Baek Kim, PhD, MS

Research Program

Cell and Molecular Biology
Phone Number

404-727-1454
Email Address

baek.kim@emory.edu

Biography

Baek Kim, PhD, MS, is a professor in the Department of Pediatrics at Emory University School of Medicine. Dr. Kim serves as director of the Children's Center for Drug Discovery.

Dr. Kim is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute. He is also a member of the Microbiology and Molecular Genetics Graduate Program and Molecular and Systems Pharmacology Graduate Program in the Graduate Division of Biological and Biomedical Sciences at Laney Graduate School of Emory University.

Education

Dr. Kim earned his PhD in biochemistry from University of Arizona in Tucson, Arizona. He obtained a Master of Science in biochemistry from Yon-Sei University in Seoul, South Korea. He completed his postdoctoral training at University of Washington in Seattle, Washington.

Titles & Roles

Professor, Department of Pediatrics

Emory University School of Medicine
Director, Center for Drug Discovery

Children's Healthcare of Atlanta and Emory University

Research

Dr. Kim's current research focuses are: 1) HIV-1 replication, mutagenesis, and evolution, 2) establishment of longliving HIV-1 myeloid reservoirs, 3) role of SAMHD1 in HIV biology. He is trained in the research field of DNA-protein interactions, particularly with transcriptional repressors and DNA polymerases involved in DNA repair and DNA replication.

Grants

View Grants

Grant Number	Title
1R01AI162633-01	SAMHD1 mediated dNTP regulation and HIV in myeloid cells
1R01CA254403-01	Elucidating SAMHD1 in DNA Double-Strand Break Repair
2R01AI136581-06A1	Lentivirus Replication Strategy and Pathogenesis
2R01AI141327-06A1	Structural and Chemical Analysis of Highly Potent ALLINI Platform
3R01CA254403-04S1	Elucidating SAMHD1 in DNA Double-Strand Break Repair (Supplement)
3R01CA254403-04S2	Elucidating SAMHD1 in DNA Double-Strand Break Repair (Supplement)
3R01CA254403-05S1	Elucidating SAMHD1 in DNA Double-Strand Break Repair
3R01CA254403-05S2	Elucidating SAMHD1 in DNA Double-Strand Break Repair
5R01AI136581-07	Lentivirus Replication Strategy and Pathogenesis
5R01AI162633-02	SAMHD1 mediated dNTP regulation and HIV in myeloid cells
5R01AI162633-03	SAMHD1 mediated dNTP regulation and HIV in myeloid cells
5R01AI162633-04	SAMHD1 mediated dNTP regulation and HIV in myeloid cells
5R01CA254403-02	Elucidating SAMHD1 in DNA Double-Strand Break Repair
5R01CA254403-03	Elucidating SAMHD1 in DNA Double-Strand Break Repair
5R01CA254403-04	Elucidating SAMHD1 in DNA Double-Strand Break Repair
5R01CA254403-05	Elucidating SAMHD1 in DNA Double-Strand Break Repair

Publications

View Recent Publications

Title/Journal	Authors	Publication Date
NOS inhibition sensitizes metaplastic breast cancer to PI3K inhibition and taxane therapy via c-JUN repression. Nature communications	T Reddy, A Puri, L Guzman-Rojas, C Thomas, W Qian, J Zhou, H Zhao, B Mahboubi, A Oo, YJ Cho, B Kim, J Thaiparambil, R Rosato, KO Martinez, MF Chervo, C Ayerbe, N Giese, D Wink, S Lockett, S Wong, J Chang, S Krishnamurthy, C Yam, S Moulder, H Piwnica-Worms, F Meric-Bernstam, J Chang	12/30/2024
Biochemical simulation of mutation synthesis and repair during SARS-CoV-2 RNA polymerization. Virology	A Oo, Z Chen, D Cao, YJ Cho, B Liang, RF Schinazi, B Kim	12/01/2024
The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir. mBio	T Dinh, Z Tber, JS Rey, S Mengshetti, AS Annamalai, R Haney, L Briganti, F Amblard, JR Fuchs, P Cherepanov, K Kim, RF Schinazi, JR Perilla, B Kim, M Kvaratskhelia	11/13/2024
Acetylation of SAMHD1 at lysine 580 is crucial for blocking HIV-1 infection. mBio	A Bulnes-Ramos, K Schott, J Rabinowitz, C Luchsinger, C Bertelli, E Miyagi, CH Yu, M Persaud, C Shepard, R König, B Kim, DN Ivanov, K Strebel, F Diaz-Griffero	09/11/2024
NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome. Blood	A Sobh, E Encinas, A Patel, G Surapaneni, E Bonilla, C Kaestner, J Poullard, M Clerio, K Vasan, T Freeman, D Lv, D Dupéré-Richer, A Riva, BG Barwick, D Zhou, LH Boise, CS Mitsiades, B Kim, RL Bennett, NS Chandel, JD Licht	07/18/2024
E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network. Cancer research communications	M Poliaková Turan, R Riedo, M Medo, C Pozzato, M Friese-Hamim, JP Koch, SA Coggins, Q Li, B Kim, J Albers, DM Aebersold, N Zamboni, Y Zimmer, M Medová	07/01/2024
The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity. Nature communications	CB Prasad, A Oo, Y Liu, Z Qiu, Y Zhong, N Li, D Singh, X Xin, YJ Cho, Z Li, X Zhang, C Yan, Q Zheng, QE Wang, D Guo, B Kim, J Zhang	05/31/2024
SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma. Blood	MH Abdelrazak Morsy, I Lilienthal, M Lord, M Merrien, AM Wasik, M Sureda-Gómez, V Amador, HJ Johansson, J Lehtiö, B Garcia-Torre, JI Martin-Subero, N Tsesmetzis, S Tao, RF Schinazi, B Kim, AL Sorteberg, M Wickström, D Sheppard, GZ Rassidakis, IA Taylor, B Christensson, E Campo, N Herold, B Sander	05/09/2024
SAMHD1 expression contributes to doxorubicin resistance and predicts survival outcomes in diffuse large B-cell lymphoma patients. NAR cancer	W Daddacha, D Monroe, AJ Schlafstein, AE Withers, EB Thompson, D Danelia, NC Luong, F Sesay, SK Rath, ER Usoro, ME Essien, AT Jung, JG Jiang, J Hu, B Mahboubi, A Williams, JE Steinbeck, X Yang, ZS Buchwald, WS Dynan, JM Switchenko, B Kim, MK Khan, DL Jaye, DS Yu	03/01/2024
Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome. Nucleic acids research	P Xu, T Yang, DL Kundnani, M Sun, S Marsili, AL Gombolay, Y Jeon, G Newnam, S Balachander, V Bazzani, U Baccarani, VS Park, S Tao, A Lori, RF Schinazi, B Kim, ZF Pursell, G Tell, C Vascotto, F Storici	02/09/2024
The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir. bioRxiv : the preprint server for biology	T Dinh, Z Tber, JS Rey, S Mengshetti, AS Annamalai, R Haney, L Briganti, F Amblard, JR Fuchs, P Cherepanov, K Kim, RF Schinazi, JR Perilla, B Kim, M Kvaratskhelia	01/26/2024
SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma. Blood	MHA Morsy, I Lilienthal, M Lord, M Merrien, AM Wasik, M Sureda-Gómez, V Amador, HJ Johansson, J Lehtiö, B Garcia-Torre, JI Martin-Subero, N Tsesmetzis, S Tao, RF Schinazi, B Kim, AL Sorteberg, M Wickström, D Sheppard, GZ Rassidakis, IA Taylor, B Christensson, E Campo, N Herold, B Sander	01/18/2024
Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells. Molecular therapy : the journal of the American Society of Gene Therapy	E Valeri, G Unali, F Piras, M Abou-Alezz, G Pais, F Benedicenti, MR Lidonnici, I Cuccovillo, I Castiglioni, S Arévalo, G Spinozzi, I Merelli, R Behrendt, A Oo, B Kim, NR Landau, G Ferrari, E Montini, A Kajaste-Rudnitski	01/03/2024
Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels. mBio	M Schüssler, K Schott, NV Fuchs, A Oo, M Zahadi, P Rauch, B Kim, R König	10/31/2023
Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi-Goutières syndrome SAMHD1 dNTPase ortholog. The Journal of biological chemistry	T Maehigashi, C Lim, LR Wade, NE Bowen, KM Knecht, NN Alvarez, WG Kelly, RF Schinazi, DH Kim, Y Xiong, B Kim	09/01/2023
Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels. bioRxiv : the preprint server for biology	M Schüssler, K Schott, NV Fuchs, A Oo, M Zahadi, P Rauch, B Kim, R König	08/25/2023
Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti-lentivirus activity of SAMHD1 in macrophages. The Journal of biological chemistry	NE Bowen, S Tao, YJ Cho, RF Schinazi, B Kim	08/01/2023
ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion. Nature communications	D Menolfi, BJ Lee, H Zhang, W Jiang, NE Bowen, Y Wang, J Zhao, A Holmes, S Gershik, R Rabadan, B Kim, S Zha	06/19/2023
The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity. Research square	CB Prasad, A Oo, Z Qiu, N Li, D Singh, X Xin, YJ Cho, Z Li, X Zhang, C Yan, Q Zheng, J Shao, QE Wang, B Kim, J Zhang	05/02/2023
The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function. mBio	MR Singer, T Dinh, L Levintov, AS Annamalai, JS Rey, L Briganti, NJ Cook, VE Pye, IA Taylor, K Kim, AN Engelman, B Kim, JR Perilla, M Kvaratskhelia, P Cherepanov	02/28/2023
Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial. Journal of internal medicine	M Jädersten, I Lilienthal, N Tsesmetzis, M Lourda, S Bengtzén, A Bohlin, C Arnroth, T Erkers, B Seashore-Ludlow, G Giraud, GS Barkhordar, S Tao, L Fogelstrand, L Saft, P Östling, RF Schinazi, B Kim, T Schaller, G Juliusson, S Deneberg, S Lehmann, GZ Rassidakis, M Höglund, JI Henter, N Herold	12/01/2022
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks. Nature communications	P Kapoor-Vazirani, SK Rath, X Liu, Z Shu, NE Bowen, Y Chen, R Haji-Seyed-Javadi, W Daddacha, EV Minten, D Danelia, D Farchi, DM Duong, NT Seyfried, X Deng, EA Ortlund, B Kim, DS Yu	11/07/2022
Mechanistic Interplay between HIV-1 Reverse Transcriptase Enzyme Kinetics and Host SAMHD1 Protein: Viral Myeloid-Cell Tropism and Genomic Mutagenesis. Viruses	NE Bowen, A Oo, B Kim	07/26/2022
MESH1 knockdown triggers proliferation arrest through TAZ repression. Cell death & disease	T Sun, CC Ding, Y Zhang, Y Zhang, CC Lin, J Wu, Y Setayeshpour, S Coggins, C Shepard, E Macias, B Kim, P Zhou, R Gordân, JT Chi	03/10/2022
Elimination of Aicardi-Goutières syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replication. The Journal of biological chemistry	A Oo, K Zandi, C Shepard, LC Bassit, K Musall, SL Goh, YJ Cho, DH Kim, RF Schinazi, B Kim	03/01/2022
Nucleotide Analogues Bearing a C2' or C3'-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors. Molecules (Basel, Switzerland)	A Manchoju, R Zelli, G Wang, C Eymard, A Oo, M Nemer, M Prévost, B Kim, Y Guindon	01/17/2022
SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide. Journal of immunology (Baltimore, Md. : 1950)	B Barrett, DH Nguyen, J Xu, K Guo, S Shetty, ST Jones, KL Mickens, C Shepard, A Roers, R Behrendt, L Wu, B Kim, ML Santiago	01/15/2022
Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins. The Journal of biological chemistry	NE Bowen, J Temple, C Shepard, A Oo, F Arizaga, P Kapoor-Vazirani, M Persaud, CH Yu, DH Kim, RF Schinazi, DN Ivanov, F Diaz-Griffero, DS Yu, Y Xiong, B Kim	10/01/2021
Distinct Antiretroviral Mechanisms Elicited by a Viral Mutagen. Journal of molecular biology	M Roth, YZ McDaniel, MB Daly, N Talledge, WM Greggs, SE Patterson, B Kim, LM Mansky	09/03/2021
Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment. Cancers	C Bothou, A Sharma, A Oo, B Kim, P Perge, P Igaz, CL Ronchi, I Shapiro, C Hantel	08/20/2021
SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells. Nature communications	C Martinat, A Cormier, J Tobaly-Tapiero, N Palmic, N Casartelli, B Mahboubi, SA Coggins, J Buchrieser, M Persaud, F Diaz-Griffero, L Espert, G Bossis, P Lesage, O Schwartz, B Kim, F Margottin-Goguet, A Saïb, A Zamborlini	07/28/2021
A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site. PLoS pathogens	T Maehigashi, S Ahn, UI Kim, J Lindenberger, A Oo, PC Koneru, B Mahboubi, AN Engelman, M Kvaratskhelia, K Kim, B Kim	07/01/2021
Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase. Microorganisms	K Zandi, K Musall, A Oo, D Cao, B Liang, P Hassandarvish, S Lan, RL Slack, KA Kirby, L Bassit, F Amblard, B Kim, S AbuBakar, SG Sarafianos, RF Schinazi	04/22/2021
In silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer. Scientific reports	ZP Lin, NN Al Zouabi, ML Xu, NE Bowen, TL Wu, ES Lavi, PH Huang, YL Zhu, B Kim, ES Ratner	04/13/2021
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification. Nature communications	CH Yu, A Bhattacharya, M Persaud, AB Taylor, Z Wang, A Bulnes-Ramos, J Xu, A Selyutina, A Martinez-Lopez, K Cano, B Demeler, B Kim, SC Hardies, F Diaz-Griffero, DN Ivanov	02/02/2021
Disproportionate presence of adenosine in mitochondrial and chloroplast DNA of Chlamydomonas reinhardtii. iScience	WMM El-Sayed, AL Gombolay, P Xu, T Yang, Y Jeon, S Balachander, G Newnam, S Tao, NE Bowen, T Brůna, M Borodovsky, RF Schinazi, B Kim, Y Chen, F Storici	01/22/2021
Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside. Current research in pharmacology and drug discovery	S Tao, K Zandi, L Bassit, YT Ong, K Verma, P Liu, JA Downs-Bowen, T McBrayer, JC LeCher, JJ Kohler, PR Tedbury, B Kim, F Amblard, SG Sarafianos, RF Schinazi	01/01/2021
Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma. Frontiers in oncology	D Ravi, A Beheshti, N Abermil, F Lansigan, W Kinlaw, NR Matthan, M Mokhtar, FC Passero, P Puliti, KA David, GG Dolnikowski, X Su, Y Chen, M Bijan, RR Varshney, B Kim, SS Dave, MC Rudolph, AM Evens	01/01/2021
Repurposing Nucleoside Analogs for Human Coronaviruses. Antimicrobial agents and chemotherapy	K Zandi, F Amblard, K Musall, J Downs-Bowen, R Kleinbard, A Oo, D Cao, B Liang, OO Russell, T McBrayer, L Bassit, B Kim, RF Schinazi	12/16/2020
Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking viral protein X. The Journal of biological chemistry	SA Coggins, DH Kim, RF Schinazi, RC Desrosier, B Kim	12/11/2020
A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity. Viruses	A Cox, J Schmierer, J D'Angelo, A Smith, D Levenson, J Treanor, B Kim, S Dewhurst	10/31/2020
Mechanistic cross-talk between DNA/RNA polymerase enzyme kinetics and nucleotide substrate availability in cells: Implications for polymerase inhibitor discovery. The Journal of biological chemistry	SA Coggins, B Mahboubi, RF Schinazi, B Kim	09/25/2020
Tetraspanin CD81 regulates HSV-1 infection. Medical microbiology and immunology	B Benayas, I Sastre, S López-Martín, A Oo, B Kim, MJ Bullido, J Aldudo, M Yáñez-Mó	08/01/2020