Byron Au-Yeung, PhD

Research Program

Cancer Immunology
Phone Number

404-712-2943
Email Address

byron.au-yeung@emory.edu

Biography

Byron Au-Yeung, PhD, is an assistant professor in the Division of Rheumatology of the Department of Medicine at Emory University School of Medicine. Dr. Au-Yeung serves on the faculty of the Immunology and Molecular Pathogenesis (IMP) program in the Graduate Division of Biological and Biomedical Sciences of Emory's Laney Graduate School.

Dr. Au-Yeung is a member of the Cancer Immunology Research Program at Winship Cancer Institute of Emory University.

Education

He earned his PhD in immunology from the University of Rochester in Rochester, New York. He completed his postdoctoral training in immunology at University of California, San Francisco in San Francisco, California.

Titles & Roles

Assistant Professor, Department of Medicine

Emory University School of Medicine

Research

Dr. Au-Yeung's laboratory investigates how T cells adapt to the strength of basal T cell antigen receptor (TCR) signaling and the subsequent effects of these adaptations on T cell activation.

Publications

Dr. Au-Yeung has been published in a number of leading scientific journals.

Title/Journal	Authors	Publication Date
An early precursor CD8⁺ T cell that adapts to acute or chronic viral infection. Nature	DT McManus, RM Valanparambil, CB Medina, CD Scharer, DJ McGuire, E Sobierajska, Y Hu, DY Chang, A Wieland, J Lee, TH Nasti, M Hashimoto, JL Ross, N Prokhnevska, MA Cardenas, AL Gill, EC Clark, K Abadie, AJ Kumar, J Kaye, BB Au-Yeung, HY Kueh, HT Kissick, R Ahmed	04/01/2025
Identification of indirect CD4⁺ T cell epitopes associated with transplant rejection provides a target for donor-specific tolerance induction. Immunity	Z Zhanzak, AC Johnson, P Foster, MA Cardenas, AB Morris, J Zhang, G Karadkhele, IR Badell, AA Morris, BB Au-Yeung, FM Roversi, JAF Silva, C Breeden, A Hadley, W Zhang, CP Larsen, HT Kissick	02/11/2025
Nr4a1 and Nr4a3 redundantly control clonal deletion and contribute to an anergy-like transcriptome in auto-reactive thymocytes to impose tolerance in mice. Nature communications	HV Nielsen, L Yang, JL Mueller, AJ Ritter, R Hiwa, I Proekt, E Rackaityte, D Aylard, M Gupta, CD Scharer, MS Anderson, BB Au-Yeung, J Zikherman	01/17/2025
Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis. Science immunology	C Elkins, C Ye, P Sivasami, R Mulpur, PP Diaz-Saldana, A Peng, M Xu, YP Chiang, S Moll, DE Rivera-Rodriguez, L Cervantes-Barragan, T Wu, BB Au-Yeung, CD Scharer, ML Ford, H Kissick, C Li	01/10/2025
Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics. Science immunology	L Turner, TN Van Le, E Cross, C Queriault, M Knight, K Trihemasava, J Davis, P Schaefer, J Nguyen, J Xu, B Goldspiel, E Hall, K Rome, M Scaglione, J Eggert, B Au-Yeung, DC Wallace, C Mesaros, JA Baur, W Bailis	03/15/2024
Early generation of a precursor CD8 T cell that can adapt to acute or chronic viral infection. Research square	DT McManus, RM Valanparambil, CB Medina, Y Hu, CD Scharer, E Sobierajska, DY Chang, A Wieland, J Lee, TH Nasti, M Hashimoto, JL Ross, N Prokhnevska, MA Cardenas, AL Gill, EC Clark, K Abadie, HY Kueh, J Kaye, BB Au-Yeung, HT Kissick, R Ahmed	02/12/2024
Cbl-b mitigates the responsiveness of naive CD8⁺ T cells that experience extensive tonic T cell receptor signaling. Science signaling	J Eggert, WM Zinzow-Kramer, Y Hu, EM Kolawole, YL Tsai, A Weiss, BD Evavold, K Salaita, CD Scharer, BB Au-Yeung	02/06/2024
The T-cell niche tunes immune function through modulation of the cytoskeleton and TCR-antigen forces. bioRxiv : the preprint server for biology	AV Kellner, R Hunter, P Do, J Eggert, M Jaffe, DK Geitgey, M Lee, JAG Hamilton, AJ Ross, RS Ank, RL Bender, R Ma, CC Porter, EC Dreaden, BB Au-Yeung, KA Haynes, CJ Henry, K Salaita	02/02/2024
Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness. bioRxiv : the preprint server for biology	J Eggert, WM Zinzow-Kramer, Y Hu, YL Tsai, A Weiss, K Salaita, CD Scharer, BB Au-Yeung	01/28/2023
The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P₂ replenishment in response to TCR signaling during T cell development and survival. Nature immunology	W Lu, YA Helou, K Shrinivas, J Liou, BB Au-Yeung, A Weiss	01/01/2023
Strong Basal/Tonic TCR Signals Are Associated with Negative Regulation of Naive CD4⁺ T Cells. ImmunoHorizons	WM Zinzow-Kramer, EM Kolawole, J Eggert, BD Evavold, CD Scharer, BB Au-Yeung	09/13/2022
Functional heterogeneity and adaptation of naive T cells in response to tonic TCR signals. Current opinion in immunology	J Eggert, BB Au-Yeung	12/01/2021
Adaptation by naïve CD4⁺ T cells to self-antigen-dependent TCR signaling induces functional heterogeneity and tolerance. Proceedings of the National Academy of Sciences of the United States of America	WM Zinzow-Kramer, A Weiss, BB Au-Yeung	07/23/2019