Biological sciences and medical sciences
AS Buchman, L Yu, HU Klein, AR Zammit, S Oveisgharan, F Grodstein, S Tasaki, AI Levey, NT Seyfried, DA Bennett 03/01/2023 Research square
R Tandon, L Zhao, CM Watson, M Elmor, C Heilman, K Sanders, CM Hales, H Yang, DW Loring, FC Goldstein, JJ Hanfelt, DM Duong, ECB Johnson, AP Wingo, TS Wingo, BR Roberts, NT Seyfried, AI Levey, CS Mitchell, JJ Lah 02/28/2023 INPP5D/SHIP1 regulates inflammasome activation in human microglia.
bioRxiv : the preprint server for biology
V Chou, SB Fancher, RV Pearse, H Lee, M Lam, NT Seyfried, DA Bennett, PL De Jager, V Menon, TL Young-Pearse 02/26/2023 bioRxiv : the preprint server for biology
H Lee, AJ Aylward, RV Pearse, YC Hsieh, ZM Augur, CR Benoit, V Chou, A Knupp, C Pan, S Goberdhan, DM Duong, NT Seyfried, DA Bennett, HU Klein, PL De Jager, V Menon, JE Young, TL Young-Pearse 02/25/2023 bioRxiv : the preprint server for biology
NH Harbin, DJ Lustberg, C Hurst, JF Pare, KM Crotty, AL Waters, SM Yeligar, Y Smith, NT Seyfried, D Weinshenker, JR Hepler 02/03/2023 Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.
bioRxiv : the preprint server for biology
S Seddighi, YA Qi, AL Brown, OG Wilkins, C Bereda, C Belair, Y Zhang, M Prudencio, MJ Keuss, A Khandeshi, S Pickles, SE Hill, J Hawrot, DM Ramos, H Yuan, J Roberts, E Kelmer Sacramento, SI Shah, MA Nalls, J Colon-Mercado, JF Reyes, VH Ryan, MP Nelson, C Cook, Z Li, L Screven, JY Kwan, A Shantaraman, L Ping, Y Koike, B Oskarsson, N Staff, DM Duong, A Ahmed, M Secrier, J Ule, S Jacobson, J Rohrer, A Malaspina, JD Glass, A Ori, NT Seyfried, M Maragkakis, L Petrucelli, P Fratta, ME Ward 01/23/2023 Alzheimer's & dementia (New York, N. Y.)
SJ Sukoff Rizzo, G Homanics, DJ Schaeffer, L Schaeffer, JE Park, J Oluoch, T Zhang, A Haber, NT Seyfried, B Paten, A Greenwood, T Murai, SH Choi, H Huhe, J Kofler, PL Strick, GW Carter, AC Silva 01/01/2023 Genetic background influences the 5XFAD Alzheimer's disease mouse model brain proteome.
Frontiers in aging neuroscience
CD Hurst, AR Dunn, EB Dammer, DM Duong, SM Shapley, NT Seyfried, CC Kaczorowski, ECB Johnson 01/01/2023 Batch Correction and Harmonization of -Omics Datasets with a Tunable Median Polish of Ratio.
Frontiers in systems biology
EB Dammer, NT Seyfried, ECB Johnson 01/01/2023 Journal of Alzheimer's disease : JAD
R Tandon, AI Levey, JJ Lah, NT Seyfried, CS Mitchell 01/01/2023 Glycoproteomics Landscape of Asymptomatic and Symptomatic Human Alzheimer's Disease Brain.
Molecular & cellular proteomics : MCP
S Suttapitugsakul, K Stavenhagen, S Donskaya, DA Bennett, RG Mealer, NT Seyfried, RD Cummings 12/01/2022 Alzheimer's research & therapy
EB Dammer, L Ping, DM Duong, ES Modeste, NT Seyfried, JJ Lah, AI Levey, ECB Johnson 11/17/2022 Association of AK4 Protein From Stem Cell-Derived Neurons With Cognitive Reserve: An Autopsy Study.
Neurology
L Yu, YC Hsieh, RV Pearse, Y Wang, VA Petyuk, JA Schneider, AS Buchman, NT Seyfried, PL De Jager, TL Young-Pearse, DA Bennett 11/15/2022 Metabolites
AL Sohn, L Ping, JD Glass, NT Seyfried, EC Hector, DC Muddiman 11/10/2022 Nature communications
P Kapoor-Vazirani, SK Rath, X Liu, Z Shu, NE Bowen, Y Chen, R Haji-Seyed-Javadi, W Daddacha, EV Minten, D Danelia, D Farchi, DM Duong, NT Seyfried, X Deng, EA Ortlund, B Kim, DS Yu 11/07/2022 Nature aging
M Del Campo, CFW Peeters, ECB Johnson, L Vermunt, YS Hok-A-Hin, M van Nee, A Chen-Plotkin, DJ Irwin, WT Hu, JJ Lah, NT Seyfried, EB Dammer, G Herradon, LH Meeter, J van Swieten, D Alcolea, A Lleó, AI Levey, AW Lemstra, YAL Pijnenburg, PJ Visser, BM Tijms, WM van der Flier, CE Teunissen 11/01/2022 Molecular neurodegeneration
YC Hsieh, J Negri, A He, RV Pearse, L Liu, DM Duong, LB Chibnik, DA Bennett, NT Seyfried, TL Young-Pearse 09/21/2022 The Journal of biological chemistry
MA Johnson, TA Nuckols, P Merino, P Bagchi, S Nandy, J Root, G Taylor, NT Seyfried, T Kukar 08/01/2022 Shared mechanisms across the major psychiatric and neurodegenerative diseases.
Nature communications
TS Wingo, Y Liu, ES Gerasimov, SM Vattathil, ME Wynne, J Liu, A Lori, V Faundez, DA Bennett, NT Seyfried, AI Levey, AP Wingo 07/26/2022 Genetic Evidence Supporting a Causal Role of Depression in Alzheimer's Disease.
Biological psychiatry
NV Harerimana, Y Liu, ES Gerasimov, D Duong, TG Beach, EM Reiman, JA Schneider, P Boyle, A Lori, DA Bennett, JJ Lah, AI Levey, NT Seyfried, TS Wingo, AP Wingo 07/01/2022 Molecular psychiatry
TS Wingo, ES Gerasimov, Y Liu, DM Duong, SM Vattathil, A Lori, J Gockley, MS Breen, AX Maihofer, CM Nievergelt, KC Koenen, DF Levey, J Gelernter, MB Stein, KJ Ressler, DA Bennett, AI Levey, NT Seyfried, AP Wingo 07/01/2022 A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment.
Brain : a journal of neurology
AI Levey, D Qiu, L Zhao, WT Hu, DM Duong, L Higginbotham, EB Dammer, NT Seyfried, TS Wingo, CM Hales, M Gámez Tansey, DS Goldstein, A Abrol, VD Calhoun, FC Goldstein, I Hajjar, AM Fagan, D Galasko, SD Edland, J Hanfelt, JJ Lah, D Weinshenker 06/30/2022 eLife
VJ Olah, AM Goettemoeller, S Rayaprolu, EB Dammer, NT Seyfried, S Rangaraju, J Dimidschstein, MJM Rowan 06/21/2022 Signatures of glial activity can be detected in the CSF proteome.
Proceedings of the National Academy of Sciences of the United States of America
T Eninger, SA Müller, M Bacioglu, M Schweighauser, M Lambert, LF Maia, JJ Neher, SM Hornfeck, U Obermüller, G Kleinberger, C Haass, PJ Kahle, M Staufenbiel, L Ping, DM Duong, AI Levey, NT Seyfried, SF Lichtenthaler, M Jucker, SA Kaeser 06/14/2022 Nature communications
S Rayaprolu, S Bitarafan, JV Santiago, R Betarbet, S Sunna, L Cheng, H Xiao, RS Nelson, P Kumar, P Bagchi, DM Duong, AM Goettemoeller, VJ Oláh, M Rowan, AI Levey, LB Wood, NT Seyfried, S Rangaraju 05/25/2022 Mitochondrial respiratory chain protein co-regulation in the human brain.
Heliyon
C Trumpff, E Owusu-Ansah, HU Klein, AJ Lee, V Petyuk, TS Wingo, AP Wingo, M Thambisetty, L Ferrucci, NT Seyfried, DA Bennett, PL De Jager, M Picard 05/01/2022 Molecular psychiatry
CI Wu, EA Vinton, RV Pearse, K Heo, AJ Aylward, YC Hsieh, Y Bi, S Adeleye, S Fancher, DM Duong, NT Seyfried, TL Schwarz, TL Young-Pearse 04/01/2022 Quantitative proteomic analysis of the lysine acetylome reveals diverse SIRT2 substrates.
Scientific reports
H Zhang, EB Dammer, DM Duong, D Danelia, NT Seyfried, DS Yu 03/09/2022 Neuropathologic Correlates of Human Cortical Proteins in Alzheimer Disease and Related Dementias.
Neurology
L Yu, PA Boyle, AP Wingo, J Yang, T Wang, AS Buchman, TS Wingo, NT Seyfried, AI Levey, PL De Jager, JA Schneider, DA Bennett 03/08/2022 Nature neuroscience
ECB Johnson, EK Carter, EB Dammer, DM Duong, ES Gerasimov, Y Liu, J Liu, R Betarbet, L Ping, L Yin, GE Serrano, TG Beach, J Peng, PL De Jager, V Haroutunian, B Zhang, C Gaiteri, DA Bennett, M Gearing, TS Wingo, AP Wingo, JJ Lah, AI Levey, NT Seyfried 02/01/2022 Brain microRNAs are associated with variation in cognitive trajectory in advanced age.
Translational psychiatry
AP Wingo, M Wang, J Liu, MS Breen, HS Yang, B Tang, JA Schneider, NT Seyfried, JJ Lah, AI Levey, DA Bennett, P Jin, PL De Jager, TS Wingo 02/01/2022 The Journal of clinical investigation
X Wang, M Allen, Ö İş, JS Reddy, FQ Tutor-New, M Castanedes Casey, MM Carrasquillo, SR Oatman, Y Min, YW Asmann, C Funk, T Nguyen, CC Ho, KG Malphrus, NT Seyfried, AI Levey, SG Younkin, ME Murray, DW Dickson, ND Price, TE Golde, N Ertekin-Taner 01/18/2022 Exploring Cortical Proteins Underlying the Relation of Neuroticism to Cognitive Resilience.
Aging brain
F Grodstein, L Yu, PL de Jager, A Levey, NT Seyfried, DA Bennett 01/01/2022 Frontiers in neuroscience
RS Nelson, EB Dammer, JV Santiago, NT Seyfried, S Rangaraju 01/01/2022 Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains.
Cell
T Arakhamia, CE Lee, Y Carlomagno, M Kumar, DM Duong, H Wesseling, SR Kundinger, K Wang, D Williams, M DeTure, DW Dickson, CN Cook, NT Seyfried, L Petrucelli, JA Steen, AWP Fitzpatrick 12/09/2021 Insights into the changes in the proteome of Alzheimer disease elucidated by a meta-analysis.
Scientific data
H Haytural, R Benfeitas, S Schedin-Weiss, E Bereczki, M Rezeli, RD Unwin, X Wang, EB Dammer, ECB Johnson, NT Seyfried, B Winblad, BM Tijms, PJ Visser, S Frykman, LO Tjernberg 12/03/2021 Nature communications
Y Ma, EB Dammer, D Felsky, DM Duong, HU Klein, CC White, M Zhou, BA Logsdon, C McCabe, J Xu, M Wang, TS Wingo, JJ Lah, B Zhang, J Schneider, M Allen, X Wang, N Ertekin-Taner, NT Seyfried, AI Levey, DA Bennett, PL De Jager 12/02/2021 Neuron
VN Lagomarsino, RV Pearse, L Liu, YC Hsieh, MA Fernandez, EA Vinton, D Paull, D Felsky, S Tasaki, C Gaiteri, B Vardarajan, H Lee, CR Muratore, CR Benoit, V Chou, SB Fancher, A He, JP Merchant, DM Duong, H Martinez, M Zhou, F Bah, MA Vicent, JMS Stricker, J Xu, EB Dammer, AI Levey, LB Chibnik, V Menon, NT Seyfried, PL De Jager, S Noggle, DJ Selkoe, DA Bennett, TL Young-Pearse 11/03/2021 FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Y Wang, R Liu, J Liao, L Jiang, GH Jeong, L Zhou, M Polite, D Duong, NT Seyfried, H Wang, H Kiyokawa, J Yin 11/01/2021 Phosphorylation regulates arginine-rich RNA-binding protein solubility and oligomerization.
The Journal of biological chemistry
SR Kundinger, EB Dammer, L Yin, C Hurst, S Shapley, L Ping, S Khoshnevis, H Ghalei, DM Duong, NT Seyfried 11/01/2021 Scientific reports
R Gorkhali, L Tian, B Dong, P Bagchi, X Deng, S Pawar, D Duong, N Fang, N Seyfried, J Yang 10/18/2021 Alzheimer's research & therapy
K Borkowski, TL Pedersen, NT Seyfried, JJ Lah, AI Levey, CM Hales, EB Dammer, C Blach, G Louie, R Kaddurah-Daouk, JW Newman 09/06/2021 American journal of physiology. Cell physiology
JN Peoples, N Ghazal, DM Duong, KR Hardin, JR Manning, NT Seyfried, V Faundez, JQ Kwong 09/01/2021 Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
A Gokhale, CE Lee, SA Zlatic, AAH Freeman, N Shearing, C Hartwig, O Ogunbona, JL Bassell, ME Wynne, E Werner, C Xu, Z Wen, D Duong, NT Seyfried, CE Bearden, VJ Oláh, MJM Rowan, JR Glausier, DA Lewis, V Faundez 08/04/2021 Omics sciences for systems biology in Alzheimer's disease: State-of-the-art of the evidence.
Ageing research reviews
H Hampel, R Nisticò, NT Seyfried, AI Levey, E Modeste, P Lemercier, F Baldacci, N Toschi, F Garaci, G Perry, E Emanuele, PL Valenzuela, A Lucia, A Urbani, GM Sancesario, M Mapstone, M Corbo, A Vergallo, S Lista 08/01/2021 Molecular neurodegeneration
L Gutierrez-Quiceno, EB Dammer, AG Johnson, JA Webster, R Shah, D Duong, L Yin, NT Seyfried, VE Alvarez, TD Stein, AC McKee, CM Hales 06/25/2021 Alzheimer's & dementia : the journal of the Alzheimer's Association
HD Li, CC Funk, K McFarland, EB Dammer, M Allen, MM Carrasquillo, Y Levites, P Chakrabarty, JD Burgess, X Wang, D Dickson, NT Seyfried, DM Duong, JJ Lah, SG Younkin, AI Levey, GS Omenn, N Ertekin-Taner, TE Golde, ND Price 06/01/2021 Extracellular signal-regulated kinase regulates microglial immune responses in Alzheimer's disease.
Journal of neuroscience research
MJ Chen, S Ramesha, LD Weinstock, T Gao, L Ping, H Xiao, EB Dammer, DD Duong, AI Levey, JJ Lah, NT Seyfried, LB Wood, S Rangaraju 06/01/2021 Brain proteome-wide association study implicates novel proteins in depression pathogenesis.
Nature neuroscience
TS Wingo, Y Liu, ES Gerasimov, J Gockley, BA Logsdon, DM Duong, EB Dammer, A Lori, PJ Kim, KJ Ressler, TG Beach, EM Reiman, MP Epstein, PL De Jager, JJ Lah, DA Bennett, NT Seyfried, AI Levey, AP Wingo 06/01/2021 A Genetic Study of Cerebral Atherosclerosis Reveals Novel Associations with NTNG1 and CNOT3.
Genes
SM Vattathil, Y Liu, NV Harerimana, A Lori, ES Gerasimov, TG Beach, EM Reiman, PL De Jager, JA Schneider, DA Bennett, NT Seyfried, AI Levey, AP Wingo, TS Wingo 05/26/2021 iScience
CD Dill, EB Dammer, TL Griffen, NT Seyfried, JW Lillard 05/21/2021 Alzheimer's research & therapy
LE Donovan, EB Dammer, DM Duong, JJ Hanfelt, AI Levey, NT Seyfried, JJ Lah 05/18/2021 Proceedings of the National Academy of Sciences of the United States of America
S Ramesha, S Rayaprolu, CA Bowen, CR Giver, S Bitarafan, HM Nguyen, T Gao, MJ Chen, N Nwabueze, EB Dammer, AK Engstrom, H Xiao, A Pennati, NT Seyfried, DJ Katz, J Galipeau, H Wulff, EK Waller, LB Wood, AI Levey, S Rangaraju 03/16/2021 Genetic control of the human brain proteome.
American journal of human genetics
C Robins, Y Liu, W Fan, DM Duong, J Meigs, NV Harerimana, ES Gerasimov, EB Dammer, DJ Cutler, TG Beach, EM Reiman, PL De Jager, DA Bennett, JJ Lah, AP Wingo, AI Levey, NT Seyfried, TS Wingo 03/04/2021 Nature genetics
AP Wingo, Y Liu, ES Gerasimov, J Gockley, BA Logsdon, DM Duong, EB Dammer, C Robins, TG Beach, EM Reiman, MP Epstein, PL De Jager, JJ Lah, DA Bennett, NT Seyfried, AI Levey, TS Wingo 02/01/2021 Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy.
International journal of molecular sciences
SA Koren, MJ Hamm, R Cloyd, SN Fontaine, E Chishti, C Lanzillotta, J Rodriguez-Rivera, A Ingram, M Bell, SM Galvis-Escobar, N Zulia, F Di Domenico, D Duong, NT Seyfried, D Powell, M Vandsburger, T Frolinger, AMS Hartz, J Koren, JM Axten, NJ Laping, JF Abisambra 01/26/2021 Frontiers in molecular neuroscience
Q Guo, EB Dammer, M Zhou, SR Kundinger, M Gearing, JJ Lah, AI Levey, JM Shulman, NT Seyfried 01/01/2021 Systems-based proteomics to resolve the biology of Alzheimer's disease beyond amyloid and tau.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
S Rayaprolu, L Higginbotham, P Bagchi, CM Watson, T Zhang, AI Levey, S Rangaraju, NT Seyfried 01/01/2021 TBK1 interacts with tau and enhances neurodegeneration in tauopathy.
The Journal of biological chemistry
MH Abreha, S Ojelade, EB Dammer, ZT McEachin, DM Duong, M Gearing, GJ Bassell, JJ Lah, AI Levey, JM Shulman, NT Seyfried 01/01/2021 Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons.
JAMA psychiatry
L Yu, S Tasaki, JA Schneider, K Arfanakis, DM Duong, AP Wingo, TS Wingo, N Kearns, GRJ Thatcher, NT Seyfried, AI Levey, PL De Jager, DA Bennett 11/01/2020 Acta neuropathologica communications
M Huang, E Modeste, E Dammer, P Merino, G Taylor, DM Duong, Q Deng, CJ Holler, M Gearing, D Dickson, NT Seyfried, T Kukar 10/07/2020 Science advances
L Higginbotham, L Ping, EB Dammer, DM Duong, M Zhou, M Gearing, C Hurst, JD Glass, SA Factor, ECB Johnson, I Hajjar, JJ Lah, AI Levey, NT Seyfried 10/01/2020 Integrated analysis of the aging brain transcriptome and proteome in tauopathy.
Molecular neurodegeneration
CG Mangleburg, T Wu, HK Yalamanchili, C Guo, YC Hsieh, DM Duong, EB Dammer, PL De Jager, NT Seyfried, Z Liu, JM Shulman 09/29/2020 Global quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer's disease.
Scientific data
L Ping, SR Kundinger, DM Duong, L Yin, M Gearing, JJ Lah, AI Levey, NT Seyfried 09/28/2020 Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.
Nature communications
ND Beckmann, WJ Lin, M Wang, AT Cohain, AW Charney, P Wang, W Ma, YC Wang, C Jiang, M Audrain, PH Comella, AK Fakira, SP Hariharan, GM Belbin, K Girdhar, AI Levey, NT Seyfried, EB Dammer, D Duong, JJ Lah, JV Haure-Mirande, B Shackleton, T Fanutza, R Blitzer, E Kenny, J Zhu, V Haroutunian, P Katsel, S Gandy, Z Tu, ME Ehrlich, B Zhang, SR Salton, EE Schadt 08/07/2020 Nature neuroscience
AP Wingo, W Fan, DM Duong, ES Gerasimov, EB Dammer, Y Liu, NV Harerimana, B White, M Thambisetty, JC Troncoso, N Kim, JA Schneider, IM Hajjar, JJ Lah, DA Bennett, NT Seyfried, AI Levey, TS Wingo 08/01/2020 Proteomic Analysis of Human Immune Responses to Live-Attenuated Tularemia Vaccine.
Vaccines
YH Chang, DM Duong, JB Goll, DC Wood, TL Jensen, L Yin, CE Gelber, NT Seyfried, E Anderson, MS Natrajan, N Rouphael, RA Johnson, P Sanz, MJ Mulligan, DF Hoft 07/24/2020 Identification of Conserved Proteomic Networks in Neurodegenerative Dementia.
Cell reports
V Swarup, TS Chang, DM Duong, EB Dammer, J Dai, JJ Lah, ECB Johnson, NT Seyfried, AI Levey, DH Geschwind 06/23/2020 Shared proteomic effects of cerebral atherosclerosis and Alzheimer's disease on the human brain.
Nature neuroscience
AP Wingo, W Fan, DM Duong, ES Gerasimov, EB Dammer, Y Liu, NV Harerimana, B White, M Thambisetty, JC Troncoso, N Kim, JA Schneider, IM Hajjar, JJ Lah, DA Bennett, NT Seyfried, AI Levey, TS Wingo 06/01/2020 Oncogene
AE Koyen, MZ Madden, D Park, EV Minten, P Kapoor-Vazirani, E Werner, NT Pfister, R Haji-Seyed-Javadi, H Zhang, J Xu, N Deng, DM Duong, TJ Pecen, Z Frazier, ZD Nagel, JB Lazaro, KW Mouw, NT Seyfried, CS Moreno, TK Owonikoko, X Deng, DS Yu 06/01/2020 Molecular neurodegeneration
S Rayaprolu, T Gao, H Xiao, S Ramesha, LD Weinstock, J Shah, DM Duong, EB Dammer, JA Webster, JJ Lah, LB Wood, R Betarbet, AI Levey, NT Seyfried, S Rangaraju 05/07/2020 Nature medicine
ECB Johnson, EB Dammer, DM Duong, L Ping, M Zhou, L Yin, LA Higginbotham, A Guajardo, B White, JC Troncoso, M Thambisetty, TJ Montine, EB Lee, JQ Trojanowski, TG Beach, EM Reiman, V Haroutunian, M Wang, E Schadt, B Zhang, DW Dickson, N Ertekin-Taner, TE Golde, VA Petyuk, PL De Jager, DA Bennett, TS Wingo, S Rangaraju, I Hajjar, JM Shulman, JJ Lah, AI Levey, NT Seyfried 05/01/2020 Journal of proteome research
SR Kundinger, I Bishof, EB Dammer, DM Duong, NT Seyfried 04/03/2020 Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains.
Cell
T Arakhamia, CE Lee, Y Carlomagno, DM Duong, SR Kundinger, K Wang, D Williams, M DeTure, DW Dickson, CN Cook, NT Seyfried, L Petrucelli, AWP Fitzpatrick 02/20/2020 Journal of proteome research
TT Nguyen, EB Dammer, SA Owino, MM Giddens, NS Madaras, DM Duong, NT Seyfried, RA Hall 02/07/2020 Alzheimer's & dementia (New York, N. Y.)
MP Vitek, JA Araujo, M Fossel, BD Greenberg, GR Howell, SJS Rizzo, NT Seyfried, AJ Tenner, PR Territo, M Windisch, LJ Bain, A Ross, MC Carrillo, BT Lamb, RM Edelmayer 01/01/2020 Clinical proteomics
M Zhou, RU Haque, EB Dammer, DM Duong, L Ping, ECB Johnson, JJ Lah, AI Levey, NT Seyfried 01/01/2020 Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells.
Frontiers in immunology
S Sarkar, EB Dammer, E Malovic, AL Olsen, SA Raza, T Gao, H Xiao, DL Oliver, D Duong, V Joers, N Seyfried, M Huang, T Kukar, MG Tansey, AG Kanthasamy, S Rangaraju 01/01/2020 NPJ genomic medicine
TS Wingo, J Yang, W Fan, S Min Canon, ES Gerasimov, A Lori, B Logsdon, B Yao, NT Seyfried, JJ Lah, AI Levey, PA Boyle, JA Schneider, PL De Jager, DA Bennett, AP Wingo 01/01/2020 Cell reports
YC Hsieh, C Guo, HK Yalamanchili, M Abreha, R Al-Ouran, Y Li, EB Dammer, JJ Lah, AI Levey, DA Bennett, PL De Jager, NT Seyfried, Z Liu, JM Shulman 10/08/2019 Glia
T Gao, J Jernigan, SA Raza, EB Dammer, H Xiao, NT Seyfried, AI Levey, S Rangaraju 10/01/2019 Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue.
Scientific reports
E Werner, A Alter, Q Deng, EB Dammer, Y Wang, DS Yu, DM Duong, NT Seyfried, PW Doetsch 08/29/2019 Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer's Disease.
Proteomes
L Higginbotham, EB Dammer, DM Duong, E Modeste, TJ Montine, JJ Lah, AI Levey, NT Seyfried 08/27/2019 Journal of proteome research
M Zhou, DM Duong, ECB Johnson, J Dai, JJ Lah, AI Levey, NT Seyfried 06/07/2019 Journal of proteome research
KJ Gerber, EB Dammer, DM Duong, Q Deng, SM Dudek, NT Seyfried, JR Hepler 06/07/2019 The Journal of biological chemistry
A Banerjee, BL Phillips, Q Deng, NT Seyfried, GK Pavlath, KE Vest, AH Corbett 05/03/2019 The Journal of neuroscience : the official journal of the Society for Neuroscience
A Gokhale, C Hartwig, AAH Freeman, JL Bassell, SA Zlatic, C Sapp Savas, T Vadlamudi, F Abudulai, TT Pham, A Crocker, E Werner, Z Wen, GM Repetto, JA Gogos, SM Claypool, JK Forsyth, CE Bearden, J Glausier, DA Lewis, NT Seyfried, JQ Kwong, V Faundez 05/01/2019 Nature communications
AP Wingo, EB Dammer, MS Breen, BA Logsdon, DM Duong, JC Troncosco, M Thambisetty, TG Beach, GE Serrano, EM Reiman, RJ Caselli, JJ Lah, NT Seyfried, AI Levey, TS Wingo 04/08/2019 Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.
Nature medicine
V Swarup, FI Hinz, JE Rexach, KI Noguchi, H Toyoshiba, A Oda, K Hirai, A Sarkar, NT Seyfried, C Cheng, SJ Haggarty, M Grossman, VM Van Deerlin, JQ Trojanowski, JJ Lah, AI Levey, S Kondou, DH Geschwind 01/01/2019 Translational psychiatry
P Srikanth, VN Lagomarsino, RV Pearse, M Liao, S Ghosh, R Nehme, N Seyfried, K Eggan, TL Young-Pearse 11/08/2018 Molecular neurodegeneration
ECB Johnson, EB Dammer, DM Duong, L Yin, M Thambisetty, JC Troncoso, JJ Lah, AI Levey, NT Seyfried 10/04/2018 Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease.
Proteomics
MH Abreha, EB Dammer, L Ping, T Zhang, DM Duong, M Gearing, JJ Lah, AI Levey, NT Seyfried 10/01/2018 Scientific data
M Wang, ND Beckmann, P Roussos, E Wang, X Zhou, Q Wang, C Ming, R Neff, W Ma, JF Fullard, ME Hauberg, J Bendl, MA Peters, B Logsdon, P Wang, M Mahajan, LM Mangravite, EB Dammer, DM Duong, JJ Lah, NT Seyfried, AI Levey, JD Buxbaum, M Ehrlich, S Gandy, P Katsel, V Haroutunian, E Schadt, B Zhang 09/11/2018 The Journal of biological chemistry
I Bishof, EB Dammer, DM Duong, SR Kundinger, M Gearing, JJ Lah, AI Levey, NT Seyfried 07/13/2018 Molecular neurodegeneration
S Rangaraju, EB Dammer, SA Raza, T Gao, H Xiao, R Betarbet, DM Duong, JA Webster, CM Hales, JJ Lah, AI Levey, NT Seyfried 06/28/2018 Molecular neurodegeneration
S Rangaraju, EB Dammer, SA Raza, P Rathakrishnan, H Xiao, T Gao, DM Duong, MW Pennington, JJ Lah, NT Seyfried, AI Levey 05/21/2018 Journal of proteome research
PR Evans, KJ Gerber, EB Dammer, DM Duong, D Goswami, DJ Lustberg, J Zou, JJ Yang, SM Dudek, PR Griffin, NT Seyfried, JR Hepler 04/06/2018 Global quantitative analysis of the human brain proteome in Alzheimer's and Parkinson's Disease.
Scientific data
L Ping, DM Duong, L Yin, M Gearing, JJ Lah, AI Levey, NT Seyfried 03/13/2018 Alzheimer's & dementia : the journal of the Alzheimer's Association
M Allen, X Wang, JD Burgess, J Watzlawik, DJ Serie, CS Younkin, T Nguyen, KG Malphrus, S Lincoln, MM Carrasquillo, C Ho, P Chakrabarty, S Strickland, ME Murray, V Swarup, DH Geschwind, NT Seyfried, EB Dammer, JJ Lah, AI Levey, TE Golde, C Funk, H Li, ND Price, RC Petersen, NR Graff-Radford, SG Younkin, DW Dickson, JR Crook, YW Asmann, N Ertekin-Taner 03/01/2018 Evidence for brain glucose dysregulation in Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Y An, VR Varma, S Varma, R Casanova, E Dammer, O Pletnikova, CW Chia, JM Egan, L Ferrucci, J Troncoso, AI Levey, J Lah, NT Seyfried, C Legido-Quigley, R O'Brien, M Thambisetty 03/01/2018 TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD.
Nature neuroscience
CC Chou, Y Zhang, ME Umoh, SW Vaughan, I Lorenzini, F Liu, M Sayegh, PG Donlin-Asp, YH Chen, DM Duong, NT Seyfried, MA Powers, T Kukar, CM Hales, M Gearing, NJ Cairns, KB Boylan, DW Dickson, R Rademakers, YJ Zhang, L Petrucelli, R Sattler, DC Zarnescu, JD Glass, W Rossoll 02/01/2018 EMBO molecular medicine
ME Umoh, EB Dammer, J Dai, DM Duong, JJ Lah, AI Levey, M Gearing, JD Glass, NT Seyfried 01/01/2018 Frontiers in immunology
S Rangaraju, SA Raza, NX Li, R Betarbet, EB Dammer, D Duong, JJ Lah, NT Seyfried, AI Levey 01/01/2018 Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease.
Frontiers in molecular neuroscience
J Dai, ECB Johnson, EB Dammer, DM Duong, M Gearing, JJ Lah, AI Levey, TS Wingo, NT Seyfried 01/01/2018 Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy.
Journal of neuropathology and experimental neurology
JD Cherry, A Zeineddin, EB Dammer, JA Webster, D Duong, NT Seyfried, AI Levey, VE Alvarez, BR Huber, TD Stein, PT Kiernan, AC McKee, JJ Lah, CM Hales 01/01/2018 Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer.
Science advances
K Bhuripanyo, Y Wang, X Liu, L Zhou, R Liu, D Duong, B Zhao, Y Bi, H Zhou, G Chen, NT Seyfried, WJ Chazin, H Kiyokawa, J Yin 01/01/2018 Molecular neurodegeneration
AT McKenzie, S Moyon, M Wang, I Katsyv, WM Song, X Zhou, EB Dammer, DM Duong, J Aaker, Y Zhao, N Beckmann, P Wang, J Zhu, JJ Lah, NT Seyfried, AI Levey, P Katsel, V Haroutunian, EE Schadt, B Popko, P Casaccia, B Zhang 11/06/2017 Enrichment of Detergent-insoluble Protein Aggregates from Human Postmortem Brain.
Journal of visualized experiments : JoVE
I Diner, T Nguyen, NT Seyfried 10/24/2017 Bioconjugate chemistry
I Diner, J Dooyema, M Gearing, LC Walker, NT Seyfried 10/18/2017 Human molecular genetics
J Rha, SK Jones, J Fidler, A Banerjee, SW Leung, KJ Morris, JC Wong, GAS Inglis, L Shapiro, Q Deng, AA Cutler, AM Hanif, MT Pardue, A Schaffer, NT Seyfried, KH Moberg, GJ Bassell, A Escayg, PS García, AH Corbett 10/01/2017 Journal of proteome research
TS Wingo, DM Duong, M Zhou, EB Dammer, H Wu, DJ Cutler, JJ Lah, AI Levey, NT Seyfried 09/01/2017 Aging cell
AA Cutler, EB Dammer, DM Doung, NT Seyfried, AH Corbett, GK Pavlath 08/01/2017 Nature structural & molecular biology
Z Zhang, SS Kang, X Liu, EH Ahn, Z Zhang, L He, PM Iuvone, DM Duong, NT Seyfried, MJ Benskey, FP Manfredsson, L Jin, YE Sun, JZ Wang, K Ye 08/01/2017 The Journal of biological chemistry
AA Ivanova, T Caspary, NT Seyfried, DM Duong, AB West, Z Liu, RA Kahn 06/30/2017 Journal of neuroinflammation
S Rangaraju, SA Raza, A Pennati, Q Deng, EB Dammer, D Duong, MW Pennington, MG Tansey, JJ Lah, R Betarbet, NT Seyfried, AI Levey 06/26/2017 Cell systems
NT Seyfried, EB Dammer, V Swarup, D Nandakumar, DM Duong, L Yin, Q Deng, T Nguyen, CM Hales, T Wingo, J Glass, M Gearing, M Thambisetty, JC Troncoso, DH Geschwind, JJ Lah, AI Levey 01/25/2017 The State of Systems Genetics in 2017.
Cell systems
NS Baliga, JL Björkegren, JD Boeke, M Boutros, NP Crawford, AM Dudley, CR Farber, A Jones, AI Levey, AJ Lusis, HC Mak, JH Nadeau, MB Noyes, E Petretto, NT Seyfried, LM Steinmetz, SC Vonesch 01/25/2017 eNeuro
Y Li, EB Dammer, X Zhang-Brotzge, S Chen, DM Duong, NT Seyfried, CY Kuan, YY Sun 01/01/2017 Proteomics
CM Hales, EB Dammer, Q Deng, DM Duong, M Gearing, JC Troncoso, M Thambisetty, JJ Lah, JM Shulman, AI Levey, NT Seyfried 12/01/2016 Molecular and cellular biology
S Soucek, Y Zeng, DL Bellur, M Bergkessel, KJ Morris, Q Deng, D Duong, NT Seyfried, C Guthrie, JP Staley, MB Fasken, AH Corbett 11/01/2016 CSF complement 3 and factor H are staging biomarkers in Alzheimer's disease.
Acta neuropathologica communications
WT Hu, KD Watts, P Tailor, TP Nguyen, JC Howell, RC Lee, NT Seyfried, M Gearing, CM Hales, AI Levey, JJ Lah, EK Lee 02/17/2016 ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.
Cell reports
H Zhang, PE Head, W Daddacha, SH Park, X Li, Y Pan, MZ Madden, DM Duong, M Xie, B Yu, MD Warren, EA Liu, VR Dhere, C Li, I Pradilla, MA Torres, Y Wang, WS Dynan, PW Doetsch, X Deng, NT Seyfried, D Gius, DS Yu 02/16/2016 Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase.
The Journal of biological chemistry
JP Owings, EG Kuiper, SM Prezioso, J Meisner, JJ Varga, N Zelinskaya, EB Dammer, DM Duong, NT Seyfried, S Albertí, GL Conn, JB Goldberg 02/12/2016 FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Q Deng, CJ Holler, G Taylor, KF Hudson, W Watkins, M Gearing, D Ito, ME Murray, DW Dickson, NT Seyfried, T Kukar 06/04/2014 The Journal of neuroscience : the official journal of the Society for Neuroscience
JH Herskowitz, Y Feng, AL Mattheyses, CM Hales, LA Higginbotham, DM Duong, TJ Montine, JC Troncoso, M Thambisetty, NT Seyfried, AI Levey, JJ Lah 12/04/2013 U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America
B Bai, CM Hales, PC Chen, Y Gozal, EB Dammer, JJ Fritz, X Wang, Q Xia, DM Duong, C Street, G Cantero, D Cheng, DR Jones, Z Wu, Y Li, I Diner, CJ Heilman, HD Rees, H Wu, L Lin, KE Szulwach, M Gearing, EJ Mufson, DA Bennett, TJ Montine, NT Seyfried, TS Wingo, YE Sun, P Jin, J Hanfelt, DM Willcock, A Levey, JJ Lah, J Peng 10/08/2013