Yue Feng, MD, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-727-0351
Email Address

yfeng@emory.edu

Biography

Yue Feng, MD, PhD, is a professor in the Department of Pharmacology and Chemical Biology at Emory University School of Medicine. Dr. Feng is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute of Emory University in Atlanta Georgia.

Dr. Feng received her PhD from Vanderbilt University in Nashville, Tennessee. She completed her postdoctoral training as a fellow and research associate at Emory University in Atlanta, Georgia.

Titles & Roles

Professor, Department of Pharmacology and Chemical Biology

Emory University School of Medicine

Research

Dr. Feng's research area is in posttranscriptional regulation in normal brain function, development and brain diseases. Her laboratory is interested in how RNA-binding proteins and microRNAs govern the normal brain development and function, and how posttranscriptional dysregulation at the steps of mRNA biogenesis and translation leads to malfunction of neurons and glia, which underlies many mental and neurological diseases.

Publications

Title/Journal	Authors	Publication Date
Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association	F Wang, Y Li, H Shen, Y Feng, B Yao	12/01/2024
Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer's disease. Genome medicine	F Wang, Y Li, H Shen, P Martinez-Feduchi, X Ji, P Teng, S Krishnakumar, J Hu, L Chen, Y Feng, B Yao	11/11/2024
Isoform balance of the long noncoding RNA NEAT1 is regulated by the RNA-binding protein QKI, governs the glioma transcriptome, and impacts cell migration. The Journal of biological chemistry	PM Zakutansky, L Ku, G Zhang, L Shi, Y Li, B Yao, GJ Bassell, RD Read, Y Feng	08/01/2024
The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases. Brain, behavior, and immunity	P Teng, Y Li, L Ku, F Wang, DR Goldsmith, Z Wen, B Yao, Y Feng	08/01/2023
Accurate identification of circRNA landscape and complexity reveals their pivotal roles in human oligodendroglia differentiation. Genome biology	Y Li, F Wang, P Teng, L Ku, L Chen, Y Feng, B Yao	02/07/2022
Carbamazepine Restores Neuronal Signaling, Protein Synthesis, and Cognitive Function in a Mouse Model of Fragile X Syndrome. International journal of molecular sciences	Q Ding, F Zhang, Y Feng, H Wang	12/07/2020
Transcriptome signature analysis repurposes trifluoperazine for the treatment of fragile X syndrome in mouse model. Communications biology	Q Ding, F Sethna, XT Wu, Z Miao, P Chen, Y Zhang, H Xiao, W Feng, Y Feng, X Li, H Wang	03/16/2020
Spontaneous Local Calcium Transients Regulate Oligodendrocyte Development in Culture through Store-Operated Ca²⁺ Entry and Release. eNeuro	Y Rui, SL Pollitt, KR Myers, Y Feng, JQ Zheng	01/01/2020
IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult. European heart journal	H Xiao, H Li, JJ Wang, JS Zhang, J Shen, XB An, CC Zhang, JM Wu, Y Song, XY Wang, HY Yu, XN Deng, ZJ Li, M Xu, ZZ Lu, J Du, W Gao, AH Zhang, Y Feng, YY Zhang	01/01/2018
Novel schizophrenia risk factor pathways regulate FEZ1 to advance oligodendroglia development. Translational psychiatry	X Chen, L Ku, R Mei, G Liu, C Xu, Z Wen, X Zhao, F Wang, L Xiao, Y Feng	12/18/2017
Active Cdk5 Immunoprecipitation and Kinase Assay. Bio-protocol	AN Bankston, L Ku, Y Feng	07/05/2017
Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model. Nature communications	F Sethna, W Feng, Q Ding, AJ Robison, Y Feng, H Wang	02/20/2017
Phosphatidylinositol-3 kinase-dependent translational regulation of Id1 involves the PPM1G phosphatase. Oncogene	K Xu, L Wang, W Feng, Y Feng, HK Shu	11/03/2016
p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic Responses. The Journal of neuroscience : the official journal of the Society for Neuroscience	W Li, ME Allen, Y Rui, L Ku, G Liu, AN Bankston, JQ Zheng, Y Feng	11/02/2016
Oligodendroglial defects during quakingviable cerebellar development. Developmental neurobiology	KR Myers, G Liu, Y Feng, JQ Zheng	09/01/2016
hnRNP-Q1 represses nascent axon growth in cortical neurons by inhibiting Gap-43 mRNA translation. Molecular biology of the cell	KR Williams, DS McAninch, S Stefanovic, L Xing, M Allen, W Li, Y Feng, MR Mihailescu, GJ Bassell	02/01/2016
Expression of Quaking RNA-Binding Protein in the Adult and Developing Mouse Retina. PloS one	T Suiko, K Kobayashi, K Aono, T Kawashima, K Inoue, L Ku, Y Feng, C Koike	01/01/2016
Oligodendroglial Development: New Roles for Chromatin Accessibility. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry	N Huang, J Niu, Y Feng, L Xiao	12/01/2015
The inhibition of Cdk5 activity after hypoxia/ischemia injury reduces infarct size and promotes functional recovery in neonatal rats. Neuroscience	X Tan, Y Chen, J Li, X Li, Z Miao, N Xin, J Zhu, W Ge, Y Feng, X Xu	04/02/2015
Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes. Neuron	B Huang, W Wei, G Wang, MA Gaertig, Y Feng, W Wang, XJ Li, S Li	03/18/2015
Post-transcriptional regulation of programmed cell death 4 (PDCD4) mRNA by the RNA-binding proteins human antigen R (HuR) and T-cell intracellular antigen 1 (TIA1). The Journal of biological chemistry	CP Wigington, J Jung, EA Rye, SL Belauret, AM Philpot, Y Feng, PJ Santangelo, AH Corbett	02/06/2015
Impairment of Oligodendroglia Maturation Leads to Aberrantly Increased Cortical Glutamate and Anxiety-Like Behaviors in Juvenile Mice. Frontiers in cellular neuroscience	X Chen, W Zhang, T Li, Y Guo, Y Tian, F Wang, S Liu, HY Shen, Y Feng, L Xiao	01/01/2015
Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing. Genes & development	Y Xu, XD Gao, JH Lee, H Huang, H Tan, J Ahn, LM Reinke, ME Peter, Y Feng, D Gius, KP Siziopikou, J Peng, X Xiao, C Cheng	06/01/2014
A cytoplasmic quaking I isoform regulates the hnRNP F/H-dependent alternative splicing pathway in myelinating glia. Nucleic acids research	MD Mandler, L Ku, Y Feng	06/01/2014
The Rpe65 rd12 allele exerts a semidominant negative effect on vision in mice. Investigative ophthalmology & visual science	CB Wright, MA Chrenek, W Feng, SE Getz, T Duncan, MT Pardue, Y Feng, TM Redmond, JH Boatright, JM Nickerson	04/17/2014
Coordination of engineered factors with TET1/2 promotes early-stage epigenetic modification during somatic cell reprogramming. Stem cell reports	G Zhu, Y Li, F Zhu, T Wang, W Jin, W Mu, W Lin, W Tan, W Li, RC Street, S Peng, J Zhang, Y Feng, ST Warren, Q Sun, P Jin, D Chen	03/11/2014
PIKE is essential for oligodendroglia development and CNS myelination. Proceedings of the National Academy of Sciences of the United States of America	CB Chan, X Liu, L Zhao, G Liu, CW Lee, Y Feng, K Ye	02/04/2014
Neuron enriched nuclear proteome isolated from human brain. Journal of proteome research	EB Dammer, DM Duong, I Diner, M Gearing, Y Feng, JJ Lah, AI Levey, NT Seyfried	07/05/2013
p39, the primary activator for cyclin-dependent kinase 5 (Cdk5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair. The Journal of biological chemistry	AN Bankston, W Li, H Zhang, L Ku, G Liu, F Papa, L Zhao, JA Bibb, F Cambi, SK Tiwari-Woodruff, Y Feng	06/21/2013
Oligodendroglia and neurotrophic factors in neurodegeneration. Neuroscience bulletin	AN Bankston, MD Mandler, Y Feng	04/01/2013
HuD promotes BDNF expression in brain neurons via selective stabilization of the BDNF long 3'UTR mRNA. PloS one	M Allen, C Bird, W Feng, G Liu, W Li, NI Perrone-Bizzozero, Y Feng	01/01/2013
Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards. Journal of proteome research	NT Seyfried, YM Gozal, LE Donovan, JH Herskowitz, EB Dammer, Q Xia, L Ku, J Chang, DM Duong, HD Rees, DS Cooper, JD Glass, M Gearing, MG Tansey, JJ Lah, Y Feng, AI Levey, J Peng	05/04/2012
MicroRNAs in neural cell development and brain diseases. Science China. Life sciences	W Feng, Y Feng	12/01/2011
Proteomic identification of novel targets regulated by the mammalian target of rapamycin pathway during oligodendrocyte differentiation. Glia	WA Tyler, MR Jain, SE Cifelli, Q Li, L Ku, Y Feng, H Li, TL Wood	11/01/2011
Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans. Proceedings of the National Academy of Sciences of the United States of America	C Pak, M Garshasbi, K Kahrizi, C Gross, LH Apponi, JJ Noto, SM Kelly, SW Leung, A Tzschach, F Behjati, SS Abedini, M Mohseni, LR Jensen, H Hu, B Huang, SN Stahley, G Liu, KR Williams, S Burdick, Y Feng, S Sanyal, GJ Bassell, HH Ropers, H Najmabadi, AH Corbett, KH Moberg, AW Kuss	07/26/2011
When MAGE meets RING: insights into biological functions of MAGE proteins. Protein & cell	Y Feng, J Gao, M Yang	01/01/2011
Quaking I controls a unique cytoplasmic pathway that regulates alternative splicing of myelin-associated glycoprotein. Proceedings of the National Academy of Sciences of the United States of America	L Zhao, MD Mandler, H Yi, Y Feng	11/02/2010
RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory. Proceedings of the National Academy of Sciences of the United States of America	SE Lee, SB Simons, SA Heldt, M Zhao, JP Schroeder, CP Vellano, DP Cowan, S Ramineni, CK Yates, Y Feng, Y Smith, JD Sweatt, D Weinshenker, KJ Ressler, SM Dudek, JR Hepler	09/28/2010
Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF). Proceedings of the National Academy of Sciences of the United States of America	AG Lau, HA Irier, J Gu, D Tian, L Ku, G Liu, M Xia, B Fritsch, JQ Zheng, R Dingledine, B Xu, B Lu, Y Feng	09/07/2010
Direct determination of molecular haplotypes by chromosome microdissection. Nature methods	L Ma, Y Xiao, H Huang, Q Wang, W Rao, Y Feng, K Zhang, Q Song	04/01/2010
The star family member QKI and cell signaling. Advances in experimental medicine and biology	Y Feng, A Bankston	01/01/2010
Retinoic acid is a cofactor for translational regulation of vascular endothelial growth factor in human endometrial stromal cells. Molecular endocrinology (Baltimore, Md.)	N Sidell, Y Feng, L Hao, J Wu, J Yu, MA Kane, JL Napoli, RN Taylor	01/01/2010
Regulation of XIAP translation and induction by MDM2 following irradiation. Cancer cell	L Gu, N Zhu, H Zhang, DL Durden, Y Feng, M Zhou	05/05/2009
Translational regulation of GluR2 mRNAs in rat hippocampus by alternative 3' untranslated regions. Journal of neurochemistry	HA Irier, R Shaw, A Lau, Y Feng, R Dingledine	04/01/2009
Iron chelators and hypoxia mimetics inhibit IFNgamma-mediated Jak-STAT signaling. The Journal of investigative dermatology	AK Gira, AP Kowalczyk, Y Feng, RA Swerlick	03/01/2009
Essential function, sophisticated regulation and pathological impact of the selective RNA-binding protein QKI in CNS myelin development. Future neurology	K Bockbrader, Y Feng	11/01/2008
Convergence and divergence in the etiology of myelin impairment in psychiatric disorders and drug addiction. Neurochemical research	Y Feng	10/01/2008
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B. Nature cell biology	X Tang, SW Jang, M Okada, CB Chan, Y Feng, Y Liu, SW Luo, Y Hong, N Rama, WC Xiong, P Mehlen, K Ye	06/01/2008
Dynamic association of the fragile X mental retardation protein as a messenger ribonucleoprotein between microtubules and polyribosomes. Molecular biology of the cell	H Wang, JB Dictenberg, L Ku, W Li, GJ Bassell, Y Feng	01/01/2008