Zhengqi Wang, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-727-5654
Email Address

zhengqi.wang@emory.edu

Biography

Zhengqi Wang, PhD, is an assistant professor in the Department of Pediatrics at Emory University School of Medicine. Dr. Wang serves as a pediatric cancer biologist at Children's Healthcare of Atlanta.

Dr. Wang is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute of Emory University.

Education

Dr. Wang earned his PhD in Molecular and Cellular Biology from University of Notre Dame in Notre Dame, Indiana. He completed a fellowship at Case Western Reserve University in Cleveland, Ohio.

Titles & Roles

Assistant Professor, Department of Pediatrics

Emory University School of Medicine

Professional Memberships

Dr. Wang is a member of the American Society of Hematology.

Research

Dr. Wang's research interests include STAT5 function in signaling mechanisms in leukemogenesis, and hematopoietic stem cell biology and transplantation.

Publications

Title/Journal	Authors	Publication Date
Stromal STAT5-Mediated Trophic Activity Regulates Hematopoietic Niche Factors. Stem cells (Dayton, Ohio)	Z Wang, G Emmel, HS Lim, W Zhu, A Kosters, EEB Ghosn, P Qiu, KD Bunting	10/08/2023
International Expert Consensus on Precision Anatomy for minimally invasive distal pancreatectomy: PAM-HBP Surgery Project. Journal of hepato-biliary-pancreatic sciences	D Ban, H Nishino, T Ohtsuka, Y Nagakawa, M Abu Hilal, HJ Asbun, U Boggi, BKP Goh, J He, G Honda, JY Jang, CM Kang, ML Kendrick, DA Kooby, R Liu, Y Nakamura, K Nakata, C Palanivelu, SV Shrikhande, K Takaori, CN Tang, SE Wang, CL Wolfgang, A Yiengpruksawan, YS Yoon, R Ciria, G Berardi, GM Garbarino, R Higuchi, N Ikenaga, Y Ishikawa, S Kozono, A Maekawa, Y Murase, Y Watanabe, G Zimmitti, F Kunzler, ZZ Wang, L Sakuma, H Osakabe, C Takishita, I Endo, M Tanaka, H Yamaue, M Tanabe, G Wakabayashi, A Tsuchida, M Nakamura	01/01/2022
ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease. Progress in neurobiology	ZH Wang, Y Xia, P Liu, X Liu, L Edgington-Mitchell, K Lei, SP Yu, XC Wang, K Ye	07/01/2021
Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia. Antioxidants (Basel, Switzerland)	Z Wang, T Mi, HL Bradley, J Metts, H Sabnis, W Zhu, J Arbiser, KD Bunting	06/15/2021
Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8⁺ T-Cell Activation. Frontiers in immunology	Z Wang, TY Vaughan, W Zhu, Y Chen, G Fu, M Medrzycki, H Nishio, ST Bunting, PA Hankey-Giblin, A Nusrat, CA Parkos, D Wang, R Wen, KD Bunting	01/01/2019
The Cooperative Relationship between STAT5 and Reactive Oxygen Species in Leukemia: Mechanism and Therapeutic Potential. Cancers	T Mi, Z Wang, KD Bunting	09/27/2018
Active N⁶-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons. Molecular cell	B Yao, Y Li, Z Wang, L Chen, M Poidevin, C Zhang, L Lin, F Wang, H Bao, B Jiao, J Lim, Y Cheng, L Huang, BL Phillips, T Xu, R Duan, KH Moberg, H Wu, P Jin	09/06/2018
Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis. The Journal of biological chemistry	JA Lee, Z Wang, D Sambo, KD Bunting, DC Pallas	06/22/2018
C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease. Nature communications	ZH Wang, K Gong, X Liu, Z Zhang, X Sun, ZZ Wei, SP Yu, FP Manfredsson, IM Sandoval, PF Johnson, J Jia, JZ Wang, K Ye	05/03/2018
Association analysis identifies 65 new breast cancer risk loci. Nature	K Michailidou, S Lindström, J Dennis, J Beesley, S Hui, S Kar, A Lemaçon, P Soucy, D Glubb, A Rostamianfar, MK Bolla, Q Wang, J Tyrer, E Dicks, A Lee, Z Wang, J Allen, R Keeman, U Eilber, JD French, X Qing Chen, L Fachal, K McCue, AE McCart Reed, M Ghoussaini, JS Carroll, X Jiang, H Finucane, M Adams, MA Adank, H Ahsan, K Aittomäki, H Anton-Culver, NN Antonenkova, V Arndt, KJ Aronson, B Arun, PL Auer, F Bacot, M Barrdahl, C Baynes, MW Beckmann, S Behrens, J Benitez, M Bermisheva, L Bernstein, C Blomqvist, NV Bogdanova, SE Bojesen, B Bonanni, AL Børresen-Dale, JS Brand, H Brauch, P Brennan, H Brenner, L Brinton, P Broberg, IW Brock, A Broeks, A Brooks-Wilson, SY Brucker, T Brüning, B Burwinkel, K Butterbach, Q Cai, H Cai, T Caldés, F Canzian, A Carracedo, BD Carter, JE Castelao, TL Chan, TY David Cheng, K Seng Chia, JY Choi, H Christiansen, CL Clarke, M Collée, DM Conroy, E Cordina-Duverger, S Cornelissen, DG Cox, A Cox, SS Cross, JM Cunningham, K Czene, MB Daly, P Devilee, KF Doheny, T Dörk, I Dos-Santos-Silva, M Dumont, L Durcan, M Dwek, DM Eccles, AB Ekici, AH Eliassen, C Ellberg, M Elvira, C Engel, M Eriksson, PA Fasching, J Figueroa, D Flesch-Janys, O Fletcher, H Flyger, L Fritschi, V Gaborieau, M Gabrielson, M Gago-Dominguez, YT Gao, SM Gapstur, JA García-Sáenz, MM Gaudet, V Georgoulias, GG Giles, G Glendon, MS Goldberg, DE Goldgar, A González-Neira, GI Grenaker Alnæs, M Grip, J Gronwald, A Grundy, P Guénel, L Haeberle, E Hahnen, CA Haiman, N Håkansson, U Hamann, N Hamel, S Hankinson, P Harrington, SN Hart, JM Hartikainen, M Hartman, A Hein, J Heyworth, B Hicks, P Hillemanns, DN Ho, A Hollestelle, MJ Hooning, RN Hoover, JL Hopper, MF Hou, CN Hsiung, G Huang, K Humphreys, J Ishiguro, H Ito, M Iwasaki, H Iwata, A Jakubowska, W Janni, EM John, N Johnson, K Jones, M Jones, A Jukkola-Vuorinen, R Kaaks, M Kabisch, K Kaczmarek, D Kang, Y Kasuga, MJ Kerin, S Khan, E Khusnutdinova, JI Kiiski, SW Kim, JA Knight, VM Kosma, VN Kristensen, U Krüger, A Kwong, D Lambrechts, L Le Marchand, E Lee, MH Lee, JW Lee, C Neng Lee, F Lejbkowicz, J Li, J Lilyquist, A Lindblom, J Lissowska, WY Lo, S Loibl, J Long, A Lophatananon, J Lubinski, C Luccarini, MP Lux, ESK Ma, RJ MacInnis, T Maishman, E Makalic, KE Malone, IM Kostovska, A Mannermaa, S Manoukian, JE Manson, S Margolin, S Mariapun, ME Martinez, K Matsuo, D Mavroudis, J McKay, C McLean, H Meijers-Heijboer, A Meindl, P Menéndez, U Menon, J Meyer, H Miao, N Miller, NAM Taib, K Muir, AM Mulligan, C Mulot, SL Neuhausen, H Nevanlinna, P Neven, SF Nielsen, DY Noh, BG Nordestgaard, A Norman, OI Olopade, JE Olson, H Olsson, C Olswold, N Orr, VS Pankratz, SK Park, TW Park-Simon, R Lloyd, JIA Perez, P Peterlongo, J Peto, KA Phillips, M Pinchev, D Plaseska-Karanfilska, R Prentice, N Presneau, D Prokofyeva, E Pugh, K Pylkäs, B Rack, P Radice, N Rahman, G Rennert, HS Rennert, V Rhenius, A Romero, J Romm, KJ Ruddy, T Rüdiger, A Rudolph, M Ruebner, EJT Rutgers, E Saloustros, DP Sandler, S Sangrajrang, EJ Sawyer, DF Schmidt, RK Schmutzler, A Schneeweiss, MJ Schoemaker, F Schumacher, P Schürmann, RJ Scott, C Scott, S Seal, C Seynaeve, M Shah, P Sharma, CY Shen, G Sheng, ME Sherman, MJ Shrubsole, XO Shu, A Smeets, C Sohn, MC Southey, JJ Spinelli, C Stegmaier, S Stewart-Brown, J Stone, DO Stram, H Surowy, A Swerdlow, R Tamimi, JA Taylor, M Tengström, SH Teo, M Beth Terry, DC Tessier, S Thanasitthichai, K Thöne, RAEM Tollenaar, I Tomlinson, L Tong, D Torres, T Truong, CC Tseng, S Tsugane, HU Ulmer, G Ursin, M Untch, C Vachon, CJ van Asperen, D Van Den Berg, AMW van den Ouweland, L van der Kolk, RB van der Luijt, D Vincent, J Vollenweider, Q Waisfisz, S Wang-Gohrke, CR Weinberg, C Wendt, AS Whittemore, H Wildiers, W Willett, R Winqvist, A Wolk, AH Wu, L Xia, T Yamaji, XR Yang, C Har Yip, KY Yoo, JC Yu, W Zheng, Y Zheng, B Zhu, A Ziogas, E Ziv, SR Lakhani, AC Antoniou, A Droit, IL Andrulis, CI Amos, FJ Couch, PDP Pharoah, J Chang-Claude, P Hall, DJ Hunter, RL Milne, M García-Closas, MK Schmidt, SJ Chanock, AM Dunning, SL Edwards, GD Bader, G Chenevix-Trench, J Simard, P Kraft, DF Easton	11/02/2017
Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells. Scientific reports	J Metts, HL Bradley, Z Wang, NP Shah, R Kapur, JL Arbiser, KD Bunting	06/30/2017
Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations. Oncotarget	Z Wang, KD Bunting	04/04/2017
Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. Cancer research	G Fehringer, P Kraft, PD Pharoah, RA Eeles, N Chatterjee, FR Schumacher, JM Schildkraut, S Lindström, P Brennan, H Bickeböller, RS Houlston, MT Landi, N Caporaso, A Risch, A Amin Al Olama, SI Berndt, EL Giovannucci, H Grönberg, Z Kote-Jarai, J Ma, K Muir, MJ Stampfer, VL Stevens, F Wiklund, WC Willett, EL Goode, JB Permuth, HA Risch, BM Reid, S Bezieau, H Brenner, AT Chan, J Chang-Claude, TJ Hudson, JK Kocarnik, PA Newcomb, RE Schoen, ML Slattery, E White, MA Adank, H Ahsan, K Aittomäki, L Baglietto, C Blomquist, F Canzian, K Czene, I Dos-Santos-Silva, AH Eliassen, JD Figueroa, D Flesch-Janys, O Fletcher, M Garcia-Closas, MM Gaudet, N Johnson, P Hall, A Hazra, R Hein, A Hofman, JL Hopper, A Irwanto, M Johansson, R Kaaks, MG Kibriya, P Lichtner, J Liu, E Lund, E Makalic, A Meindl, B Müller-Myhsok, TA Muranen, H Nevanlinna, PH Peeters, J Peto, RL Prentice, N Rahman, MJ Sanchez, DF Schmidt, RK Schmutzler, MC Southey, R Tamimi, RC Travis, C Turnbull, AG Uitterlinden, Z Wang, AS Whittemore, XR Yang, W Zheng, DD Buchanan, G Casey, DV Conti, CK Edlund, S Gallinger, RW Haile, M Jenkins, L Le Marchand, L Li, NM Lindor, SL Schmit, SN Thibodeau, MO Woods, T Rafnar, J Gudmundsson, SN Stacey, K Stefansson, P Sulem, YA Chen, JP Tyrer, DC Christiani, Y Wei, H Shen, Z Hu, XO Shu, K Shiraishi, A Takahashi, Y Bossé, M Obeidat, D Nickle, W Timens, ML Freedman, Q Li, D Seminara, SJ Chanock, J Gong, U Peters, SB Gruber, CI Amos, TA Sellers, DF Easton, DJ Hunter, CA Haiman, BE Henderson, RJ Hung	09/01/2016
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome. Nature communications	MJ Machiela, W Zhou, E Karlins, JN Sampson, ND Freedman, Q Yang, B Hicks, C Dagnall, C Hautman, KB Jacobs, CC Abnet, MC Aldrich, C Amos, LT Amundadottir, AA Arslan, LE Beane-Freeman, SI Berndt, A Black, WJ Blot, CH Bock, PM Bracci, LA Brinton, HB Bueno-de-Mesquita, L Burdett, JE Buring, MA Butler, F Canzian, T Carreón, KG Chaffee, IS Chang, N Chatterjee, C Chen, C Chen, K Chen, CC Chung, LS Cook, M Crous Bou, M Cullen, FG Davis, I De Vivo, T Ding, J Doherty, EJ Duell, CG Epstein, JH Fan, JD Figueroa, JF Fraumeni, CM Friedenreich, CS Fuchs, S Gallinger, YT Gao, SM Gapstur, M Garcia-Closas, MM Gaudet, JM Gaziano, GG Giles, EM Gillanders, EL Giovannucci, L Goldin, AM Goldstein, CA Haiman, G Hallmans, SE Hankinson, CC Harris, R Henriksson, EA Holly, YC Hong, RN Hoover, CA Hsiung, N Hu, W Hu, DJ Hunter, A Hutchinson, M Jenab, C Johansen, KT Khaw, HN Kim, YH Kim, YT Kim, AP Klein, R Klein, WP Koh, LN Kolonel, C Kooperberg, P Kraft, V Krogh, RC Kurtz, A LaCroix, Q Lan, MT Landi, LL Marchand, D Li, X Liang, LM Liao, D Lin, J Liu, J Lissowska, L Lu, AM Magliocco, N Malats, K Matsuo, LH McNeill, RR McWilliams, BS Melin, L Mirabello, L Moore, SH Olson, I Orlow, JY Park, A Patiño-Garcia, B Peplonska, U Peters, GM Petersen, L Pooler, J Prescott, L Prokunina-Olsson, MP Purdue, YL Qiao, P Rajaraman, FX Real, E Riboli, HA Risch, B Rodriguez-Santiago, AM Ruder, SA Savage, F Schumacher, AG Schwartz, KL Schwartz, A Seow, V Wendy Setiawan, G Severi, H Shen, X Sheng, MH Shin, XO Shu, DT Silverman, MR Spitz, VL Stevens, R Stolzenberg-Solomon, D Stram, ZZ Tang, PR Taylor, LR Teras, GS Tobias, D Van Den Berg, K Visvanathan, S Wacholder, JC Wang, Z Wang, N Wentzensen, W Wheeler, E White, JK Wiencke, BM Wolpin, MP Wong, C Wu, T Wu, X Wu, YL Wu, JS Wunder, L Xia, HP Yang, PC Yang, K Yu, KA Zanetti, A Zeleniuch-Jacquotte, W Zheng, B Zhou, RG Ziegler, LA Perez-Jurado, NE Caporaso, N Rothman, M Tucker, MC Dean, M Yeager, SJ Chanock	06/13/2016
DNA methylation dynamics in neurogenesis. Epigenomics	Z Wang, B Tang, Y He, P Jin	03/01/2016
STAT5 activation in B-cell acute lymphoblastic leukemia: damned if you do, damned if you don't. Cancer cell & microenvironment	Z Wang, KD Bunting	01/01/2016
Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis. Oncotarget	Z Wang, M Medrzycki, ST Bunting, KD Bunting	10/06/2015
AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis. Oncotarget	J Park, M Schlederer, M Schreiber, R Ice, O Merkel, M Bilban, S Hofbauer, S Kim, J Addison, J Zou, C Ji, ST Bunting, Z Wang, M Shoham, G Huang, Z Bago-Horvath, LF Gibson, Y Rojanasakul, S Remick, A Ivanov, E Pugacheva, KD Bunting, R Moriggl, L Kenner, W Tse	08/21/2015
Escalation with overdose control using all toxicities and time to event toxicity data in cancer Phase I clinical trials. Contemporary clinical trials	Z Chen, Y Cui, TK Owonikoko, Z Wang, Z Li, R Luo, M Kutner, FR Khuri, J Kowalski	03/01/2014
STAT5 N-domain deleted isoforms are naturally occurring hypomorphs partially rescued in hematopoiesis by transgenic Bcl-2 expression. American journal of blood research	Z Wang, G Li, KD Bunting	01/01/2014
Using microfluidics to investigate hematopoietic stem cell and microniche interactions at the single cell level. Methods in molecular biology (Clifton, N.J.)	B Ahn, Z Wang, DR Archer, WA Lam	01/01/2014
STAT5 in hematopoietic stem cell biology and transplantation. JAK-STAT	Z Wang, KD Bunting	10/01/2013
Mutation of STAT1/3 binding sites in gp130(FXXQ) knock-in mice does not alter hematopoietic stem cell repopulation or self-renewal potential. American journal of stem cells	Z Wang, Z Kang, Y Zhang, W Tse, KD Bunting	06/30/2012
HIF-1α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency. Blood	J Du, Y Chen, Q Li, X Han, C Cheng, Z Wang, D Danielpour, SL Dunwoodie, KD Bunting, YC Yang	03/22/2012
Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production. The Journal of biological chemistry	NA Pullen, BO Barnstein, YT Falanga, Z Wang, R Suzuki, TD Tamang, MC Khurana, EA Harry, P Draber, KD Bunting, K Mizuno, BS Wilson, JJ Ryan	01/13/2012
Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3. The Journal of biological chemistry	Z Liu, A Yang, Z Wang, KD Bunting, G Davuluri, MR Green, LR Devireddy	06/10/2011
Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin. Leukemia	G Li, KL Miskimen, Z Wang, XY Xie, W Tse, F Gouilleux, R Moriggl, KD Bunting	08/01/2010
STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease. Blood	G Li, KL Miskimen, Z Wang, XY Xie, J Brenzovich, JJ Ryan, W Tse, R Moriggl, KD Bunting	02/18/2010
Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5. PloS one	G Li, Z Wang, KL Miskimen, Y Zhang, W Tse, KD Bunting	02/10/2010
Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement. Blood	Z Wang, G Li, W Tse, KD Bunting	05/14/2009
IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen. Journal of immunology (Baltimore, Md. : 1950)	K Ohmori, Y Luo, Y Jia, J Nishida, Z Wang, KD Bunting, D Wang, H Huang	03/01/2009
STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells. Blood	PA Cohen, GK Koski, BJ Czerniecki, KD Bunting, XY Fu, Z Wang, WJ Zhang, CS Carter, M Awad, CA Distel, H Nagem, CC Paustian, TD Johnson, JF Tisdale, S Shu	09/01/2008
Hematopoietic stem cell transplant into non-myeloablated W/Wv mice to detect steady-state engraftment defects. Methods in molecular biology (Clifton, N.J.)	Z Wang, KD Bunting	01/01/2008