Lubing Gu, MD

Research Program

Discovery and Developmental Therapeutics
Phone Number

404-727-1420
Email Address

lbgu@emory.edu

Biography

Lubing Gu, MD, is an assistant professor in the Department of Pediatrics at Emory University School of Medicine. Dr. Gu is a member of the Discovery and Developmental Therapeutics Research Program at Winship.

Education

Dr. Gu's MD was awarded from Shanghai Medical University of China. Dr. Gu then completed residency at The First Hospital of Jiaxing City and fellowship at Shanghai Medical University.

Titles & Roles

Assistant Professor, Department of Pediatrics

Emory University School of Medicine

Research

Dr. Gu's research interests include childhood cancer and leukemia.

Grants

View Grants

Grant Number	Title
1R01CA240447-01A1	Dual inhibition of MDM2 and XIAP as a therapeutic strategy in cancer
5R01CA240447-02	Dual inhibition of MDM2 and XIAP as a therapeutic strategy in cancer
5R01CA240447-03	Dual inhibition of MDM2 and XIAP as a therapeutic strategy in cancer
5R01CA240447-04	Dual inhibition of MDM2 and XIAP as a therapeutic strategy in cancer

Publications

Title/Journal	Authors	Publication Date
An MDM2 degrader shows potent cytotoxicity to MDM2-overexpressing acute lymphoblastic leukemia cells with minimal toxicity to normal cells/tissues. Cancer letters	T Liu, L Gu, A Mui, Z Wu, N Albadari, W Li, M Zhou	08/28/2024
Synthesis and biological evaluation of dual MDM2/XIAP inhibitors based on the tetrahydroquinoline scaffold. European journal of medicinal chemistry	N Albadari, Y Xie, T Liu, R Wang, L Gu, M Zhou, Z Wu, W Li	07/05/2023
MYCN mRNA degradation and cancer suppression by a selective small-molecule inhibitor in MYCN-amplified neuroblastoma. Frontiers in oncology	T Liu, L Gu, Z Wu, N Albadari, W Li, M Zhou	01/01/2022
Discovery of N-(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor. Journal of medicinal chemistry	Z Wu, L Gu, S Zhang, T Liu, PB Lukka, B Meibohm, JC Bollinger, M Zhou, W Li	02/25/2021
Upregulation of p53 through induction of MDM2 degradation: Anthraquinone analogs. Bioorganic & medicinal chemistry	AB Draganov, X Yang, A Anifowose, LKC De La Cruz, C Dai, N Ni, W Chen, Z De Los Santos, L Gu, M Zhou, B Wang	09/01/2019
Mutual regulation of MDM4 and TOP2A in cancer cell proliferation. Molecular oncology	T Liu, H Zhang, S Yi, L Gu, M Zhou	05/01/2019
Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice. Molecular cancer therapeutics	L Gu, H Zhang, T Liu, A Draganov, S Yi, B Wang, M Zhou	02/01/2018
Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer cell	L Gu, H Zhang, T Liu, S Zhou, Y Du, J Xiong, S Yi, CK Qu, H Fu, M Zhou	10/10/2016
Targeting MYCN IRES in MYCN-amplified neuroblastoma with miR-375 inhibits tumor growth and sensitizes tumor cells to radiation. Molecular oncology	H Zhang, T Liu, S Yi, L Gu, M Zhou	08/01/2015
Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival. Molecular cancer	T Liu, H Zhang, J Xiong, S Yi, L Gu, M Zhou	03/26/2015
Inhibition of MDM2 by nilotinib contributes to cytotoxicity in both Philadelphia-positive and negative acute lymphoblastic leukemia. PloS one	H Zhang, L Gu, T Liu, KY Chiang, M Zhou	01/01/2014
Berberine represses DAXX gene transcription and induces cancer cell apoptosis. Laboratory investigation; a journal of technical methods and pathology	J Li, L Gu, H Zhang, T Liu, D Tian, M Zhou, S Zhou	03/01/2013
Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway. Molecular cancer therapeutics	M Huang, H Zhang, T Liu, D Tian, L Gu, M Zhou	02/01/2013
Methylation of RASSF1A gene promoter is regulated by p53 and DAXX. FASEB journal : official publication of the Federation of American Societies for Experimental Biology	H Zhang, J He, J Li, D Tian, L Gu, M Zhou	01/01/2013
MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells. Oncogene	L Gu, H Zhang, J He, J Li, M Huang, M Zhou	03/15/2012
Crosstalk between MYCN and MDM2-p53 signal pathways regulates tumor cell growth and apoptosis in neuroblastoma. Cell cycle (Georgetown, Tex.)	J He, L Gu, H Zhang, M Zhou	09/01/2011
Degradation of MDM2 by the interaction between berberine and DAXX leads to potent apoptosis in MDM2-overexpressing cancer cells. Cancer research	X Zhang, L Gu, J Li, N Shah, J He, L Yang, Q Hu, M Zhou	12/01/2010
Translation of TRAF1 is regulated by IRES-dependent mechanism and stimulated by vincristine. Nucleic acids research	L Yang, L Gu, Z Li, M Zhou	07/01/2010
Regulation of XIAP translation and induction by MDM2 following irradiation. Cancer cell	L Gu, N Zhu, H Zhang, DL Durden, Y Feng, M Zhou	05/05/2009
Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells. Molecular cancer therapeutics	N Zhu, L Gu, F Li, M Zhou	05/01/2008
MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2. Leukemia	L Gu, N Zhu, HW Findley, M Zhou	04/01/2008
Tissue factor/FVIIa activates Bcl-2 and prevents doxorubicin-induced apoptosis in neuroblastoma cells. BMC cancer	J Fang, L Gu, N Zhu, H Tang, CS Alvarado, M Zhou	03/06/2008

Awards

Dr. Gu is the recipient of the following awards and honors:

Outstanding Scholar in Chinese Association of Students & Scholars at Atlanta, 2002
Award from the Chinese Academy of Science for Early Diagnosis of Gastric Tumors, 1984