Michael Treadway, PhD

Research Program

Cancer Prevention and Control
Phone Number

404-727-3166
Email Address

mtreadway@emory.edu

Biography

Michael T. Treadway, PhD, is an assistant professor in the Department of Psychology at the Emory College of Arts and Sciences. Dr. Treadway is a clinical psychologist and neuroscientist focused on understanding the molecular and circuit-level mechanisms of psychiatric symptoms related to mood, anxiety and decision-making.

Dr. Treadway is a member of the Cancer Prevention and Control Research Program at Winship Cancer Institute of Emory University.

Education

Dr. Treadway received his PhD in clinical psychology from Vanderbilt University in Nashville Tennessee, and completed his clinical internship and postdoctoral training at McLean Hospital/Harvard Medical School in Belmont, Massachusetts.

Titles & Roles

Assistant Professor, Department of Psychology

Emory College of Arts and Sciences
Director

Translational Research in Affective Disorders Laboratory (TReAD Lab)

Research

Dr. Treadway's research is focused on understanding the molecular and circuit-level mechanisms of psychiatric symptoms related to mood, anxiety and decision-making. His research employs a variety of methods, including multimodal neuroimaging techniques (fMRI, MRS, and PET), behavioral paradigms, computational modeling, and clinical/personality assessment. A particular interest has been the assessment of reward motivation in psychiatric populations, for which Dr. Treadway has developed several laboratory tasks, including the Effort-Expenditure for Rewards Task (EEfRT).

Grants

View Grants

Grant Number	Title
2R25MH101079-06	Emory Psychiatry Clinical Scientist Training Program (CSTP)
5R25MH101079-07	Emory Psychiatry Clinical Scientist Training Program (CSTP)
5R25MH101079-08	Emory Psychiatry Clinical Scientist Training Program (CSTP)
5R25MH101079-09	Emory Psychiatry Clinical Scientist Training Program (CSTP)

Publications

Title/Journal	Authors	Publication Date
Computational Phenotyping of Effort-Based Decision Making in Unmedicated Adults With Remitted Depression. Biological psychiatry. Cognitive neuroscience and neuroimaging	M Kuhn, EH Palermo, G Pagnier, JM Blank, DC Steinberger, Y Long, G Nowicki, JA Cooper, MT Treadway, MJ Frank, DA Pizzagalli	06/01/2025
Anhedonia and Inflammation: Hiding in Plain Sight. The American journal of psychiatry	MT Treadway	06/01/2025
Inflammation is associated with avolition and reduced resting state functional connectivity in corticostriatal reward circuitry in patients with schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	DR Goldsmith, CS Ning, GP Strauss, RE Gross, JA Cooper, EC Wommack, E Haroon, JC Felger, EF Walker, MT Treadway, AH Miller	04/24/2025
A randomized proof-of-mechanism trial of TNF antagonism for motivational deficits and related corticostriatal circuitry in depressed patients with high inflammation. Molecular psychiatry	MT Treadway, SM Etuk, JA Cooper, S Hossein, E Hahn, SA Betters, S Liu, AR Arulpragasam, BAM DeVries, N Irfan, MR Nuutinen, EC Wommack, BJ Woolwine, M Bekhbat, PA Kragel, JC Felger, E Haroon, AH Miller	04/01/2025
Medial prefrontal glutamate response to acute stress is associated with social subordination in female rhesus macaques. Translational psychiatry	MT Treadway, SA Betters, JA Cooper, CX Li, X Zhang, V Michopoulos	03/29/2025
Sustained effects of repeated levodopa (L-DOPA) administration on reward circuitry, effort-based motivation, and anhedonia in depressed patients with higher inflammation. Brain, behavior, and immunity	M Bekhbat, Z Li, BW Dunlop, MT Treadway, ND Mehta, KP Revill, MJ Lucido, C Hong, A Ashchi, EC Wommack, DR Goldsmith, E Haroon, AH Miller, JC Felger	03/01/2025
NNFit: A Self-Supervised Deep Learning Method for Accelerated Quantification of High-Resolution Short-Echo-Time MR Spectroscopy Datasets. Radiology. Artificial intelligence	AS Giuffrida, S Sheriff, V Huang, BD Weinberg, LAD Cooper, Y Liu, BJ Soher, M Treadway, AA Maudsley, H Shim	03/01/2025
Spontaneous thought separates into clusters of negative, positive, and flexible thinking. Communications psychology	M Migó, JA Cooper, PA Kragel, MT Treadway	02/05/2025
Intrinsic and extrinsic control impact motivation and outcome sensitivity: the role of anhedonia, stress, and anxiety. Psychological medicine	MM Mehta, G Butler, C Ahn, YI Whitaker, K Bachi, Y Jacob, M Treadway, JW Murrough, LS Morris	12/27/2024
Using Computational Phenotyping to Identify Divergent Strategies for Effort Allocation Across the Psychosis Spectrum. Schizophrenia bulletin	AE Whitton, JA Cooper, JT Merchant, MT Treadway, KE Lewandowski	08/27/2024
Brain-based graph-theoretical predictive modeling to map the trajectory of anhedonia, impulsivity, and hypomania from the human functional connectome. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	R Dan, AE Whitton, MT Treadway, AV Rutherford, P Kumar, ML Ironside, RH Kaiser, B Ren, DA Pizzagalli	06/01/2024
Towards translational biomarkers for motivation: A commentary on Noback et al. (2024). Cognitive, affective & behavioral neuroscience	SM Etuk, MT Treadway	04/01/2024
A randomized proof-of-mechanism trial of TNF antagonism for motivational anhedonia and related corticostriatal circuitry in depressed patients with high inflammation. Research square	M Treadway, S Etuk, J Cooper, S Hossein, E Hahn, S Betters, S Liu, A Arulpragasam, B DeVries, N Irfan, M Nuutinen, E Wommack, B Woolwine, M Bekhbat, P Kragel, J Felger, E Haroon, A Miller	03/05/2024
Transdiagnostic or disorder-specific? Altered reinforcement learning in depression and schizophrenia. Brain : a journal of neurology	JS Ryan, MT Treadway	01/04/2024
Potential applications of temporal interference deep brain stimulation for the treatment of transdiagnostic conditions in psychiatry. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	N Fani, MT Treadway	01/01/2024
Distinct profiles of anhedonia and reward processing and their prospective associations with quality of life among individuals with mood disorders. Molecular psychiatry	AE Whitton, P Kumar, MT Treadway, AV Rutherford, ML Ironside, D Foti, G Fitzmaurice, F Du, DA Pizzagalli	12/01/2023
Effects of acute stress and depression on functional connectivity between prefrontal cortex and the amygdala. Molecular psychiatry	S Hossein, JA Cooper, BAM DeVries, MR Nuutinen, EC Hahn, PA Kragel, MT Treadway	11/01/2023
Hormone sensitivity predicts the beneficial effects of transdermal estradiol on reward-seeking behaviors in perimenopausal women: A randomized controlled trial. Psychoneuroendocrinology	DA Swales, S Lozza-Fiacco, EH Andersen, JA Cooper, MT Treadway, K Xia, CE Schiller, SS Girdler, GS Dichter	10/01/2023
Brain-based graph-theoretical predictive modeling to map the trajectory of transdiagnostic symptoms of anhedonia, impulsivity, and hypomania from the human functional connectome. Research square	D Pizzagalli, A Whitton, M Treadway, A Rutherford, P Kumar, M Ironside, R Kaiser, B Ren, R Dan	09/28/2023
A mesocorticolimbic signature of pleasure in the human brain. Nature human behaviour	PA Kragel, MT Treadway, R Admon, DA Pizzagalli, EC Hahn	08/01/2023
Treating Motivational and Consummatory Aspects of Anhedonia. Focus (American Psychiatric Publishing)	MT Treadway	07/01/2023
Correction to: Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study. Molecular psychiatry	M Bekhbat, Z Li, ND Mehta, MT Treadway, MJ Lucido, BJ Woolwine, E Haroon, AH Miller, JC Felger	10/01/2022
Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study. Molecular psychiatry	M Bekhbat, Z Li, ND Mehta, MT Treadway, MJ Lucido, BJ Woolwine, E Haroon, AH Miller, JC Felger	10/01/2022
Inflammation as a Pathophysiologic Pathway to Anhedonia: Mechanisms and Therapeutic Implications. Current topics in behavioral neurosciences	M Bekhbat, MT Treadway, JC Felger	01/01/2022
Vigor, Effort-Related Aspects of Motivation and Anhedonia. Current topics in behavioral neurosciences	MT Treadway, JD Salamone	01/01/2022
Acute drug effects differentially predict desire to take dextroamphetamine again for work and recreation. Psychopharmacology	JK Hoots, HE Webber, C Nunez, JA Cooper, P Lopez-Gamundi, VM Lawlor, SD Lane, MT Treadway, MC Wardle	10/01/2021
Mapping Disease Course Across the Mood Disorder Spectrum Through a Research Domain Criteria Framework. Biological psychiatry. Cognitive neuroscience and neuroimaging	AE Whitton, P Kumar, MT Treadway, AV Rutherford, ML Ironside, D Foti, G Fitzmaurice, F Du, DA Pizzagalli	07/01/2021
Two scene navigation systems dissociated by deliberate versus automatic processing. Cortex; a journal devoted to the study of the nervous system and behavior	S Suzuki, FS Kamps, DD Dilks, MT Treadway	07/01/2021
Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications. Pharmacological reviews	MJ Lucido, M Bekhbat, DR Goldsmith, MT Treadway, E Haroon, JC Felger, AH Miller	07/01/2021
Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression. Nature communications	JA Cooper, MR Nuutinen, VM Lawlor, BAM DeVries, EM Barrick, S Hossein, DJ Cole, CV Leonard, EC Hahn, AP Teer, GS Shields, GM Slavich, D Ongur, JE Jensen, F Du, DA Pizzagalli, MT Treadway	05/26/2021
Inflammation is associated with future depressive symptoms among older adults. Brain, behavior, & immunity - health	E Bondy, SA Norton, M Voss, RB Marks, MJ Boudreaux, MT Treadway, TF Oltmanns, R Bogdan	05/01/2021
Dose-response effects of d-amphetamine on effort-based decision-making and reinforcement learning. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	HE Soder, JA Cooper, P Lopez-Gamundi, JK Hoots, C Nunez, VM Lawlor, SD Lane, MT Treadway, MC Wardle	05/01/2021
Distinct regions of the striatum underlying effort, movement initiation and effort discounting. Nature human behaviour	S Suzuki, VM Lawlor, JA Cooper, AR Arulpragasam, MT Treadway	03/01/2021
The effort-doors task: Examining the temporal dynamics of effort-based reward processing using ERPs. NeuroImage	C Bowyer, CJ Brush, H Threadgill, E Harmon-Jones, M Treadway, CJ Patrick, G Hajcak	03/01/2021
Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia. Brain, behavior, and immunity	M Bekhbat, MT Treadway, DR Goldsmith, BJ Woolwine, E Haroon, AH Miller, JC Felger	08/01/2020
Effortful goal-directed behavior in schizophrenia: Computational subtypes and associations with cognition. Journal of abnormal psychology	JA Cooper, DM Barch, LF Reddy, WP Horan, MF Green, MT Treadway	10/01/2019
Depression genetic risk score is associated with anhedonia-related markers across units of analysis. Translational psychiatry	G Guffanti, P Kumar, R Admon, MT Treadway, MH Hall, M Mehta, S Douglas, AR Arulpragasam, DA Pizzagalli	09/19/2019
Effort-based decision-making impairment in patients with clinically-stabilized first-episode psychosis and its relationship with amotivation and psychosocial functioning. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology	WC Chang, AOK Chu, MT Treadway, GP Strauss, SKW Chan, EHM Lee, CLM Hui, YN Suen, EYH Chen	05/01/2019
Can't or Won't? Immunometabolic Constraints on Dopaminergic Drive. Trends in cognitive sciences	MT Treadway, JA Cooper, AH Miller	05/01/2019
The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology. Biological psychiatry	EL Belleau, MT Treadway, DA Pizzagalli	03/15/2019
Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation. Cerebral cortex (New York, N.Y. : 1991)	RH Kaiser, MT Treadway, DW Wooten, P Kumar, F Goer, L Murray, M Beltzer, P Pechtel, A Whitton, AL Cohen, NM Alpert, G El Fakhri, MD Normandin, DA Pizzagalli	12/01/2018
Anhedonia in depression: biological mechanisms and computational models. Current opinion in behavioral sciences	JA Cooper, AR Arulpragasam, MT Treadway	08/01/2018
Common and Dissociable Neural Activity After Mindfulness-Based Stress Reduction and Relaxation Response Programs. Psychosomatic medicine	G Sevinc, BK Hölzel, J Hashmi, J Greenberg, A McCallister, M Treadway, ML Schneider, JA Dusek, J Carmody, SW Lazar	06/01/2018
Corticoinsular circuits encode subjective value expectation and violation for effortful goal-directed behavior. Proceedings of the National Academy of Sciences of the United States of America	AR Arulpragasam, JA Cooper, MR Nuutinen, MT Treadway	05/29/2018
Social motivation in schizophrenia: The impact of oxytocin on vigor in the context of social and nonsocial reinforcement. Journal of abnormal psychology	D Fulford, M Treadway, J Woolley	01/01/2018
Association Between Interleukin-6 and Striatal Prediction-Error Signals Following Acute Stress in Healthy Female Participants. Biological psychiatry	MT Treadway, R Admon, AR Arulpragasam, M Mehta, S Douglas, G Vitaliano, DP Olson, JA Cooper, DA Pizzagalli	10/15/2017
Vicarious Effort-Based Decision-Making in Autism Spectrum Disorders. Journal of autism and developmental disorders	MG Mosner, JL Kinard, S McWeeny, JS Shah, ND Markiewitz, CR Damiano-Goodwin, MR Burchinal, HJV Rutherford, RK Greene, MT Treadway, GS Dichter	10/01/2017
Reduced Willingness to Expend Effort for Reward in Obesity: Link to Adherence to a 3-Month Weight Loss Intervention. Obesity (Silver Spring, Md.)	F Mata, M Treadway, A Kwok, H Truby, M Yücel, JC Stout, A Verdejo-Garcia	10/01/2017
Distinct Trajectories of Cortisol Response to Prolonged Acute Stress Are Linked to Affective Responses and Hippocampal Gray Matter Volume in Healthy Females. The Journal of neuroscience : the official journal of the Society for Neuroscience	R Admon, MT Treadway, L Valeri, M Mehta, S Douglas, DA Pizzagalli	08/16/2017
Working hard for oneself or others: Effects of oxytocin on reward motivation in social anxiety disorder. Biological psychology	A Fang, MT Treadway, SG Hofmann	07/01/2017
Reward Processing, Neuroeconomics, and Psychopathology. Annual review of clinical psychology	DH Zald, MT Treadway	05/08/2017
Lipopolysaccharide Alters Motivated Behavior in a Monetary Reward Task: a Randomized Trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	J Lasselin, MT Treadway, TE Lacourt, A Soop, MJ Olsson, B Karshikoff, S Paues-Göranson, J Axelsson, R Dantzer, M Lekander	03/01/2017
Inflammation Effects on Motivation and Motor Activity: Role of Dopamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	JC Felger, MT Treadway	01/01/2017
Inflammatory markers are associated with decreased psychomotor speed in patients with major depressive disorder. Brain, behavior, and immunity	DR Goldsmith, E Haroon, BJ Woolwine, MY Jung, EC Wommack, PD Harvey, MT Treadway, JC Felger, AH Miller	08/01/2016
Inefficient effort allocation and negative symptoms in individuals with schizophrenia. Schizophrenia research	JM McCarthy, MT Treadway, ME Bennett, JJ Blanchard	02/01/2016
Clashing Diagnostic Approaches: DSM-ICD Versus RDoC. Annual review of clinical psychology	SO Lilienfeld, MT Treadway	01/01/2016
Effect of failure/success feedback and the moderating influence of personality on reward motivation. Cognition & emotion	D Anand, KA Oehlberg, MT Treadway, R Nusslock	01/01/2016
The Neurobiology of Motivational Deficits in Depression--An Update on Candidate Pathomechanisms. Current topics in behavioral neurosciences	MT Treadway	01/01/2016
From Blame to Punishment: Disrupting Prefrontal Cortex Activity Reveals Norm Enforcement Mechanisms. Neuron	JW Buckholtz, JW Martin, MT Treadway, K Jan, DH Zald, O Jones, R Marois	09/23/2015
Effort-Based Decision-Making Paradigms for Clinical Trials in Schizophrenia: Part 1—Psychometric Characteristics of 5 Paradigms. Schizophrenia bulletin	LF Reddy, WP Horan, DM Barch, RW Buchanan, E Dunayevich, JM Gold, N Lyons, SR Marder, MT Treadway, JK Wynn, JW Young, MF Green	09/01/2015
Perceived life stress exposure modulates reward-related medial prefrontal cortex responses to acute stress in depression. Journal of affective disorders	P Kumar, GM Slavich, LH Berghorst, MT Treadway, NH Brooks, SJ Dutra, DN Greve, A O'Donovan, ME Bleil, N Maninger, DA Pizzagalli	07/15/2015
Motivation and effort in individuals with social anhedonia. Schizophrenia research	JM McCarthy, MT Treadway, JJ Blanchard	06/01/2015
Illness progression, recent stress, and morphometry of hippocampal subfields and medial prefrontal cortex in major depression. Biological psychiatry	MT Treadway, ML Waskom, DG Dillon, AJ Holmes, MTM Park, MM Chakravarty, SJ Dutra, FE Polli, DV Iosifescu, M Fava, JDE Gabrieli, DA Pizzagalli	02/01/2015
Impaired effort allocation in patients with schizophrenia. Schizophrenia research	MT Treadway, JS Peterman, DH Zald, S Park	02/01/2015
Reward processing dysfunction in major depression, bipolar disorder and schizophrenia. Current opinion in psychiatry	AE Whitton, MT Treadway, DA Pizzagalli	01/01/2015
Effect of social influence on effort-allocation for monetary rewards. PloS one	JM Gilman, MT Treadway, MT Curran, V Calderon, AE Evins	01/01/2015
Trait Anticipatory Pleasure Predicts Effort Expenditure for Reward. PloS one	JT Geaney, MT Treadway, LD Smillie	01/01/2015
Corticolimbic gating of emotion-driven punishment. Nature neuroscience	MT Treadway, JW Buckholtz, JW Martin, K Jan, CL Asplund, MR Ginther, OD Jones, R Marois	09/01/2014
Effort, anhedonia, and function in schizophrenia: reduced effort allocation predicts amotivation and functional impairment. Journal of abnormal psychology	DM Barch, MT Treadway, N Schoen	05/01/2014
Imaging the pathophysiology of major depressive disorder - from localist models to circuit-based analysis. Biology of mood & anxiety disorders	MT Treadway, DA Pizzagalli	03/07/2014
A thalamocorticostriatal dopamine network for psychostimulant-enhanced human cognitive flexibility. Biological psychiatry	GR Samanez-Larkin, JW Buckholtz, RL Cowan, ND Woodward, R Li, MS Ansari, CM Arrington, RM Baldwin, CE Smith, MT Treadway, RM Kessler, DH Zald	07/15/2013
Parsing Anhedonia: Translational Models of Reward-Processing Deficits in Psychopathology. Current directions in psychological science	MT Treadway, DH Zald	06/01/2013
Perceived stress predicts altered reward and loss feedback processing in medial prefrontal cortex. Frontiers in human neuroscience	MT Treadway, JW Buckholtz, DH Zald	01/01/2013
Caffeine increases psychomotor performance on the effort expenditure for rewards task. Pharmacology, biochemistry, and behavior	MC Wardle, MT Treadway, H de Wit	10/01/2012
Effort-based decision-making in major depressive disorder: a translational model of motivational anhedonia. Journal of abnormal psychology	MT Treadway, NA Bossaller, RC Shelton, DH Zald	08/01/2012
Adults with autism spectrum disorders exhibit decreased sensitivity to reward parameters when making effort-based decisions. Journal of neurodevelopmental disorders	CR Damiano, J Aloi, M Treadway, JW Bodfish, GS Dichter	05/21/2012
Dopaminergic mechanisms of individual differences in human effort-based decision-making. The Journal of neuroscience : the official journal of the Society for Neuroscience	MT Treadway, JW Buckholtz, RL Cowan, ND Woodward, R Li, MS Ansari, RM Baldwin, AN Schwartzman, RM Kessler, DH Zald	05/02/2012
Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks conference. Behavioural brain research	VB McGinty, BY Hayden, SR Heilbronner, EC Dumont, SM Graves, MM Mirrione, J du Hoffmann, GC Sartor, RA España, EZ Millan, AG Difeliceantonio, NJ Marchant, TC Napier, DH Root, SL Borgland, MT Treadway, SB Floresco, JF McGinty, S Haber	11/20/2011
Amping up effort: effects of d-amphetamine on human effort-based decision-making. The Journal of neuroscience : the official journal of the Society for Neuroscience	MC Wardle, MT Treadway, LM Mayo, DH Zald, H de Wit	11/16/2011
On the use and misuse of genomic and neuroimaging science in forensic psychiatry: current roles and future directions. Child and adolescent psychiatric clinics of North America	MT Treadway, JW Buckholtz	07/01/2011
Reconsidering anhedonia in depression: lessons from translational neuroscience. Neuroscience and biobehavioral reviews	MT Treadway, DH Zald	01/01/2011
Dopaminergic network differences in human impulsivity. Science (New York, N.Y.)	JW Buckholtz, MT Treadway, RL Cowan, ND Woodward, R Li, MS Ansari, RM Baldwin, AN Schwartzman, ES Shelby, CE Smith, RM Kessler, DH Zald	07/30/2010
Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. Nature neuroscience	JW Buckholtz, MT Treadway, RL Cowan, ND Woodward, SD Benning, R Li, MS Ansari, RM Baldwin, AN Schwartzman, ES Shelby, CE Smith, D Cole, RM Kessler, DH Zald	04/01/2010
Worth the 'EEfRT'? The effort expenditure for rewards task as an objective measure of motivation and anhedonia. PloS one	MT Treadway, JW Buckholtz, AN Schwartzman, WE Lambert, DH Zald	08/12/2009
Early adverse events, HPA activity and rostral anterior cingulate volume in MDD. PloS one	MT Treadway, MM Grant, Z Ding, SD Hollon, JC Gore, RC Shelton	01/01/2009