James Dahlman, PhD
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Research Program
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Phone Number
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Email Address
Biography
James Dahlman, PhD, is an associate professor and holds the McCamish Foundation Early Career Professorship in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech University. Dr. Dahlman is a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute of Emory University in Atlanta, Georgia.
Education
Dr. Dahlman received his PhD from MIT and Harvard Medical School in 2014, where he studied RNA delivery with Robert Langer and Daniel Anderson. He studied RNA design and gene editing as a post-doc with Feng Zhang at The Broad Institute.
Titles & Roles
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Associate Professor, McCamish Foundation Early Career Professorship, Department of Biomedical EngineeringGeorgia Institute of Technology
Research
Dr. Dahlman is interested in drug delivery, targeted in vivo gene editing and using genomics to improve biomaterial design. He has designed and synthesized nanoparticles that efficiently deliver RNAs to the lung and heart. These nanoparticles can deliver multiple RNAs at once, and can simultaneously knockdown five genes concurrently in vivo. They have been used by over 10 labs across the United States to study cancer, atherosclerosis, inflammation, emphysema and pulmonary hypertension, and are being evaluated for clinical trials.
Publications
| Title/Journal | Authors | Publication Date |
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Tumor agnostic drug delivery with dynamic nanohydrogels. Nature communications |
SN Housley, AR Bourque, LV Matyunina, IA Panicker, ES Echeverri, M Izykowicz, OA Herrmann, S Lee, JC Arboleda, V Jamali, JF McDonald, JE Dahlman, MG Finn | 01/07/2026 |
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ACS nano |
E Michalaki, K Jeong, R Chin, Z Qi, L Liebman, Y González-Vargas, ES Echeverri, K Paunovska, H Muramatsu, N Pardi, BJ Tamburini, Z Jakus, JE Dahlman, JB Dixon | 11/21/2025 |
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Glycolipid nanoparticles target the spleen and detarget the liver without charge. Proceedings of the National Academy of Sciences of the United States of America |
K Gentry, L Lian, H Kim, O Celik, C Jones, AR Podilapu, A Shakked, D Loughrey, R Zenhausern, B Jang, J Doan, S Rudden, JE Dahlman | 11/11/2025 |
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Microfluidic Device Type Improves Heart mRNA Delivery In Vivo. Langmuir : the ACS journal of surfaces and colloids |
E Schrader Echeverri, H Kim, B Jang, A Shakked, C Park, KI Baek, L Choi, DW Kang, RC Hung, K Jeong, HE Peck, AR Podilapu, KE Tiegreen, PJ Santangelo, H Jo, JE Dahlman | 10/02/2025 |
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V |
SH Sakers, G Fiduccia, KE Byrne, BPK Reddy, JE Dahlman, MR Prausnitz | 10/01/2025 |
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Gastrointestinal delivery of mRNA lipid nanoparticles selectively targets the pancreas. bioRxiv : the preprint server for biology |
AM Abbas, R Ghanim, S Rudden, D Schultz, A Shakked, H Kim, JE Dahlman, A Abramson | 09/18/2025 |
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Development of a microneedle patch for delivery of mRNA-lipid nanoparticles. Drug delivery and translational research |
SH Sakers, BPK Reddy, G Fiduccia, KE Byrne, I Stén, J Kim, A Radmand, JE Dahlman, MR Prausnitz | 09/02/2025 |
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Lipid nanoparticle screening in nonhuman primates with minimal loss of life. Nature biotechnology |
R Zenhausern, B Jang, E Schrader Echeverri, K Gentry, R Calkins, EH Curran, JS Wood, RL Stammen, D Loughrey, P Chappa, D Koveal, H Kim, JE Dahlman | 06/26/2025 |
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In utero lipid nanoparticle delivery achieves robust editing in hematopoietic stem cells. bioRxiv : the preprint server for biology |
AK Worthington, B Borges, T Lum, ES Echeverri, FM Zada, MA Cordero, H Kim, R Zenhausern, O Celik, C Shaw, P Gutierrez-Martinez, M Omarova, C Blanchard, S Burns, MK Cromer, JE Dahlman, TC MacKenzie | 05/12/2025 |
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Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses. Nature communications |
SG Huayamares, L Lian, R Rab, Y Hou, A Radmand, H Kim, R Zenhausern, BR Achyut, M Gilbert Ross, MP Lokugamage, D Loughrey, HE Peck, ES Echeverri, AJ Da Silva Sanchez, A Shajii, A Li, KE Tiegreen, PJ Santangelo, EJ Sorscher, JE Dahlman | 04/12/2025 |
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The time course of in vivo cellular responses to LNPs. Chemical communications (Cambridge, England) |
D Loughrey, K Paunovska, ES Echeverri, KE Tiegreen, JE Dahlman | 03/13/2025 |
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Blood advances |
NA Linthorst, YK Jongejan, RJ Dirven, SNJ Laan, R Bierings, C Casari, RA Cordfunke, JE Dahlman, N Dolezal, JW Drijfhout, FWG Leebeek, LR Ruhaak, E Schrader Echeverri, J Voorberg, BJM van Vlijmen, CV Denis, JCJ Eikenboom | 01/28/2025 |
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Research and practice in thrombosis and haemostasis |
YK Jongejan, RJ Dirven, E Schrader Echeverri, AJL de Jong, ACM Pronk, S Kooijman, PCN Rensen, JE Dahlman, JCJ Eikenboom, BJM van Vlijmen | 01/01/2025 |
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Lipid nanoparticle-mediated mRNA delivery to CD34+ cells in rhesus monkeys. Nature biotechnology |
H Kim, R Zenhausern, K Gentry, L Lian, SG Huayamares, A Radmand, D Loughrey, AR Podilapu, MZC Hatit, H Ni, A Li, A Shajii, HE Peck, K Han, X Hua, S Jia, M Martinez, C Lee, PJ Santangelo, A Tarantal, JE Dahlman | 11/22/2024 |
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bioRxiv : the preprint server for biology |
E Michalaki, R Chin, K Jeong, Z Qi, LN Liebman, Y González-Vargas, ES Echeverri, K Paunovska, H Muramatsu, N Pardi, BJ Tamburini, Z Jakus, JE Dahlman, JB Dixon | 07/31/2024 |
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Advanced healthcare materials |
AJDS Sanchez, D Loughrey, ES Echeverri, SG Huayamares, A Radmand, K Paunovska, M Hatit, KE Tiegreen, PJ Santangelo, JE Dahlman | 07/01/2024 |
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Nucleic acid-based drugs for patients with solid tumours. Nature reviews. Clinical oncology |
SG Huayamares, D Loughrey, H Kim, JE Dahlman, EJ Sorscher | 06/01/2024 |
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Thrombosis research |
YK Jongejan, NA Linthorst, E Schrader Echeverri, SNJ Laan, RJ Dirven, JE Dahlman, BJM van Vlijmen, CV Denis, JCJ Eikenboom | 04/01/2024 |
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Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart. Proceedings of the National Academy of Sciences of the United States of America |
A Radmand, H Kim, J Beyersdorf, CN Dobrowolski, R Zenhausern, K Paunovska, SG Huayamares, X Hua, K Han, D Loughrey, MZC Hatit, A Del Cid, H Ni, A Shajii, A Li, A Muralidharan, HE Peck, KE Tiegreen, S Jia, PJ Santangelo, JE Dahlman | 03/12/2024 |
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Proceedings of the National Academy of Sciences of the United States of America |
SN Bhatia, JE Dahlman | 03/12/2024 |
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Nature communications |
X Hua, K Han, B Mandracchia, A Radmand, W Liu, H Kim, Z Yuan, SM Ehrlich, K Li, C Zheng, J Son, AD Silva Trenkle, GA Kwong, C Zhu, JE Dahlman, S Jia | 03/04/2024 |
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Multivalent Targeting of the Asialoglycoprotein Receptor by Virus-Like Particles. Small (Weinheim an der Bergstrasse, Germany) |
R Hincapie, S Bhattacharya, MM Baksh, CA Sanhueza, ES Echeverri, H Kim, K Paunovska, AR Podilapu, M Xu, JE Dahlman, MG Finn | 12/01/2023 |
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Drug delivery systems for CRISPR-based genome editors. Nature reviews. Drug discovery |
V Madigan, F Zhang, JE Dahlman | 11/01/2023 |
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Blood advances |
YK Jongejan, E Schrader Echeverri, RJ Dirven, K Paunovska, NA Linthorst, A de Jong, JC Wellershoff, KD van der Gouw, BJM van Vlijmen, JE Dahlman, JCJ Eikenboom | 10/24/2023 |
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Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery. Nature chemistry |
MZC Hatit, CN Dobrowolski, MP Lokugamage, D Loughrey, H Ni, C Zurla, AJ Da Silva Sanchez, A Radmand, SG Huayamares, R Zenhausern, K Paunovska, HE Peck, J Kim, M Sato, JI Feldman, MA Rivera, A Cristian, Y Kim, PJ Santangelo, JE Dahlman | 04/01/2023 |
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The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo. Nano letters |
A Radmand, MP Lokugamage, H Kim, C Dobrowolski, R Zenhausern, D Loughrey, SG Huayamares, MZC Hatit, H Ni, A Del Cid, AJ Da Silva Sanchez, K Paunovska, E Schrader Echeverri, A Shajii, H Peck, PJ Santangelo, JE Dahlman | 02/08/2023 |
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Journal of extracellular vesicles |
G Li, T Chen, J Dahlman, L Eniola-Adefeso, IC Ghiran, P Kurre, WA Lam, JK Lang, E Marbán, P Martín, S Momma, M Moos, DJ Nelson, RL Raffai, X Ren, JPG Sluijter, SL Stott, G Vunjak-Novakovic, ND Walker, Z Wang, KW Witwer, PC Yang, MS Lundberg, MJ Ochocinska, R Wong, G Zhou, SY Chan, S Das, P Sundd | 02/01/2023 |
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Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery. Journal of controlled release : official journal of the Controlled Release Society |
AJ Da Silva Sanchez, K Zhao, SG Huayamares, MZC Hatit, MP Lokugamage, D Loughrey, C Dobrowolski, S Wang, H Kim, K Paunovska, Y Kuzminich, JE Dahlman | 01/01/2023 |
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Nano letters |
K Paunovska, AJ Da Silva Sanchez, MP Lokugamage, D Loughrey, ES Echeverri, A Cristian, MZC Hatit, PJ Santangelo, K Zhao, JE Dahlman | 12/28/2022 |
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What are the current bottlenecks in developing and applying CRISPR technologies? Cell systems |
EH Kellogg, J Gootenberg, O Abudayyeh, ASL Wong, JE Dahlman, A Lapinaite, C Myhrvold, CC Liu, PD Hsu, P Mali, LS Qi | 08/17/2022 |
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Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo. Nature communications |
H Ni, MZC Hatit, K Zhao, D Loughrey, MP Lokugamage, HE Peck, AD Cid, A Muralidharan, Y Kim, PJ Santangelo, JE Dahlman | 08/15/2022 |
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Nature nanotechnology |
C Dobrowolski, K Paunovska, E Schrader Echeverri, D Loughrey, AJ Da Silva Sanchez, H Ni, MZC Hatit, MP Lokugamage, Y Kuzminich, HE Peck, PJ Santangelo, JE Dahlman | 08/01/2022 |
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Universal Barcoding Predicts In Vivo ApoE-Independent Lipid Nanoparticle Delivery. Nano letters |
AJ Da Silva Sanchez, C Dobrowolski, A Cristian, ES Echeverri, K Zhao, MZC Hatit, D Loughrey, K Paunovska, JE Dahlman | 06/22/2022 |
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Drug delivery systems for RNA therapeutics. Nature reviews. Genetics |
K Paunovska, D Loughrey, JE Dahlman | 05/01/2022 |
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Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles. Nature nanotechnology |
MZC Hatit, MP Lokugamage, CN Dobrowolski, K Paunovska, H Ni, K Zhao, D Vanover, J Beyersdorf, HE Peck, D Loughrey, M Sato, A Cristian, PJ Santangelo, JE Dahlman | 03/01/2022 |
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Nature biomedical engineering |
CD Sago, MP Lokugamage, D Loughrey, KE Lindsay, R Hincapie, BR Krupczak, S Kalathoor, M Sato, ES Echeverri, JP Fitzgerald, Z Gan, L Gamboa, K Paunovska, CA Sanhueza, MZC Hatit, MG Finn, PJ Santangelo, JE Dahlman | 02/01/2022 |
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Accounts of chemical research |
D Loughrey, JE Dahlman | 01/04/2022 |
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Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs. Nature biomedical engineering |
MP Lokugamage, D Vanover, J Beyersdorf, MZC Hatit, L Rotolo, ES Echeverri, HE Peck, H Ni, JK Yoon, Y Kim, PJ Santangelo, JE Dahlman | 09/01/2021 |
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Therapeutic RNA Delivery for COVID and Other Diseases. Advanced healthcare materials |
C Dobrowolski, K Paunovska, MZC Hatit, MP Lokugamage, JE Dahlman | 08/01/2021 |
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Frataxin deficiency promotes endothelial senescence in pulmonary hypertension. The Journal of clinical investigation |
MK Culley, J Zhao, YY Tai, Y Tang, D Perk, V Negi, Q Yu, CC Woodcock, A Handen, G Speyer, S Kim, YC Lai, T Satoh, AM Watson, YA Aaraj, J Sembrat, M Rojas, D Goncharov, EA Goncharova, OF Khan, DG Anderson, JE Dahlman, AU Gurkar, R Lafyatis, AU Fayyaz, MM Redfield, MT Gladwin, M Rabinovitch, M Gu, T Bertero, SY Chan | 06/01/2021 |
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The NIH Somatic Cell Genome Editing program. Nature |
K Saha, EJ Sontheimer, PJ Brooks, MR Dwinell, CA Gersbach, DR Liu, SA Murray, SQ Tsai, RC Wilson, DG Anderson, A Asokan, JF Banfield, KS Bankiewicz, G Bao, JWM Bulte, N Bursac, JM Campbell, DF Carlson, EL Chaikof, ZY Chen, RH Cheng, KJ Clark, DT Curiel, JE Dahlman, BE Deverman, ME Dickinson, JA Doudna, SC Ekker, ME Emborg, G Feng, BS Freedman, DM Gamm, G Gao, IC Ghiran, PM Glazer, S Gong, JD Heaney, JD Hennebold, JT Hinson, A Khvorova, S Kiani, WR Lagor, KS Lam, KW Leong, JE Levine, JA Lewis, CM Lutz, DH Ly, S Maragh, PB McCray, TC McDevitt, O Mirochnitchenko, R Morizane, N Murthy, RS Prather, JA Ronald, S Roy, S Roy, V Sabbisetti, WM Saltzman, PJ Santangelo, DJ Segal, M Shimoyama, MC Skala, AF Tarantal, JC Tilton, GA Truskey, M Vandsburger, JK Watts, KD Wells, SA Wolfe, Q Xu, W Xue, G Yi, J Zhou | 04/01/2021 |
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Nature biotechnology |
N Annabi, M Baker, A Boettiger, D Chakraborty, Y Chen, KS Corbett, B Correia, J Dahlman, T de Oliveira, A Ertuerk, MF Yanik, E Henaff, M Huch, ID Iliev, T Jacobs, H Junca, A Keung, I Kolodkin-Gal, S Krishnaswamy, M Lancaster, E Macosko, MA Martínez-Núñez, K Miura, J Molloy, AO Cruz, RJ Platt, AD Posey, H Shao, M Simunovic, N Slavov, T Takebe, LH Vandenberghe, RK Varshney, J Wang | 03/01/2021 |
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Bioengineering & translational medicine |
Z Gan, MP Lokugamage, MZC Hatit, D Loughrey, K Paunovska, M Sato, A Cristian, JE Dahlman | 09/01/2020 |
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Treating Cystic Fibrosis with mRNA and CRISPR. Human gene therapy |
A Da Silva Sanchez, K Paunovska, A Cristian, JE Dahlman | 09/01/2020 |
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Increased PIP3 activity blocks nanoparticle mRNA delivery. Science advances |
K Paunovska, A Da Silva Sanchez, MT Foster, D Loughrey, EL Blanchard, FZ Islam, Z Gan, A Mantalaris, PJ Santangelo, JE Dahlman | 07/01/2020 |
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Mild Innate Immune Activation Overrides Efficient Nanoparticle-Mediated RNA Delivery. Advanced materials (Deerfield Beach, Fla.) |
MP Lokugamage, Z Gan, C Zurla, J Levin, FZ Islam, S Kalathoor, M Sato, CD Sago, PJ Santangelo, JE Dahlman | 01/01/2020 |
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Constrained Nanoparticles Deliver siRNA and sgRNA to T Cells In Vivo without Targeting Ligands. Advanced materials (Deerfield Beach, Fla.) |
MP Lokugamage, CD Sago, Z Gan, BR Krupczak, JE Dahlman | 10/01/2019 |
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Using Large Datasets to Understand Nanotechnology. Advanced materials (Deerfield Beach, Fla.) |
K Paunovska, D Loughrey, CD Sago, R Langer, JE Dahlman | 10/01/2019 |
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Cell Subtypes Within the Liver Microenvironment Differentially Interact with Lipid Nanoparticles. Cellular and molecular bioengineering |
CD Sago, BR Krupczak, MP Lokugamage, Z Gan, JE Dahlman | 10/01/2019 |
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Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing. Nucleic acid therapeutics |
JM Brown, JE Dahlman, KK Neuman, CAH Prata, MC Krampert, PM Hadwiger, HP Vornlocher | 10/01/2019 |
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Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nature metabolism |
PY Chen, L Qin, G Li, Z Wang, JE Dahlman, J Malagon-Lopez, S Gujja, NA Cilfone, KJ Kauffman, L Sun, H Sun, X Zhang, B Aryal, A Canfran-Duque, R Liu, P Kusters, A Sehgal, Y Jiao, DG Anderson, J Gulcher, C Fernandez-Hernando, E Lutgens, MA Schwartz, JS Pober, TW Chittenden, G Tellides, M Simons | 09/01/2019 |
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All the World's Data Could Fit in an Egg. Scientific American |
J Dahlman | 06/01/2019 |
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Circulation |
Q Yu, YY Tai, Y Tang, J Zhao, V Negi, MK Culley, J Pilli, W Sun, K Brugger, J Mayr, R Saggar, R Saggar, WD Wallace, DJ Ross, AB Waxman, SG Wendell, SJ Mullett, J Sembrat, M Rojas, OF Khan, JE Dahlman, M Sugahara, N Kagiyama, T Satoh, M Zhang, N Feng, J Gorcsan, SO Vargas, KJ Haley, R Kumar, BB Graham, R Langer, DG Anderson, B Wang, S Shiva, T Bertero, SY Chan | 05/07/2019 |
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Advanced materials (Deerfield Beach, Fla.) |
K Paunovska, AJ Da Silva Sanchez, CD Sago, Z Gan, MP Lokugamage, FZ Islam, S Kalathoor, BR Krupczak, JE Dahlman | 04/01/2019 |
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Nanoparticles That Deliver RNA to Bone Marrow Identified by in Vivo Directed Evolution. Journal of the American Chemical Society |
CD Sago, MP Lokugamage, FZ Islam, BR Krupczak, M Sato, JE Dahlman | 12/12/2018 |
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Modifying a Commonly Expressed Endocytic Receptor Retargets Nanoparticles in Vivo. Nano letters |
CD Sago, MP Lokugamage, GN Lando, N Djeddar, NN Shah, C Syed, AV Bryksin, JE Dahlman | 12/12/2018 |
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Barcoding chemical modifications into nucleic acids improves drug stability in vivo. Journal of materials chemistry. B |
CD Sago, S Kalathoor, JP Fitzgerald, GN Lando, N Djeddar, AV Bryksin, JE Dahlman | 11/28/2018 |
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Editing nature: Local roots of global governance. Science (New York, N.Y.) |
N Kofler, JP Collins, J Kuzma, E Marris, K Esvelt, MP Nelson, A Newhouse, LJ Rothschild, VS Vigliotti, M Semenov, R Jacobsen, JE Dahlman, S Prince, A Caccone, T Brown, OJ Schmitz | 11/02/2018 |
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Proceedings of the National Academy of Sciences of the United States of America |
CD Sago, MP Lokugamage, K Paunovska, DA Vanover, CM Monaco, NN Shah, M Gamboa Castro, SE Anderson, TG Rudoltz, GN Lando, P Munnilal Tiwari, JL Kirschman, N Willett, YC Jang, PJ Santangelo, AV Bryksin, JE Dahlman | 10/16/2018 |
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Testing thousands of nanoparticles in vivo using DNA barcodes. Current opinion in biomedical engineering |
MP Lokugamage, CD Sago, JE Dahlman | 09/01/2018 |
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ACS nano |
K Paunovska, CJ Gil, MP Lokugamage, CD Sago, M Sato, GN Lando, M Gamboa Castro, AV Bryksin, JE Dahlman | 08/28/2018 |
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Nano letters |
K Paunovska, CD Sago, CM Monaco, WH Hudson, MG Castro, TG Rudoltz, S Kalathoor, DA Vanover, PJ Santangelo, R Ahmed, AV Bryksin, JE Dahlman | 03/14/2018 |
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Journal of the American Heart Association |
M Budatha, J Zhang, ZW Zhuang, S Yun, JE Dahlman, DG Anderson, MA Schwartz | 01/30/2018 |
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Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics. Proceedings of the National Academy of Sciences of the United States of America |
JE Dahlman, KJ Kauffman, Y Xing, TE Shaw, FF Mir, CC Dlott, R Langer, DG Anderson, ET Wang | 02/21/2017 |
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Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling. Nature cell biology |
S Yun, M Budatha, JE Dahlman, BG Coon, RT Cameron, R Langer, DG Anderson, G Baillie, MA Schwartz | 10/01/2016 |
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Circulation research |
HB Sager, M Hulsmans, KJ Lavine, MB Moreira, T Heidt, G Courties, Y Sun, Y Iwamoto, B Tricot, OF Khan, JE Dahlman, A Borodovsky, K Fitzgerald, DG Anderson, R Weissleder, P Libby, FK Swirski, M Nahrendorf | 09/16/2016 |
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Science translational medicine |
HB Sager, P Dutta, JE Dahlman, M Hulsmans, G Courties, Y Sun, T Heidt, C Vinegoni, A Borodovsky, K Fitzgerald, GR Wojtkiewicz, Y Iwamoto, B Tricot, OF Khan, KJ Kauffman, Y Xing, TE Shaw, P Libby, R Langer, R Weissleder, FK Swirski, DG Anderson, M Nahrendorf | 06/08/2016 |
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Corrigendum: Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease. Nature biotechnology |
JE Dahlman, OO Abudayyeh, J Joung, JS Gootenberg, F Zhang, S Konermann | 04/01/2016 |