Jun Zhou, PhD

Research Program

Discovery and Developmental Therapeutics
Phone Number

404-551-2873
Email Address

jun.zhou@emory.edu

Biography

Jun Zhou, PhD, is an associate professor in the Division of Medical Physics of the Department of Radiation Oncology at Emory University School of Medicine. An ABR board-certified medical physicist, Dr. Zhou serves as lead physicist at the Emory Proton Therapy Center.

Education

Dr. Zhou earned his PhD from Tsinghua University in China. He completed his postdoctoral training as a research associate in diagnostic radiologic physics at State University of New York in Stony Brook, New York and as research postdoctoral fellow in therapeutic radiologic physics at Columbia University in New York, New York.

Titles & Roles

Associate Professor, Department of Radiation Oncology

Emory University School of Medicine

Research

Dr. Zhou's research is focused on proton treatment planning, proton stereotactic body radiotherapy (SBRT), proton arc therapy, proton imaging and image-guided adaptive radiotherapy.

Publications

Title/Journal	Authors	Publication Date
Technical Considerations on Proton Therapy in NRG's Multi-Institutional Clinical Trials. International journal of radiation oncology, biology, physics	X Liang, PA Taylor, H Li, H Paganetti, M Pankuch, CJ Beltan, S Flampouri, BS Hoppe, H Kooy, H Lin, L Lin, W Liu, N Sahoo, CB Simone, BK Teo, Y Xiao, J Zhou, JC Buchsbaum	05/17/2026
Optimizing Transmission FLASH Radiotherapy for Large-Field Post-Mastectomy Breast Treatment. International journal of radiation oncology, biology, physics	AJ Zafar, SW Dutta, MJ Case, Z Diamond, D Bohannon, R Jagsi, X Yang, J Zhou	05/08/2026
Stereotactic arrhythmia radioablation for refractory ventricular tachycardia: A narrative review and pooled analysis of clinical outcomes and treatment delivery approaches. Journal of applied clinical medical physics	KD Shah, CW Chang, S Tian, P Patel, R Qiu, S Momin, J Roper, J Zhou, Z Tian, X Yang	05/01/2026
Clinically Interpretable Survival Risk Stratification in Head and Neck Cancer Using Bayesian Networks and Markov Blankets. International journal of radiation oncology, biology, physics	KD Shah, I Chamseddine, X Yuan, S Tian, R Qiu, J Zhou, A Dhabaan, H Al-Hallaq, DS Yu, H Paganetti, X Yang	03/01/2026
Knowledge-based plan library-guided adaptive proton stereotactic ablative radiotherapy (SABR) for localized prostate cancer. Medical physics	KD Shah, CW Chang, DH Bohannon, HS McGinnis, AJ Zafar, Z Diamond, VR Dhere, P Patel, A Dhabaan, H Al-Hallaq, X Yang, SA Patel, J Zhou	11/01/2025
Three-dimensional proton FLASH dose rate measurement at high spatiotemporal resolution using a novel multi-layer strip ionization chamber (MLSIC) device. Medical physics	S Zhou, A Darafsheh, Z Xiao, A Mascia, Y Zhang, J Zhou, L Lin, D Zhang, L Shen, H Jiang, Q Chen, T Zhao, S Perkins, T Zhang	10/01/2025
The effect of interfractional variation on delivered dose with ultrahypofractionated pencil beam scanning proton therapy for localized prostate cancer. Journal of applied clinical medical physics	KD Shah, DH Bohannon, SA Patel, CW Chang, VR Dhere, Y Wang, A Dhabaan, H Al-Hallaq, X Yang, J Zhou	09/01/2025
An adaptive proton FLASH therapy using modularized pin ridge filter. Medical physics	AJ Zafar, X Yang, Z Diamond, T Sibo, D Yu, PR Patel, J Zhou	09/01/2025
Patient-Specific Deep Reinforcement Learning for Automatic Replanning in Head-and-Neck Cancer Proton Therapy. ArXiv	M Madondo, Y Shao, Y Liu, J Zhou, X Yang, Z Tian	08/11/2025
NRG Oncology Liver Proton SBRT and Hypofractionated Radiation Therapy: Current Treatment Technical Assessment and Practice Patterns. Cancers	M Kang, PA Taylor, J Shen, J Zhou, J Saini, TS Hong, K Higgins, W Liu, Y Xiao, CB Simone, L Lin	07/17/2025
Comparison of proton and photon therapy in stereotactic arrhythmia radioablation for ventricular tachycardia. Physics and imaging in radiation oncology	KD Shah, CW Chang, P Patel, S Tian, Y Shao, KA Higgins, Y Wang, J Roper, J Zhou, Z Tian, X Yang	07/01/2025
Photon-counting CT in cancer radiotherapy: technological advances and clinical benefits. Physics in medicine and biology	KD Shah, J Zhou, J Roper, A Dhabaan, H Al-Hallaq, A Pourmorteza, X Yang	05/16/2025
Gantry-based pencil beam scanning proton therapy for uveal melanoma: IMPT versus proton arc therapy. Radiation oncology (London, England)	H Qi, L Hu, S Huang, YP Lee, F Yu, Q Chen, Y Yang, M Kang, H Zhai, M Vermeulen, A Shim, P Park, X Ding, J Zhou, DH Abramson, JH Francis, CB Simone, CA Barker, H Lin	04/02/2025
Evaluation and failure analysis of four commercial deep learning-based autosegmentation software for abdominal organs at risk. Journal of applied clinical medical physics	M Fan, T Wang, Y Lei, PR Patel, S Dresser, BB Ghavidel, RLJ Qiu, J Zhou, K Luca, O Kayode, JD Bradley, X Yang, J Roper	04/01/2025
A Comparative Dosimetric Study of Proton and Photon Therapy in Stereotactic Arrhythmia Radioablation for Ventricular Tachycardia. ArXiv	KD Shah, CW Chang, P Patel, S Tian, Y Shao, KA Higgins, Y Wang, J Roper, J Zhou, Z Tian, X Yang	02/04/2025
Exploration of an adaptive proton therapy strategy using CBCT with the concept of digital twins. Physics in medicine and biology	CW Chang, Z Tian, RLJ Qiu, H Scott Mcginnis, D Bohannon, P Patel, Y Wang, DS Yu, SA Patel, J Zhou, X Yang	01/17/2025
Photon-Counting CT in Cancer Radiotherapy: Technological Advances and Clinical Benefits. ArXiv	KD Shah, J Zhou, J Roper, A Dhabaan, H Al-Hallaq, A Pourmorteza, X Yang	12/04/2024
Feasibility study of modularized pin ridge filter implementation in proton FLASH planning for liver stereotactic ablative body radiotherapy. Physics in medicine and biology	C Ma, X Yang, J Setianegara, Y Wang, Y Gao, D Yu, P Patel, J Zhou	12/03/2024
Proton Therapy for Spinal Tumors: A Consensus Statement From the Particle Therapy Cooperative Group. International journal of radiation oncology, biology, physics	AM Chhabra, JW Snider, AJ Kole, M Stock, AL Holtzman, R Press, CJ Wang, H Li, H Lin, C Shi, M McDonald, M Soike, J Zhou, P Sabouri, S Mossahebi, R Colaco, F Albertini, CB Simone	11/15/2024
Deep learning-based Fast Volumetric Image Generation for Image-guided Proton Radiotherapy. IEEE transactions on radiation and plasma medical sciences	CW Chang, Y Lei, T Wang, S Tian, J Roper, L Lin, J Bradley, T Liu, J Zhou, X Yang	11/01/2024
Exploring dual energy CT synthesis in CBCT-based adaptive radiotherapy and proton therapy: application of denoising diffusion probabilistic models. Physics in medicine and biology	D Viar-Hernandez, J Manuel Molina-Maza, S Pan, E Salari, CW Chang, Z Eidex, J Zhou, J Antonio Vera-Sanchez, B Rodriguez-Vila, N Malpica, A Torrado-Carvajal, X Yang	10/18/2024
Impact of Rectal Spacer on Toxicity Reduction in Men Treated With Proton Versus Photon Therapy. International journal of particle therapy	VR Dhere, S Goyal, J Zhou, NT Sebastian, AB Patel, S Hanasoge, PR Patel, J Shelton, KD Godette, BW Hershatter, AB Jani, SA Patel	09/01/2024
CT-based synthetic iodine map generation using conditional denoising diffusion probabilistic model. Medical physics	Y Gao, H Xie, CW Chang, J Peng, S Pan, RLJ Qiu, T Wang, B Ghavidel, J Roper, J Zhou, X Yang	09/01/2024
Diffeomorphic transformer-based abdomen MRI-CT deformable image registration. Medical physics	Y Lei, LA Matkovic, J Roper, T Wang, J Zhou, B Ghavidel, M McDonald, P Patel, X Yang	09/01/2024
CT-based synthetic contrast-enhanced dual-energy CT generation using conditional denoising diffusion probabilistic model. Physics in medicine and biology	Y Gao, RLJ Qiu, H Xie, CW Chang, T Wang, B Ghavidel, J Roper, J Zhou, X Yang	08/02/2024
NRG Oncology and Particle Therapy Co-Operative Group Patterns of Practice Survey and Consensus Recommendations on Pencil-Beam Scanning Proton Stereotactic Body Radiation Therapy and Hypofractionated Radiation Therapy for Thoracic Malignancies. International journal of radiation oncology, biology, physics	W Liu, H Feng, PA Taylor, M Kang, J Shen, J Saini, J Zhou, HB Giap, NY Yu, TS Sio, P Mohindra, JY Chang, JD Bradley, Y Xiao, CB Simone, L Lin	07/15/2024
A Novel Inverse Algorithm To Solve the Integrated Optimization of Dose, Dose Rate, and Linear Energy Transfer of Proton FLASH Therapy With Sparse Filters. International journal of radiation oncology, biology, physics	N Harrison, M Kang, R Liu, S Charyyev, N Wahl, W Liu, J Zhou, KA Higgins, CB Simone, JD Bradley, WS Dynan, L Lin	07/01/2024
Proton 3D dose measurement with a multi-layer strip ionization chamber (MLSIC) device. Physics in medicine and biology	S Zhou, Q Chen, J Haefner, W Smith, A Darafsheh, T Zhao, NA Harrison, J Zhou, L Lin, W Lu, L Shen, H Jiang, T Zhang	06/26/2024
Author Correction: MRI-only based material mass density and relative stopping power estimation via deep learning for proton therapy: a preliminary study. Scientific reports	Y Gao, CW Chang, S Mandava, R Marants, JE Scholey, M Goette, Y Lei, H Mao, JD Bradley, T Liu, J Zhou, A Sudhyadhom, X Yang	06/25/2024
Targeting EED as a key PRC2 complex mediator toward novel epigenetic therapeutics. Drug discovery today	Q Bao, A Kumar, D Wu, J Zhou	06/01/2024
Immune System Dose With Proton Versus Photon Radiotherapy for Treatment of Locally Advanced NSCLC. International journal of particle therapy	JS Patel, NS McCall, M Thomas, J Zhou, KA Higgins, JD Bradley, S Tian, MW McDonald, AH Kesarwala, WA Stokes	06/01/2024
Cardiac MRI segmentation using shifted-window multilayer perceptron mixer networks. Physics in medicine and biology	E Abouei, S Pan, M Hu, AH Kesarwala, RLJ Qiu, J Zhou, J Roper, X Yang	05/30/2024
MRI-only based material mass density and relative stopping power estimation via deep learning for proton therapy: a preliminary study. Scientific reports	Y Gao, CW Chang, S Mandava, R Marants, JE Scholey, M Goette, Y Lei, H Mao, JD Bradley, T Liu, J Zhou, A Sudhyadhom, X Yang	05/15/2024
Diffeomorphic Transformer-based Abdomen MRI-CT Deformable Image Registration. ArXiv	Y Lei, LA Matkovic, J Roper, T Wang, J Zhou, B Ghavidel, M McDonald, P Patel, X Yang	05/04/2024
A retrospective study on the investigation of potential dosimetric benefits of online adaptive proton therapy for head and neck cancer. Journal of applied clinical medical physics	CW Chang, D Bohannon, Z Tian, Y Wang, MW Mcdonald, DS Yu, T Liu, J Zhou, X Yang	05/01/2024
Streamlined pin-ridge-filter design for single-energy proton FLASH planning. Medical physics	C Ma, J Zhou, CW Chang, Y Wang, PR Patel, DS Yu, S Tian, X Yang	04/01/2024
The Status and Challenges for Prostate Stereotactic Body Radiation Therapy Treatments in United States Proton Therapy Centers: An NRG Oncology Practice Survey. International journal of particle therapy	J Shen, PA Taylor, CE Vargas, M Kang, J Saini, J Zhou, P Wang, W Liu, CB Simone, Y Xiao, L Lin	03/01/2024
The status and challenges for prostate SBRT treatments in United States proton therapy centers: An NRG Oncology practice survey. ArXiv	J Shen, PA Taylor, CE Vargas, M Kang, J Saini, J Zhou, P Wang, W Liu, CBS Ii, Y Xiao, L Lin	02/27/2024
Proton Pencil-Beam Scanning Stereotactic Body Radiation Therapy and Hypofractionated Radiation Therapy for Thoracic Malignancies: Patterns of Practice Survey and Recommendations for Future Development from NRG Oncology and PTCOG. ArXiv	W Liu, H Feng, PA Taylor, M Kang, J Shen, J Saini, J Zhou, HB Giap, NY Yu, TS Sio, P Mohindra, JY Chang, JD Bradley, Y Xiao, CB Simone, L Lin	02/01/2024
Deep learning-based synthetic dose-weighted LET map generation for intensity modulated proton therapy. Physics in medicine and biology	Y Gao, CW Chang, S Pan, J Peng, C Ma, P Patel, J Roper, J Zhou, X Yang	01/05/2024
Initial experience and patient tolerance of proton stereotactic body radiotherapy. Journal of radiosurgery and SBRT	N Ali, J Zhou, BR Eaton, JM Switchenko, Y Cao, WA Stokes, PR Patel, KM Langen, R Slopsema, JD Bradley, MW McDonald	01/01/2024
Multimodal imaging-based material mass density estimation for proton therapy using supervised deep learning. The British journal of radiology	CW Chang, R Marants, Y Gao, M Goette, JE Scholey, JD Bradley, T Liu, J Zhou, A Sudhyadhom, X Yang	12/01/2023
Streamlined Pin-Ridge-Filter Design for Single-energy Proton FLASH Planning. ArXiv	C Ma, J Zhou, CW Chang, Y Wang, PR Patel, DS Yu, S Tian, X Yang	10/03/2023
An optimized framework for cone-beam computed tomography-based online evaluation for proton therapy. Medical physics	CW Chang, R Nilsson, S Andersson, D Bohannon, SA Patel, PR Patel, T Liu, X Yang, J Zhou	09/01/2023
Deep learning-based Fast Volumetric Image Generation for Image-guided Proton FLASH Radiotherapy. Research square	CW Chang, Y Lei, T Wang, S Tian, J Roper, L Lin, J Bradley, T Liu, J Zhou, X Yang	07/26/2023
An Integrated Physical Optimization Framework for Proton Stereotactic Body Radiation Therapy FLASH Treatment Planning Allows Dose, Dose Rate, and Linear Energy Transfer Optimization Using Patient-Specific Ridge Filters. International journal of radiation oncology, biology, physics	R Liu, S Charyyev, N Wahl, W Liu, M Kang, J Zhou, X Yang, F Baltazar, M Palkowitsch, K Higgins, W Dynan, J Bradley, L Lin	07/15/2023
Measurement of the time structure of FLASH beams using prompt gamma rays and secondary neutrons as surrogates. Physics in medicine and biology	S Charyyev, R Liu, X Yang, J Zhou, A Dhabaan, WS Dynan, C Oancea, L Lin	07/12/2023
Prediction of plan adaptation in head and neck cancer proton therapy using clinical, radiographic, and dosimetric features. Acta oncologica (Stockholm, Sweden)	D Bohannon, J Janopaul-Naylor, S Rudra, X Yang, CW Chang, Y Wang, C Ma, SA Patel, MW McDonald, J Zhou	06/01/2023
Feasibility study of hybrid inverse planning with transmission beams and single-energy spread-out Bragg peaks for proton FLASH radiotherapy. Medical physics	C Ma, X Yang, CW Chang, R Liu, D Bohannon, L Lin, T Liu, S Tian, J Zhou	06/01/2023
Deep learning-based protoacoustic signal denoising for proton range verification. Biomedical physics & engineering express	J Wang, JJ Sohn, Y Lei, W Nie, J Zhou, S Avery, T Liu, X Yang	05/12/2023
Early in vivo Radiation Damage Quantification for Pediatric Craniospinal Irradiation Using Longitudinal MRI for Intensity Modulated Proton Therapy. Advances in radiation oncology	CW Chang, M Goette, N Kadom, Y Wang, J Wynne, T Wang, T Liu, N Esiashvili, J Zhou, BR Eaton, X Yang	01/01/2023
Single energy CT-based mass density and relative stopping power estimation for proton therapy using deep learning method. Frontiers in oncology	Y Gao, CW Chang, J Roper, M Axente, Y Lei, S Pan, JD Bradley, J Zhou, T Liu, X Yang	01/01/2023
Advances in treatment planning and management for the safety and accuracy of lung stereotactic body radiation therapy using proton pencil beam scanning: Simulation, planning, quality assurance, and delivery recommendations. Journal of radiosurgery and SBRT	M Kang, JI Choi, K Souris, J Zhou, G Yu, AF Shepherd, N Ohri, S Lazarev, L Lin, H Lin, CB Simone	01/01/2023
Proton liver stereotactic body radiation therapy: Treatment techniques and dosimetry feasibility from a single institution. Journal of radiosurgery and SBRT	J Zhou, M Kang, Y Wang, KA Higgins, CB Simone, P Patel, MW McDonald, L Lin, D Bohannon	01/01/2023
Deformable CT image registration via a dual feasible neural network. Medical physics	Y Lei, Y Fu, Z Tian, T Wang, X Dai, J Roper, DS Yu, M McDonald, JD Bradley, T Liu, J Zhou, X Yang	12/01/2022
Validation of a deep learning-based material estimation model for Monte Carlo dose calculation in proton therapy. Physics in medicine and biology	CW Chang, S Zhou, Y Gao, L Lin, T Liu, JD Bradley, T Zhang, J Zhou, X Yang	10/19/2022
A potential revolution in cancer treatment: A topical review of FLASH radiotherapy. Journal of applied clinical medical physics	Y Gao, R Liu, CW Chang, S Charyyev, J Zhou, JD Bradley, T Liu, X Yang	10/01/2022
Dual-energy CT based mass density and relative stopping power estimation for proton therapy using physics-informed deep learning. Physics in medicine and biology	CW Chang, Y Gao, T Wang, Y Lei, Q Wang, S Pan, A Sudhyadhom, JD Bradley, T Liu, L Lin, J Zhou, X Yang	05/26/2022
Onboard cone-beam CT-based replan evaluation for head and neck proton therapy. Journal of applied clinical medical physics	A Stanforth, L Lin, JJ Beitler, JR Janopaul-Naylor, CW Chang, RH Press, SA Patel, J Zhao, B Eaton, EE Schreibmann, J Jung, D Bohannon, T Liu, X Yang, MW McDonald, J Zhou	05/01/2022
Review of Machine Learning in Lung Ultrasound in COVID-19 Pandemic. Journal of imaging	J Wang, X Yang, B Zhou, JJ Sohn, J Zhou, JT Jacob, KA Higgins, JD Bradley, T Liu	03/05/2022
Multi-organ auto-delineation in head-and-neck MRI for radiation therapy using regional convolutional neural network. Physics in medicine and biology	X Dai, Y Lei, T Wang, J Zhou, S Rudra, M McDonald, WJ Curran, T Liu, X Yang	01/21/2022
Bone Marrow Suppression during Postoperative Radiation for Bladder Cancer and Comparative Benefit of Proton Therapy-Phase 2 Trial Secondary Analysis. International journal of particle therapy	RH Press, JW Shelton, C Zhang, Q Dang, S Tian, T Shu, CS Seldon, S Hasan, AB Jani, J Zhou, MW McDonald	01/01/2022
Learning-based synthetic dual energy CT imaging from single energy CT for stopping power ratio calculation in proton radiation therapy. The British journal of radiology	S Charyyev, T Wang, Y Lei, B Ghavidel, JJ Beitler, M McDonald, WJ Curran, T Liu, J Zhou, X Yang	01/01/2022
Automated delineation of head and neck organs at risk using synthetic MRI-aided mask scoring regional convolutional neural network. Medical physics	X Dai, Y Lei, T Wang, J Zhou, J Roper, M McDonald, JJ Beitler, WJ Curran, T Liu, X Yang	10/01/2021
Is proton beam therapy ready for single fraction spine SBRS? - a feasibility study to use spot-scanning proton arc (SPArc) therapy to improve the robustness and dosimetric plan quality. Acta oncologica (Stockholm, Sweden)	G Liu, X Li, A Qin, J Zhou, W Zheng, L Zhao, J Han, S Zhang, D Yan, C Stevens, I Grills, X Ding	05/01/2021
Synthetic dual-energy CT for MRI-only based proton therapy treatment planning using label-GAN. Physics in medicine and biology	R Liu, Y Lei, T Wang, J Zhou, J Roper, L Lin, MW McDonald, JD Bradley, WJ Curran, T Liu, X Yang	03/09/2021
Learning-Based Stopping Power Mapping on Dual-Energy CT for Proton Radiation Therapy. International journal of particle therapy	T Wang, Y Lei, J Harms, B Ghavidel, L Lin, JJ Beitler, M McDonald, WJ Curran, T Liu, J Zhou, X Yang	01/01/2021
High quality proton portal imaging using deep learning for proton radiation therapy: a phantom study. Biomedical physics & engineering express	S Charyyev, Y Lei, J Harms, B Eaton, M McDonald, WJ Curran, T Liu, J Zhou, R Zhang, X Yang	04/27/2020
Block copolymer-based gadolinium nanoparticles as MRI contrast agents with high T1 relaxivity. Nanomedicine (London, England)	S Hou, S Tong, J Zhou, G Bao	02/01/2012