David L. Jaye, MD

Role

Pathology
Specialty

Leukemia Lymphoma Myeloma and Plasma Cell Disorders Myelodysplastic Syndromes
Research Program

Cancer Immunology
Practicing Since

1997

Background

David L. Jaye, MD, is an Associate Professor in the Department of Pathology & Laboratory Medicine at Emory University School of Medicine. Dr. Jaye is an attending physician on the hematopathology service for Emory Healthcare and a consultant at Children's Healthcare of Atlanta and Grady Memorial Hospital. A board certified pathologist, he began practicing with Emory Healthcare in 2002.

Dr. Jaye is a member of the Cancer Immunology Research Program with an extensive research background.

Dr. Jaye earned his medical degree from Washington University School of Medicine. He then completed a residency in anatomic pathology at Washington University School of Medicine and clinical pathology at the University of Alabama at Birmingham School of Medicine. Dr. Jaye conducted his fellowship in hematopathology at the Emory University School of Medicine in 1998.

Dr. Jaye's research efforts encompass projects broadly related to biology, laboratory diagnosis and treatment of hematolymphoid disorders. Ongoing research endeavors include studies of B-lineage neoplasms (lymphoma, multiple myeloma) including clinico-pathologic correlations, and machine-learning approaches to analysis of digital pathology slide images.

PubMed

Titles & Roles

Associate Professor, Department of Pathology and Laboratory Medicine

Emory University School of Medicine

Education & Training

Education

Fellowship, Pathology, 2001
Emory University School of Medicine
Fellowship, Hematopathology, 1998
Emory University School of Medicine
Residency, Anatomic & Clinical Pathology, 1997
University of Alabama Health System
Residency, Anatomic & Clinical Pathology, 1995
Washington University School of Medicine
Medical Education, MD, 1991
Washington University School of Medicine

Board Certifications

Hematology
American Board of Pathology, 2004
Clinical Pathology
American Board of Pathology, 1997
Anatomic Pathology
American Board of Pathology, 1997

Research

Publications

Title/Journal	Authors	Publication Date
Interleukin-1 receptor antagonist is a conserved early factor for exacerbating tuberculosis susceptibility. bioRxiv : the preprint server for biology	OV Lee, DX Ji, BA Rosa, DL Jaye, S Suliman, M Mitreva, C Gabay, RE Vance, DI Kotov	03/29/2025
Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine biosynthesis. Blood	R Nair, AH Vu, AK Freer, KS Bhatia, D Wang, MR Savani, SM Matulis, S Lonial, DL Jaye, LH Boise, SY Seo, TW Corson, AK Nooka, S Bhatt, SK McBrayer, VA Gupta, X Hu, BG Barwick, AR Reddi, M Shanmugam	02/13/2025
Real-world impact of differences in the WHO and ICC classifications of non-Hodgkin lymphoma: a LEO cohort study analysis. Blood	B Abro, MJ Maurer, TM Habermann, WR Burack, JR Chapman, JB Cohen, JW Friedberg, G Inghirami, BS Kahl, MC Larson, BK Link, IS Lossos, P Martin, TJ McDonnell, LJ Nastoupil, SM Riska, S Syrbu, F Vega, KR Vij, CR Flowers, JR Cerhan, DL Jaye, AL Feldman	11/07/2024
The unnecessary use of short tandem repeat testing on bone marrow samples in patients after 1 year following allogeneic hematopoietic stem cell transplant. American journal of clinical pathology	AB Morris, HC Sullivan, MS Wooten, EK Waller, DL Jaye	11/04/2024
The Lymphoma Epidemiology of Outcomes cohort study: Design, baseline characteristics, and early outcomes. American journal of hematology	JR Cerhan, MJ Maurer, BK Link, AL Feldman, TM Habermann, DL Jaye, WR Burack, TJ McDonnell, F Vega, JR Chapman, S Syrbu, KR Vij, G Inghirami, JP Leonard, L Bernal-Mizrachi, U Farooq, TE Witzig, GJ Weiner, Y Wang, JP Alderuccio, SL Slager, MC Larson, SM Riska, BJ Gysbers, JJ Lunde, TW Reicks, AA Ayers, CB O'Leary, KJ Yost, H Liu, GS Nowakowski, J Ruan, D Chihara, JL Koff, C Casulo, CA Thompson, JB Cohen, BS Kahl, LJ Nastoupil, IS Lossos, JW Friedberg, P Martin, CR Flowers	03/01/2024
SAMHD1 expression contributes to doxorubicin resistance and predicts survival outcomes in diffuse large B-cell lymphoma patients. NAR cancer	W Daddacha, D Monroe, AJ Schlafstein, AE Withers, EB Thompson, D Danelia, NC Luong, F Sesay, SK Rath, ER Usoro, ME Essien, AT Jung, JG Jiang, J Hu, B Mahboubi, A Williams, JE Steinbeck, X Yang, ZS Buchwald, WS Dynan, JM Switchenko, B Kim, MK Khan, DL Jaye, DS Yu	03/01/2024
Translating prognostic quantification of c-MYC and BCL2 from tissue microarrays to whole slide images in diffuse large B-cell lymphoma using deep learning. Diagnostic pathology	TE Tavolara, MKK Niazi, AL Feldman, DL Jaye, C Flowers, LAD Cooper, MN Gurcan	01/19/2024
Automated Deep Learning-Based Diagnosis and Molecular Characterization of Acute Myeloid Leukemia Using Flow Cytometry. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc	JE Lewis, LAD Cooper, DL Jaye, O Pozdnyakova	01/01/2024
Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis. Cell	DI Kotov, OV Lee, SA Fattinger, CA Langner, JV Guillen, JM Peters, A Moon, EM Burd, KC Witt, DB Stetson, DL Jaye, BD Bryson, RE Vance	12/07/2023
Profiling endogenous, environmental, and infectious disease mutational signatures in blastic plasmacytoid dendritic cell neoplasms. International journal of laboratory hematology	C Small, S Mukerjee, D Jangam, S Gollapudi, K Singh, DL Jaye, PP Aung, C Querfeld, K Yao, KM Chisholm, S Pullarkat, S Wang, A Gru, M Hussaini, TI George, RS Ohgami	10/01/2023
Automated Deep Learning-Based Diagnosis and Molecular Characterization of Acute Myeloid Leukemia using Flow Cytometry. bioRxiv : the preprint server for biology	JE Lewis, LAD Cooper, DL Jaye, O Pozdnyakova	09/25/2023
Regulation of antigen-specific T cell infiltration and spatial architecture in multiple myeloma and premalignancy. The Journal of clinical investigation	MH Robinson, NY Villa, DL Jaye, AK Nooka, A Duffy, SS McCachren, J Manalo, JM Switchenko, S Barnes, S Potdar, MI Azeem, AA Horvat, VC Parihar, J Gong, Y Liang, GH Smith, VA Gupta, LH Boise, JL Kaufman, CC Hofmeister, NS Joseph, S Lonial, KM Dhodapkar, MV Dhodapkar	08/01/2023
An Analysis of the Pathologic Features of Blastic Plasmacytoid Dendritic Cell Neoplasm Based on a Comprehensive Literature Database of Cases. Archives of pathology & laboratory medicine	RS Ohgami, PP Aung, AA Gru, M Hussaini, K Singh, C Querfeld, K Yao, C Small, S Gollapudi, D Jaye, SA Wang, S Pullarkat, TI George	07/01/2023
ALK-negative anaplastic large cell lymphoma with JAK2 rearrangement mimicking classic Hodgkin lymphoma. Blood	DL Jaye, AL Feldman	04/27/2023
An Automated Pipeline for Differential Cell Counts on Whole-Slide Bone Marrow Aspirate Smears. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc	JE Lewis, CW Shebelut, BR Drumheller, X Zhang, N Shanmugam, M Attieh, MC Horwath, A Khanna, GH Smith, DA Gutman, A Aljudi, LAD Cooper, DL Jaye	02/01/2023
Herpes simplex virus lymphadenitis is associated with tumor reduction in a patient with chronic lymphocytic leukemia. The Journal of clinical investigation	A Chang, AM Sholukh, A Wieland, DL Jaye, M Carrington, ML Huang, H Xie, KR Jerome, P Roychoudhury, AL Greninger, JL Koff, JB Cohen, DM Koelle, L Corey, CR Flowers, R Ahmed	09/15/2022
Venetoclax ex vivo functional profiling predicts improved progression-free survival. Blood cancer journal	VA Gupta, SM Matulis, BG Barwick, RD Bog, CW Shebelut, M Shanmugam, P Neri, NJ Bahlis, MV Dhodapkar, LT Heffner, CC Hofmeister, NS Joseph, S Lonial, JL Kaufman, DL Jaye, AK Nooka, LH Boise	08/04/2022
NuCLS: A scalable crowdsourcing approach and dataset for nucleus classification and segmentation in breast cancer. GigaScience	M Amgad, LA Atteya, H Hussein, KH Mohammed, E Hafiz, MAT Elsebaie, AM Alhusseiny, MA AlMoslemany, AM Elmatboly, PA Pappalardo, RA Sakr, P Mobadersany, A Rachid, AM Saad, AM Alkashash, IA Ruhban, A Alrefai, NM Elgazar, A Abdulkarim, AA Farag, A Etman, AG Elsaeed, Y Alagha, YA Amer, AM Raslan, MK Nadim, MAT Elsebaie, A Ayad, LE Hanna, A Gadallah, M Elkady, B Drumheller, D Jaye, D Manthey, DA Gutman, H Elfandy, LAD Cooper	05/17/2022
Erythropoietic properties of human induced pluripotent stem cells-derived red blood cells in immunodeficient mice. American journal of hematology	J Deng, M Lancelot, R Jajosky, Q Deng, K Deeb, N Saakadze, Y Gao, D Jaye, S Liu, SR Stowell, L Cheng, JD Roback	02/01/2022
Lightweight, open source, easy-use algorithm and web service for paraprotein screening using spatial frequency domain analysis of electrophoresis studies. Journal of pathology informatics	R Chen, DL Jaye, JD Roback, MA Sherman, GH Smith	01/01/2022
Venetoclax sensitivity in multiple myeloma is associated with B-cell gene expression. Blood	VA Gupta, BG Barwick, SM Matulis, R Shirasaki, DL Jaye, JJ Keats, B Oberlton, NS Joseph, CC Hofmeister, LT Heffner, MV Dhodapkar, AK Nooka, S Lonial, CS Mitsiades, JL Kaufman, LH Boise	07/01/2021
Chromatin Accessibility Identifies Regulatory Elements Predictive of Gene Expression and Disease Outcome in Multiple Myeloma. Clinical cancer research : an official journal of the American Association for Cancer Research	BG Barwick, VA Gupta, SM Matulis, JC Patton, DR Powell, Y Gu, DL Jaye, KN Conneely, YC Lin, CC Hofmeister, AK Nooka, JJ Keats, S Lonial, PM Vertino, LH Boise	06/01/2021
A Mimic of Posttransplant Lymphoproliferative Disease Following Liver Transplant. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation	WH Kitchens, DL Jaye, JP Wedd, JF Magliocca	11/01/2020
Clinician-ordered peripheral blood smears have low reimbursement and variable clinical value: a three-institution study, with suggestions for operational efficiency. Diagnostic pathology	AK Beckman, VL Ng, DL Jaye, M Gaddh, SA Williams, SL Yohe, L Zhang, MA Linden	09/17/2020
Clinical features and survival of multiple myeloma patients harboring t(14;16) in the era of novel agents. Blood cancer journal	R Mina, NS Joseph, F Gay, E Kastritis, MT Petrucci, JL Kaufman, V Montefusco, M Gavriatopoulou, F Patriarca, P Omedé, LH Boise, M Roussou, N Giuliani, S Oliva, M Offidani, A Belotti, DL Jaye, L De Paoli, E Terpos, S Lonial, M Boccadoro, AK Nooka, MA Dimopoulos	04/14/2020
Rituximab leads to early elimination of circulating CD20+ T and B lymphocytes in patients with iTTP despite ongoing TPEx. Blood advances	MA Carden, M Gaddh, A Hoskote, M Brown, V Merrill, SR Stowell, S Chandrakasan, A Antun, R Kudchadkar, S Kotanchiyev, DL Jaye, I Bodó	02/11/2020
Retroperitoneal Follicular Dendritic Cell Sarcoma: A Case Report. Advances in radiation oncology	C Jiang, YA Syed, EB Burdette, DL Jaye, CR Flowers, MK Khan	01/01/2020
Machine-based detection and classification for bone marrow aspirate differential counts: initial development focusing on nonneoplastic cells. Laboratory investigation; a journal of technical methods and pathology	R Chandradevan, AA Aljudi, BR Drumheller, N Kunananthaseelan, M Amgad, DA Gutman, LAD Cooper, DL Jaye	01/01/2020
Gain of Chromosome 1q is associated with early progression in multiple myeloma patients treated with lenalidomide, bortezomib, and dexamethasone. Blood cancer journal	TM Schmidt, BG Barwick, N Joseph, LT Heffner, CC Hofmeister, L Bernal, MV Dhodapkar, VA Gupta, DL Jaye, J Wu, S Goyal, Z Chen, LH Boise, S Lonial, AK Nooka, JL Kaufman	11/25/2019
Multiple myeloma immunoglobulin lambda translocations portend poor prognosis. Nature communications	BG Barwick, P Neri, NJ Bahlis, AK Nooka, MV Dhodapkar, DL Jaye, CC Hofmeister, JL Kaufman, VA Gupta, D Auclair, JJ Keats, S Lonial, PM Vertino, LH Boise	04/23/2019
Oligoclonal T Cells Transiently Expand and Express Tim-3 and PD-1 Following Anti-CD19 CAR T Cell Therapy: A Case Report. International journal of molecular sciences	CR Funk, CT Petersen, N Jagirdar, S Ravindranathan, DL Jaye, CR Flowers, A Langston, EK Waller	12/19/2018
Is a 500-Cell Count Necessary for Bone Marrow Differentials?: A Proposed Analytical Method for Validating a Lower Cutoff. American journal of clinical pathology	AA Abdulrahman, KH Patel, T Yang, DD Koch, SM Sivers, GH Smith, DL Jaye	05/31/2018
Isolated myeloperoxidase expression in pediatric B/myeloid mixed phenotype acute leukemia is linked with better survival. Blood	SS Raikar, SI Park, T Leong, DL Jaye, FG Keller, JT Horan, WG Woods	02/01/2018
Diagnosis of GATA2 haplo-insufficiency in a young woman prompted by pancytopenia with deficiencies of B-cell and dendritic cell development. Biomarker research	A Sanyi, DL Jaye, CB Rosand, A Box, C Shanmuganathan, EK Waller	01/01/2018
Informatics Approaches to Address New Challenges in the Classification of Lymphoid Malignancies. JCO clinical cancer informatics	J Jordan, JS Goldstein, DL Jaye, M Gurcan, CR Flowers, LAD Cooper	01/01/2018
Multimodality Technologies in the Assessment of Hematolymphoid Neoplasms. Archives of pathology & laboratory medicine	S Li, DL Jaye, KT Bradley, L Zhang, D Saxe, G Deeb, CE Hill, KP Mann	03/01/2017
PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients. PloS one	MS Hossain, GM Kunter, VF El-Najjar, DL Jaye, Z Al-Kadhimi, OK Taofeek, JM Li, EK Waller	01/01/2017
Bortezomib-induced heat shock response protects multiple myeloma cells and is activated by heat shock factor 1 serine 326 phosphorylation. Oncotarget	SP Shah, AK Nooka, DL Jaye, NJ Bahlis, S Lonial, LH Boise	09/13/2016
Identification of human plasma cells with a lamprey monoclonal antibody. JCI insight	C Yu, Y Liu, JTH Chan, J Tong, Z Li, M Shi, D Davani, M Parsons, S Khan, W Zhan, S Kyu, E Grunebaum, P Campisi, EJ Propst, DL Jaye, S Trudel, MF Moran, M Ostrowski, BR Herrin, FE Lee, I Sanz, MD Cooper, GR Ehrhardt	01/01/2016
A Phase 2 Trial of Fludarabine Combined With Subcutaneous Alemtuzumab for the Treatment of Relapsed/Refractory B-Cell Chronic Lymphocytic Leukemia. Clinical lymphoma, myeloma & leukemia	CR Flowers, JR Brown, H Rosenthal, W Stock, HI Katzen, JB Cohen, R Sinha, S Lakhanpal, JF Leis, EK Waller, DL Jaye	11/01/2015
Successful treatment of severe immune hemolytic anemia after allogeneic stem cell transplantation with bortezomib: report of a case and review of literature. Transfusion	S Hosoba, DL Jaye, C Cohen, JD Roback, EK Waller	02/01/2015
Sensitivity and specificity of cerebrospinal fluid flow cytometry for the diagnosis of leukemic meningitis in acute lymphoblastic leukemia/lymphoma. Leukemia & lymphoma	Z Mitri, MT Siddiqui, F El Rassi, JT Holden, LT Heffner, A Langston, EK Waller, E Winton, M McLemore, L Bernal-Mizrachi, D Jaye, M Arellano, HJ Khoury	07/01/2014
Examining racial differences in diffuse large B-cell lymphoma presentation and survival. Leukemia & lymphoma	CR Flowers, PJ Shenoy, U Borate, K Bumpers, T Douglas-Holland, N King, OW Brawley, J Lipscomb, MJ Lechowicz, R Sinha, RS Grover, L Bernal-Mizrachi, J Kowalski, W Donnellan, A The, V Reddy, DL Jaye, J Foran	02/01/2013
VIPhyb, an antagonist of vasoactive intestinal peptide receptor, enhances cellular antiviral immunity in murine cytomegalovirus infected mice. PloS one	JM Li, KA Darlak, L Southerland, MS Hossain, DL Jaye, CD Josephson, H Rosenthal, EK Waller	01/01/2013
Purification and identification of cell surface antigens using lamprey monoclonal antibodies. Journal of immunological methods	C Yu, S Ali, J St-Germain, Y Liu, X Yu, DL Jaye, MF Moran, MD Cooper, GR Ehrhardt	12/14/2012
Characteristics and outcomes of diffuse large B-cell lymphoma presenting in leukaemic phase. British journal of haematology	D Muringampurath-John, DL Jaye, CR Flowers, D Saxe, Z Chen, MJ Lechowicz, DD Weisenburger, M Bast, ML Arellano, L Bernal-Mizrachi, LT Heffner, M McLemore, JL Kaufman, EF Winton, S Lonial, JO Armitage, HJ Khoury	09/01/2012
Translational applications of flow cytometry in clinical practice. Journal of immunology (Baltimore, Md. : 1950)	DL Jaye, RA Bray, HM Gebel, WA Harris, EK Waller	05/15/2012
Rituximab-hyperfractionated cyclophosphamide, vincristine, adriamycin and dexamethasone alternating with high-dose cytarabine and methotrexate for aggressive non-Hodgkin lymphoma. Leukemia & lymphoma	D Muringampurath-John, CR Flowers, M Toscano, C Zhengjia, JL Kaufman, M Arellano, L Bernal-Mizrachi, LT Heffner, MJ Lechowicz, M McLemore, E Winton, DL Jaye, S Lonial, HJ Khoury	04/01/2012
Flagellin, a TLR5 agonist, reduces graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients while enhancing antiviral immunity. Journal of immunology (Baltimore, Md. : 1950)	MS Hossain, DL Jaye, BP Pollack, AB Farris, ML Tselanyane, E David, JD Roback, AT Gewirtz, EK Waller	11/15/2011
Rapid recovery from panobinostat (LBH589)-induced thrombocytopenia in mice involves a rebound effect of bone marrow megakaryocytes. Leukemia	CR Giver, DL Jaye, EK Waller, JL Kaufman, S Lonial	02/01/2011
The role of CD11c expression in the diagnosis of mantle cell lymphoma. American journal of clinical pathology	TS Kraus, CN Sillings, DF Saxe, S Li, DL Jaye	08/01/2010
Activation, immune polarization, and graft-versus-leukemia activity of donor T cells are regulated by specific subsets of donor bone marrow antigen-presenting cells in allogeneic hemopoietic stem cell transplantation. Journal of immunology (Baltimore, Md. : 1950)	JM Li, LT Southerland, Y Lu, KA Darlak, CR Giver, DW McMillin, WA Harris, DL Jaye, EK Waller	12/15/2009
Selective targeting of nanocarriers to neutrophils and monocytes. Annals of biomedical engineering	E Karathanasis, CM Geigerman, CA Parkos, L Chan, RV Bellamkonda, DL Jaye	10/01/2009
Neutropenia in a patient treated with ipilimumab (anti-CTLA-4 antibody). Journal of immunotherapy (Hagerstown, Md. : 1997)	M Akhtari, EK Waller, DL Jaye, DH Lawson, R Ibrahim, NE Papadopoulos, ML Arellano	04/01/2009
Rational identification of a novel peptide for targeting nanocarriers to 9L glioma. Journal of biomedical materials research. Part A	A Agarwal, DL Jaye, CM Giegerman, RV Bellamkonda	12/01/2008
Chronic GvHD decreases antiviral immune responses in allogeneic BMT. Blood	MS Hossain, JD Roback, BP Pollack, DL Jaye, A Langston, EK Waller	05/15/2007
Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma. Blood	S Lonial, EK Waller, PG Richardson, S Jagannath, RZ Orlowski, CR Giver, DL Jaye, D Francis, S Giusti, C Torre, B Barlogie, JR Berenson, S Singhal, DP Schenkein, DL Esseltine, J Anderson, H Xiao, LT Heffner, KC Anderson	12/01/2005
Ex vivo fludarabine exposure inhibits graft-versus-host activity of allogeneic T cells while preserving graft-versus-leukemia effects. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation	CR Giver, RO Montes, S Mittelstaedt, JM Li, DL Jaye, S Lonial, MW Boyer, EK Waller	10/01/2003

Awards

Dr. Jaye has been named an Avon Breast Cancer Crusade Scholar and received the CAP Foundation Scholars Award. He has also been the recipient of grant support from the National Institutes of Health.

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