Jeremy Boss, PhD

Research Program

Cancer Immunology
Phone Number

404-727-5973
Email Address

jmboss@emory.edu

Biography

Jeremy M. Boss, PhD, is Professor and Chair of the Department of Microbiology and Immunology at Emory University School of Medicine in Atlanta, Georgia. Dr. Boss is the Emory Chair in Basic Sciences Research and also serves as associate dean of basic research at Emory University School of Medicine. He is a member of the Cancer Immunology Research Program at Winship Cancer Institute.

Education

Dr. Boss received his PhD in Molecular Biology from the State University of New York in Albany, NY. He completed his postdoctoral training in Immunology at Harvard University in Cambridge, MA.

Titles & Roles

Emory Chair in Basic Science Research

Emory University School of Medicine
Professor and Chair, Department of Microbiology and Immunology

Emory University School of Medicine
Associate Dean of Basic Research

Emory University School of Medicine

Research

Dr. Boss uses genetic, biochemical, immunological, and molecular biological technologies to unravel the mechanisms by which immune system genes are regulated. Several systems are studied. The first focuses is on the major histocompatibility complex class II (MHC-II) genes, which are responsible for the presentation of foreign antigens to T lymphocytes. Proper tissue specific regulation of MHC-II genes is essential for the control and development of immune-based responses to pathogens and protecting from cancer and autoimmune disorders. His lab's studies examine the role that modifiers of chromatin structure play in organizing the architecture and expression of MHC-II genes.

Recently, his lab found that interactions between transcriptional insulators and gene promoters form a unique architecture within the nucleus of each cell that is critical to expression of the gene system. Identification of the factors that control this architecture is a current thrust of the work as these are potential targets to manipulate immune responses and improve the efficacy of vaccination protocols.

The second involves studies that focus on the molecular regulation of programmed cell death-1 (PD-1) during viral infection and cancer. PD-1 expression controls the ability of T cells to function and remove virus-infected cells or cancer cells. PD-1 is regulated by a complex set of transcription factors that activate or repress the expression. Manipulating these factors leads to prolonged PD-1 expression and failure to clear tumors or fight infection.

Third, his lab is also determining the epigenetic mechanisms that control lymphocyte cell fate using mouse models of infection as well as studies examining B cells associated with systemic lupus erythematosus (SLE). These studies are expected to lead to novel therapeutic targets to help improve vaccination and cancer therapies and treat autoimmune diseases.

Grants

View Grants

Grant Number	Title
1R01AI153102-01	Role of the DR/DQ super enhancer in MHC-II expression
5R01AI153102-02	Role of the DR/DQ super enhancer in MHC-II expression
5R01AI153102-03	Role of the DR/DQ super enhancer in MHC-II expression
5R01AI153102-04	Role of the DR/DQ super enhancer in MHC-II expression
5R01AI153102-05	Role of the DR/DQ super enhancer in MHC-II expression

Publications

Title/Journal	Authors	Publication Date
EZH2 coordinates memory B-cell programming and recall responses. Journal of immunology (Baltimore, Md. : 1950)	KJ Wiggins, ME Williams, SL Hicks, HO Padilla-Quirarte, J Akther, TD Randall, JM Boss, CD Scharer	05/01/2025
MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson's HLA locus exhibits epigenetic regulation. Scientific reports	EM Kline, JE Jernigan, CD Scharer, J Maurer, SL Hicks, MK Herrick, RL Wallings, SD Kelly, J Chang, KB Menees, NR McFarland, JM Boss, MG Tansey, V Joers	04/21/2025
MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson's HLA locus exhibits epigenetic regulation. bioRxiv : the preprint server for biology	EM Kline, JE Jernigan, CD Scharer, J Maurer, S Hicks Sl, MK Herrick M, RL Wallings, SD Kelly, J Chang, KB Menees, NR McFarland, JM Boss, MG Tansey, V Joers	03/04/2025
Human immune organoids to decode B cell response in healthy donors and patients with lymphoma. Nature materials	Z Zhong, M Quiñones-Pérez, Z Dai, VM Juarez, E Bhatia, CR Carlson, SB Shah, A Patel, Z Fang, T Hu, M Allam, SL Hicks, M Gupta, SL Gupta, E Weeks, SD Vagelos, A Molina, A Mulero-Russe, A Mora-Boza, DJ Joshi, RP Sekaly, T Sulchek, SL Goudy, J Wrammert, K Roy, JM Boss, AF Coskun, CD Scharer, AJ García, JL Koff, A Singh	02/01/2025
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control. Nature immunology	SA Weiss, AY Huang, ME Fung, D Martinez, ACY Chen, TJ LaSalle, BC Miller, CD Scharer, M Hegde, TH Nguyen, JH Rowe, JF Osborn, DG Patterson, N Sifnugel, C Mei-An Nolan, RA Davidson, MA Schwartz, APR Bally, DK Neeld, MW LaFleur, JM Boss, JG Doench, W Nicholas Haining, AH Sharpe, DR Sen	10/01/2024
Chronic viral infection alters PD-1 locus subnuclear localization in cytotoxic CD8⁺ T cells. Cell reports	C Sacristán, BA Youngblood, P Lu, APR Bally, JX Xu, K McGary, SL Hewitt, JM Boss, JA Skok, R Ahmed, ML Dustin	08/27/2024
Factors associated with immune responses to SARS-CoV-2 vaccination in individuals with autoimmune diseases. JCI insight	E Anderson, M Powell, E Yang, A Kar, TM Leung, C Sison, R Steinberg, R Mims, A Choudhury, C Espinosa, J Zelmanovich, NC Okoye, EJ Choi, G Marder, S Narain, PK Gregersen, M Mackay, B Diamond, T Levy, TP Zanos, A Khosroshahi, I Sanz, ET Luning Prak, A Bar-Or, J Merrill, C Arriens, G Pardo, J Guthridge, J James, A Payne, PJ Utz, JM Boss, C Aranow, A Davidson	06/04/2024
Exploration of potential immune mechanisms in cervical dystonia. Parkinsonism & related disorders	LM Scorr, G Kilic-Berkmen, DJ Sutcliffe, AR Dinasarapu, JL McKay, P Bagchi, MD Powell, JM Boss, N Cereb, M Little, L Gragert, J Hanfelt, A McKeon, W Tyor, HA Jinnah	05/01/2024
Prevention of respiratory virus transmission by resident memory CD8⁺ T cells. Nature	I Uddbäck, SE Michalets, A Saha, C Mattingly, KN Kost, ME Williams, LA Lawrence, SL Hicks, AC Lowen, H Ahmed, AR Thomsen, CJ Russell, CD Scharer, JM Boss, K Koelle, R Antia, JP Christensen, JE Kohlmeier	02/01/2024
CRISPR/Cas9 editing reveals IRF8 regulated gene signatures restraining plasmablast differentiation. Heliyon	Z Zuo, AK Kania, DG Patterson, SL Hicks, J Maurer, M Gupta, JM Boss, CD Scharer	06/01/2023
The 'omics of obesity in B-cell acute lymphoblastic leukemia. Journal of the National Cancer Institute. Monographs	DK Geitgey, M Lee, KA Cottrill, M Jaffe, W Pilcher, S Bhasin, J Randall, AJ Ross, M Salemi, M Castillo-Castrejon, MB Kilgore, AC Brown, JM Boss, R Johnston, AM Fitzpatrick, ML Kemp, R English, E Weaver, P Bagchi, R Walsh, CD Scharer, M Bhasin, JD Chandler, KA Haynes, EA Wellberg, CJ Henry	05/04/2023
A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans. Immunity	A Nellore, E Zumaquero, CD Scharer, CF Fucile, CM Tipton, RG King, T Mi, B Mousseau, JE Bradley, F Zhou, S Mutneja, PA Goepfert, JM Boss, TD Randall, I Sanz, AF Rosenberg, FE Lund	04/11/2023
Distinct transcriptomic and epigenomic modalities underpin human memory T cell subsets and their activation potential. Communications biology	JR Rose, B Akdogan-Ozdilek, AR Rahmberg, MD Powell, SL Hicks, CD Scharer, JM Boss	04/03/2023
Aiolos represses CD4⁺ T cell cytotoxic programming via reciprocal regulation of T_FH transcription factors and IL-2 sensitivity. Nature communications	KA Read, DM Jones, S Pokhrel, EDS Hales, A Varkey, JA Tuazon, CD Eisele, O Abdouni, A Saadey, MR Leonard, RT Warren, MD Powell, JM Boss, EA Hemann, JS Yount, G Xin, HE Ghoneim, CJ Lio, AG Freud, PL Collins, KJ Oestreich	03/24/2023
Deletion of histone demethylase Lsd1 (Kdm1a) during retinal development leads to defects in retinal function and structure. Frontiers in cellular neuroscience	S Ferdous, DA Shelton, TE Getz, MA Chrenek, N L'Hernault, JT Sellers, VR Summers, PM Iuvone, JM Boss, JH Boatright, JM Nickerson	01/01/2023
IL-6/STAT3 Signaling Axis Enhances and Prolongs Pdcd1 Expression in Murine CD8 T Cells. ImmunoHorizons	MD Powell, P Lu, DK Neeld, AK Kania, LMM George-Alexander, APR Bally, CD Scharer, JM Boss	12/01/2022
Persistent Antigen Harbored by Alveolar Macrophages Enhances the Maintenance of Lung-Resident Memory CD8⁺ T Cells. Journal of immunology (Baltimore, Md. : 1950)	JL Lobby, I Uddbäck, CD Scharer, T Mi, JM Boss, AR Thomsen, JP Christensen, JE Kohlmeier	11/01/2022
The Regulation of Immunity. Journal of immunology (Baltimore, Md. : 1950)	JM Boss	06/01/2022
Somatic Diversification of Rearranged Antibody Gene Segments by Intra- and Interchromosomal Templated Mutagenesis. Journal of immunology (Baltimore, Md. : 1950)	GA Dale, DJ Wilkins, J Rowley, CD Scharer, CM Tipton, J Hom, JM Boss, V Corces, I Sanz, J Jacob	05/01/2022
H3K27me3 Demethylase UTX Restrains Plasma Cell Formation. Journal of immunology (Baltimore, Md. : 1950)	AK Kania, MJ Price, LE George-Alexander, DG Patterson, SL Hicks, CD Scharer, JM Boss	04/15/2022
Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia. Nature communications	M Lee, JAG Hamilton, GR Talekar, AJ Ross, L Michael, M Rupji, B Dwivedi, SS Raikar, J Boss, CD Scharer, DK Graham, D DeRyckere, CC Porter, CJ Henry	03/03/2022
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting. Life science alliance	CJ Joyner, AM Ley, DC Nguyen, M Ali, A Corrado, C Tipton, CD Scharer, T Mi, MC Woodruff, J Hom, JM Boss, M Duan, G Gibson, D Roberts, J Andrews, S Lonial, I Sanz, FE Lee	03/01/2022
Germline ETV6 mutation promotes inflammation and disrupts lymphoid development of early hematopoietic progenitors. Experimental hematology	C Zhou, R Uluisik, JW Rowley, C David, CL Jones, CD Scharer, L Noetzli, MH Fisher, GD Kirkpatrick, K Bark, JM Boss, CJ Henry, EM Pietras, J Di Paola, CC Porter	01/01/2022
Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs. Frontiers in cell and developmental biology	M Lee, DK Geitgey, JAG Hamilton, JM Boss, CD Scharer, JM Spangle, KA Haynes, CJ Henry	01/01/2022
Inhibition of H3K27me3 Demethylases Promotes Plasmablast Formation. ImmunoHorizons	AK Kania, M Guo, CD Scharer, JM Boss	12/08/2021
An IRF4-MYC-mTORC1 Integrated Pathway Controls Cell Growth and the Proliferative Capacity of Activated B Cells during B Cell Differentiation In Vivo. Journal of immunology (Baltimore, Md. : 1950)	DG Patterson, AK Kania, MJ Price, JR Rose, CD Scharer, JM Boss	10/01/2021
Epigenetic gene regulation in plasma cells. Immunological reviews	DG Patterson, AK Kania, Z Zuo, CD Scharer, JM Boss	09/01/2021
Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa. Mucosal immunology	A Corrado, RP Ramonell, MC Woodruff, C Tipton, S Wise, J Levy, J DelGaudio, ME Kuruvilla, KR Magliocca, D Tomar, S Garimalla, CD Scharer, JM Boss, H Wu, S Gumber, C Fucile, G Gibson, A Rosenberg, I Sanz, FE Lee	09/01/2021
The Murine MHC Class II Super Enhancer IA/IE-SE Contains a Functionally Redundant CTCF-Binding Component and a Novel Element Critical for Maximal Expression. Journal of immunology (Baltimore, Md. : 1950)	P Majumder, JT Lee, BG Barwick, DG Patterson, APR Bally, CD Scharer, JM Boss	05/01/2021
Conserved Epigenetic Programming and Enhanced Heme Metabolism Drive Memory B Cell Reactivation. Journal of immunology (Baltimore, Md. : 1950)	MJ Price, CD Scharer, AK Kania, TD Randall, JM Boss	04/01/2021
Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes. Frontiers in immunology	MA Rivas, C Durmaz, A Kloetgen, CR Chin, Z Chen, B Bhinder, A Koren, AD Viny, CD Scharer, JM Boss, O Elemento, CE Mason, AM Melnick	01/01/2021
Selective DNA Demethylation Accompanies T Cell Homeostatic Proliferation and Gene Regulation in Lupus-Prone lpr Mice. ImmunoHorizons	CD Scharer, KA Fortner, JA Dragon, S Tighe, JM Boss, RC Budd	10/23/2020
Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons. Human molecular genetics	GAS Inglis, Y Zhou, DG Patterson, CD Scharer, Y Han, JM Boss, Z Wen, A Escayg	08/29/2020
Antibody-secreting cell destiny emerges during the initial stages of B-cell activation. Nature communications	CD Scharer, DG Patterson, T Mi, MJ Price, SL Hicks, JM Boss	08/10/2020
Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment. PLoS pathogens	CM Collins, CD Scharer, TJ Murphy, JM Boss, SH Speck	04/01/2020
Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8⁺ T cells. Nature immunology	SL Hayward, CD Scharer, EK Cartwright, S Takamura, ZT Li, JM Boss, JE Kohlmeier	03/01/2020
A super enhancer controls expression and chromatin architecture within the MHC class II locus. The Journal of experimental medicine	P Majumder, JT Lee, AR Rahmberg, G Kumar, T Mi, CD Scharer, JM Boss	02/03/2020
PD-1 Expression during Acute Infection Is Repressed through an LSD1-Blimp-1 Axis. Journal of immunology (Baltimore, Md. : 1950)	APR Bally, DK Neeld, P Lu, P Majumder, Y Tang, BG Barwick, Q Wang, JM Boss	01/15/2020
Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus. Immunity	SA Jenks, KS Cashman, E Zumaquero, UM Marigorta, AV Patel, X Wang, D Tomar, MC Woodruff, Z Simon, R Bugrovsky, EL Blalock, CD Scharer, CM Tipton, C Wei, SS Lim, M Petri, TB Niewold, JH Anolik, G Gibson, F Eun-Hyung Lee, JM Boss, FE Lund, I Sanz	01/14/2020
Signaling through the Inhibitory Fc Receptor FcγRIIB Induces CD8⁺ T Cell Apoptosis to Limit T Cell Immunity. Immunity	AB Morris, CR Farley, DF Pinelli, LE Adams, MS Cragg, JM Boss, CD Scharer, M Fribourg, P Cravedi, PS Heeger, ML Ford	01/14/2020
Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression. Molecular cancer research : MCR	S Chandrasekaran, M Sasaki, CD Scharer, HT Kissick, DG Patterson, KR Magliocca, JT Seykora, B Sapkota, DA Gutman, LA Cooper, GB Lesinski, EK Waller, SN Thomas, SV Kotenko, JM Boss, CS Moreno, RA Swerlick, BP Pollack	12/01/2019
Understanding and measuring human B-cell tolerance and its breakdown in autoimmune disease. Immunological reviews	KS Cashman, SA Jenks, MC Woodruff, D Tomar, CM Tipton, CD Scharer, F Eun-Hyung Lee, JM Boss, I Sanz	11/01/2019
IgM, IgG, and IgA Influenza-Specific Plasma Cells Express Divergent Transcriptomes. Journal of immunology (Baltimore, Md. : 1950)	MJ Price, SL Hicks, JE Bradley, TD Randall, JM Boss, CD Scharer	10/15/2019
LSD1 Cooperates with Noncanonical NF-κB Signaling to Regulate Marginal Zone B Cell Development. Journal of immunology (Baltimore, Md. : 1950)	RR Haines, CD Scharer, JL Lobby, JM Boss	10/01/2019
Epigenetic programming underpins B cell dysfunction in human SLE. Nature immunology	CD Scharer, EL Blalock, T Mi, BG Barwick, SA Jenks, T Deguchi, KS Cashman, BE Neary, DG Patterson, SL Hicks, A Khosroshahi, F Eun-Hyung Lee, C Wei, I Sanz, JM Boss	08/01/2019
T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells. Immunity	SL Stone, JN Peel, CD Scharer, CA Risley, DA Chisolm, MD Schultz, B Yu, A Ballesteros-Tato, W Wojciechowski, B Mousseau, RS Misra, A Hanidu, H Jiang, Z Qi, JM Boss, TD Randall, SR Brodeur, AW Goldrath, AS Weinmann, AF Rosenberg, FE Lund	05/21/2019
IFNγ induces epigenetic programming of human T-bet^hi B cells and promotes TLR7/8 and IL-21 induced differentiation. eLife	E Zumaquero, SL Stone, CD Scharer, SA Jenks, A Nellore, B Mousseau, A Rosal-Vela, D Botta, JE Bradley, W Wojciechowski, T Ptacek, MI Danila, JC Edberg, SL Bridges, RP Kimberly, WW Chatham, TR Schoeb, AF Rosenberg, JM Boss, I Sanz, FE Lund	05/15/2019
The Histone Demethylase LSD1 Regulates B Cell Proliferation and Plasmablast Differentiation. Journal of immunology (Baltimore, Md. : 1950)	RR Haines, BG Barwick, CD Scharer, P Majumder, TD Randall, JM Boss	11/01/2018
Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus. Immunity	SA Jenks, KS Cashman, E Zumaquero, UM Marigorta, AV Patel, X Wang, D Tomar, MC Woodruff, Z Simon, R Bugrovsky, EL Blalock, CD Scharer, CM Tipton, C Wei, SS Lim, M Petri, TB Niewold, JH Anolik, G Gibson, FE Lee, JM Boss, FE Lund, I Sanz	10/16/2018
Progressive Upregulation of Oxidative Metabolism Facilitates Plasmablast Differentiation to a T-Independent Antigen. Cell reports	MJ Price, DG Patterson, CD Scharer, JM Boss	06/12/2018
B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation. Nature communications	BG Barwick, CD Scharer, RJ Martinez, MJ Price, AN Wein, RR Haines, APR Bally, JE Kohlmeier, JM Boss	05/15/2018
Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs. Nature communications	CD Scharer, BG Barwick, M Guo, APR Bally, JM Boss	04/27/2018
EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. Journal of immunology (Baltimore, Md. : 1950)	M Guo, MJ Price, DG Patterson, BG Barwick, RR Haines, AK Kania, JE Bradley, TD Randall, JM Boss, CD Scharer	02/01/2018
LSD1 protects against hippocampal and cortical neurodegeneration. Nature communications	MA Christopher, DA Myrick, BG Barwick, AK Engstrom, KA Porter-Stransky, JM Boss, D Weinshenker, AI Levey, DJ Katz	10/09/2017
The molecular signature of murine T cell homeostatic proliferation reveals both inflammatory and immune inhibition patterns. Journal of autoimmunity	KA Fortner, JP Bond, JW Austin, JM Boss, RC Budd	08/01/2017
ChIP-seq analysis of genomic binding regions of five major transcription factors highlights a central role for ZIC2 in the mouse epiblast stem cell gene regulatory network. Development (Cambridge, England)	K Matsuda, T Mikami, S Oki, H Iida, M Andrabi, JM Boss, K Yamaguchi, S Shigenobu, H Kondoh	06/01/2017
Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory. Journal of immunology (Baltimore, Md. : 1950)	CD Scharer, AP Bally, B Gandham, JM Boss	03/15/2017
Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory. Journal of immunology (Baltimore, Md. : 1950)	AP Bally, Y Tang, JT Lee, BG Barwick, R Martinez, BD Evavold, JM Boss	01/01/2017
LRRK2 levels in immune cells are increased in Parkinson's disease. NPJ Parkinson's disease	DA Cook, GT Kannarkat, AF Cintron, LM Butkovich, KB Fraser, J Chang, N Grigoryan, SA Factor, AB West, JM Boss, MG Tansey	01/01/2017
Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation. Nature immunology	BG Barwick, CD Scharer, APR Bally, JM Boss	10/01/2016
ZBTB32 Restricts the Duration of Memory B Cell Recall Responses. Journal of immunology (Baltimore, Md. : 1950)	A Jash, Y Wang, FJ Weisel, CD Scharer, JM Boss, MJ Shlomchik, D Bhattacharya	08/15/2016
ATAC-seq on biobanked specimens defines a unique chromatin accessibility structure in naïve SLE B cells. Scientific reports	CD Scharer, EL Blalock, BG Barwick, RR Haines, C Wei, I Sanz, JM Boss	06/01/2016
Genetic and Epigenetic Regulation of PD-1 Expression. Journal of immunology (Baltimore, Md. : 1950)	AP Bally, JW Austin, JM Boss	03/15/2016
NF-κB regulates PD-1 expression in macrophages. Journal of immunology (Baltimore, Md. : 1950)	AP Bally, P Lu, Y Tang, JW Austin, CD Scharer, R Ahmed, JM Boss	05/01/2015
Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment. Nucleic acids research	CD Scharer, NM Choi, BG Barwick, P Majumder, S Lohsen, JM Boss	03/31/2015
Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study. NPJ Parkinson's disease	GT Kannarkat, DA Cook, JK Lee, J Chang, J Chung, E Sandy, KC Paul, B Ritz, J Bronstein, SA Factor, JM Boss, MG Tansey	01/01/2015
Common distal elements orchestrate CIITA isoform-specific expression in multiple cell types. Genes and immunity	S Lohsen, P Majumder, CD Scharer, BG Barwick, JW Austin, WM Zinzow-Kramer, JM Boss	12/01/2014
STAT3, STAT4, NFATc1, and CTCF regulate PD-1 through multiple novel regulatory regions in murine T cells. Journal of immunology (Baltimore, Md. : 1950)	JW Austin, P Lu, P Majumder, R Ahmed, JM Boss	05/15/2014
B cell differentiation is associated with reprogramming the CCCTC binding factor-dependent chromatin architecture of the murine MHC class II locus. Journal of immunology (Baltimore, Md. : 1950)	P Majumder, CD Scharer, NM Choi, JM Boss	04/15/2014
Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection. The Journal of experimental medicine	P Lu, BA Youngblood, JW Austin, AU Mohammed, R Butler, R Ahmed, JM Boss	03/10/2014
Transcriptional regulation of YWHAZ, the gene encoding 14-3-3ζ. PloS one	A Kasinski, X Dong, FR Khuri, J Boss, H Fu	01/01/2014
Global DNA methylation remodeling accompanies CD8 T cell effector function. Journal of immunology (Baltimore, Md. : 1950)	CD Scharer, BG Barwick, BA Youngblood, R Ahmed, JM Boss	09/15/2013
Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells. Journal of immunology (Baltimore, Md. : 1950)	B Youngblood, A Noto, F Porichis, RS Akondy, ZM Ndhlovu, JW Austin, R Bordi, FA Procopio, T Miura, TM Allen, J Sidney, A Sette, BD Walker, R Ahmed, JM Boss, RP Sékaly, DE Kaufmann	07/15/2013
Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergence. PLoS genetics	O Gokcumen, Q Zhu, LC Mulder, RC Iskow, C Austermann, CD Scharer, T Raj, JM Boss, S Sunyaev, A Price, B Stranger, V Simon, C Lee	04/01/2013
The role of innate and adaptive immunity in Parkinson's disease. Journal of Parkinson's disease	GT Kannarkat, JM Boss, MG Tansey	01/01/2013
ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells. Journal of immunology (Baltimore, Md. : 1950)	HS Yoon, CD Scharer, P Majumder, CW Davis, R Butler, W Zinzow-Kramer, I Skountzou, DG Koutsonanos, R Ahmed, JM Boss	09/01/2012
CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments. Genes and immunity	WM Zinzow-Kramer, AB Long, BA Youngblood, KM Rosenthal, R Butler, AU Mohammed, I Skountzou, R Ahmed, BD Evavold, JM Boss	06/01/2012
Multiple histone methyl and acetyltransferase complex components bind the HLA-DRA gene. PloS one	NM Choi, JM Boss	01/01/2012
Cohesin regulates MHC class II genes through interactions with MHC class II insulators. Journal of immunology (Baltimore, Md. : 1950)	P Majumder, JM Boss	10/15/2011
Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells. Immunity	B Youngblood, KJ Oestreich, SJ Ha, J Duraiswamy, RS Akondy, EE West, Z Wei, P Lu, JW Austin, JL Riley, JM Boss, R Ahmed	09/23/2011
DNA methylation dysregulates and silences the HLA-DQ locus by altering chromatin architecture. Genes and immunity	P Majumder, JM Boss	06/01/2011
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nature immunology	C Kao, KJ Oestreich, MA Paley, A Crawford, JM Angelosanto, MA Ali, AM Intlekofer, JM Boss, SL Reiner, AS Weinmann, EJ Wherry	05/29/2011
Regulation of major histocompatibility complex class II genes. Current opinion in immunology	NM Choi, P Majumder, JM Boss	02/01/2011
Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex. Journal of molecular biology	KM Laird, LL Briggs, JM Boss, MF Summers, CW Garvie	10/15/2010
CTCF controls expression and chromatin architecture of the human major histocompatibility complex class II locus. Molecular and cellular biology	P Majumder, JM Boss	09/01/2010
PU.1 binds to a distal regulatory element that is necessary for B cell-specific expression of CIITA. Journal of immunology (Baltimore, Md. : 1950)	H Yoon, JM Boss	05/01/2010
Formation of the RFX gene regulatory complex induces folding of the interaction domain of RFXAP. Proteins	L Briggs, K Laird, JM Boss, CW Garvie	08/15/2009
Identification of infected B-cell populations by using a recombinant murine gammaherpesvirus 68 expressing a fluorescent protein. Journal of virology	CM Collins, JM Boss, SH Speck	07/01/2009
Yin yang 1 regulates the expression of snail through a distal enhancer. Molecular cancer research : MCR	MB Palmer, P Majumder, JC Cooper, H Yoon, PA Wade, JM Boss	02/01/2009
Ultraviolet radiation-induced transcription is associated with gene-specific histone acetylation. Photochemistry and photobiology	BP Pollack, B Sapkota, JM Boss	01/01/2009
Assembly of the RFX complex on the MHCII promoter: role of RFXAP and RFXB in relieving autoinhibition of RFX5. Biochimica et biophysica acta	CW Garvie, JM Boss	12/01/2008
NFATc1 regulates PD-1 expression upon T cell activation. Journal of immunology (Baltimore, Md. : 1950)	KJ Oestreich, H Yoon, R Ahmed, JM Boss	10/01/2008
Tomorrow's JI Today. Journal of immunology (Baltimore, Md. : 1950)	JM Boss	07/01/2008
New dimensions of CIITA. Nature immunology	W Reith, JM Boss	07/01/2008
The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions. The Journal of experimental medicine	P Majumder, JA Gomez, BP Chadwick, JM Boss	04/14/2008
The NLR gene family: a standard nomenclature. Immunity	JP Ting, RC Lovering, ES Alnemri, J Bertin, JM Boss, BK Davis, RA Flavell, SE Girardin, A Godzik, JA Harton, HM Hoffman, JP Hugot, N Inohara, A Mackenzie, LJ Maltais, G Nunez, Y Ogura, LA Otten, D Philpott, JC Reed, W Reith, S Schreiber, V Steimle, PA Ward	03/01/2008
Mentoring and networking: how to make it work. Nature immunology	L Haynes, SL Adams, JM Boss	01/01/2008