Melinda G. Pauly, MD

Research Program

Discovery and Developmental Therapeutics
Email Address

melinda.pauly@choa.org

Biography

Melinda G. Pauly, MD, is an associate professor in the Department of Pediatrics at Emory University School of Medicine. Dr. Pauly is a member of the Discovery and Developmental Therapeutics Research Program at Winship.

Education

Dr. Pauly received her medical degree from Medical College of Georgia. She completed her residency at University of Alabama at Birmingham School of Medicine, and her fellowship at Emory University School of Medicine.

Titles & Roles

Associate Professor, Department of Pediatrics

Emory University School of Medicine

Research

View Current Clinical Trials


A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia Phase II Conditions Recurrent Acute Leukemia of Ambiguous Lineage, Recurrent Acute Lymphoblastic Leukemia, Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage, Recurrent Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-Rearranged, Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute Leukemia, Recurrent Mixed Phenotype Acute Leukemia, Refractory Acute Leukemia of Ambiguous Lineage, Refractory Acute Lymphoblastic Leukemia, Refractory Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage, Refractory Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-Rearranged, Refractory Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute Leukemia, Refractory Mixed Phenotype Acute Leukemia
A Study of Revumenib in Combination With Chemotherapy in Participants With R/R Acute Leukemia Phase I Conditions Relapsed/Refractory Leukemias, Acute Lymphoblastic Leukemia, Acute Lymphocytic Leukemia, Mixed Phenotype Acute Leukemia, Acute Myeloid Leukemia, Acute Undifferentiated Leukemia

A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia
- Phase
  
  II
- Conditions
  
  Recurrent Acute Leukemia of Ambiguous Lineage, Recurrent Acute Lymphoblastic Leukemia, Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage, Recurrent Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-Rearranged, Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute Leukemia, Recurrent Mixed Phenotype Acute Leukemia, Refractory Acute Leukemia of Ambiguous Lineage, Refractory Acute Lymphoblastic Leukemia, Refractory Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage, Refractory Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-Rearranged, Refractory Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute Leukemia, Refractory Mixed Phenotype Acute Leukemia

A Study of Revumenib in Combination With Chemotherapy in Participants With R/R Acute Leukemia
- Phase
  
  I
- Conditions
  
  Relapsed/Refractory Leukemias, Acute Lymphoblastic Leukemia, Acute Lymphocytic Leukemia, Mixed Phenotype Acute Leukemia, Acute Myeloid Leukemia, Acute Undifferentiated Leukemia

Publications

Title/Journal	Authors	Publication Date
Vincristine Sulfate Liposome Injection With Combination Chemotherapy for Children, Adolescents, and Young Adults With Relapsed Acute Lymphoblastic Leukemia: A Therapeutic Advances in Childhood Leukemia and Lymphoma Consortium Trial. Pediatric blood & cancer	NN Shah, ES Schafer, YY Chi, J Malvar, KM Heym, AE Place, M Burns, BH Chang, T Slone, A Verma, N Gossai, PH Shaw, MJ Burke, M Hermiston, RJ Schore, T Cooper, M Pauly, T Rushing, P Jarosinski, E Florendo, B Yates, BC Widemann, CJ Peer, WD Figg, LB Silverman, D Bhojwani, AS Wayne	05/01/2025
Azacitidine as epigenetic priming for chemotherapy is safe and well-tolerated in infants with newly diagnosed KMT2A-rearranged acute lymphoblastic leukemia: Children's Oncology Group trial AALL15P1. Haematologica	EM Guest, JA Kairalla, M Devidas, E Hibbitts, AJ Carroll, NA Heerema, HR Kubaney, MA August, S Ramesh, B Yoo, MS Farooqi, MG Pauly, DS Wechsler, RR Miles, JM Reid, CD Kihei, L Gore, EA Raetz, SP Hunger, ML Loh, PA Brown	12/01/2024
Nivolumab Plus 5-Azacitidine in Pediatric Relapsed/Refractory Acute Myeloid Leukemia (AML): Phase I/II Trial Results from the Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium. Cancers	A Verma, YY Chi, J Malvar, A Lamble, S Chaudhury, A Agarwal, HT Li, G Liang, R Leong, PA Brown, J Kaplan, ES Schafer, T Slone, M Pauly, BH Chang, E Stieglitz, AS Wayne, N Hijiya, D Bhojwani	01/24/2024
Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia. Nature communications	H Mumme, BE Thomas, SS Bhasin, U Krishnan, B Dwivedi, P Perumalla, D Sarkar, GB Ulukaya, HS Sabnis, SI Park, D DeRyckere, SS Raikar, M Pauly, RJ Summers, SM Castellino, DS Wechsler, CC Porter, DK Graham, M Bhasin	10/05/2023
BCMA CAR-T induces complete and durable remission in refractory plasmablastic lymphoma. Journal for immunotherapy of cancer	S Raghunandan, M Pauly, WG Blum, M Qayed, MV Dhodapkar, M Elkhalifa, B Watkins, M Schoettler, E Horwitz, S Parikh, S Chandrakasan, K Leung, E Bryson, L Deeb, JL Kaufman, D Worthington-White, A Alazraki, JM Schecter, D Madduri, CC Jackson, E Zudaire, A Taraseviciute-Morris, A Babich, T Nesheiwat, M Vogel, N Lendvai, L Pacaud, KM Williams	05/01/2023
Mismatched Unrelated Donor Hematopoietic Stem Cell Transplantation Rescues Marrow Failure From Acute Leukemia Therapy in a Patient With Previously Undiagnosed Ligase IV Syndrome. Journal of pediatric hematology/oncology	DM Fridlyand, S Chandrakasan, A Aljudi, WK Aumann, E Westfall, B Kirwan, EW Bryson, FG Keller, SD Arnold, AL Hong, M Pauly, KM Williams	01/01/2023
Comprehensive Genomic Profiling of High-Risk Pediatric Cancer Patients Has a Measurable Impact on Clinical Care. JCO precision oncology	RJ Summers, SM Castellino, CC Porter, TJ MacDonald, GD Basu, S Szelinger, MK Bhasin, T Cash, AB Carter, RC Castellino, JR Fangusaro, SG Mitchell, MG Pauly, B Pencheva, DS Wechsler, DK Graham, KC Goldsmith	04/01/2022
Cryptic t(6;11) KMT2A rearrangement in a pediatric acute myeloid leukemia patient detected by next-generation sequencing and dual-fusion FISH analysis. Pediatric blood & cancer	S Raghunandan, J Jain, D Saxe, M Pauly, AA Aljudi, RP Ketterling, AB Carter, SS Raikar	03/01/2022
Immune responses and therapeutic challenges in paediatric patients with new-onset acute myeloid leukaemia and concomitant COVID-19. British journal of haematology	PA Patel, SA Lapp, G Grubbs, VV Edara, CA Rostad, CL Stokes, MG Pauly, EJ Anderson, A Piantadosi, MS Suthar, S Khurana, HS Sabnis	08/01/2021
Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium. Cancer discovery	Y Pikman, SK Tasian, ML Sulis, K Stevenson, TM Blonquist, B Apsel Winger, TM Cooper, M Pauly, KW Maloney, MJ Burke, PA Brown, N Gossai, JL McNeer, NN Shukla, PD Cole, JM Kahn, J Chen, MJ Barth, JA Magee, L Gennarini, AA Adhav, CM Clinton, N Ocasio-Martinez, G Gotti, Y Li, S Lin, A Imamovic, CE Tognon, T Patel, HL Faust, CF Contreras, A Cremer, WA Cortopassi, D Garrido Ruiz, MP Jacobson, NV Dharia, A Su, AL Robichaud, A Saur Conway, K Tarlock, E Stieglitz, AE Place, A Puissant, SP Hunger, AS Kim, NI Lindeman, L Gore, KA Janeway, LB Silverman, JW Tyner, MH Harris, ML Loh, K Stegmaier	06/01/2021
Severe COVID-19 disease in two pediatric oncology patients. Pediatric blood & cancer	CL Stokes, PA Patel, HS Sabnis, SG Mitchell, IB Yildirim, MG Pauly	09/01/2020
Evaluating approaches to enhance survival in children with hypodiploid acute lymphoblastic leukaemia (ALL). British journal of haematology	L Miller, S Kobayashi, M Pauly, G Lew, D Saxe, F Keller, M Qayed, S Castellino	05/01/2019
Germline mutations in the bone marrow microenvironment and dysregulated hematopoiesis. Experimental hematology	LH Miller, CK Qu, M Pauly	10/01/2018
Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection. Cell	EO Saphire, SL Schendel, ML Fusco, K Gangavarapu, BM Gunn, AZ Wec, PJ Halfmann, JM Brannan, AS Herbert, X Qiu, K Wagh, S He, EE Giorgi, J Theiler, KBJ Pommert, TB Krause, HL Turner, CD Murin, J Pallesen, E Davidson, R Ahmed, MJ Aman, A Bukreyev, DR Burton, JE Crowe, CW Davis, G Georgiou, F Krammer, CA Kyratsous, JR Lai, C Nykiforuk, MH Pauly, P Rijal, A Takada, AR Townsend, V Volchkov, LM Walker, CI Wang, L Zeitlin, BJ Doranz, AB Ward, B Korber, GP Kobinger, KG Andersen, Y Kawaoka, G Alter, K Chandran, JM Dye	08/09/2018
Phase I trial of the mTOR inhibitor everolimus in combination with multi-agent chemotherapy in relapsed childhood acute lymphoblastic leukemia. Pediatric blood & cancer	AE Place, Y Pikman, KE Stevenson, MH Harris, M Pauly, ML Sulis, N Hijiya, L Gore, TM Cooper, ML Loh, G Roti, DS Neuberg, SK Hunt, S Orloff-Parry, K Stegmaier, SE Sallan, LB Silverman	07/01/2018
Hyperleukocytosis in infant acute leukemia: a role for manual exchange transfusion for leukoreduction. Transfusion	DV Runco, CD Josephson, SS Raikar, KC Goldsmith, G Lew, M Pauly, RM Fasano	05/01/2018
Outcomes of adults and children with primary mediastinal B-cell lymphoma treated with dose-adjusted EPOCH-R. British journal of haematology	L Giulino-Roth, T O'Donohue, Z Chen, NL Bartlett, A LaCasce, W Martin-Doyle, MJ Barth, K Davies, KA Blum, B Christian, C Casulo, SM Smith, J Godfrey, A Termuhlen, MJ Oberley, S Alexander, S Weitzman, B Appel, B Mizukawa, J Svoboda, Z Afify, M Pauly, H Dave, R Gardner, DM Stephens, WA Zeitler, C Forlenza, J Levine, ME Williams, JL Sima, CM Bollard, JP Leonard	12/01/2017
Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment. Nature	L Dong, WM Yu, H Zheng, ML Loh, ST Bunting, M Pauly, G Huang, M Zhou, HE Broxmeyer, DT Scadden, CK Qu	11/10/2016