Victor Corces, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-727-3289
Email Address

vcorces@emory.edu

Biography

Victor Corces, PhD, is a professor in the Department of Human Genetics at Emory University School of Medicine. Dr. Corces is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute of Emory University and the HERCULES Exposome Research Center in the Rollins School of Public Health.

Education

Dr. Corces received his PhD from Universidad Autónoma de Madrid in Madrid, Spain.

Titles & Roles

Professor, Department of Human Genetics

Emory University School of Medicine

Research

The cancer-related research in Dr. Corces's laboratory is studying the mechanisms by which the three-dimensional organization of the chromatin is established and maintained. The transcriptional repressor CTCF and cohesin proteins involved in these processes are often mutated in leukemia and other cancers.

Grants

View Grants

Grant Number	Title
2R01ES027859-06A1	Mechanisms of transgenerational epigenetic inheritance
5R01ES027859-07	Mechanisms of transgenerational epigenetic inheritance
5R01ES027859-08	Mechanisms of transgenerational epigenetic inheritance
5R35GM139408-05	Nuclear Organization and Function

Publications

In 2021, Dr. Corces was named to the MilliPub Club, which recognizes current Emory faculty who have published one or more individual papers throughout their careers that have garnered more than 1,000 citations.

Title/Journal	Authors	Publication Date
Peripheral amylin modulation rebalances brain glycolysis and Tau-Ser214 phosphorylation via cAMP-PKA signaling. iScience	RS Davargaon, N Verma, D Kotiya, N Leibold, GV Velmurugan, H Coburn, KC Chen, D Ruiz, V Corces, H Liu, P Kachroo, PK Singh, MS Gentry, S Despa, F Despa	03/20/2026
Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons. Proceedings of the National Academy of Sciences of the United States of America	JD Rodriguez, MN Reeves, SR Chavez, HV Wang, JZ Chavez, R Rastogi, LI Sun, MS Roberson, EA Preston, Z Massenburg, KN Cruz, MS Chadha, EJ Hill, ML Soares, VG Corces, BS Carpenter, KL Schmeichel, JI Murray, DJ Katz	09/30/2025
NKX2-1 drives neuroendocrine transdifferentiation of prostate cancer via epigenetic and 3D chromatin remodeling. Nature genetics	X Lu, V Keo, I Cheng, W Xie, G Gritsina, J Wang, L Lu, CK Shiau, Y He, Q Jin, P Jin, MG Sanda, VG Corces, N Altemose, R Gao, JC Zhao, J Yu	08/01/2025
pTDP-43 levels correlate with cell type-specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients. Proceedings of the National Academy of Sciences of the United States of America	HV Wang, JF Xiang, C Yuan, AM Veire, TF Gendron, ME Murray, MG Tansey, J Hu, M Gearing, JD Glass, P Jin, VG Corces, ZT McEachin	03/04/2025
Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma. Nature cell biology	C Sojka, HV Wang, TN Bhatia, Y Li, P Chopra, A Sing, A Voss, A King, F Wang, K Joseph, VM Ravi, J Olson, K Hoang, E Nduom, VG Corces, B Yao, SA Sloan	02/01/2025
Epigenetic remodeling and 3D chromatin reorganization governed by NKX2-1 drive neuroendocrine prostate cancer. bioRxiv : the preprint server for biology	X Lu, V Keo, I Cheng, W Xie, G Gritsina, J Wang, Q Jin, P Jin, F Yue, MG Sanda, V Corces, N Altemose, JC Zhao, J Yu	12/07/2024
Ectopic transcription due to inappropriately inherited histone methylation may interfere with the ongoing function of terminally differentiated cells. bioRxiv : the preprint server for biology	JD Rodriguez, MN Reeves, HV Wang, JZ Chavez, R Rastogi, SR Chavez, EA Preston, MS Chadha, LI Sun, EJ Hill, VG Corces, KL Schmeichel, JI Murray, DJ Katz	11/11/2024
pTDP-43 levels correlate with cell type specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients. bioRxiv : the preprint server for biology	HV Wang, JF Xiang, C Yuan, AM Veire, TF Gendron, ME Murray, MG Tansey, J Hu, M Gearing, JD Glass, P Jin, VG Corces, ZT McEachin	06/13/2024
TDP-43 chronic deficiency leads to dysregulation of transposable elements and gene expression by affecting R-loop and 5hmC crosstalk. Cell reports	Y Hou, Y Li, JF Xiang, K Tilahun, J Jiang, VG Corces, B Yao	01/23/2024
Regulation of CTCF loop formation during pancreatic cell differentiation. Nature communications	X Lyu, MJ Rowley, MJ Kulik, S Dalton, VG Corces	10/09/2023
Structures of CTCF-DNA complexes including all 11 zinc fingers. Nucleic acids research	J Yang, JR Horton, B Liu, VG Corces, RM Blumenthal, X Zhang, X Cheng	09/08/2023
Characterization of a strain-specific CD-1 reference genome reveals potential inter- and intra-strain functional variability. BMC genomics	YH Jung, HV Wang, S Ali, VG Corces, I Kremsky	08/03/2023
Chromatin alternates between A and B compartments at kilobase scale for subgenic organization. Nature communications	HL Harris, H Gu, M Olshansky, A Wang, I Farabella, Y Eliaz, A Kalluchi, A Krishna, M Jacobs, G Cauer, M Pham, SSP Rao, O Dudchenko, A Omer, K Mohajeri, S Kim, MH Nichols, ES Davis, D Gkountaroulis, D Udupa, AP Aiden, VG Corces, DH Phanstiel, WS Noble, G Nir, M Di Pierro, JS Seo, ME Talkowski, EL Aiden, MJ Rowley	06/06/2023
Expansion of the genotypic and phenotypic spectrum of CTCF-related disorder guides clinical management: 43 new subjects and a comprehensive literature review. American journal of medical genetics. Part A	HG Valverde de Morales, HV Wang, K Garber, X Cheng, VG Corces, H Li	03/01/2023
Activation of HIV-1 proviruses increases downstream chromatin accessibility. iScience	R Shah, CM Gallardo, YH Jung, B Clock, JR Dixon, WM McFadden, K Majumder, DJ Pintel, VG Corces, BE Torbett, PR Tedbury, SG Sarafianos	12/22/2022
Recruitment of CTCF to an Fto enhancer is responsible for transgenerational inheritance of BPA-induced obesity. Proceedings of the National Academy of Sciences of the United States of America	YH Jung, HV Wang, D Ruiz, BJ Bixler, H Linsenbaum, JF Xiang, S Forestier, AM Shafik, P Jin, VG Corces	12/13/2022
Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders. Journal of autism and developmental disorders	J Escher, W Yan, EF Rissman, HV Wang, A Hernandez, VG Corces	10/01/2022
The Cupid shuffle: Do enhancers prefer specific promoters? Molecular cell	HV Wang, VG Corces	07/07/2022
Somatic Diversification of Rearranged Antibody Gene Segments by Intra- and Interchromosomal Templated Mutagenesis. Journal of immunology (Baltimore, Md. : 1950)	GA Dale, DJ Wilkins, J Rowley, CD Scharer, CM Tipton, J Hom, JM Boss, V Corces, I Sanz, J Jacob	05/01/2022
Indolium 1 Exerts Activity against Vemurafenib-Resistant Melanoma In Vivo. Antioxidants (Basel, Switzerland)	R Radi, C Huang, J Elsey, YH Jung, VG Corces, JL Arbiser	04/19/2022
Introduction of Mutant GNAQ into Endothelial Cells Induces a Vascular Malformation Phenotype with Therapeutic Response to Imatinib. Cancers	M Sasaki, Y Jung, P North, J Elsey, K Choate, MA Toussaint, C Huang, R Radi, AJ Perricone, VG Corces, JL Arbiser	01/14/2022
Is developmental synchrony enabled by CTCF residence time? Developmental cell	HV Wang, VG Corces	09/27/2021
Exploring the role of nongenetic inheritance in the etiology of human disease. Biology of reproduction	J Escher, V Corces, I Mansuy, W Yan	09/14/2021
Exposure to sevoflurane results in changes of transcription factor occupancy in sperm and inheritance of autism†. Biology of reproduction	HV Wang, S Forestier, VG Corces	09/14/2021
Principles of 3D compartmentalization of the human genome. Cell reports	MH Nichols, VG Corces	06/29/2021
Replication timing maintains the global epigenetic state in human cells. Science (New York, N.Y.)	KN Klein, PA Zhao, X Lyu, T Sasaki, DA Bartlett, AM Singh, I Tasan, M Zhang, LP Watts, SI Hiraga, T Natsume, X Zhou, T Baslan, D Leung, MT Kanemaki, AD Donaldson, H Zhao, S Dalton, VG Corces, DM Gilbert	04/23/2021
Regulation of 3D chromatin organization by CTCF. Current opinion in genetics & development	JF Xiang, VG Corces	04/01/2021
Haspin kinase modulates nuclear architecture and Polycomb-dependent gene silencing. PLoS genetics	U Fresán, MA Rodríguez-Sánchez, O Reina, VG Corces, ML Espinàs	08/01/2020
Analysis of Hi-C data using SIP effectively identifies loops in organisms from C. elegans to mammals. Genome research	MJ Rowley, A Poulet, MH Nichols, BJ Bixler, AL Sanborn, EA Brouhard, K Hermetz, H Linsenbaum, G Csankovszki, E Lieberman Aiden, VG Corces	03/01/2020
Mini-review: Epigenetic mechanisms that promote transgenerational actions of endocrine disrupting chemicals: Applications to behavioral neuroendocrinology. Hormones and behavior	M Martini, VG Corces, EF Rissman	03/01/2020
Author Correction: Widespread long-range cis-regulatory elements in the maize genome. Nature plants	WA Ricci, Z Lu, L Ji, AP Marand, CL Ethridge, NG Murphy, JM Noshay, M Galli, MK Mejía-Guerra, M Colomé-Tatché, F Johannes, MJ Rowley, VG Corces, J Zhai, MJ Scanlon, ES Buckler, A Gallavotti, NM Springer, RJ Schmitz, X Zhang	03/01/2020
Widespread long-range cis-regulatory elements in the maize genome. Nature plants	WA Ricci, Z Lu, L Ji, AP Marand, CL Ethridge, NG Murphy, JM Noshay, M Galli, MK Mejía-Guerra, M Colomé-Tatché, F Johannes, MJ Rowley, VG Corces, J Zhai, MJ Scanlon, ES Buckler, A Gallavotti, NM Springer, RJ Schmitz, X Zhang	12/01/2019
Chromatin accessibility and transcription dynamics during in vitro astrocyte differentiation of Huntington's Disease Monkey pluripotent stem cells. Epigenetics & chromatin	AV Goodnight, I Kremsky, S Khampang, YH Jung, JM Billingsley, SE Bosinger, VG Corces, AWS Chan	11/13/2019
Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus. Nature neuroscience	J Fernandez-Albert, M Lipinski, MT Lopez-Cascales, MJ Rowley, AM Martin-Gonzalez, B Del Blanco, VG Corces, A Barco	10/01/2019
Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb. Cell reports	I Gutierrez-Perez, MJ Rowley, X Lyu, V Valadez-Graham, DM Vallejo, E Ballesta-Illan, JP Lopez-Atalaya, I Kremsky, E Caparros, VG Corces, M Dominguez	09/03/2019
Seeing Is Believing: ORCA Allows Visualization of Three-Dimensional Genome Organization at Single-Cell Resolution. Biochemistry	HV Wang, VG Corces	08/20/2019
Maintenance of CTCF- and Transcription Factor-Mediated Interactions from the Gametes to the Early Mouse Embryo. Molecular cell	YH Jung, I Kremsky, HB Gold, MJ Rowley, K Punyawai, A Buonanotte, X Lyu, BJ Bixler, AWS Chan, VG Corces	07/11/2019
Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment. Stem cell reports	V Dileep, KA Wilson, C Marchal, X Lyu, PA Zhao, B Li, A Poulet, DA Bartlett, JC Rivera-Mulia, ZS Qin, AJ Robins, TC Schulz, MJ Kulik, RP McCord, J Dekker, S Dalton, VG Corces, DM Gilbert	07/09/2019
Condensin II Counteracts Cohesin and RNA Polymerase II in the Establishment of 3D Chromatin Organization. Cell reports	MJ Rowley, X Lyu, V Rana, M Ando-Kuri, R Karns, G Bosco, VG Corces	03/12/2019
Pach-ing It in: The Peculiar Organization of Mammalian Pachytene Chromosomes. Molecular cell	YH Jung, VG Corces	02/07/2019
Chromatin changes in Anopheles gambiae induced by Plasmodium falciparum infection. Epigenetics & chromatin	JL Ruiz, RS Yerbanga, T Lefèvre, JB Ouedraogo, VG Corces, E Gómez-Díaz	01/07/2019
Engineering 3D genome organization. Cell research	X Lyu, VG Corces	01/01/2019
Resolution of the DNA methylation state of single CpG dyads using in silico strand annealing and WGBS data. Nature protocols	C Xu, VG Corces	01/01/2019
Organizational principles of 3D genome architecture. Nature reviews. Genetics	MJ Rowley, VG Corces	12/01/2018
A tethered-inchworm model of SMC DNA translocation. Nature structural & molecular biology	MH Nichols, VG Corces	10/01/2018
Architectural Proteins and Pluripotency Factors Cooperate to Orchestrate the Transcriptional Response of hESCs to Temperature Stress. Molecular cell	X Lyu, MJ Rowley, VG Corces	09/20/2018
Not just heads and tails: The complexity of the sperm epigenome. The Journal of biological chemistry	HB Gold, YH Jung, VG Corces	09/07/2018
Developing in 3D: the role of CTCF in cell differentiation. Development (Cambridge, England)	RG Arzate-Mejía, F Recillas-Targa, VG Corces	03/22/2018
Nascent DNA methylome mapping reveals inheritance of hemimethylation at CTCF/cohesin sites. Science (New York, N.Y.)	C Xu, VG Corces	03/09/2018
Analysis of Chromatin Interactions Mediated by Specific Architectural Proteins in Drosophila Cells. Methods in molecular biology (Clifton, N.J.)	M Ando-Kuri, ISM Rivera, MJ Rowley, VG Corces	01/01/2018
Genome-Wide Mapping of Protein-DNA Interactions on Nascent Chromatin. Methods in molecular biology (Clifton, N.J.)	C Xu, VG Corces	01/01/2018
Capturing native interactions: intrinsic methods to study chromatin conformation. Molecular systems biology	MJ Rowley, VG Corces	12/09/2016
Minute-Made Data Analysis: Tools for Rapid Interrogation of Hi-C Contacts. Molecular cell	MJ Rowley, VG Corces	10/06/2016
Towards a predictive model of chromatin 3D organization. Seminars in cell & developmental biology	C Xu, VG Corces	09/01/2016
The three-dimensional genome: principles and roles of long-distance interactions. Current opinion in cell biology	MJ Rowley, VG Corces	06/01/2016
The three-dimensional cancer genome. Current opinion in genetics & development	MR Corces, VG Corces	02/01/2016
HiFive: a tool suite for easy and efficient HiC and 5C data analysis. Genome biology	ME Sauria, JE Phillips-Cremins, VG Corces, J Taylor	10/24/2015
Architectural proteins, transcription, and the three-dimensional organization of the genome. FEBS letters	C Cubeñas-Potts, VG Corces	10/07/2015
Integrated tRNA, transcript, and protein profiles in response to steroid hormone signaling. RNA (New York, N.Y.)	K Van Bortle, MH Nichols, E Ramos, VG Corces	10/01/2015
A CTCF Code for 3D Genome Architecture. Cell	MH Nichols, VG Corces	08/13/2015
Topologically Associating Domains: An invariant framework or a dynamic scaffold? Nucleus (Austin, Tex.)	C Cubeñas-Potts, VG Corces	01/01/2015
Architectural proteins: regulators of 3D genome organization in cell fate. Trends in cell biology	E Gómez-Díaz, VG Corces	11/01/2014
Lost in transition: dynamic enhancer organization across naive and primed stem cell states. Cell stem cell	K Van Bortle, VG Corces	06/05/2014
Editorial overview: Genome architecture and expression: the nucleus, top and bottom. Current opinion in genetics & development	D Levens, V Corces	04/01/2014
CTCF: an architectural protein bridging genome topology and function. Nature reviews. Genetics	CT Ong, VG Corces	04/01/2014
Insights into the epigenomic landscape of the human malaria vector Anopheles gambiae. Frontiers in genetics	E Gómez-Díaz, A Rivero, F Chandre, VG Corces	01/01/2014
Poly(ADP-ribosyl)ation regulates insulator function and intrachromosomal interactions in Drosophila. Cell	CT Ong, K Van Bortle, E Ramos, VG Corces	09/26/2013
Chromatin insulators: linking genome organization to cellular function. Molecular cell	JE Phillips-Cremins, VG Corces	05/23/2013
The role of chromatin insulators in nuclear architecture and genome function. Current opinion in genetics & development	K Van Bortle, VG Corces	04/01/2013
Spinning the web of cell fate. Cell	K Van Bortle, VG Corces	03/14/2013
A subset of Drosophila Myc sites remain associated with mitotic chromosomes colocalized with insulator proteins. Nature communications	J Yang, E Sung, PG Donlin-Asp, VG Corces	01/01/2013
The BEAF-32 insulator coordinates genome organization and function during the evolution of Drosophila species. Genome research	J Yang, E Ramos, VG Corces	11/01/2012
The BEAF insulator regulates genes involved in cell polarity and neoplastic growth. Developmental biology	BV Gurudatta, E Ramos, VG Corces	09/01/2012
Enhancers: emerging roles in cell fate specification. EMBO reports	CT Ong, VG Corces	04/10/2012
Throwing transcription for a loop: expression of the genome in the 3D nucleus. Chromosoma	C Hou, VG Corces	04/01/2012
Insulators, long-range interactions, and genome function. Current opinion in genetics & development	J Yang, VG Corces	04/01/2012
Nuclear organization and genome function. Annual review of cell and developmental biology	K Van Bortle, VG Corces	01/01/2012
tDNA insulators and the emerging role of TFIIIC in genome organization. Transcription	K Van Bortle, VG Corces	01/01/2012
Opening pathways for underrepresented high school students to biomedical research careers: the Emory University RISE program. Genetics	MC Rohrbaugh, VG Corces	12/01/2011
Wt1 flip-flops chromatin in a CTCF domain. Developmental cell	BV Gurudatta, VG Corces	09/13/2011
Enhancer function: new insights into the regulation of tissue-specific gene expression. Nature reviews. Genetics	CT Ong, VG Corces	04/01/2011
Chromatin insulators: a role in nuclear organization and gene expression. Advances in cancer research	J Yang, VG Corces	01/01/2011
Insulators and imprinting from flies to mammals. BMC biology	C Hou, VG Corces	07/30/2010
Nups take leave of the nuclear envelope to regulate transcription. Cell	C Hou, VG Corces	02/05/2010
Insulators as mediators of intra- and inter-chromosomal interactions: a common evolutionary theme. Journal of biology	CT Ong, VG Corces	08/27/2009
CTCF: master weaver of the genome. Cell	JE Phillips, VG Corces	06/26/2009
Three subclasses of a Drosophila insulator show distinct and cell type-specific genomic distributions. Genes & development	AM Bushey, E Ramos, VG Corces	06/01/2009
The Lawc protein is required for proper transcription by RNA polymerase II in Drosophila. Molecular genetics and genomics : MGG	T Brandt, VG Corces	11/01/2008
Chromatin insulators: regulatory mechanisms and epigenetic inheritance. Molecular cell	AM Bushey, ER Dorman, VG Corces	10/10/2008
Modulation of CTCF insulator function by transcription of a noncoding RNA. Developmental cell	CT Ong, VG Corces	10/01/2008