Monika Raj, PhD

Research Program

Discovery and Developmental Therapeutics
Phone Number

404-727-4049
Email Address

monika.raj@emory.edu

Biography

Monika Raj, PhD, is an associate professor in the Department of Chemistry at Emory University. Dr. Raj is a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute of Emory University.

Education

Dr. Raj obtained her PhD in Organic Chemistry from Indian Institute of Technology in Kanpur, India. She completed her postdoctoral fellowship at University of Pennsylvania and then at New York University.

Titles & Roles

Associate Professor, Department of Chemistry

Emory University

Research

Research in the Raj Group takes place at the interface between the fields of organic synthesis, bioorganic chemistry and catalysis. They are interested in utilizing organic chemistry tools to solve problems in the field of biology, leading to the development of new chemical reactions, catalysis and ligation methodologies for the synthesis of biological molecules.

Publications

Title/Journal	Authors	Publication Date
Spatiotemporal Imaging of Catechol Aldehydes in Neural Tissue. JACS Au	JM Talbott, R Wills, R Shirke, L Hassanein, D Weinshenker, M Raj	04/28/2025
Coarctate reaction for synthesis of fluorescent N-heterocycles, late-stage functionalization, and photo-triggered drug delivery. Nature communications	S Sahu, ZE Paikin, JM Talbott, P Czabala, M Raj	04/22/2025
Chemical Carbonylation of Arginine in Peptides and Proteins. Journal of the American Chemical Society	L Prosser, B Emenike, P Sihag, R Shirke, M Raj	03/26/2025
Dynamic In Vivo Mapping of the Methylproteome Using a Chemoenzymatic Approach. Journal of the American Chemical Society	J Farhi, B Emenike, RS Lee, K Sad, DV Fawwal, CM Beusch, RB Jones, AK Verma, CY Jones, M Foroozani, M Reeves, KK Parwani, P Bagchi, RB Deal, DJ Katz, AH Corbett, DE Gordon, M Raj, JM Spangle	03/05/2025
Acrolein-Mediated Conversion of Lysine to Electrophilic Heterocycles for Protein Diversification and Toxicity Profiling. Journal of the American Chemical Society	ZE Paikin, B Emenike, R Shirke, CM Beusch, DE Gordon, M Raj	02/19/2025
Solvent-Dependent Chemoselectivity Switch to Arg-Lys Imidazole Cross-Links. Organic letters	AV Galindo, M Raj	10/04/2024
Bioinspired Synthesis of Allysine for Late-Stage Functionalization of Peptides. Angewandte Chemie (International ed. in English)	B Emenike, S Shahin, M Raj	05/27/2024
A Tag-Free Platform for Synthesis and Screening of Cyclic Peptide Libraries. Angewandte Chemie (International ed. in English)	A Bruce, V Adebomi, P Czabala, J Palmer, WM McFadden, ZC Lorson, RL Slack, G Bhardwaj, SG Sarafianos, M Raj	05/21/2024
Copper(I)-nitrene platform for chemoproteomic profiling of methionine. Nature communications	S Sahu, B Emenike, CM Beusch, P Bagchi, DE Gordon, M Raj	05/18/2024
Tertiary Amine Coupling by Oxidation for Selective Labeling of Dimethyl Lysine Post-Translational Modifications. Journal of the American Chemical Society	B Emenike, P Czabala, J Farhi, J Swaminathan, EV Anslyn, J Spangle, M Raj	04/17/2024
Tunable fluorescent probes for detecting aldehydes in living systems. Chemical science	R Wills, R Shirke, H Hrncir, JM Talbott, K Sad, JM Spangle, AD Gracz, M Raj	03/27/2024
Correction to "C-Terminal Arginine-Selective Cleavage of Peptides as a Method for Mimicking Carboxypeptidase B". Organic letters	LC Prosser, JM Talbott, RP Garrity, M Raj	10/13/2023
Intramolecular Hydrogen Bonding Enables a Zwitterionic Mechanism for Macrocyclic Peptide Formation: Computational Mechanistic Studies of CyClick Chemistry. Angewandte Chemie (International ed. in English)	H Shao, V Adebomi, A Bruce, M Raj, KN Houk	10/09/2023
Chemoselective Methods for Labeling and Modification of Peptides and Proteins. Organic letters	MA Brimble, L Ackermann, YM Li, M Raj	09/15/2023
C-Terminal Arginine-Selective Cleavage of Peptides as a Method for Mimicking Carboxypeptidase B. Organic letters	LC Prosser, JM Talbott, RP Garrity, M Raj	08/25/2023
Chemical sensors for imaging total cellular aliphatic aldehydes in live cells. Chemical science	R Wills, J Farhi, P Czabala, S Shahin, J M Spangle, M Raj	08/09/2023
Multicomponent Oxidative Nitrile Thiazolidination Reaction for Selective Modification of N-terminal Dimethylation Posttranslational Modification. Journal of the American Chemical Society	B Emenike, J Donovan, M Raj	08/02/2023
Bioinspired one-pot furan-thiol-amine multicomponent reaction for making heterocycles and its applications. Nature communications	Y Wang, P Czabala, M Raj	07/10/2023
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy. Tetrahedron	R Wills, V Adebomi, C Spancake, RD Cohen, M Raj	11/05/2022
Selective Conversion of Unactivated C-N Amide Bond to C-C bond via Steric and Electronic Resonance Destabilization. Organic letters	V Adebomi, Y Wang, M Sriram, M Raj	09/16/2022
Introduction to 'Synthesis and chemical biology of macrocycles'. RSC chemical biology	G Chen, M Raj, A Yudin	08/03/2022
Rapid Arene Triazene Chemistry for Macrocyclization. Journal of the American Chemical Society	O Nwajiobi, AK Verma, M Raj	03/16/2022
Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angewandte Chemie (International ed. in English)	KC Tang, J Cao, LM Boatner, L Li, J Farhi, KN Houk, J Spangle, KM Backus, M Raj	01/26/2022
Tunable heteroaromatic azoline thioethers (HATs) for cysteine profiling. Chemical science	KC Tang, SM Maddox, KM Backus, M Raj	01/19/2022
Covalent Chemical Tools for Profiling Post-Translational Modifications. Frontiers in chemistry	B Emenike, O Nwajiobi, M Raj	01/01/2022
Rotten to the core: antivirals targeting the HIV-1 capsid core. Retrovirology	WM McFadden, AA Snyder, KA Kirby, PR Tedbury, M Raj, Z Wang, SG Sarafianos	12/22/2021
Metal-Free Selective Modification of Secondary Amides: Application in Late-Stage Diversification of Peptides. Organic letters	V Adebomi, M Sriram, X Streety, M Raj	08/20/2021
Selective Triazenation Reaction (STaR) of Secondary Amines for Tagging Monomethyl Lysine Post-Translational Modifications. Angewandte Chemie (International ed. in English)	O Nwajiobi, S Mahesh, X Streety, M Raj	03/22/2021
One-Step Azolation Strategy for Site- and Chemo-Selective Labeling of Proteins with Mass-Sensitive Probes. Angewandte Chemie (International ed. in English)	KC Tang, M Raj	01/25/2021
Site-Selective Peptide Macrocyclization. Chembiochem : a European journal of chemical biology	R Wills, V Adebomi, M Raj	01/05/2021