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Shanmuganathan Chandrakasan, MD

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Biography

Shanmuganathan Chandrakasan, MD, is an associate professor in the Department of Pediatrics at Emory University School of Medicine and a member of the Cancer Immunology Research Program at Winship Cancer Institute of Emory University. He also leads one of the largest comprehensive immunohematology and immune dysregulation programs in the United States at Children's Healthcare of Atlanta.

Education

Dr. Chandrakasan earned his MD from the Postgraduate Institute of Medical Education and Research in Chandigarh, following his MBBS from Jawaharlal Institute of Post-Graduate Medicine and Research in Puducherry. Dr. Chandrakasan completed an advanced research fellowship in transplant biology at Cincinnati Children's Hospital Medical Center. He also completed a fellowship in pediatric hematology-oncology and bone marrow transplantation at the same institution. Prior to that, he finished his pediatrics residency at Children's Hospital of Michigan.

Titles & Roles

  • Associate Professor, Department of Pediatrics
    Emory University School of Medicine
  • Director, Immunohematology/Immune dysregulation and Immune Defects Transplant Programs
    Children's Healthcare of Atlanta

Professional Memberships

Dr. Chandrakasan is part of the following professional memberships:

  • Member, Planning Committee, ASPHO
  • Member, HLH steering committee, Histiocyte Society
  • Publication committee member, Primary Immune Deficiency Treatment Consortium (PIDTC)
  • Chair, Research committee of Clinical Immunology special interest group in ASPHO
  • Member, Scientific Advisory Board, Hyper IGM syndrome

Research

Dr. Chandrakasan's lab has been conducting translational research with multi-institutional collaboration in the area of multilineage immune cytopenia and helped establish the concept of broad immune dysregulation in these patients. They also established a scoring system to identify immune cytopenia patients with a high risk of underlying immune morbidity. Immune dysregulation in these patients is characterized by circulating T follicular cell expansion and Th1 skew (Kumar et.al Blood Jan 2022).

Grants

Publications

Title/Journal Authors Publication Date

Biomarkers of Immune Dysregulation and What They Tell Us: Gene Sequencing Is Not the Answer to Every Question.

Immunology and allergy clinics of North America

 TH Nguyen, S Chandrakasan 05/01/2025

Perspectives on the current diagnostic and treatment paradigms in secondary hemophagocytic lymphohistiocytosis (HLH).

Orphanet journal of rare diseases

 L Naymagon, P Roehrs, M Hermiston, J Connelly, J Bednarski, JJ Boelens, S Chandrakasan, B Dávila Saldaña, MM Henry, P Satwani, A Ray, K Walkovich, D Teachey, EM Behrens, SW Canna, A Kumar 04/26/2025

Characterizing the heterogeneity of Castleman disease and oligocentric subtype: findings from the ACCELERATE registry.

Blood advances

 SK Pierson, JD Brandstadter, DA Torigian, A Bagg, MJ Lechowicz, D Alapat, C Casper, A Chadburn, S Chandrakasan, A Dispenzieri, A Fosså, C Hoffmann, M Ide, R Kurzrock, S Mukherjee, S Nasta, JT Navarro, A Noy, E Oksenhendler, MS Bustamante, S Shyamsundar, M Streetly, RSM Wong, L Zhang, MS Lim, G Srkalovic, F van Rhee, DC Fajgenbaum 04/22/2025

Expert-based, institutional approaches for reducing the diagnostic odyssey of patients with IEIs.

The journal of allergy and clinical immunology. In practice

 NL Rider, L Bastarache, JT Anderson, EM Behrens, N Chaimowitz, S Chandrakasan, B Hartline, A Liu, RA Marsh, JA Connelly 04/03/2025

Allogeneic haematopoietic stem-cell transplantation for children with refractory systemic juvenile idiopathic arthritis and associated lung disease: outcomes from an international, retrospective cohort study.

The Lancet. Rheumatology

 MG Matt, D Drozdov, E Bendstrup, M Glerup, EM Hauge, T Masmas, EC Schneider, UB Zeilhofer, RF Abu-Arja, KD Driest, JH Oved, K Onel, CL Ebens, D Chellapandian, S Chandrakasan, S Prahalad, J Roth, SE Prockop, J Silva, AH Schapiro, C Towe, S Chandra, A Grom, GS Schulert, RA Marsh 04/01/2025

Emapalumab Treatment in Patients With Rheumatologic Disease-Associated Hemophagocytic Lymphohistiocytosis in the United States: A Retrospective Medical Chart Review Study.

Arthritis & rheumatology (Hoboken, N.J.)

 S Chandrakasan, CE Allen, D Bhatla, J Carter, M Chien, R Cooper, L Draper, OS Eckstein, R Hanna, JA Hays, ML Hermiston, AP Hinson, PM Hobday, MS Isakoff, MB Jordan, JW Leiding, R Modica, TA Nakano, A Oladapo, SA Patel, P Pednekar, M Riskalla, SN Sarangi, P Satwani, A Tandra, KJ Walkovich, JD Yee, A Zoref-Lorenz, EM Behrens 02/01/2025

Current treatment in macrophage activation syndrome worldwide: a systematic literature review to inform the METAPHOR project.

Rheumatology (Oxford, England)

 F Baldo, RGA Erkens, M Mizuta, G Rogani, F Lucioni, C Bracaglia, D Foell, M Gattorno, M Jelusic, J Anton, P Brogan, S Canna, S Chandrakasan, RQ Cron, F De Benedetti, A Grom, M Heshin-Bekenstein, A Horne, R Khubchandani, S Ozen, P Quartier, A Ravelli, M Shimizu, G Schulert, C Scott, R Sinha, N Ruperto, JF Swart, S Vastert, F Minoia 01/01/2025

Systemic T-cell activation and IFN-γ activity in indeterminate severe hepatitis are reminiscent of hemophagocytic lymphohistiocytosis: Implications for T-cell- and IFN-γ-directed therapies.

The Journal of allergy and clinical immunology

 TH Nguyen, P Satwani, D Kumar, U Kapoor, S Malik, C Prince, T Montminy, K Smiley, M Martinez, D Goldner, R Marsh, HE Remotti, L Fazlollahi, HB Rytting, R Romero, S Chandrakasan 01/01/2025

Expanding the Spectrum of Immune Abnormalities in VICI Syndrome.

Journal of clinical immunology

 EL Frost, LL Youngblood, Y Hammers, T Fitch, B Pencheva, S Chandrakasan 11/18/2024

Pediatric lymphoproliferative disorders associated with inborn errors of immunity.

Clinical immunology (Orlando, Fla.)

 J Cheng, BJ Dávila Saldaña, S Chandrakasan, M Keller 09/01/2024

Prototypical innate immune mechanism hijacked by leukemia-initiating mutant stem cells for selective advantage and immune evasion in Ptpn11-associated juvenile myelomonocytic leukemia.

Research square

 H Zheng, P Zhao, Z Tan, WM Yu, J Werner, E Stieglitz, C Porter, S Chandrakasan, D Wechsler, S Mendez-Ferrer, CK Qu 08/02/2024

HLH and Recurrent EBV Lymphoma as the presenting manifestation of MAGT1 Deficiency: A Systematic Review of the Expanding Disease Spectrum.

Journal of clinical immunology

 K Golloshi, W Mitchell, D Kumar, S Malik, S Parikh, AA Aljudi, SM Castellino, S Chandrakasan 06/19/2024

Real-world treatment patterns and outcomes in patients with primary hemophagocytic lymphohistiocytosis treated with emapalumab.

Blood advances

 S Chandrakasan, MB Jordan, A Baker, EM Behrens, D Bhatla, M Chien, OS Eckstein, MM Henry, ML Hermiston, AP Hinson, JW Leiding, A Oladapo, SA Patel, P Pednekar, AK Ray, B Dávila Saldaña, SN Sarangi, KJ Walkovich, JD Yee, A Zoref-Lorenz, CE Allen 05/14/2024

Allogeneic hematopoietic cell transplantation is effective for p47phox chronic granulomatous disease: A  Primary Immune Deficiency Treatment Consortium study.

The Journal of allergy and clinical immunology

 E Grunebaum, DE Arnold, B Logan, S Parikh, RA Marsh, LM Griffith, K Mallhi, D Chellapandian, SS Lim, CL Deal, N Kapoor, L Murguía-Favela, EL Falcone, VK Prasad, F Touzot, JJ Bleesing, S Chandrakasan, JR Heimall, JJ Bednarski, LA Broglie, HJ Chong, M Kapadia, S Prockop, BJ Dávila Saldaña, E Schaefer, AL Bauchat, P Teira, S Chandra, M Parta, MJ Cowan, CC Dvorak, E Haddad, DB Kohn, LD Notarangelo, SY Pai, JM Puck, MA Pulsipher, TR Torgerson, HL Malech, EM Kang, JW Leiding 05/01/2024

WAS-Related Disorders

GeneReviews®

 MP Adam, J Feldman, GM Mirzaa, RA Pagon, SE Wallace, A Amemiya, S Chandra, CB Nagaraj, M Sun, S Chandrakasan, K Zhang 01/01/1993

Awards

Dr. Chandrakasan has earned the following awards and honors:

  • Best basic science research award in Aflac Cancer and Blood Disorders Center for 2021
  • Immune Deficiency Foundation Visiting Professorship, 2021
  • Lata Kumar visiting Professorship and Oration, 2020
  • Travel award, Federation of Clinical Immunology Societies, 2013
  • Travel award, Clinical Immunology Society, 2013
  • Bonita F. Stanton Award for professionalism in Pediatrics, Children’s Hospital of Michigan, 2011
  • Sanford N. Cohen award for outstanding Graduating resident, Children’s Hospital of Michigan, 2011
  • Travel Scholarship for Oxford -Infection and Immunity in Children, European and British Society of Pediatric Infectious Disease Society, 2007