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Ahmet Coskun, PhD

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Biography

Ahmet F. Coskun, PhD, is an assistant professor and the Bernie-Marcus Early-Career Professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech School of Engineering and Emory University School of Medicine.

Dr. Coskun is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute of Emory University in Atlanta, Georgia.

Education

Dr. Coskun received his PhD in Electrical Engineering and Bioengineering from the University of California, Los Angeles. He completed his postdoctoral training at the California Institute of Technology and at the Beckman Research Institute.

Titles & Roles

  • Bernie Marcus Early-Career Professor, Wallace H. Coulter Department of Biomedical Engineering
    Georgia Institute of Technology and Emory University

Research

Dr. Coskun's research interests include:

  • Bioimaging, Biodynamics and Biocomputation: Multiplexed Spatially-resolved Single Cell Analysis and Subcellular Networks
  • Tumor Microenvironment and Pediatric Diseases
  • Machine Learning
  • BioArt
  • 3DVisualBio
  • BioEMediaLab
  • Demonstration-based Learning


Dr. Coskun directs an interdisciplinary research team at the Single Cell Biotechnology Laboratory.

Publications

Title/Journal Authors Publication Date

Multi-niche human bone marrow on-a-chip for studying the interactions of adoptive CAR-T cell therapies with multiple myeloma.

Biomaterials

 D Ghoshal, I Petersen, R Ringquist, L Kramer, E Bhatia, T Hu, A Richard, R Park, J Corbin, S Agarwal, A Thomas, S Ramirez, J Tharayil, E Downey, F Ketchum, A Ochal, N Sonthi, S Lonial, JN Kochenderfer, R Tran, M Zhu, WA Lam, AF Coskun, K Roy 05/01/2025

Clinically relevant clot resolution via a thromboinflammation-on-a-chip.

Nature

 Y Qiu, J Lin, A Wang, Z Fang, Y Sakurai, H Choi, EK Williams, ET Hardy, K Maher, AF Coskun, G Woods, WA Lam 05/01/2025

Microbial Changes Occurring During Oronasal Fistula Wound Healing.

Microorganisms

 SL Goudy, HL Bradley, CA Gacasan, A Toma, KPC Sekar, WM Wuest, M Tomov, V Serpooshan, A Coskun, RM Jones 02/02/2025

Human immune organoids to decode B cell response in healthy donors and patients with lymphoma.

Nature materials

 Z Zhong, M Quiñones-Pérez, Z Dai, VM Juarez, E Bhatia, CR Carlson, SB Shah, A Patel, Z Fang, T Hu, M Allam, SL Hicks, M Gupta, SL Gupta, E Weeks, SD Vagelos, A Molina, A Mulero-Russe, A Mora-Boza, DJ Joshi, RP Sekaly, T Sulchek, SL Goudy, J Wrammert, K Roy, JM Boss, AF Coskun, CD Scharer, AJ García, JL Koff, A Singh 02/01/2025

High cell throughput, programmable fixation reveals the RNA and protein co-regulation with spatially resolved NFκB pseudo-signaling.

APL bioengineering

 N Zhang, M Wang, D Nambiar, S Iyer, P Kadakia, Q Luo, S Pang, A Qu, NS Bharadwaj, P Qiu, AF Coskun 12/01/2024

Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omics.

npj aging

 A Venkataraman, I Kordic, J Li, N Zhang, NS Bharadwaj, Z Fang, S Das, AF Coskun 11/26/2024

Spatially resolved subcellular protein-protein interactomics in drug-perturbed lung-cancer cultures and tissues.

Nature biomedical engineering

 S Cai, T Hu, A Venkataraman, FG Rivera Moctezuma, E Ozturk, N Zhang, M Wang, T Zvidzai, S Das, A Pillai, F Schneider, SS Ramalingam, YT Oh, SY Sun, AF Coskun 10/30/2024

Super Resolved Single-Cell Spatial Metabolomics from Multimodal Mass Spectrometry Imaging guided by Imaging Mass Cytometry.

bioRxiv : the preprint server for biology

 E Ozturk, A Venkataraman, FG Rivera Moctezuma, AF Coskun 10/24/2024

Graph-Based Spatial Proximity of Super-Resolved Protein-Protein Interactions Predicts Cancer Drug Responses in Single Cells.

Cellular and molecular bioengineering

 N Zhang, S Cai, M Wang, T Hu, F Schneider, SY Sun, AF Coskun 10/01/2024

Combining spatial metabolomics and proteomics profiling of single cells.

Nature reviews. Immunology

 M Allam, AF Coskun 10/01/2024

Spatial immunophenotyping using multiplexed imaging of immune follicles in secondary lymphoid tissues.

PNAS nexus

 M Allam, T Hu, Z Fang, M Pi, A Singh, AF Coskun 08/01/2024

Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive CAR-T Cell Therapies with Multiple Myeloma.

bioRxiv : the preprint server for biology

 D Ghoshal, I Petersen, R Ringquist, L Kramer, E Bhatia, T Hu, A Richard, R Park, J Corbin, S Agarwal, A Thomas, S Ramirez, J Tharayil, E Downey, F Ketchum, A Ochal, N Sonthi, S Lonial, JN Kochenderfer, R Tran, M Zhu, WA Lam, AF Coskun, K Roy 04/12/2024

Comprehensive biomechanical and anatomical atherosclerotic plaque metrics predict major adverse cardiovascular events: A new tool for clinical decision making.

Atherosclerosis

 SZ Gu, ME Ahmed, Y Huang, D Hakim, C Maynard, NV Cefalo, AU Coskun, C Costopoulos, A Maehara, GW Stone, PH Stone, MR Bennett 03/01/2024

Spatial Morphoproteomic Features Predict Uniqueness of Immune Microarchitectures and Responses in Lymphoid Follicles.

bioRxiv : the preprint server for biology

 T Hu, M Allam, V Kaushik, SL Goudy, Q Xu, P Mudd, K Manthiram, AF Coskun 01/07/2024

Single-cell spatial metabolomics with cell-type specific protein profiling for tissue systems biology.

Nature communications

 T Hu, M Allam, S Cai, W Henderson, B Yueh, A Garipcan, AV Ievlev, M Afkarian, S Beyaz, AF Coskun 12/13/2023

Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application.

Journal of pharmaceutical analysis

 D Li, Z Fang, Q Shi, N Zhang, B Gong, W Tong, AF Coskun, J Xu 07/01/2023

Microbial Changes occurring during oronasal fistula wound healing.

bioRxiv : the preprint server for biology

 SL Goudy, H Bradley, CA Gacasan, A Toma, CR Naudin, WM Wuest, M Tomov, V Serpooshan, A Coskun, RM Jones 06/06/2023

Subcellular spatially resolved gene neighborhood networks in single cells.

Cell reports methods

 Z Fang, AJ Ford, T Hu, N Zhang, A Mantalaris, AF Coskun 05/22/2023

Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas.

Nature materials

 SB Shah, CR Carlson, K Lai, Z Zhong, G Marsico, KM Lee, NE Félix Vélez, EB Abeles, M Allam, T Hu, LD Walter, KE Martin, K Gandhi, SD Butler, R Puri, AL McCleary-Wheeler, W Tam, O Elemento, K Takata, C Steidl, DW Scott, L Fontan, H Ueno, BD Cosgrove, G Inghirami, AJ García, AF Coskun, JL Koff, A Melnick, A Singh 04/01/2023

Spatial subcellular organelle networks in single cells.

Scientific reports

 M Venkatesan, N Zhang, B Marteau, Y Yajima, NO De Zarate Garcia, Z Fang, T Hu, S Cai, A Ford, H Olszewski, A Borst, AF Coskun 04/01/2023

Single-Cell and Spatial Analysis of Emergent Organoid Platforms.

Methods in molecular biology (Clifton, N.J.)

 A Kumar, S Cai, M Allam, S Henderson, M Ozbeyler, L Saiontz, AF Coskun 01/01/2023

Multiplexed protein profiling reveals spatial subcellular signaling networks.

iScience

 S Cai, T Hu, M Venkatesan, M Allam, F Schneider, SS Ramalingam, SY Sun, AF Coskun 09/16/2022

Spatially variant immune infiltration scoring in human cancer tissues.

NPJ precision oncology

 M Allam, T Hu, J Lee, J Aldrich, SS Badve, Y Gökmen-Polar, M Bhave, SS Ramalingam, F Schneider, AF Coskun 09/01/2022

Extracellular Matrix in Synthetic Hydrogel-Based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 Inhibitors.

Advanced materials (Deerfield Beach, Fla.)

 MJ Mosquera, S Kim, R Bareja, Z Fang, S Cai, H Pan, M Asad, ML Martin, M Sigouros, FM Rowdo, S Ackermann, J Capuano, J Bernheim, C Cheung, A Doane, N Brady, R Singh, DS Rickman, V Prabhu, JE Allen, L Puca, AF Coskun, MA Rubin, H Beltran, JM Mosquera, O Elemento, A Singh 01/01/2022

Subcellular localization of biomolecules and drug distribution by high-definition ion beam imaging.

Nature communications

 X Rovira-Clavé, S Jiang, Y Bai, B Zhu, G Barlow, S Bhate, AF Coskun, G Han, CK Ho, C Hitzman, SY Chen, FA Bava, GP Nolan 07/30/2021

Virtual and augmented reality for biomedical applications.

Cell reports. Medicine

 M Venkatesan, H Mohan, JR Ryan, CM Schürch, GP Nolan, DH Frakes, AF Coskun 07/20/2021

Spatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease.

Communications biology

 M Allam, T Hu, S Cai, K Laxminarayanan, RB Hughley, AF Coskun 05/27/2021

Single-cell analysis reveals effective siRNA delivery in brain tumors with microbubble-enhanced ultrasound and cationic nanoparticles.

Science advances

 Y Guo, H Lee, Z Fang, A Velalopoulou, J Kim, MB Thomas, J Liu, RG Abramowitz, Y Kim, AF Coskun, DP Krummel, S Sengupta, TJ MacDonald, C Arvanitis 04/01/2021