Chris Yun, PhD
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Chang-Hyon Chris Yun, PhD, is a professor in the Department of Medicine at Emory University School of Medicine. Dr. Yun joined Emory University in 2002 from Johns Hopkins University. Dr. Yun is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute. He is also a member of Biochemistry, Cell and Developmental Biology (BCDB) program and Nutrition and Health Sciences (NHS) program at Emory University. Dr. Yun earned his PhD in Biophysics from University of Illinois at Urbana-Champaign, and went on to do postdoctoral training at Johns Hopkins University in electrolyte transport.Education
Dr. Yun holds professional memberships with the American Physiological Society and American Gastroenterology Association.
Dr. Yun's research is in mammalian intestine NHE3, a component of electroneutral NaCl absorption, which is a major constituent in basal Na+ and fluid absorption. This is a frequent target of inhibition in many diarrheal diseases. Another site of NHE3 is the kidney where 70% of HCO3- reabsorption can be attributed to Na+/H+ exchanger NHE3. NHE3 is regulated by hormones, growth factor, and external stimuli that target protein kinases. The first goal is to understand the mechanisms of NHE3 regulation by G protein-coupled receptors and protein kinases. The second goal is to delineate how the interaction of NHE3 with accessory proteins (NHERF1, NHERF2, and IRBIT) affects the signaling targeting NHE3. We are focusing on the cellular signaling elicited by glucocorticoids, angiotensin and lysophosphatidic acid (LPA).
Title/Journal | Authors | Publication Date |
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Lysophosphatidic Acid Signaling in the Gastrointestinal System. Cellular and molecular gastroenterology and hepatology |
CC Yun, Y Han, B McConnell | 09/02/2024 |
LPA5-Dependent signaling regulates regeneration of the intestinal epithelium following irradiation. American journal of physiology. Gastrointestinal and liver physiology |
BB McConnell, Z Liang, C Xu, Y Han, CC Yun | 06/01/2024 |
American journal of physiology. Cell physiology |
Y Han, P Bagchi, CC Yun | 01/01/2024 |
American journal of physiology. Endocrinology and metabolism |
Y Han, S Srinivasan, CC Yun | 09/01/2023 |
Cells |
Z Liang, CC Yun | 07/20/2022 |
Cellular and molecular gastroenterology and hepatology |
KA Jenkin, Y Han, S Lin, P He, CC Yun | 01/01/2022 |
Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPA5-Dependent Signaling. Cellular and molecular gastroenterology and hepatology |
Z Liang, P He, Y Han, CC Yun | 01/01/2022 |
Metformin Inhibits Na+/H+ Exchanger NHE3 Resulting in Intestinal Water Loss. Frontiers in physiology |
Y Han, CC Yun | 01/01/2022 |
Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5. Cellular and molecular gastroenterology and hepatology |
M Wang, P He, Y Han, L Dong, CC Yun | 01/01/2021 |
FASEB journal : official publication of the Federation of American Societies for Experimental Biology |
Y Han, CC Yun | 12/01/2020 |
Cancers |
CC Yun | 07/09/2019 |
Autotaxin determines colitis severity in mice and is secreted by B cells in the colon. FASEB journal : official publication of the Federation of American Societies for Experimental Biology |
S Lin, A Haque, R Raeman, L Guo, P He, TL Denning, B El-Rayes, WH Moolenaar, CC Yun | 03/01/2019 |
FASEB journal : official publication of the Federation of American Societies for Experimental Biology |
L Zhao, T Bartnikas, X Chu, J Klein, C Yun, S Srinivasan, P He | 03/01/2019 |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology |
Y Yu, A Seidler, K Zhou, Z Yuan, S Yeruva, M Amiri, CC Yun, K Nikolovska, U Seidler | 01/01/2019 |
American journal of physiology. Gastrointestinal and liver physiology |
P He, A Haque, S Lin, F Cominelli, CC Yun | 11/01/2018 |
American journal of physiology. Gastrointestinal and liver physiology |
KA Jenkin, P He, CC Yun | 10/01/2018 |
The American journal of pathology |
S Lin, Y Han, K Jenkin, SJ Lee, M Sasaki, JM Klapproth, P He, CC Yun | 02/01/2018 |
Neuroscience |
SL Ritter-Makinson, M Paquet, JW Bogenpohl, RE Rodin, C Chris Yun, EJ Weinman, Y Smith, RA Hall | 06/14/2017 |
Development of CXCR4 modulators by virtual HTS of a novel amide-sulfamide compound library. European journal of medicinal chemistry |
R Bai, Q Shi, Z Liang, Y Yoon, Y Han, A Feng, S Liu, Y Oum, CC Yun, H Shim | 01/27/2017 |
American journal of physiology. Renal physiology |
P He, L Zhao, YR No, S Karvar, CC Yun | 08/01/2016 |
American journal of physiology. Gastrointestinal and liver physiology |
M Yoshida, L Zhao, G Grigoryan, H Shim, P He, CC Yun | 04/15/2016 |
PloS one |
M Yoshida, P He, CC Yun | 01/01/2016 |
Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2. American journal of physiology. Cell physiology |
YR No, P He, BK Yoo, CC Yun | 07/01/2015 |
Diverse roles of LPA signaling in the intestinal epithelium. Experimental cell research |
CC Yun, A Kumar | 05/01/2015 |
HIF1α-Induced by Lysophosphatidic Acid Is Stabilized via Interaction with MIF and CSN5. PloS one |
YR No, SJ Lee, A Kumar, CC Yun | 01/01/2015 |
The Journal of biological chemistry |
YR No, P He, BK Yoo, CC Yun | 06/27/2014 |
Physiological reports |
HJ Lee, MH Kwon, S Lee, RA Hall, CC Yun, I Choi | 05/01/2014 |
The Journal of biological chemistry |
SJ Lee, YR No, DT Dang, LH Dang, VW Yang, H Shim, CC Yun | 08/30/2013 |
Molecular and cellular biology |
SJ Lee, G Leoni, PA Neumann, J Chun, A Nusrat, CC Yun | 05/01/2013 |
The Journal of biological chemistry |
Z Hu, J Hu, Z Zhang, WJ Shen, CC Yun, CH Berlot, FB Kraemer, S Azhar | 04/19/2013 |
Human intestinal epithelial cell line SK-CO15 is a new model system to study Na(+)/H(+) exchanger 3. American journal of physiology. Gastrointestinal and liver physiology |
BK Yoo, MK Yanda, YR No, CC Yun | 07/15/2012 |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology |
S Lee, HS Yang, E Kim, EJ Ju, MH Kwon, RK Dudley, Y Smith, CC Yun, I Choi | 01/01/2012 |
Development of a unique small molecule modulator of CXCR4. PloS one |
Z Liang, W Zhan, A Zhu, Y Yoon, S Lin, M Sasaki, JM Klapproth, H Yang, HE Grossniklaus, J Xu, M Rojas, RJ Voll, MM Goodman, RF Arrendale, J Liu, CC Yun, JP Snyder, DC Liotta, H Shim | 01/01/2012 |
American journal of physiology. Cell physiology |
BK Yoo, P He, SJ Lee, CC Yun | 11/01/2011 |
Molecular biology of the cell |
P He, SJ Lee, S Lin, U Seidler, F Lang, G Fejes-Toth, A Naray-Fejes-Toth, CC Yun | 10/01/2011 |
MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells. Gastroenterology |
SJ Lee, SL Ritter, H Zhang, H Shim, RA Hall, CC Yun | 03/01/2011 |
GLAST stability and activity are enhanced by interaction with the PDZ scaffold NHERF-2. Neuroscience letters |
SL Ritter, MJ Asay, M Paquet, KJ Paavola, RE Reiff, CC Yun, RA Hall | 01/03/2011 |
The Journal of physiology |
M Chen, A Sultan, A Cinar, S Yeruva, B Riederer, AK Singh, J Li, J Bonhagen, G Chen, C Yun, M Donowitz, B Hogema, H de Jonge, U Seidler | 12/15/2010 |
Colorectal cancer cells - Proliferation, survival and invasion by lysophosphatidic acid. The international journal of biochemistry & cell biology |
SJ Lee, CC Yun | 12/01/2010 |
The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine. American journal of physiology. Gastrointestinal and liver physiology |
S Lin, SJ Lee, H Shim, J Chun, CC Yun | 11/01/2010 |
The Journal of biological chemistry |
P He, J Klein, CC Yun | 09/03/2010 |
Gastroenterology |
S Lin, S Yeruva, P He, AK Singh, H Zhang, M Chen, G Lamprecht, HR de Jonge, M Tse, M Donowitz, BM Hogema, J Chun, U Seidler, CC Yun | 02/01/2010 |
Mechanisms of the regulation of the intestinal Na+/H+ exchanger NHE3. Journal of biomedicine & biotechnology |
P He, CC Yun | 01/01/2010 |
Gastroenterology |
S Lin, D Wang, S Iyer, AM Ghaleb, H Shim, VW Yang, J Chun, CC Yun | 05/01/2009 |
The European journal of neuroscience |
DS Cooper, HS Yang, P He, E Kim, I Rajbhandari, CC Yun, I Choi | 02/01/2009 |
The Journal of biological chemistry |
P He, H Zhang, CC Yun | 11/28/2008 |