Steven Sloan, MD, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-727-7208
Email Address

sasloan@emory.edu

Biography

Steven Sloan, MD, PhD, is an associate professor in the Department of Human Genetics at the Emory University School of Medicine. Dr. Sloan is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute.

Education

Dr. Sloan received his MD and his PhD from Stanford University in Stanford, California.

Titles & Roles

Associate Professor, Department of Human Genetics

Emory University School of Medicine

Research

Dr. Sloan's laboratory team is interested in understanding human astrocyte development and what mechanisms underlie astrocyte maturation. They have a great interest in glioblastoma because it represents a pathological model of abnormal astrocyte development. They are attempting to find synthetic drivers of astrocyte maturation during development and believe that we could apply these approaches to glioblastomas as potential therapeutic interventions.

Grants

View Grants

Grant Number	Title
1R01MH125956-01A1	Molecular Drivers of Human Gliogenesis
1R01MH126195-01	Leveraging 3D bioprinted organoid constructs to pattern and model human brain development
1R01NS123562-01	Shared mechanisms of astrocyte maturation in development and glioblastoma
5R01MH125956-02	Molecular Drivers of Human Gliogenesis
5R01MH125956-03	Molecular Drivers of Human Gliogenesis
5R01MH125956-04	Molecular Drivers of Human Gliogenesis
5R01MH126195-02	Leveraging 3D bioprinted organoid constructs to pattern and model human brain development
5R01MH126195-03	Leveraging 3D bioprinted organoid constructs to pattern and model human brain development
5R01MH126195-04	Leveraging 3D bioprinted organoid constructs to pattern and model human brain development
5R01NS123562-02	Shared mechanisms of astrocyte maturation in development and glioblastoma
5R01NS123562-03	Shared mechanisms of astrocyte maturation in development and glioblastoma
5R01NS123562-04	Shared mechanisms of astrocyte maturation in development and glioblastoma

Publications

Title/Journal	Authors	Publication Date
Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma. Nature cell biology	C Sojka, HV Wang, TN Bhatia, Y Li, P Chopra, A Sing, A Voss, A King, F Wang, K Joseph, VM Ravi, J Olson, K Hoang, E Nduom, VG Corces, B Yao, SA Sloan	01/08/2025
WebSEQ: A New Tool for Democratizing Omics Data Sharing. Glia	SA Liddelow, Y Zhang, SA Sloan	12/25/2024
Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association	CC Ramelow, H Xiao, L Cheng, P Kumar, EB Dammer, M Sampson, RS Nelson, S Malepati, Q Quo, P Bagchi, DM Duong, NT Seyfried, SA Sloan, S Rangaraju	12/01/2024
Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association	L Blackmer-Raynolds, M Sampson, AM Hamilton, A Yang, A Kozlov, L Lipson, J Chang, SD Kelly, SA Sloan, TR Sampson	12/01/2024
Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association	U Srivastava, CA Bowen, P Kumar, M Sampson, H Xiao, H Zeng, A Sing, C Sojka, T Bhatia, H Wulff, SA Sloan, S Rangaraju	12/01/2024
Implementation and validation of single-cell genomics experiments in neuroscience. Nature neuroscience	M Colonna, G Konopka, SA Liddelow, T Nowakowski, R Awatramani, HS Bateup, CR Cadwell, E Caglayan, JL Chen, J Gillis, M Kampmann, F Krienen, SE Marsh, M Monje, MR O'Dea, R Patani, AA Pollen, FJ Quintana, M Scavuzzo, M Schmitz, SA Sloan, PJ Tesar, J Tollkuhn, MA Tosches, ME Urbanek, JM Werner, OA Bayraktar, O Gokce, N Habib	12/01/2024
Primary cilia shape postnatal astrocyte development through Sonic Hedgehog signaling. bioRxiv : the preprint server for biology	R Bear, SA Sloan, T Caspary	10/17/2024
Schwann cell-secreted PGE₂ promotes sensory neuron excitability during development. Cell	H Kantarci, PD Elvira, AP Thottumkara, EM O'Connell, M Iyer, LJ Donovan, MQ Dugan, N Ambiel, A Granados, H Zeng, NL Saw, A Brosius Lutz, SA Sloan, EE Gray, KV Tran, A Vichare, AK Yeh, AE Münch, M Huber, A Agrawal, M Morri, H Zhong, M Shamloo, TA Anderson, VL Tawfik, J Du Bois, JB Zuchero	08/22/2024
Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus. bioRxiv : the preprint server for biology	AF Iannitelli, L Hassenein, B Mulvey, HE Blankenship, LC Liles, AL Sharpe, JF Pare, A Segal, SA Sloan, K Martinowich, KE McCann, JD Dougherty, Y Smith, MJ Beckstead, D Weinshenker	08/04/2024
Single-cell investigation of lead toxicity from neurodevelopment to neurodegeneration: Current review and future opportunities. Current opinion in toxicology	MM Sampson, RK Morgan, SA Sloan, KM Bakulski	06/01/2024
Neural and metabolic dysregulation in PMM2-deficient human in vitro neural models. Cell reports	S Radenkovic, R Budhraja, T Klein-Gunnewiek, AT King, TN Bhatia, AN Ligezka, K Driesen, R Shah, B Ghesquière, A Pandey, NN Kasri, SA Sloan, E Morava, T Kozicz	03/26/2024
ScISOr-ATAC reveals convergent and divergent splicing and chromatin specificities between matched cell types across cortical regions, evolution, and in Alzheimer's Disease. bioRxiv : the preprint server for biology	W Hu, C Foord, J Hsu, L Fan, MJ Corley, TN Bhatia, S Xu, N Belchikov, Y He, AP Pang, SN Lanjewar, J Jarroux, A Joglekar, TA Milner, LC Ndhlovu, J Zhang, E Butelman, SA Sloan, VM Lee, L Gan, HU Tilgner	02/28/2024
Gliomas: a reflection of temporal gliogenic principles. Communications biology	C Sojka, SA Sloan	02/06/2024
Neuron-Astrocyte Interactions: A Human Perspective. Advances in neurobiology	T Pio, EJ Hill, N Kebede, J Andersen, SA Sloan	01/01/2024
Author Correction: Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia. Nature neuroscience	X Zhu, B Zhou, R Pattni, K Gleason, C Tan, A Kalinowski, S Sloan, AS Fiston-Lavier, J Mariani, D Petrov, BA Barres, L Duncan, A Abyzov, H Vogel, JV Moran, FM Vaccarino, CA Tamminga, DF Levinson, AE Urban	10/01/2023
Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion. Science advances	RH Purcell, E Sefik, E Werner, AT King, TJ Mosley, ME Merritt-Garza, P Chopra, ZT McEachin, S Karne, N Raj, BJ Vaglio, D Sullivan, BL Firestein, K Tilahun, MI Robinette, ST Warren, Z Wen, V Faundez, SA Sloan, GJ Bassell, JG Mulle	08/18/2023
GPR37L1 controls maturation and organization of cortical astrocytes during development. Glia	TT Nguyen, CR Camp, JK Doan, SF Traynelis, SA Sloan, RA Hall	08/01/2023
Identification of ligand-receptor pairs that drive human astrocyte development. Nature neuroscience	AJ Voss, SN Lanjewar, MM Sampson, A King, EJ Hill, A Sing, C Sojka, TN Bhatia, JM Spangle, SA Sloan	08/01/2023
The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease. eNeuro	AF Iannitelli, MA Kelberman, DJ Lustberg, A Korukonda, KE McCann, B Mulvey, A Segal, LC Liles, SA Sloan, JD Dougherty, D Weinshenker	01/01/2023
Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue. Nature biotechnology	SA Hardwick, W Hu, A Joglekar, L Fan, PG Collier, C Foord, J Balacco, S Lanjewar, MM Sampson, F Koopmans, AD Prjibelski, A Mikheenko, N Belchikov, J Jarroux, AB Lucas, M Palkovits, W Luo, TA Milner, LC Ndhlovu, AB Smit, JQ Trojanowski, VMY Lee, O Fedrigo, SA Sloan, D Tombácz, ME Ross, E Jarvis, Z Boldogkői, L Gan, HU Tilgner	07/01/2022
An RNA-sequencing transcriptome of the rodent Schwann cell response to peripheral nerve injury. Journal of neuroinflammation	A Brosius Lutz, TA Lucas, GA Carson, C Caneda, L Zhou, BA Barres, MS Buckwalter, SA Sloan	04/30/2022
3D Bioprinting of Neural Tissues. Advanced healthcare materials	M Cadena, L Ning, A King, B Hwang, L Jin, V Serpooshan, SA Sloan	08/01/2021
Glia in neurodegeneration. Neurobiology of disease	FC Bennett, SA Sloan	04/01/2021
Elevated preoptic brain activity in zebrafish glial glycine transporter mutants is linked to lethargy-like behaviors and delayed emergence from anesthesia. Scientific reports	MJ Venincasa, O Randlett, SH Sumathipala, R Bindernagel, MJ Stark, Q Yan, SA Sloan, E Buglo, QC Meng, F Engert, S Züchner, MB Kelz, S Syed, JE Dallman	02/04/2021
Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia. Nature neuroscience	X Zhu, B Zhou, R Pattni, K Gleason, C Tan, A Kalinowski, S Sloan, AS Fiston-Lavier, J Mariani, D Petrov, BA Barres, L Duncan, A Abyzov, H Vogel, JV Moran, FM Vaccarino, CA Tamminga, DF Levinson, AE Urban	02/01/2021
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain. Nature communications	A Joglekar, A Prjibelski, A Mahfouz, P Collier, S Lin, AK Schlusche, J Marrocco, SR Williams, B Haase, A Hayes, JG Chew, NI Weisenfeld, MY Wong, AN Stein, SA Hardwick, T Hunt, Q Wang, C Dieterich, Z Bent, O Fedrigo, SA Sloan, D Risso, ED Jarvis, P Flicek, W Luo, GS Pitt, A Frankish, AB Smit, ME Ross, HU Tilgner	01/19/2021
Growing Glia: Cultivating Human Stem Cell Models of Gliogenesis in Health and Disease. Frontiers in cell and developmental biology	SN Lanjewar, SA Sloan	01/01/2021

Awards

Dr. Sloan is a recipient of the Emory 1% Award which recognizes Emory faculty whose National Institutes of Health (NIH) proposals have been ranked in the top 1% by NIH reviewers.