Xingming Deng, PhD

Research Program

Discovery and Developmental Therapeutics
Phone Number

404-778-3398
Email Address

xdeng4@emory.edu

Biography

Xingming Deng, MD, PhD, is a professor and the inaugural Chair in Cancer Biology in the Department of Radiation Oncology of Emory University School of Medicine. Dr. Deng is a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute of Emory University in Atlanta, Georgia. Prior to joining Emory in 2009, he was an assistant professor in the Division of Hematology/Oncology of the Department of Medicine at the University of Florida.

Dr. Deng is an active member of the American Association for Cancer Research. He has been the recipient of 18 research grants, including Clinical Innovator Awards from Flight Attendant Medical Research Institute, NASA research grant and several R01 grants from NIH/NCI. He has served on several national and international grant review panels.

Dr. Deng teaches the advanced course for cancer biology to graduate students and medical residents. He has mentored a number of undergraduates, graduates, postdoctoral fellows, medical residents and junior faculty members at the University of Florida and Emory University. He currently serves as a course director in Advanced Graduate Cancer Biology Program at Emory's Laney Graduate School.

Education

Dr. Deng received his MD/PhD at Hunan Medical University and Beijing Medical University in China. He completed his postdoctoral training in Molecular Biology at the University of Texas Medical Branch.

Titles & Roles

Professor and Chair in Cancer Biology, Department of Radiation Oncology

Emory University School of Medicine
Director of Discovery Theme, Discovery and Developmental Therapeutics Research Program

Winship Cancer Institute of Emory University

Research

Dr. Deng's major research interests are to uncover cell death mechanisms, especially Bcl2 family, to investigate molecular and signaling mechanisms of DNA repair, DNA replication stress, genomic instability and carcinogenesis, to study signaling mechanisms of tumor invasion/metastasis, to develop novel small molecule anti-cancer agents and new therapeutic strategies for cancer therapy by targeting apoptosis and DNA repair signaling pathways, and to target novel signal mechanisms of PD-1 and PD-L1 for immunotherapy. Additionally, he is also studying environmental carcinogenesis, specifically mechanisms of tobacco smoke- or space radiation-induced DNA damage, genomic instability and carcinogenesis at the cellular, molecular and animal levels.

Grants

View Grants

Grant Number	Title
1R01CA255257-01A1	Modulation of Mcl-1 for Treatment of Lung Cancer
5K12CA237806-05	Emory Clinical Oncology Career Development Award K12 Program
5R01CA255257-02	Modulation of Mcl-1 for Treatment of Lung Cancer
5R01CA255257-03	Modulation of Mcl-1 for Treatment of Lung Cancer
5R01CA255257-04	Modulation of Mcl-1 for Treatment of Lung Cancer

Publications

Deng has published many excellent research articles in high impact journals such as Molecular Cell, Cancer Cell, Nature Communications, The Journal of Clinical Investigation, PNAS, Cancer Research, Cell Death Differentiation, Nucleic Acid Research, MCB, Blood, and The Journal of Biological Chemistry among others. He serves on the editorial board for several journals and is frequently invited to serve as reviewer for numerous biomedical journals. He has also obtained three patents for new anticancer drug discovery.

Title/Journal	Authors	Publication Date
PD-L1 deglycosylation promotes its nuclear translocation and accelerates DNA double-strand-break repair in cancer. Nature communications	Z Shu, B Dwivedi, JM Switchenko, DS Yu, X Deng	08/09/2024
DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining. Nucleic acids research	PE Head, P Kapoor-Vazirani, GP Nagaraju, H Zhang, SK Rath, NC Luong, R Haji-Seyed-Javadi, F Sesay, SY Wang, DM Duong, W Daddacha, EV Minten, B Song, D Danelia, X Liu, S Li, EA Ortlund, NT Seyfried, DM Smalley, Y Wang, X Deng, WS Dynan, B El-Rayes, AJ Davis, DS Yu	08/25/2023
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks. Nature communications	P Kapoor-Vazirani, SK Rath, X Liu, Z Shu, NE Bowen, Y Chen, R Haji-Seyed-Javadi, W Daddacha, EV Minten, D Danelia, D Farchi, DM Duong, NT Seyfried, X Deng, EA Ortlund, B Kim, DS Yu	11/07/2022
Overcoming acquired resistance to third-generation EGFR inhibitors by targeting activation of intrinsic apoptotic pathway through Mcl-1 inhibition, Bax activation, or both. Oncogene	G Ma, Y Deng, L Qian, KA Vallega, G Zhang, X Deng, TK Owonikoko, SS Ramalingam, DD Fang, Y Zhai, SY Sun	03/01/2022
Epigenetic modulation of FBW7/Mcl-1 pathway for lung cancer therapy. Cancer biology & therapy	MJ Kim, G Chen, GL Sica, X Deng	01/02/2021
Discovery of Small Molecule Bak Activator for Lung Cancer Therapy. Theranostics	D Park, ASM Anisuzzaman, AT Magis, G Chen, M Xie, G Zhang, M Behera, GL Sica, SS Ramalingam, TK Owonikoko, X Deng	01/01/2021
Bcl2-induced DNA replication stress promotes lung carcinogenesis in response to space radiation. Carcinogenesis	M Xie, D Park, GL Sica, X Deng	11/13/2020
EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair. Oncogene	AE Koyen, MZ Madden, D Park, EV Minten, P Kapoor-Vazirani, E Werner, NT Pfister, R Haji-Seyed-Javadi, H Zhang, J Xu, N Deng, DM Duong, TJ Pecen, Z Frazier, ZD Nagel, JB Lazaro, KW Mouw, NT Seyfried, CS Moreno, TK Owonikoko, X Deng, DS Yu	06/01/2020
Correction to: Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy. Molecular cancer	K Xu, D Park, AT Magis, J Zhang, W Zhou, GL Sica, SS Ramalingam, WJ Curran, X Deng	05/20/2020
Withdrawal: Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing. The Journal of biological chemistry	H Wang, X Wang, G Chen, X Zhang, X Tang, D Park, FA Cucinotta, DS Yu, X Deng, WS Dynan, PW Doetsch, Y Wang	05/01/2020
TGF-β causes Docetaxel resistance in Prostate Cancer via the induction of Bcl-2 by acetylated KLF5 and Protein Stabilization. Theranostics	Y Li, B Zhang, L Xiang, S Xia, O Kucuk, X Deng, LH Boise, JT Dong	01/01/2020
Mcl-1 Interacts with Akt to Promote Lung Cancer Progression. Cancer research	D Park, AT Magis, M Behera, SS Ramalingam, TK Owonikoko, GL Sica, K Ye, C Zhang, Z Chen, WJ Curran, X Deng	12/15/2019
Acetylation regulates ribonucleotide reductase activity and cancer cell growth. Nature communications	G Chen, Y Luo, K Warncke, Y Sun, DS Yu, H Fu, M Behera, SS Ramalingam, PW Doetsch, DM Duong, M Lammers, WJ Curran, X Deng	07/19/2019
Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy. Molecular cancer	K Xu, D Park, AT Magis, J Zhang, W Zhou, GL Sica, SS Ramalingam, WJ Curran, X Deng	04/10/2019
Cell Synchronization by Double Thymidine Block. Bio-protocol	G Chen, X Deng	09/05/2018
Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin. Clinical cancer research : an official journal of the American Association for Cancer Research	X Wang, JJ Beitler, W Huang, G Chen, G Qian, K Magliocca, MR Patel, AY Chen, J Zhang, S Nannapaneni, S Kim, Z Chen, X Deng, NF Saba, ZG Chen, JL Arbiser, DM Shin	02/15/2018
Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy. The Journal of clinical investigation	G Chen, AT Magis, K Xu, D Park, DS Yu, TK Owonikoko, GL Sica, SW Satola, SS Ramalingam, WJ Curran, PW Doetsch, X Deng	01/02/2018
The Influential Role of BCL2 Family Members in Synovial Sarcomagenesis. Molecular cancer research : MCR	JJ Barrott, JF Zhu, K Smith-Fry, AM Susko, D Nollner, LD Burrell, A Pozner, MR Capecchi, JT Yap, LA Cannon-Albright, X Deng, KB Jones	12/01/2017
Targeting miR-21 with Sophocarpine Inhibits Tumor Progression and Reverses Epithelial-Mesenchymal Transition in Head and Neck Cancer. Molecular therapy : the journal of the American Society of Gene Therapy	W Liu, B Zhang, G Chen, W Wu, L Zhou, Y Shi, Q Zeng, Y Li, Y Sun, X Deng, F Wang	09/06/2017
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination. Cell reports	W Daddacha, AE Koyen, AJ Bastien, PE Head, VR Dhere, GN Nabeta, EC Connolly, E Werner, MZ Madden, MB Daly, EV Minten, DR Whelan, AJ Schlafstein, H Zhang, R Anand, C Doronio, AE Withers, C Shepard, RK Sundaram, X Deng, WS Dynan, Y Wang, RS Bindra, P Cejka, E Rothenberg, PW Doetsch, B Kim, DS Yu	08/22/2017
Modulation of Bax and mTOR for Cancer Therapeutics. Cancer research	R Li, C Ding, J Zhang, M Xie, D Park, Y Ding, G Chen, G Zhang, M Gilbert-Ross, W Zhou, AI Marcus, SY Sun, ZG Chen, GL Sica, SS Ramalingam, AT Magis, H Fu, FR Khuri, WJ Curran, TK Owonikoko, DM Shin, J Zhou, X Deng	06/01/2017
Inhibition of TRPC6 reduces non-small cell lung cancer cell proliferation and invasion. Oncotarget	LL Yang, BC Liu, XY Lu, Y Yan, YJ Zhai, Q Bao, PW Doetsch, X Deng, TL Thai, AA Alli, DC Eaton, BZ Shen, HP Ma	01/17/2017
Establishment of Patient-derived Xenografts in Mice. Bio-protocol	D Park, D Wang, G Chen, X Deng	11/20/2016
Targeting DNA Replication Stress for Cancer Therapy. Genes	J Zhang, Q Dai, D Park, X Deng	08/19/2016
BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth. Oncotarget	J Deng, D Park, M Wang, A Nooka, Q Deng, S Matulis, J Kaufman, S Lonial, LH Boise, J Galipeau, X Deng	05/10/2016
Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer. Journal of translational medicine	TK Owonikoko, G Zhang, HS Kim, RM Stinson, R Bechara, C Zhang, Z Chen, NF Saba, S Pakkala, R Pillai, X Deng, SY Sun, MR Rossi, GL Sica, SS Ramalingam, FR Khuri	05/03/2016
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA. Cell reports	H Zhang, PE Head, W Daddacha, SH Park, X Li, Y Pan, MZ Madden, DM Duong, M Xie, B Yu, MD Warren, EA Liu, VR Dhere, C Li, I Pradilla, MA Torres, Y Wang, WS Dynan, PW Doetsch, X Deng, NT Seyfried, D Gius, DS Yu	02/16/2016
Targeting KRAS-mutant non-small cell lung cancer: challenges and opportunities. Acta biochimica et biophysica Sinica	J Zhang, D Park, DM Shin, X Deng	01/01/2016
Bcl2 inhibition of mitochondrial DNA repair. BMC cancer	M Xie, PW Doetsch, X Deng	08/13/2015
mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation. Molecular and cellular biology	J Koo, P Yue, X Deng, FR Khuri, SY Sun	07/01/2015
Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy. Cancer cell	B Han, D Park, R Li, M Xie, TK Owonikoko, G Zhang, GL Sica, C Ding, J Zhou, AT Magis, ZG Chen, DM Shin, SS Ramalingam, FR Khuri, WJ Curran, X Deng	06/08/2015
A Translational, Pharmacodynamic, and Pharmacokinetic Phase IB Clinical Study of Everolimus in Resectable Non-Small Cell Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research	TK Owonikoko, SS Ramalingam, DL Miller, SD Force, GL Sica, J Mendel, Z Chen, A Rogatko, M Tighiouart, RD Harvey, S Kim, NF Saba, A Pickens, M Behera, RW Fu, MR Rossi, WF Auffermann, WE Torres, R Bechara, X Deng, SY Sun, H Fu, AA Gal, FR Khuri	04/15/2015
Bcl2 inhibits recruitment of Mre11 complex to DNA double-strand breaks in response to high-linear energy transfer radiation. Nucleic acids research	M Xie, D Park, S You, R Li, TK Owonikoko, Y Wang, PW Doetsch, X Deng	01/01/2015
Targeting Bcl2 in cancer. Oncoscience	G Chen, X Deng	01/01/2015
Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer. Cancer medicine	TK Owonikoko, G Zhang, X Deng, MR Rossi, JM Switchenko, GH Doho, Z Chen, S Kim, S Strychor, SM Christner, J Beumer, C Li, P Yue, A Chen, GL Sica, SS Ramalingam, J Kowalski, FR Khuri, SY Sun	12/01/2014
Exercise-induced lung cancer regression: mechanistic findings from a mouse model. Cancer	KA Higgins, D Park, GY Lee, WJ Curran, X Deng	11/01/2014
Small-molecule Bax agonists for cancer therapy. Nature communications	M Xin, R Li, M Xie, D Park, TK Owonikoko, GL Sica, PE Corsino, J Zhou, C Ding, MA White, AT Magis, SS Ramalingam, WJ Curran, FR Khuri, X Deng	09/17/2014
Targeting Epstein-Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy. Oncogene	L Xiao, ZY Hu, X Dong, Z Tan, W Li, M Tang, L Chen, L Yang, Y Tao, Y Jiang, J Li, B Yi, B Li, S Fan, S You, X Deng, F Hu, L Feng, AM Bode, Z Dong, LQ Sun, Y Cao	09/11/2014
Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis. Cell death and differentiation	B Wang, M Xie, R Li, TK Owonikoko, SS Ramalingam, FR Khuri, WJ Curran, Y Wang, X Deng	07/01/2014
Disruption of STAT3 by niclosamide reverses radioresistance of human lung cancer. Molecular cancer therapeutics	S You, R Li, D Park, M Xie, GL Sica, Y Cao, ZQ Xiao, X Deng	03/01/2014
Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase. Cancer research	M Xie, Y Yen, TK Owonikoko, SS Ramalingam, FR Khuri, WJ Curran, PW Doetsch, X Deng	01/01/2014
Altered glutamine metabolism and therapeutic opportunities for lung cancer. Clinical lung cancer	A Mohamed, X Deng, FR Khuri, TK Owonikoko	01/01/2014
Bcl2 Family Functions as Signaling Target in Nicotine-/NNK-Induced Survival of Human Lung Cancer Cells. Scientifica	X Deng	01/01/2014
The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis. Molecular cancer	H Ren, J Koo, B Guan, P Yue, X Deng, M Chen, FR Khuri, SY Sun	11/22/2013
EBV-LMP1-targeted DNAzyme induces DNA damage and causes cell cycle arrest in LMP1-positive nasopharyngeal carcinoma cells. International journal of oncology	X Ma, Z Xu, L Yang, L Xiao, M Tang, J Lu, S Xu, Y Tang, X Wen, X Deng, L Sun, Y Cao	11/01/2013
Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer. Molecular cancer therapeutics	R Li, Z Hu, SY Sun, ZG Chen, TK Owonikoko, GL Sica, SS Ramalingam, WJ Curran, FR Khuri, X Deng	10/01/2013
The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis. Cancer letters	H Ren, L Zhao, Y Li, P Yue, X Deng, TK Owonikoko, M Chen, FR Khuri, SY Sun	09/28/2013
Novel small-molecule inhibitors of Bcl-XL to treat lung cancer. Cancer research	D Park, AT Magis, R Li, TK Owonikoko, GL Sica, SY Sun, SS Ramalingam, FR Khuri, WJ Curran, X Deng	09/01/2013
Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis. Cell division	KR Hagen, X Zeng, MY Lee, S Tucker Kahn, MK Harrison Pitner, SS Zaky, Y Liu, RM O'Regan, X Deng, HI Saavedra	07/25/2013
RRM2 regulates Bcl-2 in head and neck and lung cancers: a potential target for cancer therapy. Clinical cancer research : an official journal of the American Association for Cancer Research	MA Rahman, AR Amin, D Wang, L Koenig, S Nannapaneni, Z Chen, Z Wang, G Sica, X Deng, ZG Chen, DM Shin	07/01/2013
Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation. The Journal of biological chemistry	Y Li, X Wang, P Yue, H Tao, SS Ramalingam, TK Owonikoko, X Deng, Y Wang, H Fu, FR Khuri, SY Sun	05/10/2013
Inhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer. PloS one	R Li, S You, Z Hu, ZG Chen, GL Sica, FR Khuri, WJ Curran, DM Shin, X Deng	01/01/2013
The function and significance of SELENBP1 downregulation in human bronchial epithelial carcinogenic process. PloS one	GQ Zeng, H Yi, PF Zhang, XH Li, R Hu, MY Li, C Li, JQ Qu, X Deng, ZQ Xiao	01/01/2013
c-Myc suppression of DNA double-strand break repair. Neoplasia (New York, N.Y.)	Z Li, TK Owonikoko, SY Sun, SS Ramalingam, PW Doetsch, ZQ Xiao, FR Khuri, WJ Curran, X Deng	12/01/2012
Identification of candidate biomarkers for early detection of human lung squamous cell cancer by quantitative proteomics. Molecular & cellular proteomics : MCP	GQ Zeng, PF Zhang, X Deng, FL Yu, C Li, Y Xu, H Yi, MY Li, R Hu, JH Zuo, XH Li, XX Wan, JQ Qu, QY He, JH Li, X Ye, Y Chen, JY Li, ZQ Xiao	06/01/2012
NNK promotes migration and invasion of lung cancer cells through activation of c-Src/PKCι/FAK loop. Cancer letters	J Shen, L Xu, TK Owonikoko, SY Sun, FR Khuri, WJ Curran, X Deng	05/01/2012
Reversion of multidrug resistance by co-encapsulation of doxorubicin and curcumin in chitosan/poly(butyl cyanoacrylate) nanoparticles. International journal of pharmaceutics	J Duan, HM Mansour, Y Zhang, X Deng, Y Chen, J Wang, Y Pan, J Zhao	04/15/2012
Rapamycin induces Bad phosphorylation in association with its resistance to human lung cancer cells. Molecular cancer therapeutics	Y Liu, SY Sun, TK Owonikoko, GL Sica, WJ Curran, FR Khuri, X Deng	01/01/2012
Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells. Molecular cancer	M Liao, J Zhao, T Wang, J Duan, Y Zhang, X Deng	04/20/2011
Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles. International journal of pharmaceutics	J Duan, Y Zhang, S Han, Y Chen, B Li, M Liao, W Chen, X Deng, J Zhao, B Huang	11/15/2010
Mono- or double-site phosphorylation distinctly regulates the proapoptotic function of Bax. PloS one	Q Wang, SY Sun, F Khuri, WJ Curran, X Deng	10/14/2010
Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E. Neoplasia (New York, N.Y.)	Y Li, P Yue, X Deng, T Ueda, R Fukunaga, FR Khuri, SY Sun	10/01/2010
Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation. The Journal of biological chemistry	C Li, S Chen, P Yue, X Deng, S Lonial, FR Khuri, SY Sun	05/21/2010
Nicotine enhances the antiapoptotic function of Mcl-1 through phosphorylation. Molecular cancer research : MCR	J Zhao, M Xin, T Wang, Y Zhang, X Deng	12/01/2009

Awards

Dr. Deng has received a number of awards in his career including AACR-Bristol-Myers Squibb Young Investigator Award, three ASH Travel Awards, Basic Science Research Winner, Excellence in Research Award, Emory University Winship Scholar and the Emory 1% Award with NIH R01 grant scoring in the top 1% at peer review.