Haian Fu, PhD

Research Program

Discovery and Developmental Therapeutics
Phone Number

404-727-0368
Email Address

hfu@emory.edu

Biography

Haian Fu, PhD, is Professor and Chair of the Department of Pharmacology and Chemical Biology at Emory University School of Medicine. Dr. Fu also serves as the director of the Emory Chemical Biology Discovery Center and co-leader of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute of Emory University in Atlanta, Georgia.

Dr. Fu earned his PhD in biochemistry at the University of Wisconsin-Madison in Madison, Wisconsin. He completed a fellowship in microbiology and molecular genetics at Harvard Medical School.

Titles & Roles

Professor and Chair, Department of Pharmacology and Chemical Biology

Emory University School of Medicine
Professor, Department of Hematology and Medical Oncology

Emory University School of Medicine
Co-Leader, Discovery and Developmental Therapeutics Program

Winship Cancer Institute of Emory University
Director, Emory Chemical Biology Discovery Center

Winship Cancer Institute of Emory University
Associate Dean for Therapeutic Discovery and Development

Emory University School of Medicine
Winship Partner in Research Endowed Chair

Winship Cancer Institute of Emory University

Professional Memberships

Dr. Fu serves on two national steering committees in the US, the National Cancer Institute's Chemical Biology Consortium Steering Committee (since 2009) and the NCI Cancer Target Discovery and Development Network Steering Committee (since 2012). Dr. Fu served as the President of the International Chemical Biology Society (2012-2013).

Research

Dr. Fu's research focuses on protein-protein interactions in signal transduction, targeting these interactions for drug discovery and collaborating with physician scientists to translate such bench research to clinical applications.

Grants

View Grants

Grant Number	Title
1P01CA257906-01A1	Deciphering LKB1-associated immunotherapy resistance in lung adenocarcinoma (LUAD)
5P01CA257906-02	Deciphering LKB1-associated immunotherapy resistance in lung adenocarcinoma (LUAD)
5P01CA257906-03	Deciphering LKB1-associated immunotherapy resistance in lung adenocarcinoma (LUAD)

Publications

Beside publishing original research in prestigious journals, Dr. Fu edited the widely-circulated books on Protein-Protein Interactions (2004) and Chemical Genomics (2012) and serves as associate editor for Molecular Pharmacology. He served on various national and international review panels, including NIH study sections, the NIH site visit team for NCI laboratories.

Title/Journal	Authors	Publication Date
Uncovering the rewired IAP-JAK regulatory axis as an immune-dependent vulnerability of LKB1-mutant lung cancer. Nature communications	C Shu, J Li, J Rui, D Fan, Q Niu, R Bai, D Cicka, S Doyle, A Wahafu, X Zheng, Y Du, AA Ivanov, DB Doxie, KM Dhodapkar, J Carlisle, T Owonikoko, G Sica, Y Liu, S Ramalingam, MV Dhodapkar, W Zhou, X Mo, H Fu	03/08/2025
Decoding the functional impact of the cancer genome through protein-protein interactions. Nature reviews. Cancer	H Fu, X Mo, AA Ivanov	03/01/2025
Protocol to discover actionable cancer vulnerabilities enabled by neomorph protein-protein interactions with the AVERON Notebook. STAR protocols	H Chen, B Revennaugh, H Fu, AA Ivanov	12/20/2024
Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association	B Siciliano, Q Li, R Ayoubi, C Laflamme, E Zoeller, Y Du, H Fu, Z Wen, AI Levey, R Betarbet	12/01/2024
Drug Development. Alzheimer's & dementia : the journal of the Alzheimer's Association	K Leal, AD Axtman, R Betarbet, PE Brennan, GW Carter, H Fu, AK Greenwood, FM Longo, AM Edwards, AI Levey, ET Center	12/01/2024
Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in LKB1-Mutant Lung Cancer. Cancer research	J Koo, CS Seong, RE Parker, A Herrera, B Dwivedi, RA Arthur, AR Dinasarapu, HR Johnston, H Claussen, C Tucker-Burden, SS Ramalingam, H Fu, W Zhou, AI Marcus, M Gilbert-Ross	11/15/2024
Development of a time-resolved fluorescence resonance energy transfer ultra-high throughput screening assay targeting SYK and FCER1G interaction. SLAS discovery : advancing life sciences R & D	Y Du, D Wang, VL Katis, EL Zoeller, M Qui, AI Levey, O Gileadi, H Fu	09/01/2024
AVERON notebook to discover actionable cancer vulnerabilities enabled by neomorph protein-protein interactions. iScience	H Chen, B Revennaugh, H Fu, AA Ivanov	06/21/2024
Development of a Time-Resolved Fluorescence Resonance Energy Transfer ultra-high throughput screening assay for targeting SYK and FCER1G interaction. bioRxiv : the preprint server for biology	Y Du, D Wang, VL Katis, EL Zoeller, M Qui, AI Levey, O Gileadi, H Fu	06/13/2024
Bisbiguanide analogs induce mitochondrial stress to inhibit lung cancer cell invasion. iScience	CM Knippler, JL Arnst, IE Robinson, V Matsuk, TO Khatib, RD Harvey, M Shanmugam, JK Mouw, H Fu, T Ganesh, AI Marcus	04/19/2024
A multiplexed time-resolved fluorescence resonance energy transfer ultrahigh-throughput screening assay for targeting the SMAD4-SMAD3-DNA complex. Journal of molecular cell biology	W Ouyang, Q Li, Q Niu, M Qui, H Fu, Y Du, X Mo	04/10/2024
Frequency-potency analysis of IgG+ memory B cells delineates neutralizing antibody responses at single-cell resolution. Cell reports	MK Tenggara, SH Oh, C Yang, HK Nariya, AM Metz, AA Upadhyay, DR Gudipati, L Guo, EG McGhee, K Gill, EG Viox, RD Mason, NA Doria-Rose, KE Foulds, JR Mascola, Y Du, H Fu, JD Altman, Q Yan, Z Sheng, SE Bosinger, R Kong	03/26/2024
Pharmacological suppression of the OTUD4/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers. The Journal of clinical investigation	Y Zhu, A Banerjee, P Xie, AA Ivanov, A Uddin, Q Jiao, JJ Chi, L Zeng, JY Lee, Y Xue, X Lu, M Cristofanilli, WJ Gradishar, CJ Henry, TW Gillespie, MA Bhave, K Kalinsky, H Fu, I Bahar, B Zhang, Y Wan	03/26/2024
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. PloS one	FM Bashore, VL Katis, Y Du, A Sikdar, D Wang, WJ Bradshaw, KA Rygiel, TM Leisner, R Chalk, S Mishra, CA Williams, O Gileadi, PE Brennan, JC Wiley, J Gockley, GA Cary, GW Carter, JE Young, KH Pearce, H Fu, AD Axtman	01/01/2024
Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. The Journal of biological chemistry	Y Du, WJ Bradshaw, TM Leisner, JK Annor-Gyamfi, K Qian, FM Bashore, A Sikdar, FO Nwogbo, AA Ivanov, SV Frye, O Gileadi, PE Brennan, AI Levey, AD Axtman, KH Pearce, H Fu, VL Katis	12/01/2023
Fused Tetrahydroquinolines Are Interfering with Your Assay. Journal of medicinal chemistry	FM Bashore, J Annor-Gyamfi, Y Du, V Katis, F Nwogbo, RG Flax, SV Frye, KH Pearce, H Fu, TM Willson, DH Drewry, AD Axtman	11/09/2023
A Novel 7H-[1,2,4]Triazolo[3,4-b]thiadiazine-based Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Directed toward Treatment of Cystic Fibrosis. ACS medicinal chemistry letters	A Rab, X Yang, WF Tracy, JS Hong, D Joshi, C Manfredi, SS Ponnaluri, AA Kolykhalov, M Qui, H Fu, Y Du, HML Davies, EJ Sorscher	10/12/2023
Nicardipine is a putative EED inhibitor and has high selectivity and potency against chemoresistant prostate cancer in preclinical models. British journal of cancer	X Li, Y Chen, L Bai, R Zhao, Y Wu, ZR Xie, JM Wu, NJ Bowen, A Danaher, N Cook, D Li, M Qui, Y Du, H Fu, AO Osunkoya, O Kucuk, D Wu	09/01/2023
Development of constitutively synergistic nanoformulations to enhance chemosensitivity in T-cell leukemia. Journal of controlled release : official journal of the Controlled Release Society	JM Kelvin, ML Chimenti, DY Zhang, EK Williams, SG Moore, GM Humber, TA Baxter, LA Birnbaum, M Qui, H Zecca, A Thapa, J Jain, NT Jui, X Wang, H Fu, Y Du, ML Kemp, WA Lam, DK Graham, D DeRyckere, EC Dreaden	09/01/2023
Constitutively Synergistic Multiagent Drug Formulations Targeting MERTK, FLT3, and BCL-2 for Treatment of AML. Pharmaceutical research	JM Kelvin, J Jain, A Thapa, M Qui, LA Birnbaum, SG Moore, H Zecca, RJ Summers, JM Switchenko, E Costanza, B Uricoli, X Wang, NT Jui, H Fu, Y Du, D DeRyckere, DK Graham, EC Dreaden	09/01/2023
TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS. Journal of molecular cell biology	D Cicka, Q Niu, M Qui, K Qian, E Miller, D Fan, X Mo, AA Ivanov, SG Sarafianos, Y Du, H Fu	08/03/2023
Bromocriptine monotherapy overcomes prostate cancer chemoresistance in preclinical models. Translational oncology	L Bai, X Li, Y Yang, R Zhao, EZ White, A Danaher, NJ Bowen, CV Hinton, N Cook, D Li, AY Wu, M Qui, Y Du, H Fu, O Kucuk, D Wu	08/01/2023
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. bioRxiv : the preprint server for biology	FM Bashore, VL Katis, Y Du, A Sikdar, D Wang, WJ Bradshaw, KA Rygiel, TM Leisner, R Chalk, S Mishra, AC Williams, O Gileadi, PE Brennan, JC Wiley, J Gockley, GA Cary, GW Carter, JE Young, KH Pearce, H Fu, AD Axtman	07/29/2023
A multiplexed time-resolved fluorescence resonance energy transfer ultrahigh-throughput screening assay for targeting SMAD4-SMAD3-DNA complex. bioRxiv : the preprint server for biology	W Ouyang, Q Niu, M Qui, H Fu, Y Du, X Mo	07/15/2023
Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer. bioRxiv : the preprint server for biology	J Koo, CS Seong, RE Parker, B Dwivedi, RA Arthur, AR Dinasarapu, HR Johnston, H Claussen, C Tucker-Burden, SS Ramalingam, H Fu, W Zhou, AI Marcus, M Gilbert-Ross	06/14/2023
Cyclosporines Antagonize the Antiviral Activity of IFITMProteins by Redistributing Them toward the Golgi Apparatus. Biomolecules	D Prikryl, M Marin, TM Desai, Y Du, H Fu, GB Melikyan	06/03/2023
Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer's disease. bioRxiv : the preprint server for biology	Y Du, WJ Bradshaw, TM Leisner, JK Annor-Gyamfi, K Qian, FM Bashore, A Sikdar, FO Nwogbo, AA Ivanov, SV Frye, O Gileadi, PE Brennan, AI Levey, AD Axtman, KH Pearce, H Fu, VL Katis	05/22/2023
Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice. Nature communications	SA Druzak, M Tardelli, SG Mays, M El Bejjani, X Mo, KM Maner-Smith, T Bowen, ML Cato, MC Tillman, A Sugiyama, Y Xie, H Fu, DE Cohen, EA Ortlund	05/12/2023
Constitutively synergistic multiagent drug formulations targeting MERTK, FLT3, and BCL-2 for treatment of AML. bioRxiv : the preprint server for biology	JM Kelvin, J Jain, A Thapa, M Qui, LA Birnbaum, SG Moore, H Zecca, RJ Summers, E Costanza, B Uricoli, X Wang, NT Jui, H Fu, Y Du, D DeRyckere, DK Graham, EC Dreaden	03/15/2023
Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis. bioRxiv : the preprint server for biology	CS Seong, C Huang, AC Boese, Y Hou, J Koo, JK Mouw, M Rupji, G Joseph, HR Johnston, H Claussen, JM Switchenko, M Behera, M Churchman, JM Kolesar, SM Arnold, K Kerrigan, W Akerley, H Colman, MA Johns, C Arciero, W Zhou, AI Marcus, SS Ramalingam, H Fu, M Gilbert-Ross	01/27/2023
Open drug discovery in Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.)	AD Axtman, PE Brennan, T Frappier-Brinton, R Betarbet, GW Carter, H Fu, O Gileadi, AK Greenwood, K Leal, FM Longo, LM Mangravite, AM Edwards, AI Levey	01/01/2023
Validation and in vivo characterization of research antibodies for Moesin, CD44, Midkine, and sFRP-1. F1000Research	S Doolen, R Ayoubi, C Laflamme, R Betarbet, E Zoeller, SG Williams, H Fu, AI Levey, SJ Sukoff Rizzo	01/01/2023
EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer. Cell reports	J Kang, J Chun, JS Hwang, C Pan, J Li, AC Boese, I Young, CM Malin, Y Kang, DL Gibbons, G Sica, H Fu, SS Ramalingam, L Jin, S Kang	12/13/2022
High-throughput screening strategies for space-based radiation countermeasure discovery. Life sciences in space research	KS Putt, Y Du, H Fu, ZY Zhang	11/01/2022
Correction for Puckett et al., "Integration of Apoptosis Signal-Regulating Kinase 1-Mediated Stress Signaling with the Akt/Protein Kinase B-IκB Kinase Cascade". Molecular and cellular biology	MC Puckett, EH Goldman, LM Cockrell, B Huang, AL Kasinski, Y Du, CY Wang, A Lin, H Ichijo, F Khuri, H Fu	10/20/2022
Acquisition of taxane resistance by p53 inactivation in ovarian cancer cells. Acta pharmacologica Sinica	C Shu, X Zheng, A Wuhafu, D Cicka, S Doyle, Q Niu, D Fan, K Qian, AA Ivanov, Y Du, X Mo, H Fu	09/01/2022
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. Cell	X Mo, Q Niu, AA Ivanov, YH Tsang, C Tang, C Shu, Q Li, K Qian, A Wahafu, SP Doyle, D Cicka, X Yang, D Fan, MA Reyna, LAD Cooper, CS Moreno, W Zhou, TK Owonikoko, S Lonial, FR Khuri, Y Du, SS Ramalingam, GB Mills, H Fu	05/26/2022
A time-resolved fluorescence resonance energy transfer screening assay for discovery of protein-protein interaction modulators. STAR protocols	C Tang, Q Niu, D Cicka, Y Du, X Mo, H Fu	09/17/2021
Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer. Bioorganic & medicinal chemistry	X Yang, D Fan, AH Troha, HM Ahn, K Qian, B Liang, Y Du, H Fu, AA Ivanov	09/01/2021
A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation. Cancer discovery	YH Lo, KS Kolahi, Y Du, CY Chang, A Krokhotin, A Nair, WD Sobba, K Karlsson, SJ Jones, TA Longacre, AT Mah, B Tercan, A Sockell, H Xu, JA Seoane, J Chen, I Shmulevich, JS Weissman, C Curtis, A Califano, H Fu, GR Crabtree, CJ Kuo	06/01/2021
Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling. Cell chemical biology	C Tang, X Mo, Q Niu, A Wahafu, X Yang, M Qui, AA Ivanov, Y Du, H Fu	05/20/2021
Functional and molecular effects of TNF-α on human iPSC-derived cardiomyocytes. Stem cell research	A Saraf, A Rampoldi, M Chao, D Li, L Armand, H Hwang, R Liu, R Jha, H Fu, JT Maxwell, C Xu	04/01/2021
An expanded universe of cancer targets. Cell	WC Hahn, JS Bader, TP Braun, A Califano, PA Clemons, BJ Druker, AJ Ewald, H Fu, S Jagu, CJ Kemp, W Kim, CJ Kuo, M McManus, G B Mills, X Mo, N Sahni, SL Schreiber, JA Talamas, P Tamayo, JW Tyner, BK Wagner, WA Weiss, DS Gerhard	03/04/2021
YAP1 Expression in SCLC Defines a Distinct Subtype With T-cell-Inflamed Phenotype. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer	TK Owonikoko, B Dwivedi, Z Chen, C Zhang, B Barwick, V Ernani, G Zhang, M Gilbert-Ross, J Carlisle, FR Khuri, WJ Curran, AA Ivanov, H Fu, S Lonial, SS Ramalingam, SY Sun, EK Waller, GL Sica	03/01/2021
Expression and purification of active human kinases using Pichia pastoris as a general-purpose host. Protein expression and purification	MH Abdel Aziz, Y Fan, L Liu, MM Moasser, H Fu, N Jura, MR Arkin	03/01/2021
Pharmacological inhibition of noncanonical EED-EZH2 signaling overcomes chemoresistance in prostate cancer. Theranostics	X Li, L Gera, S Zhang, Y Chen, L Lou, LM Wilson, ZR Xie, G Sautto, D Liu, A Danaher, K Mamouni, Y Yang, Y Du, H Fu, O Kucuk, AO Osunkoya, J Zhou, D Wu	01/01/2021
Melphalan induces cardiotoxicity through oxidative stress in cardiomyocytes derived from human induced pluripotent stem cells. Stem cell research & therapy	R Liu, D Li, F Sun, A Rampoldi, JT Maxwell, R Wu, P Fischbach, SM Castellino, Y Du, H Fu, A Mandawat, C Xu	11/05/2020
Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma. Journal of hematology & oncology	K Lei, X Gu, AG Alvarado, Y Du, S Luo, EH Ahn, SS Kang, B Ji, X Liu, H Mao, H Fu, HI Kornblum, L Jin, H Li, K Ye	10/21/2020
High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients. Journal of translational medicine	X Yang, M Amgad, LAD Cooper, Y Du, H Fu, AA Ivanov	09/01/2020
Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening. Journal of molecular cell biology	Y Du, X Li, Q Niu, X Mo, M Qui, T Ma, CJ Kuo, H Fu	08/01/2020
NSD3S stabilizes MYC through hindering its interaction with FBXW7. Journal of molecular cell biology	V Gonzalez-Pecchi, AK Kwan, S Doyle, AA Ivanov, Y Du, H Fu	07/03/2020
14-3-3γ, a novel regulator of the large-conductance Ca²⁺-activated K⁺ channel. American journal of physiology. Renal physiology	S Chen, X Feng, X Chen, Z Zhuang, J Xiao, H Fu, JD Klein, XH Wang, RS Hoover, DC Eaton, H Cai	07/01/2020
Human beige adipocytes for drug discovery and cell therapy in metabolic diseases. Nature communications	AM Singh, L Zhang, J Avery, A Yin, Y Du, H Wang, Z Li, H Fu, H Yin, S Dalton	06/02/2020
Down-regulation of 14-3-3zeta reduces proliferation and increases apoptosis in human glioblastoma. Cancer gene therapy	X Yang, W Cao, X Wang, X Zhang, W Zhang, Z Li, H Fu	06/01/2020
Online informatics resources to facilitate cancer target and chemical probe discovery. RSC medicinal chemistry	X Yang, H Fu, AA Ivanov	06/01/2020
Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion. Nature communications	R Commander, C Wei, A Sharma, JK Mouw, LJ Burton, E Summerbell, D Mahboubi, RJ Peterson, J Konen, W Zhou, Y Du, H Fu, M Shanmugam, AI Marcus	03/24/2020
Acetylation regulates ribonucleotide reductase activity and cancer cell growth. Nature communications	G Chen, Y Luo, K Warncke, Y Sun, DS Yu, H Fu, M Behera, SS Ramalingam, PW Doetsch, DM Duong, M Lammers, WJ Curran, X Deng	07/19/2019
HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform to Reveal IAP Antagonists as Anti-cancer Immune Enhancers. Cell chemical biology	X Mo, C Tang, Q Niu, T Ma, Y Du, H Fu	03/21/2019
Identification of higenamine as a novel α₁ -adrenergic receptor antagonist. Phytotherapy research : PTR	N Zhang, K Qu, M Wang, Q Yin, W Wang, L Xue, H Fu, H Zhu, Z Li	03/01/2019
Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A. Journal of medicinal chemistry	JR Horton, CB Woodcock, Q Chen, X Liu, X Zhang, J Shanks, G Rai, BT Mott, DJ Jansen, SC Kales, MJ Henderson, M Cyr, K Pohida, X Hu, P Shah, X Xu, A Jadhav, DJ Maloney, MD Hall, A Simeonov, H Fu, PM Vertino, X Cheng	12/13/2018
Polyethylene-glycol-coated gold nanoparticles improve cardiac function after myocardial infarction in mice. Canadian journal of physiology and pharmacology	A Tian, C Yang, B Zhu, W Wang, K Liu, Y Jiang, Y Qiao, H Fu, Z Li	12/01/2018
Large tumor suppressor 2, LATS2, activates JNK in a kinase-independent mechanism through ASK1. Journal of molecular cell biology	L Rusnak, C Tang, Q Qi, X Mo, H Fu	12/01/2018
Repositioning Dopamine D2 Receptor Agonist Bromocriptine to Enhance Docetaxel Chemotherapy and Treat Bone Metastatic Prostate Cancer. Molecular cancer therapeutics	Y Yang, K Mamouni, X Li, Y Chen, S Kavuri, Y Du, H Fu, O Kucuk, D Wu	09/01/2018
Ophiopogonin B suppresses the metastasis and angiogenesis of A549 cells in vitro and in vivo by inhibiting the EphA2/Akt signaling pathway. Oncology reports	M Chen, C Hu, Y Guo, R Jiang, H Jiang, Y Zhou, H Fu, M Wu, X Zhang	09/01/2018
In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer. Nature communications	CL Grzeskowiak, ST Kundu, X Mo, AA Ivanov, O Zagorodna, H Lu, RH Chapple, YH Tsang, D Moreno, M Mosqueda, K Eterovic, JJ Fradette, S Ahmad, F Chen, Z Chong, K Chen, CJ Creighton, H Fu, GB Mills, DL Gibbons, KL Scott	07/16/2018
Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screening. Scientific reports	ASA Mady, C Liao, N Bajwa, KJ Kump, FA Abulwerdi, KL Lev, L Miao, SM Grigsby, A Perdih, JA Stuckey, Y Du, H Fu, Z Nikolovska-Coleska	07/05/2018
BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma. Cell death & disease	W Sime, Q Niu, Y Abassi, KC Masoumi, R Zarrizi, JB Køhler, S Kjellström, VA Lasorsa, M Capasso, H Fu, R Massoumi	05/01/2018
Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma. ACS chemical biology	DJE Huard, VM Crowley, Y Du, RA Cordova, Z Sun, MO Tomlin, CA Dickey, J Koren, L Blair, H Fu, BSJ Blagg, RL Lieberman	04/20/2018
Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A. Journal of medicinal chemistry	JR Horton, X Liu, L Wu, K Zhang, J Shanks, X Zhang, G Rai, BT Mott, DJ Jansen, SC Kales, MJ Henderson, K Pohida, Y Fang, X Hu, A Jadhav, DJ Maloney, MD Hall, A Simeonov, H Fu, PM Vertino, Q Yan, X Cheng	04/12/2018
The OncoPPi Portal: an integrative resource to explore and prioritize protein-protein interactions for cancer target discovery. Bioinformatics (Oxford, England)	AA Ivanov, B Revennaugh, L Rusnak, V Gonzalez-Pecchi, X Mo, MA Johns, Y Du, LAD Cooper, CS Moreno, FR Khuri, H Fu	04/01/2018
14-3-3ζ binds the proteasome, limits proteolytic function and enhances sensitivity to proteasome inhibitors. Leukemia	Y Gu, K Xu, C Torre, M Samur, BG Barwick, M Rupji, J Arora, P Neri, J Kaufman, A Nooka, L Bernal-Mizrachi, P Vertino, SY Sun, J Chen, N Munshi, H Fu, J Kowalski, LH Boise, S Lonial	03/01/2018
Dual gene activation and knockout screen reveals directional dependencies in genetic networks. Nature biotechnology	M Boettcher, R Tian, JA Blau, E Markegard, RT Wagner, D Wu, X Mo, A Biton, N Zaitlen, H Fu, F McCormick, M Kampmann, MT McManus	02/01/2018
Development of a Time-Resolved Fluorescence Resonance Energy Transfer Ultrahigh-Throughput Screening Assay for Targeting the NSD3 and MYC Interaction. Assay and drug development technologies	J Xiong, VG Pecchi, M Qui, AA Ivanov, X Mo, Q Niu, X Chen, H Fu, Y Du	01/01/2018
Regulation of ASK1 signaling by scaffold and adaptor proteins. Advances in biological regulation	L Rusnak, H Fu	12/01/2017
OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene	AA Ivanov, V Gonzalez-Pecchi, LF Khuri, Q Niu, Y Wang, Y Xu, Y Bai, X Mo, EV Prochownik, MA Johns, Y Du, FR Khuri, H Fu	10/19/2017
Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis. Journal of medicinal chemistry	Q Qi, O Obianyo, Y Du, H Fu, S Li, K Ye	09/14/2017
Co-amplification of phosphoinositide 3-kinase enhancer A and cyclin-dependent kinase 4 triggers glioblastoma progression. Oncogene	Q Qi, SS Kang, S Zhang, C Pham, H Fu, DJ Brat, K Ye	08/10/2017
Modulation of Bax and mTOR for Cancer Therapeutics. Cancer research	R Li, C Ding, J Zhang, M Xie, D Park, Y Ding, G Chen, G Zhang, M Gilbert-Ross, W Zhou, AI Marcus, SY Sun, ZG Chen, GL Sica, SS Ramalingam, AT Magis, H Fu, FR Khuri, WJ Curran, TK Owonikoko, DM Shin, J Zhou, X Deng	06/01/2017
Aurora kinase A interacts with H-Ras and potentiates Ras-MAPK signaling. Oncotarget	M Umstead, J Xiong, Q Qi, Y Du, H Fu	04/25/2017
Corrigendum: The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies. Nature communications	Z Li, AA Ivanov, R Su, V Gonzalez-Pecchi, Q Qi, S Liu, P Webber, E McMillan, L Rusnak, C Pham, X Chen, X Mo, B Revennaugh, W Zhou, A Marcus, S Harati, X Chen, MA Johns, MA White, CS Moreno, LAD Cooper, Y Du, FR Khuri, H Fu	04/18/2017
AKT1, LKB1, and YAP1 Revealed as MYC Interactors with NanoLuc-Based Protein-Fragment Complementation Assay. Molecular pharmacology	X Mo, Q Qi, AA Ivanov, Q Niu, Y Luo, J Havel, R Goetze, S Bell, CS Moreno, LA Cooper, MA Johns, FR Khuri, Y Du, H Fu	04/01/2017
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nature communications	Z Zhang, O Obianyo, E Dall, Y Du, H Fu, X Liu, SS Kang, M Song, SP Yu, C Cabrele, M Schubert, X Li, JZ Wang, H Brandstetter, K Ye	03/27/2017
Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma. JCI insight	M Gilbert-Ross, J Konen, J Koo, J Shupe, BS Robinson, WG Wiles, C Huang, WD Martin, M Behera, GH Smith, CE Hill, MR Rossi, GL Sica, M Rupji, Z Chen, J Kowalski, AL Kasinski, SS Ramalingam, H Fu, FR Khuri, W Zhou, AI Marcus	03/09/2017
The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies. Nature communications	Z Li, AA Ivanov, R Su, V Gonzalez-Pecchi, Q Qi, S Liu, P Webber, E McMillan, L Rusnak, C Pham, X Chen, X Mo, B Revennaugh, W Zhou, A Marcus, S Harati, X Chen, MA Johns, MA White, C Moreno, LA Cooper, Y Du, FR Khuri, H Fu	02/16/2017
Screening and Functional Profiling of Small-Molecule HIV-1 Entry and Fusion Inhibitors. Assay and drug development technologies	C Giroud, Y Du, M Marin, Q Min, NT Jui, H Fu, GB Melikyan	01/01/2017
Study on Inhibitory Effect of MaiMenDong Decoction and WeiJing Decoction Combination with Cisplatin on NCI-A549 Xenograft in Nude Mice and Its Mechanism. Journal of Cancer	F Xiong, M Jiang, M Chen, X Wang, S Zhang, J Zhou, K Li, Y Sheng, L Yin, Y Tang, L Ye, M Wu, H Fu, X Zhang	01/01/2017
MEDICI: Mining Essentiality Data to Identify Critical Interactions for Cancer Drug Target Discovery and Development. PloS one	S Harati, LA Cooper, JD Moran, FO Giuste, Y Du, AA Ivanov, MA Johns, FR Khuri, H Fu, CS Moreno	01/01/2017
Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer cell	L Gu, H Zhang, T Liu, S Zhou, Y Du, J Xiong, S Yi, CK Qu, H Fu, M Zhou	10/10/2016
Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell chemical biology	JR Horton, X Liu, M Gale, L Wu, JR Shanks, X Zhang, PJ Webber, JSK Bell, SC Kales, BT Mott, G Rai, DJ Jansen, MJ Henderson, DJ Urban, MD Hall, A Simeonov, DJ Maloney, MA Johns, H Fu, A Jadhav, PM Vertino, Q Yan, X Cheng	07/21/2016
Ophiopogonin B induces apoptosis, mitotic catastrophe and autophagy in A549 cells. International journal of oncology	M Chen, Y Guo, R Zhao, X Wang, M Jiang, H Fu, X Zhang	07/01/2016
Enabling systematic interrogation of protein-protein interactions in live cells with a versatile ultra-high-throughput biosensor platform. Journal of molecular cell biology	XL Mo, Y Luo, AA Ivanov, R Su, JJ Havel, Z Li, FR Khuri, Y Du, H Fu	06/01/2016
LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion. Molecular biology of the cell	J Konen, S Wilkinson, B Lee, H Fu, W Zhou, Y Jiang, AI Marcus	04/01/2016
Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. The Journal of biological chemistry	JR Horton, A Engstrom, EL Zoeller, X Liu, JR Shanks, X Zhang, MA Johns, PM Vertino, H Fu, X Cheng	02/05/2016
LKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions. Oncotarget	F Liu, R Jin, X Liu, H Huang, SC Wilkinson, D Zhong, FR Khuri, H Fu, A Marcus, Y He, W Zhou	01/19/2016
BRET: NanoLuc-Based Bioluminescence Resonance Energy Transfer Platform to Monitor Protein-Protein Interactions in Live Cells. Methods in molecular biology (Clifton, N.J.)	XL Mo, H Fu	01/01/2016
2-Deoxyglucose Suppresses ERK Phosphorylation in LKB1 and Ras Wild-Type Non-Small Cell Lung Cancer Cells. PloS one	L Sun, X Liu, H Fu, W Zhou, D Zhong	01/01/2016
Downregulation of urea transporter UT-A1 activity by 14-3-3 protein. American journal of physiology. Renal physiology	X Feng, Z Li, Y Du, H Fu, JD Klein, H Cai, JM Sands, G Chen	07/01/2015
Chromosome instability in diffuse large B cell lymphomas is suppressed by activation of the noncanonical NF-κB pathway. International journal of cancer	S Ramachandiran, A Adon, X Guo, Y Wang, H Wang, Z Chen, J Kowalski, UR Sunay, AN Young, T Brown, JC Mar, Y Du, H Fu, KP Mann, Y Natkunam, LH Boise, HI Saavedra, IS Lossos, L Bernal-Mizrachi	05/15/2015
Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3. Oncogene	Z Shi, Z Li, ZJ Li, K Cheng, Y Du, H Fu, FR Khuri	05/07/2015
A Translational, Pharmacodynamic, and Pharmacokinetic Phase IB Clinical Study of Everolimus in Resectable Non-Small Cell Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research	TK Owonikoko, SS Ramalingam, DL Miller, SD Force, GL Sica, J Mendel, Z Chen, A Rogatko, M Tighiouart, RD Harvey, S Kim, NF Saba, A Pickens, M Behera, RW Fu, MR Rossi, WF Auffermann, WE Torres, R Bechara, X Deng, SY Sun, H Fu, AA Gal, FR Khuri	04/15/2015
High-Throughput HIV-Cell Fusion Assay for Discovery of Virus Entry Inhibitors. Assay and drug development technologies	M Marin, Y Du, C Giroud, JH Kim, M Qui, H Fu, GB Melikyan	04/01/2015
Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway. Oncogene	JJ Havel, Z Li, D Cheng, J Peng, H Fu	03/19/2015
Glycyrrhetinic acid induces G1‑phase cell cycle arrest in human non‑small cell lung cancer cells through endoplasmic reticulum stress pathway. International journal of oncology	J Zhu, M Chen, N Chen, A Ma, C Zhu, R Zhao, M Jiang, J Zhou, L Ye, H Fu, X Zhang	03/01/2015
Stress induces p38 MAPK-mediated phosphorylation and inhibition of Drosha-dependent cell survival. Molecular cell	Q Yang, W Li, H She, J Dou, DM Duong, Y Du, SH Yang, NT Seyfried, H Fu, G Gao, Z Mao	02/19/2015
Cables1 complex couples survival signaling to the cell death machinery. Cancer research	Z Shi, HR Park, Y Du, Z Li, K Cheng, SY Sun, Z Li, H Fu, FR Khuri	01/01/2015
Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways. Journal of Cancer	R Zhao, M Chen, Z Jiang, F Zhao, B Xi, X Zhang, H Fu, K Zhou	01/01/2015
Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells. Oncoscience	PJ Webber, C Park, M Qui, SS Ramalingam, FR Khuri, H Fu, Y Du	01/01/2015
Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. Bioorganic & medicinal chemistry letters	ZH Shi, NG Li, YP Tang, QP Shi, W Zhang, PX Zhang, ZX Dong, W Li, X Zhang, HA Fu, JA Duan	09/15/2014
Synthesis and evaluation of bisbenzylidenedioxotetrahydrothiopranones as activators of endoplasmic reticulum (ER) stress signaling pathways and apoptotic cell death in acute promyelocytic leukemic cells. Journal of medicinal chemistry	KL Tan, A Ali, Y Du, H Fu, HX Jin, TM Chin, M Khan, ML Go	07/24/2014
Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs. Oncotarget	Z Li, HR Park, Z Shi, Z Li, CD Pham, Y Du, FR Khuri, Y Zhang, Q Han, H Fu	05/30/2014
The Emory Chemical Biology Discovery Center: leveraging academic innovation to advance novel targets through HTS and beyond. Combinatorial chemistry & high throughput screening	MA Johns, CL Meyerkord-Belton, Y Du, H Fu	03/01/2014
A novel herbal formula induces cell cycle arrest and apoptosis in association with suppressing the PI3K/AKT pathway in human lung cancer A549 cells. Integrative cancer therapies	F Xiong, M Jiang, Z Huang, M Chen, K Chen, J Zhou, L Yin, Y Tang, M Wang, L Ye, Z Zhan, J Duan, H Fu, X Zhang	03/01/2014
Ligands for glaucoma-associated myocilin discovered by a generic binding assay. ACS chemical biology	SD Orwig, PV Chi, Y Du, SE Hill, MA Cavitt, A Suntharalingam, KC Turnage, CA Dickey, S France, H Fu, RL Lieberman	02/21/2014
Synthetic curcumin analog UBS109 inhibits the growth of head and neck squamous cell carcinoma xenografts. Current cancer drug targets	S Zhu, TW Moore, N Morii, RB Howard, D Culver, RF Arrendale, P Reddy, TJ Evers, H Zhang, G Sica, ZG Chen, A Sun, H Fu, FR Khuri, DM Shin, JP Snyder, M Shoji	01/01/2014
Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: a novel curcumin analog. PloS one	T Zhou, L Ye, Y Bai, A Sun, B Cox, D Liu, Y Li, D Liotta, JP Snyder, H Fu, B Huang	01/01/2014
Transcriptional regulation of YWHAZ, the gene encoding 14-3-3ζ. PloS one	A Kasinski, X Dong, FR Khuri, J Boss, H Fu	01/01/2014
Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Organic & biomolecular chemistry	K Liu, D Zhang, J Chojnacki, Y Du, H Fu, S Grant, S Zhang	08/07/2013
A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitors. Assay and drug development technologies	Y Du, RW Fu, B Lou, J Zhao, M Qui, FR Khuri, H Fu	07/01/2013
p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms. Molecular and cellular biology	L Jin, D Li, JS Lee, S Elf, GN Alesi, J Fan, HB Kang, D Wang, H Fu, J Taunton, TJ Boggon, M Tucker, TL Gu, ZG Chen, DM Shin, FR Khuri, S Kang	07/01/2013
Targeting protein-protein interactions as an anticancer strategy. Trends in pharmacological sciences	AA Ivanov, FR Khuri, H Fu	07/01/2013
Integration of apoptosis signal-regulating kinase 1-mediated stress signaling with the Akt/protein kinase B-IκB kinase cascade. Molecular and cellular biology	MC Puckett, EH Goldman, LM Cockrell, B Huang, AL Kasinski, Y Du, CY Wang, A Lin, H Ichijo, F Khuri, H Fu	06/01/2013
Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation. The Journal of biological chemistry	Y Li, X Wang, P Yue, H Tao, SS Ramalingam, TK Owonikoko, X Deng, Y Wang, H Fu, FR Khuri, SY Sun	05/10/2013
Phase II study of docetaxel in combination with everolimus for second- or third-line therapy of advanced non-small-cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer	SS Ramalingam, TK Owonikoko, M Behera, J Subramanian, NF Saba, SA Kono, AA Gal, G Sica, RD Harvey, Z Chen, CM Klass, DM Shin, H Fu, SY Sun, R Govindan, FR Khuri	03/01/2013
Disrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion and colony formation. Oncogene	Q Qi, K He, X Liu, C Pham, C Meyerkord, H Fu, K Ye	02/21/2013
Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway. Oncology reports	M Chen, Y Du, M Qui, M Wang, K Chen, Z Huang, M Jiang, F Xiong, J Chen, J Zhou, F Jiang, L Yin, Y Tang, L Ye, Z Zhan, JΑ Duan, HΑ Fu, X Zhang	02/01/2013
Expression Profiling and Proteomic Analysis of JIN Chinese Herbal Formula in Lung Carcinoma H460 Xenografts. Evidence-based complementary and alternative medicine : eCAM	L Zheng, W Zhang, M Jiang, H Zhang, F Xiong, Y Yu, M Chen, J Zhou, X Dai, Y Tang, M Jiang, M Wang, G Cheng, J Duan, W Yu, B Lin, H Fu, X Zhang	01/01/2013
Biological activity evaluation and structure-activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer. Bioorganic & medicinal chemistry letters	W Li, N Li, Y Tang, B Li, L Liu, X Zhang, H Fu, JA Duan	10/01/2012
Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits. Chemistry & biology	SM Smith, J Min, T Ganesh, B Diebold, T Kawahara, Y Zhu, J McCoy, A Sun, JP Snyder, H Fu, Y Du, I Lewis, JD Lambeth	06/22/2012
Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis. Bioorganic & medicinal chemistry letters	YM Yan, HQ Dai, Y Du, B Schneider, H Guo, DP Li, LX Zhang, H Fu, XP Dong, YX Cheng	06/15/2012
Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts. Integrative biology : quantitative biosciences from nano to macro	S Zhu, TW Moore, X Lin, N Morii, A Mancini, RB Howard, D Culver, RF Arrendale, P Reddy, TJ Evers, H Zhang, G Sica, ZG Chen, A Sun, H Fu, FR Khuri, DM Shin, JP Snyder, M Shoji	06/01/2012
The Smac mimetic RMT5265.2HCL induces apoptosis in EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C and Smac. Leukemia research	S Ramachandiran, J Cain, A Liao, Y He, X Guo, LH Boise, H Fu, L Ratner, HJ Khoury, L Bernal-Mizrachi	06/01/2012
14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function. FEBS letters	Y Bai, T Zhou, H Fu, H Sun, B Huang	04/24/2012
14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. DNA repair	SD Andersen, G Keijzers, E Rampakakis, K Engels, P Luhn, M El-Shemerly, FC Nielsen, Y Du, A May, VA Bohr, S Ferrari, M Zannis-Hadjopoulos, H Fu, LJ Rasmussen	03/01/2012
Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinases. The Journal of biological chemistry	Q Qi, K He, MH Yoo, CB Chan, X Liu, Z Zhang, JJ Olson, G Xiao, L Wang, H Mao, H Fu, H Tao, SS Ramalingam, SY Sun, PS Mischel, K Ye	02/24/2012
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Molecular cell	T Hitosugi, J Fan, TW Chung, K Lythgoe, X Wang, J Xie, Q Ge, TL Gu, RD Polakiewicz, JL Roesel, GZ Chen, TJ Boggon, S Lonial, H Fu, FR Khuri, S Kang, J Chen	12/23/2011
Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proceedings of the National Academy of Sciences of the United States of America	J Zhao, Y Du, JR Horton, AK Upadhyay, B Lou, Y Bai, X Zhang, L Du, M Li, B Wang, L Zhang, JT Barbieri, FR Khuri, X Cheng, H Fu	09/27/2011
A novel high-throughput screening assay for discovery of molecules that increase cellular tetrahydrobiopterin. Journal of biomolecular screening	L Li, Y Du, W Chen, H Fu, DG Harrison	09/01/2011
14-3-3 proteins as potential therapeutic targets. Seminars in cell & developmental biology	J Zhao, CL Meyerkord, Y Du, FR Khuri, H Fu	09/01/2011
A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions. Assay and drug development technologies	Y Du, Z Nikolovska-Coleska, M Qui, L Li, I Lewis, R Dingledine, JA Stuckey, K Krajewski, PP Roller, S Wang, H Fu	08/01/2011
NMR spectroscopy of 14-3-3ζ reveals a flexible C-terminal extension: differentiation of the chaperone and phosphoserine-binding activities of 14-3-3ζ. The Biochemical journal	DM Williams, H Ecroyd, KL Goodwin, H Dai, H Fu, JM Woodcock, L Zhang, JA Carver	08/01/2011
Discovering small-molecule estrogen receptor α/coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency. ChemMedChem	A Sun, TW Moore, JR Gunther, MS Kim, E Rhoden, Y Du, H Fu, JP Snyder, JA Katzenellenbogen	04/04/2011
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proceedings of the National Academy of Sciences of the United States of America	R Cencic, DR Hall, F Robert, Y Du, J Min, L Li, M Qui, I Lewis, S Kurtkaya, R Dingledine, H Fu, D Kozakov, S Vajda, J Pelletier	01/18/2011
Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway. Journal of medicinal chemistry	X Qiu, Y Du, B Lou, Y Zuo, W Shao, Y Huo, J Huang, Y Yu, B Zhou, J Du, H Fu, X Bu	12/09/2010
Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. Biochemical pharmacology	SL Thomas, J Zhao, Z Li, B Lou, Y Du, J Purcell, JP Snyder, FR Khuri, D Liotta, H Fu	11/01/2010
Phase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancer. Cancer	SS Ramalingam, RD Harvey, N Saba, TK Owonikoko, J Kauh, DM Shin, SY Sun, S Strychor, M Tighiouart, MJ Egorin, H Fu, FR Khuri	08/15/2010
Dual engagement of 14-3-3 proteins controls signal relay from ASK2 to the ASK1 signalosome. Oncogene	LM Cockrell, MC Puckett, EH Goldman, FR Khuri, H Fu	02/11/2010
14-3-3{eta} Amplifies Androgen Receptor Actions in Prostate Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research	MA Titus, JA Tan, CW Gregory, OH Ford, RR Subramanian, H Fu, EM Wilson, JL Mohler, FS French	12/15/2009
Transcription variants of the prostate-specific PrLZ gene and their interaction with 14-3-3 proteins. Biochemical and biophysical research communications	R Wang, H He, X Sun, J Xu, FF Marshall, H Zhau, LW Chung, H Fu, D He	11/20/2009
Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. The Journal of biological chemistry	SW Jang, X Liu, H Fu, H Rees, M Yepes, A Levey, K Ye	09/04/2009
14-3-3zeta mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen. The Journal of biological chemistry	SA Maxwell, Z Li, D Jaya, S Ballard, J Ferrell, H Fu	08/14/2009
Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening. Molecular cancer therapeutics	AB Bialkowska, Y Du, H Fu, VW Yang	03/01/2009
How does arrestin assemble MAPKs into a signaling complex? The Journal of biological chemistry	X Song, S Coffa, H Fu, VV Gurevich	01/02/2009
Cancer and virus leads by HTS, chemical design and SEA data mining. Current topics in medicinal chemistry	P Thepchatri, J Min, T Ganesh, Y Du, I Lewis, S Kurtkaya, A Prussia, L Li, B Sneed, RK Plemper, H Fu, DC Liotta, JP Snyder, R Dingledine, A Sun	01/01/2009
Distinct growth factor-induced dynamic mass redistribution (DMR) profiles for monitoring oncogenic signaling pathways in various cancer cells. Journal of receptor and signal transduction research	Y Du, Z Li, L Li, ZG Chen, SY Sun, P Chen, DM Shin, FR Khuri, H Fu	01/01/2009
Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacy. Cancer biology & therapy	X Wang, N Hawk, P Yue, J Kauh, SS Ramalingam, H Fu, FR Khuri, SY Sun	12/01/2008
A homogenous luminescent proximity assay for 14-3-3 interactions with both phosphorylated and nonphosphorylated client peptides. Current chemical genomics	Y Du, FR Khuri, H Fu	11/06/2008
Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay. Bioorganic & medicinal chemistry letters	T Ganesh, P Thepchatri, L Li, Y Du, H Fu, JP Snyder, A Sun	09/15/2008
Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation. Cancer research	X Wang, P Yue, YA Kim, H Fu, FR Khuri, SY Sun	09/15/2008
Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Molecular pharmacology	AL Kasinski, Y Du, SL Thomas, J Zhao, SY Sun, FR Khuri, CY Wang, M Shoji, A Sun, JP Snyder, D Liotta, H Fu	09/01/2008
Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling. Bioorganic & medicinal chemistry	T Ganesh, J Min, P Thepchatri, Y Du, L Li, I Lewis, L Wilson, H Fu, G Chiosis, R Dingledine, D Liotta, JP Snyder, A Sun	07/15/2008
Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation. Proceedings of the National Academy of Sciences of the United States of America	Z Li, J Zhao, Y Du, HR Park, SY Sun, L Bernal-Mizrachi, A Aitken, FR Khuri, H Fu	01/08/2008
14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells. Blood	S Dong, S Kang, TL Gu, S Kardar, H Fu, S Lonial, HJ Khoury, F Khuri, J Chen	07/01/2007
Inhibition of Protein-Protein Interactions: Non-Cellular Assay Formats Assay Guidance Manual	S Markossian, A Grossman, H Baskir, M Arkin, D Auld, C Austin, J Baell, K Brimacombe, TDY Chung, NP Coussens, JL Dahlin, V Devanarayan, TL Foley, M Glicksman, K Gorshkov, S Grotegut, MD Hall, S Hoare, J Inglese, PW Iversen, M Lal-Nag, Z Li, JR Manro, J McGee, A Norvil, M Pearson, T Riss, P Saradjian, GS Sittampalam, MA Tarselli, OJ Trask, JR Weidner, MJ Wildey, K Wilson, M Xia, X Xu, MR Arkin, MA Glicksman, H Fu, JJ Havel, Y Du	01/01/2004

Awards

Dr. Fu's recent awards include:

Susan Band Horwitz Award Lecture in Cancer Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2025
Elected American Society for Pharmacology and Experimental Therapeutics Fellow (ASPET), 2024
Emory University Millipub Club (inaugural member; >1,000 citations for a single publication), 2009, 2017
Elected American Association for the Advancement of Science Fellow (AAAS), 2014
One in One Hundred Mentor Award for being an outstanding postdoctoral fellow mentor, Emory Office of Postdoctoral Education, 2011
Co-founder & Board of Directors, International Chemical Biology Society, 2010
External Advisory Board, H. Lee Moffitt Cancer Center & Research Institute, P01 drug discovery program project, 2010
Georgia Cancer Coalition (GCC) Distinguished Cancer Scholar, 2007-2011
Emory University Faculty Distinction Fund Award, 2006-2009
Georgia Research Alliance Distinguished Investigator Award, 2006-2011
Emory Pharmacology Teaching Excellence Award, 2006
Elected member of the Council of Gordon Research Conferences, 2004-2006
Co-founder and inaugural Chair, Gordon Research Conference on "The Biology of 14-3-3 Proteins", Ventura, California, 2004