David E. Gordon, PhD

Research Program

Discovery and Developmental Therapeutics
Email Address

david.ezra.gordon@emory.edu

Biography

David Ezra Gordon, PhD, is assistant professor and an investigator with the Pathology Advanced Translational Research Unit (PATRU) in the Department of Pathology and Laboratory Medicine at Emory University School of Medicine.Dr. Gordon is a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute.

Education

Dr. Gordon received his PhD and MPhil in Clinical Biochemistry from University of Cambridge. He completed a postdoctoral fellowship at University of California in San Francisco, California.

Titles & Roles

Assistant Professor, Department of Pathology and Laboratory Medicine

Emory University School of Medicine

Research

The Gordon laboratory utilizes high-throughput experimental genetics and proteomics to build mechanistic models of biological functions and applies this knowledge to invent new therapeutic treatments. We are interested in all aspects of human biology, with a focus on virology and the human immune system as these offer tractable genetic systems, an ample supply of primary tissues, and opportunities to rapidly test therapeutic interventions.

Dr. Gordon has a diverse research background spanning cell and molecular biology, experimental genetics, proteomics, virology, and systems biology.

Publications

Title/Journal	Authors	Publication Date
Microbiome-Derived Metabolites Shape CD4⁺ T-Cell Differentiation and Immune Aging in HIV-1 Infection. JCI insight	A Cabral da Silva, L Flantzer, J Weinberg, S Kyu, LP Daley-Bauer, A Godoy, AC Santana, A Talla, A Rittgers, S Welbourn, DE Gordon, JA Tomalka, VC Marconi, DP Jones, SA Younes	07/21/2026
Toward mechanistic virtual immune cells. Nature biotechnology	CM Beusch, B Edelman, CA Hubbard, JS Brockett, J Skolnick, DE Gordon	06/25/2026
Expanding the Chemoproteomic Toolkit to Asparagine and Glutamine. ACS chemical biology	B Emenike, JM Talbott, ZE Paikin, CM Beusch, S Khoshnevis, DE Gordon, M Raj	04/09/2026
Interleukin-6 restricts pre-thymic T cell lineage commitment of progenitors driving loss of SIV control. bioRxiv : the preprint server for biology	S Anwar, S Naseem, CM Beusch, AF Coskun, MS Abdel-Hakeem, RP Johnson, FJT Staal, V Velu, M Paiardini, BF Keele, G Silvestri, DE Gordon, JA Tomalka, SA Rahman	02/02/2026
Identification and characterization of a TGF-β-independent SMAD4-NFATc1-STAT3 regulatory axis. Journal of molecular cell biology	W Ouyang, J Hao, Q Niu, EF Douglass, CM Beusch, DE Gordon, M Hall, RA Moffitt, Y Du, X Mo	01/24/2026
Microbiome-Derived Metabolites Shape CD4⁺ T-Cell Differentiation and Immune Aging in Chronic HIV-1 Infection. bioRxiv : the preprint server for biology	ACD Silva, L Flantzer, J Weinberg, S Kyu, L Daley-Bauer, AC Santana, A Talla, AL Rittgers, S Welbourn, DE Gordon, JA Tomalka, VC Marconi, DP Jones, SA Younes	01/14/2026
Proteotoxic stress response drives T cell exhaustion and immune evasion. Nature	Y Wang, A Ma, NJ Song, AE Shannon, YS Amankwah, X Chen, W Wu, Z Wang, AA Saadey, A Yousif, G Ghosh, JK Mandula, M Velegraki, T Xiao, H Wen, SC Huang, R Wang, CM Beusch, AS Dawood, DE Gordon, MS Abdel-Hakeem, HE Ghoneim, G Xin, BC Searle, Z Li	11/01/2025
A scalable proteogenomic framework for dissecting phospho-signaling pathways in primary immune cells. bioRxiv : the preprint server for biology	CM Beusch, C Morningstar, M Semaan, CM Monaco, S Welbourn, H Swaldi, JK Ko, D Kenney, A Sousa, H Sakai, D Liu, H Akiyama, M Saeed, DE Gordon	10/08/2025
Mechano-ID: Proximity Labeling of Mechanically Active Receptors Reveals the Mechanome and Tags Mechanically Active Cells. Journal of the American Chemical Society	R Ma, MHB Abdul Rahman, CM Beusch, BR Deal, DE Gordon, K Salaita	10/08/2025
SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses. Proceedings of the National Academy of Sciences of the United States of America	A Caobi, CM Su, CM Beusch, D Kenney, TL Darling, S Feng, M Semaan, A Wacquiez, NL Sanders, ES Tully, DY Chen, M Evdokimova, Z Ding, D Jones, KD Alysandratos, JP Mizgerd, RN Kirchdoerfer, DN Kotton, F Douam, NA Crossland, ACM Boon, DE Gordon, SC Baker, M Saeed	06/17/2025
Dynamic In Vivo Mapping of the Methylproteome Using a Chemoenzymatic Approach. Journal of the American Chemical Society	J Farhi, B Emenike, RS Lee, K Sad, DV Fawwal, CM Beusch, RB Jones, AK Verma, CY Jones, M Foroozani, M Reeves, KK Parwani, P Bagchi, RB Deal, DJ Katz, AH Corbett, DE Gordon, M Raj, JM Spangle	03/05/2025
Acrolein-Mediated Conversion of Lysine to Electrophilic Heterocycles for Protein Diversification and Toxicity Profiling. Journal of the American Chemical Society	ZE Paikin, B Emenike, R Shirke, CM Beusch, DE Gordon, M Raj	02/19/2025
Distinct SIV-specific CD8⁺ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence. Nature immunology	Z Strongin, L Raymond Marchand, C Deleage, MB Pampena, MA Cardenas, CM Beusch, TN Hoang, EA Urban, M Gourves, K Nguyen, GK Tharp, S Lapp, AR Rahmberg, J Harper, PM Del Rio Estrada, M Gonzalez-Navarro, F Torres-Ruiz, YA Luna-Villalobos, S Avila-Rios, G Reyes-Teran, R Sekaly, G Silvestri, DA Kulpa, A Saez-Cirion, JM Brenchley, SE Bosinger, DE Gordon, MR Betts, HT Kissick, M Paiardini	07/01/2024
Copper(I)-nitrene platform for chemoproteomic profiling of methionine. Nature communications	S Sahu, B Emenike, CM Beusch, P Bagchi, DE Gordon, M Raj	05/18/2024
Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques. Science immunology	EG Viox, TN Hoang, AA Upadhyay, R Nchioua, M Hirschenberger, Z Strongin, GK Tharp, M Pino, K Nguyen, JL Harper, M Gagne, S Marciano, AK Boddapati, KL Pellegrini, A Pradhan, J Tisoncik-Go, LS Whitmore, KA Karunakaran, M Roy, S Kirejczyk, EH Curran, C Wallace, JS Wood, F Connor-Stroud, EA Voigt, CM Monaco, DE Gordon, SP Kasturi, RD Levit, M Gale, TH Vanderford, G Silvestri, K Busman-Sahay, JD Estes, M Vaccari, DC Douek, KMJ Sparrer, RP Johnson, F Kirchhoff, G Schreiber, SE Bosinger, M Paiardini	07/28/2023
Establishing SARS-CoV-2 membrane protein-specific antibodies as a valuable serological target via high-content microscopy. iScience	DM Williams, HR Hornsby, OM Shehata, R Brown, M Gallis, N Meardon, TAH Newman, M Plowright, D Zafred, ASM Shun-Shion, AJ Hodder, D Bliss, A Metcalfe, JR Edgar, DE Gordon, JR Sayers, MJ Nicklin, M Carroll, PJ Collini, S Brown, TI de Silva, AA Peden	07/21/2023