Shan Ping Yu, MD, PhD

Research Program

Discovery and Developmental Therapeutics
Phone Number

404-712-8678
Email Address

spyu@emory.edu

Biography

Shan Ping Yu, MD, PhD, is the O. Wayne Rollins Professor in the Department of Anesthesiology at Emory University School of Medicine. Dr. Yu has served in NIH and AHA study sections for several terms and in editorial boards of several national and international journals. He is an expert in the investigation of ionic and molecular mechanisms of neuronal cell death and stem cell differentiation.

Education

Dr. Yu received his PhD from State University of New York in Stony Brook, NY. He received his MD/MS from Capital University of Medical Sciences and Institute of Pharmacology and Toxicology in Beijing, China.

Titles & Roles

O. Wayne Rollins Professor, Department of Anesthesiology

Emory University School of Medicine

Research

Dr. Yu's research includes the development of novel therapies for stroke, cancer and pain.

Publications

Title/Journal	Authors	Publication Date
Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease. Neural regeneration research	SP Yu, E Choi, MQ Jiang, L Wei	07/01/2025
Reprogramming Glioblastoma Cells into Non-Cancerous Neuronal Cells as a Novel Anti-Cancer Strategy. Cells	MQ Jiang, SP Yu, T Estaba, E Choi, K Berglund, X Gu, L Wei	05/23/2024
Predictors of body image dissatisfaction among women at different stages of pregnancy:A cross-sectional study. Midwifery	Y Wu, S Yu, J Dai, T Zang, X Fan, Y Huang, X Xu, Y Lin, H Chen, C Zhou, J Bai, B Feng, Y Liu	02/01/2024
FSH and ApoE4 contribute to Alzheimer's disease-like pathogenesis via C/EBPβ/δ-secretase in female mice. Nature communications	J Xiong, SS Kang, M Wang, Z Wang, Y Xia, J Liao, X Liu, SP Yu, Z Zhang, V Ryu, T Yuen, M Zaidi, K Ye	10/18/2023
Strain hypothesis and additional evidence of the GluN3A deficiency-mediated pathogenesis of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association	SP Yu, M Jiang, K Berglund, L Wei	09/01/2023
Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer's disease. Molecular neurodegeneration	SP Yu, MQ Jiang, SS Shim, S Pourkhodadad, L Wei	07/03/2023
Lithium: An Old Drug for New Therapeutic Strategy for Alzheimer's Disease and Related Dementia. Neuro-degenerative diseases	SS Shim, K Berglund, SP Yu	01/01/2023
Glycosaminoglycan scaffolding and neural progenitor cell transplantation promotes regenerative immunomodulation in the mouse ischemic brain. Experimental neurology	MR McCrary, MQ Jiang, K Jesson, X Gu, MT Logun, A Wu, N Gonsalves, L Karumbaiah, SP Yu, L Wei	11/01/2022
C/EBPβ/AEP signaling couples atherosclerosis to the pathogenesis of Alzheimer's disease. Molecular psychiatry	J Liao, G Chen, X Liu, ZZ Wei, SP Yu, Q Chen, K Ye	07/01/2022
Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression. Science advances	Y Xia, H Qadota, ZH Wang, P Liu, X Liu, CJ Matheny, K Berglund, SP Yu, D Drake, DA Bennett, XC Wang, BA Yankner, GM Benian, K Ye	04/01/2022
FSH blockade improves cognition in mice with Alzheimer's disease. Nature	J Xiong, SS Kang, Z Wang, X Liu, TC Kuo, F Korkmaz, A Padilla, S Miyashita, P Chan, Z Zhang, P Katsel, J Burgess, A Gumerova, K Ievleva, D Sant, SP Yu, V Muradova, T Frolinger, D Lizneva, J Iqbal, KA Goosens, S Gera, CJ Rosen, V Haroutunian, V Ryu, T Yuen, M Zaidi, K Ye	03/01/2022
Pathogenesis of sporadic Alzheimer's disease by deficiency of NMDA receptor subunit GluN3A. Alzheimer's & dementia : the journal of the Alzheimer's Association	W Zhong, A Wu, K Berglund, X Gu, MQ Jiang, J Talati, J Zhao, L Wei, SP Yu	02/01/2022
Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer's disease pathology in a mouse model. Progress in neurobiology	ZH Wang, Y Xia, Z Wu, SS Kang, JC Zhang, P Liu, X Liu, W Song, V Huin, CM Dhaenens, SP Yu, XC Wang, K Ye	02/01/2022
DL-3-n-butylphthalide Increases Collateriogenesis and Functional Recovery after Focal Ischemic Stroke in Mice. Aging and disease	ZZ Wei, D Chen, MJH Lee, Y Zhao, X Gu, SP Yu, L Wei	10/01/2021
C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease. Molecular psychiatry	Y Xia, ZH Wang, J Zhang, X Liu, SP Yu, KX Ye, JZ Wang, K Ye, XC Wang	10/01/2021
Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease. Progress in neurobiology	Y Xia, ZH Wang, Z Zhang, X Liu, SP Yu, JZ Wang, XC Wang, K Ye	09/01/2021
ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease. Progress in neurobiology	ZH Wang, Y Xia, P Liu, X Liu, L Edgington-Mitchell, K Lei, SP Yu, XC Wang, K Ye	07/01/2021
Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America	Z Wu, C Chen, SS Kang, X Liu, X Gu, SP Yu, CD Keene, L Cheng, K Ye	06/22/2021
Systematic Review of Erythropoietin (EPO) for Neuroprotection in Human Studies. Neurochemical research	S Hemani, O Lane, S Agarwal, SP Yu, A Woodbury	04/01/2021
δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease. Molecular psychiatry	Z Zhang, XG Li, ZH Wang, M Song, SP Yu, SS Kang, X Liu, Z Zhang, M Xie, GP Liu, JZ Wang, K Ye	02/01/2021
Conversion of Reactive Astrocytes to Induced Neurons Enhances Neuronal Repair and Functional Recovery After Ischemic Stroke. Frontiers in aging neuroscience	MQ Jiang, SP Yu, ZZ Wei, W Zhong, W Cao, X Gu, A Wu, MR McCrary, K Berglund, L Wei	01/01/2021
DPP-4 Inhibitor Linagliptin is Neuroprotective in Hyperglycemic Mice with Stroke via the AKT/mTOR Pathway and Anti-apoptotic Effects. Neuroscience bulletin	G Zhang, S Kim, X Gu, SP Yu, L Wei	04/01/2020
Cortical Transplantation of Brain-Mimetic Glycosaminoglycan Scaffolds and Neural Progenitor Cells Promotes Vascular Regeneration and Functional Recovery after Ischemic Stroke in Mice. Advanced healthcare materials	MR McCrary, K Jesson, ZZ Wei, M Logun, C Lenear, S Tan, X Gu, MQ Jiang, L Karumbaiah, SP Yu, L Wei	03/01/2020
Improved trafficking and expression of luminopsins for more efficient optical and pharmacological control of neuronal activity. Journal of neuroscience research	JY Zhang, JK Tung, Z Wang, SP Yu, RE Gross, L Wei, K Berglund	03/01/2020
Neuropsychological Deficits Chronically Developed after Focal Ischemic Stroke and Beneficial Effects of Pharmacological Hypothermia in the Mouse. Aging and disease	W Zhong, Y Yuan, X Gu, SI Kim, R Chin, M Loye, TA Dix, L Wei, SP Yu	02/01/2020
Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology. Progress in neurobiology	Z Wu, ZH Wang, X Liu, Z Zhang, X Gu, SP Yu, CD Keene, L Cheng, K Ye	02/01/2020
Author Correction: C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease. Nature communications	ZH Wang, K Gong, X Liu, Z Zhang, X Sun, ZZ Wei, SP Yu, FP Manfredsson, IM Sandoval, PF Johnson, J Jia, JZ Wang, K Ye	11/26/2019
Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease. Cell reports	ZH Wang, J Xiang, X Liu, SP Yu, FP Manfredsson, IM Sandoval, S Wu, JZ Wang, K Ye	07/16/2019
Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies. Proceedings of the National Academy of Sciences of the United States of America	J Xiang, ZH Wang, EH Ahn, X Liu, SP Yu, FP Manfredsson, IM Sandoval, G Ju, S Wu, K Ye	04/30/2019
Neonatal Maternal Deprivation Followed by Adult Stress Enhances Adrenergic Signaling to Advance Visceral Hypersensitivity. Neuroscience bulletin	WJ Du, S Hu, X Li, PA Zhang, X Jiang, SP Yu, GY Xu	02/01/2019
Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies. The Journal of experimental medicine	ZH Wang, P Liu, X Liu, SP Yu, JZ Wang, K Ye	12/03/2018
BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT. JCI insight	ZH Wang, W Wu, SS Kang, X Liu, Z Wu, J Peng, SP Yu, FP Manfredsson, IM Sandoval, X Liu, JZ Wang, K Ye	08/23/2018
Impaired social behaviors and minimized oxytocin signaling of the adult mice deficient in the N-methyl-d-aspartate receptor GluN3A subunit. Experimental neurology	JH Lee, JY Zhang, ZZ Wei, SP Yu	07/01/2018
Correction to: Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities after Ischemic Stroke in Adult Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics	D Chen, L Wei, ZR Liu, JJ Yang, X Gu, ZZ Wei, LP Liu, SP Yu	07/01/2018
Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics	D Chen, L Wei, ZR Liu, JJ Yang, X Gu, ZZ Wei, LP Liu, SP Yu	07/01/2018
C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease. Nature communications	ZH Wang, K Gong, X Liu, Z Zhang, X Sun, ZZ Wei, SP Yu, FP Manfredsson, IM Sandoval, PF Johnson, J Jia, JZ Wang, K Ye	05/03/2018
Delayed and repeated intranasal delivery of bone marrow stromal cells increases regeneration and functional recovery after ischemic stroke in mice. BMC neuroscience	MJ Chau, TC Deveau, X Gu, YS Kim, Y Xu, SP Yu, L Wei	04/12/2018
Enhanced Neurogenesis and Collaterogenesis by Sodium Danshensu Treatment After Focal Cerebral Ischemia in Mice. Cell transplantation	ZZ Wei, D Chen, LP Liu, X Gu, W Zhong, YB Zhang, Y Wang, SP Yu, L Wei	04/01/2018
Intranasally Delivered Wnt3a Improves Functional Recovery after Traumatic Brain Injury by Modulating Autophagic, Apoptotic, and Regenerative Pathways in the Mouse Brain. Journal of neurotrauma	JY Zhang, JH Lee, X Gu, ZZ Wei, MJ Harris, SP Yu, L Wei	03/01/2018
Molecular Targets and Natural Compounds in Drug Development for the Treatment of Inflammatory Pain. Current drug targets	A Woodbury, MR McCrary, SP Yu	01/01/2018
DL-3-n-butylphthalide induced neuroprotection, regenerative repair, functional recovery and psychological benefits following traumatic brain injury in mice. Neurochemistry international	Y Zhao, JH Lee, D Chen, X Gu, A Caslin, J Li, SP Yu, L Wei	12/01/2017
Transplantation of iPS cell-derived neural progenitors overexpressing SDF-1α increases regeneration and functional recovery after ischemic stroke. Oncotarget	M Chau, TC Deveau, M Song, ZZ Wei, X Gu, SP Yu, L Wei	11/14/2017
Priming of the Cells: Hypoxic Preconditioning for Stem Cell Therapy. Chinese medical journal	ZZ Wei, YB Zhu, JY Zhang, MR McCrary, S Wang, YB Zhang, SP Yu, L Wei	10/05/2017
Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke. Progress in neurobiology	L Wei, ZZ Wei, MQ Jiang, O Mohamad, SP Yu	10/01/2017
Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease. Molecular cell	ZH Wang, P Liu, X Liu, FP Manfredsson, IM Sandoval, SP Yu, JZ Wang, K Ye	09/07/2017
Long-term survival and regeneration of neuronal and vasculature cells inside the core region after ischemic stroke in adult mice. Brain pathology (Zurich, Switzerland)	MQ Jiang, YY Zhao, W Cao, ZZ Wei, X Gu, L Wei, SP Yu	07/01/2017
Delayed treatment of 6-Bromoindirubin-3'-oxime stimulates neurogenesis and functional recovery after focal ischemic stroke in mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience	LL Wang, J Li, X Gu, L Wei, SP Yu	04/01/2017
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nature communications	Z Zhang, O Obianyo, E Dall, Y Du, H Fu, X Liu, SS Kang, M Song, SP Yu, C Cabrele, M Schubert, X Li, JZ Wang, H Brandstetter, K Ye	03/27/2017
Neuroprotective mechanisms and translational potential of therapeutic hypothermia in the treatment of ischemic stroke. Neural regeneration research	JH Lee, J Zhang, SP Yu	03/01/2017
Optogenetic stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice. Neurobiology of disease	M Song, SP Yu, O Mohamad, W Cao, ZZ Wei, X Gu, MQ Jiang, L Wei	02/01/2017
Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice. Neurobiology of disease	JH Lee, ZZ Wei, W Cao, S Won, X Gu, M Winter, TA Dix, L Wei, SP Yu	12/01/2016
Inhibition of cystathionine β-synthetase suppresses sodium channel activities of dorsal root ganglion neurons of rats with lumbar disc herniation. Scientific reports	J Yan, S Hu, K Zou, M Xu, Q Wang, X Miao, SP Yu, GY Xu	12/01/2016
Expression of the NMDA receptor subunit GluN3A (NR3A) in the olfactory system and its regulatory role on olfaction in the adult mouse. Brain structure & function	JH Lee, L Wei, TC Deveau, X Gu, SP Yu	07/01/2016
Improved Therapeutic Benefits by Combining Physical Cooling With Pharmacological Hypothermia After Severe Stroke in Rats. Stroke	JH Lee, L Wei, X Gu, S Won, ZZ Wei, TA Dix, SP Yu	07/01/2016
Neonatal inflammatory pain and systemic inflammatory responses as possible environmental factors in the development of autism spectrum disorder of juvenile rats. Journal of neuroinflammation	JH Lee, AR Espinera, D Chen, KE Choi, AY Caslin, S Won, V Pecoraro, GY Xu, L Wei, SP Yu	05/16/2016
Regeneration after stroke: Stem cell transplantation and trophic factors. Brain circulation	M Chau, J Zhang, L Wei, SP Yu	01/01/2016
Intracranial Transplantation of Hypoxia-Preconditioned iPSC-Derived Neural Progenitor Cells Alleviates Neuropsychiatric Defects After Traumatic Brain Injury in Juvenile Rats. Cell transplantation	ZZ Wei, JH Lee, Y Zhang, YB Zhu, TC Deveau, X Gu, MM Winter, J Li, L Wei, SP Yu	01/01/2016
Non-genetic Purification of Ventricular Cardiomyocytes from Differentiating Embryonic Stem Cells through Molecular Beacons Targeting IRX-4. Stem cell reports	K Ban, B Wile, KW Cho, S Kim, MK Song, SY Kim, J Singer, A Syed, SP Yu, M Wagner, G Bao, YS Yoon	12/08/2015
Honokiol for the Treatment of Neonatal Pain and Prevention of Consequent Neurobehavioral Disorders. Journal of natural products	A Woodbury, SP Yu, D Chen, X Gu, JH Lee, J Zhang, A Espinera, PS García, L Wei	11/25/2015
Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angiogenesis After Ischemic Stroke in Mice. ASN neuro	D Chen, J Lee, X Gu, L Wei, SP Yu	01/01/2015
Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in human glioblastoma cells. BMC cancer	D Chen, M Song, O Mohamad, SP Yu	09/26/2014
The TRPC channel blocker SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na(+) /Ca(2+) exchanger and increasing intracellular Ca(2+). British journal of pharmacology	M Song, D Chen, SP Yu	07/01/2014