Jean Koff, MD, MS

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Rating: 4.7 out of 5 (100 ratings)

Role

Hematology Oncology
Specialty

Lymphoma
Research Program

Discovery and Developmental Therapeutics
Practicing Since

2016

Call 404-778-0519

Background

A hematologist, Dr. Koff specializes in the treatment of lymphoid malignancies and joined the clinical staff at Winship Cancer Institute as a practicing physician in 2016. Dr. Koff is a clinical investigator in the Bone Marrow and Stem Cell Transplant Center with a disease focus in lymphoma.

Dr. Koff received her MD and graduated magna cum laude from Emory University School of Medicine in Atlanta, Georgia. Her postgraduate medical education included a J. Willis Hurst Residency in Internal Medicine at Emory University and a Fellowship in Hematology and Medical Oncology at Winship Cancer Institute, where she was Chief Fellow in her final year.

Dr. Koff's academic focus is in epidemiology, outcomes, and translational research in lymphoma, with a particular interest in the intersection between autoimmune disorders and lymphoid malignancies.

Dr. Koff's work has been published in many leading journals, including Cancer, Cell, and Leukemia & Lymphoma, as well as presented at multiple international conferences.

Titles & Roles

Associate Professor, Department of Hematology and Medical Oncology

Emory University School of Medicine

Education & Training

Education

Fellowship, Hematology & Oncology, 2016
Emory University School of Medicine
Residency, Internal Medicine, 2012
Emory University School of Medicine
Medical Education, MD, 2010
Emory University School of Medicine

Board Certifications

Medical Oncology
American Board of Internal Medicine, 2016
Hematology
American Board of Internal Medicine, 2016
Internal Medicine
American Board of Internal Medicine, 2013

Professional Memberships

American Medical Association
American Society of Clinical Oncology
American Society of Hematology
American Association for Cancer Research

Research

View Current Clinical Trials


Open-label of Loncastuximab Tesirine (ADCT-402) in Relapsed/Refractory Marginal Zone Lymphoma Phase II Conditions Marginal Zone Lymphoma Location Winship Cancer Institute

Publications

Title/Journal	Authors	Publication Date
Plasma Cytokine and Chemokine Profiles Predict Efficacy and Toxicity of Anti-CD19 CAR-T Cell Therapy in Large B-Cell Lymphoma. Clinical lymphoma, myeloma & leukemia	F Zeng, H Zhang, S Wang, T Passang, Y Li, CR Funk, S Wyman, CB O'Leary, AI Abousaud, Y Liu, M Rupji, KM Dhodapkar, EK Waller, JL Koff	07/01/2025
Outcomes of Relapsed or Refractory Diffuse Large B-Cell Lymphoma Treated With R-GemOx: A Multicenter Cohort Study. American journal of hematology	S Yamshon, JL Koff, MC Larson, BS Kahl, C Casulo, IS Lossos, S Haddadi, M Stanchina, D Chihara, A Ayers, TM Habermann, Y Wang, A Khurana, GS Nowakowski, TW Reicks, U Farooq, BK Link, JB Cohen, P Martin, J Li, A Shewade, CL Batlevi, A Lo-Rossi, D Fox, A Masaquel, Y Mun, JR Cerhan, CR Flowers, MJ Maurer, LJ Nastoupil	04/01/2025
Real-World Effectiveness of Chemoimmunotherapy and Novel Therapies for Patients With Relapsed/Refractory Aggressive Large B-Cell Lymphoma. Clinical lymphoma, myeloma & leukemia	LJ Nastoupil, CR Andersen, A Ayers, Y Wang, TM Habermann, D Chihara, BS Kahl, BK Link, JL Koff, JB Cohen, P Martin, IS Lossos, M Stanchina, S Haddadi, C Casulo, S Ayyappan, R Lin, Z Li, MA Larson, MJ Maurer, L Huynh, C Gao, R Ramasubramanian, MS Duh, A Mutebi, T Wang, M Jun, A Wang, R Kamalakar, A Kalsekar, JR Cerhan, CR Flowers	04/01/2025
Treatment patterns and outcomes in follicular lymphoma with POD24: an analysis from the LEO Consortium. Blood advances	JR Day, MC Larson, U Durani, JL Koff, Y Wang, TM Habermann, IS Lossos, LJ Nastoupil, C Strouse, D Chihara, P Martin, JP Leonard, JB Cohen, BS Kahl, J Ruan, WR Burack, JW Friedberg, JR Cerhan, CR Flowers, BK Link, MJ Maurer, C Casulo	03/11/2025
Addressing Health Disparities in Hematologic Malignancies: from Genes to Outreach. Blood cancer discovery	CR Flowers, RW Anantha, V Leautaud, P Desai, CE Donald, MAT Hildebrandt, JL Koff, RM Tamimi, W Cozen, C Nze, AM Melnick	03/04/2025
T Cells Spatially Regulate B Cell Receptor Signaling in Lymphomas through H3K9me3 Modifications. Advanced healthcare materials	LS Britto, D Balasubramani, S Desai, P Phillips, N Trehan, E Cesarman, JL Koff, A Singh	02/01/2025
Human immune organoids to decode B cell response in healthy donors and patients with lymphoma. Nature materials	Z Zhong, M Quiñones-Pérez, Z Dai, VM Juarez, E Bhatia, CR Carlson, SB Shah, A Patel, Z Fang, T Hu, M Allam, SL Hicks, M Gupta, SL Gupta, E Weeks, SD Vagelos, A Molina, A Mulero-Russe, A Mora-Boza, DJ Joshi, RP Sekaly, T Sulchek, SL Goudy, J Wrammert, K Roy, JM Boss, AF Coskun, CD Scharer, AJ García, JL Koff, A Singh	02/01/2025
Transformation in marginal zone lymphoma: results from a prospective cohort and a meta-analysis of the literature. Blood advances	C Bommier, BK Link, BJ Gysbers, MJ Maurer, MC Larson, A Khurana, Y Wang, CA Thompson, D Chihara, JP Alderuccio, JL Koff, N Epperla, A Conconi, IS Lossos, GS Nowakowski, AL Feldman, TM Habermann, RL King, JR Cerhan	12/10/2024
Matching-adjusted indirect comparison from the Lymphoma Epidemiology of Outcomes Consortium for Real World Evidence (LEO CReWE) study to a clinical trial of mosunetuzumab in relapsed or refractory follicular lymphoma. Haematologica	MJ Maurer, C Casulo, MC Larson, TM Habermann, IS Lossos, Y Wang, LJ Nastoupil, C Strouse, D Chihara, P Martin, JB Cohen, BS Kahl, WR Burack, JL Koff, Y Mun, A Masaquel, M Wu, MC Wei, A Shewade, J Li, JR Cerhan, BK Link, CR Flowers	07/01/2024
Engineering Improved CAR T Cell Products with A Multi-Cytokine Particle Platform for Hematologic and Solid Tumors. Advanced healthcare materials	HK Lin, B Uricoli, R Freeman, AN Hossian, Z He, JYL Anderson, M Neffling, JM Legier, DA Blake, DB Doxie, R Nair, JL Koff, KM Dhodapkar, M Shanmugam, EC Dreaden, S Rafiq	06/01/2024
The Lymphoma Epidemiology of Outcomes cohort study: Design, baseline characteristics, and early outcomes. American journal of hematology	JR Cerhan, MJ Maurer, BK Link, AL Feldman, TM Habermann, DL Jaye, WR Burack, TJ McDonnell, F Vega, JR Chapman, S Syrbu, KR Vij, G Inghirami, JP Leonard, L Bernal-Mizrachi, U Farooq, TE Witzig, GJ Weiner, Y Wang, JP Alderuccio, SL Slager, MC Larson, SM Riska, BJ Gysbers, JJ Lunde, TW Reicks, AA Ayers, CB O'Leary, KJ Yost, H Liu, GS Nowakowski, J Ruan, D Chihara, JL Koff, C Casulo, CA Thompson, JB Cohen, BS Kahl, LJ Nastoupil, IS Lossos, JW Friedberg, P Martin, CR Flowers	03/01/2024
Important Considerations in the Diagnosis and Management of Post-transplant Lymphoproliferative Disorder. Current oncology reports	M Lee, A Abousaud, RA Harkins, E Marin, D Balasubramani, MC Churnetski, D Peker, A Singh, JL Koff	08/01/2023
Low neutralizing activity of AZD7442 against current SARS-CoV-2 Omicron variants in patients with B-cell malignancies. Blood advances	A Chang, JL Koff, L Lai, VM Orellana-Noia, M Surati, AMK Leal, ML Ellis, B Wali, A Moreno, SL Linderman, CB O'Leary, PB Allen, MC Churnetski, MV Dhodapkar, MS Suthar, JB Cohen, R Ahmed	06/13/2023
Predictive value of staging PET/CT to detect bone marrow involvement and early outcomes in marginal zone lymphoma. Blood	JP Alderuccio, IM Reis, JL Koff, MC Larson, D Chihara, W Zhao, S Haddadi, TM Habermann, P Martin, JR Chapman, C Strouse, BS Kahl, JB Cohen, JW Friedberg, JR Cerhan, CR Flowers, IS Lossos	04/13/2023
Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas. Nature materials	SB Shah, CR Carlson, K Lai, Z Zhong, G Marsico, KM Lee, NE Félix Vélez, EB Abeles, M Allam, T Hu, LD Walter, KE Martin, K Gandhi, SD Butler, R Puri, AL McCleary-Wheeler, W Tam, O Elemento, K Takata, C Steidl, DW Scott, L Fontan, H Ueno, BD Cosgrove, G Inghirami, AJ García, AF Coskun, JL Koff, A Melnick, A Singh	04/01/2023
Isoform-specific knockdown of long and intermediate prolactin receptors interferes with evolution of B-cell neoplasms. Communications biology	A Taghi Khani, A Kumar, A Sanchez Ortiz, KC Radecki, S Aramburo, SJ Lee, Z Hu, B Damirchi, MY Lorenson, X Wu, Z Gu, W Stohl, I Sanz, E Meffre, M Müschen, SJ Forman, JL Koff, AM Walker, S Swaminathan	03/20/2023
Post-transplant lymphoproliferative disorder risk and outcomes in renal transplant patients treated with belatacept immunosuppression. Frontiers in transplantation	JL Koff, GM Karadkhele, JM Switchenko, M Rupji, K Little, CP Larsen	01/01/2023
Antibody binding and neutralization of live SARS-CoV-2 variants including BA.4/5 following booster vaccination of patients with B-cell malignancies. Cancer research communications	A Chang, A Akhtar, L Lai, VM Orellana-Noia, SL Linderman, AA McCook-Veal, JM Switchenko, M Saini, RM Valanparambil, KA Blum, PB Allen, MJ Lechowicz, JT Romancik, A Ayers, A Leal, CB O'Leary, MC Churnetski, K Baird, M Kives, J Wrammert, AK Nooka, JL Koff, MV Dhodapkar, MS Suthar, JB Cohen, R Ahmed	12/01/2022
CLL-515 Antibody Responses Against SARS-CoV-2 Variants after Booster Vaccination in Patients With B Cell Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia. Clinical lymphoma, myeloma & leukemia	A Chang, L Lai, A Akhtar, S Linderman, V Orellana-Noia, M Saini, R Valanparambil, K Blum, P Allen, M Lechowicz, J Romancik, A Ayers, C O'Leary, M Churnetski, M Kives, A Nooka, J Koff, M Dhodapkar, M Suthar, J Cohen, R Ahmed	09/27/2022
Herpes simplex virus lymphadenitis is associated with tumor reduction in a patient with chronic lymphocytic leukemia. The Journal of clinical investigation	A Chang, AM Sholukh, A Wieland, DL Jaye, M Carrington, ML Huang, H Xie, KR Jerome, P Roychoudhury, AL Greninger, JL Koff, JB Cohen, DM Koelle, L Corey, CR Flowers, R Ahmed	09/15/2022
Humoral Responses Against SARS-CoV-2 and Variants of Concern After mRNA Vaccines in Patients With Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology	A Chang, A Akhtar, SL Linderman, L Lai, VM Orellana-Noia, R Valanparambil, H Ahmed, VI Zarnitsyna, AA McCook-Veal, JM Switchenko, JL Koff, KA Blum, AA Ayers, CB O'Leary, MC Churnetski, S Sulaiman, M Kives, P Sheng, CW Davis, AK Nooka, R Antia, MV Dhodapkar, MS Suthar, JB Cohen, R Ahmed	09/10/2022
Improving eligibility criteria for first-line trials for patients with DLBCL using a US-based Delphi-method survey. Blood advances	RA Harkins, SP Patel, MJ Lee, JM Switchenko, SM Ansell, NL Bartlett, KA Blum, AF Cashen, C Casulo, JW Friedberg, PB Johnston, BS Kahl, JP Leonard, BK Link, IS Lossos, P Martin, MJ Maurer, N Mehta-Shah, PM Reagan, JR Westin, JL Koff, CR Flowers	05/10/2022
Treatment patterns and outcomes of patients with relapsed or refractory follicular lymphoma receiving three or more lines of systemic therapy (LEO CReWE): a multicentre cohort study. The Lancet. Haematology	C Casulo, MC Larson, JJ Lunde, TM Habermann, IS Lossos, Y Wang, LJ Nastoupil, C Strouse, D Chihara, P Martin, JB Cohen, BS Kahl, WR Burack, JL Koff, Y Mun, A Masaquel, M Wu, MC Wei, A Shewade, J Li, J Cerhan, CR Flowers, BK Link, MJ Maurer	04/01/2022
PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity. Blood	CR Funk, S Wang, KZ Chen, A Waller, A Sharma, CL Edgar, VA Gupta, S Chandrakasan, JT Zoine, A Fedanov, SS Raikar, JL Koff, CR Flowers, S Coma, JA Pachter, S Ravindranathan, HT Spencer, M Shanmugam, EK Waller	01/27/2022
Gene expression profiling-based risk prediction and profiles of immune infiltration in diffuse large B-cell lymphoma. Blood cancer journal	S Merdan, K Subramanian, T Ayer, J Van Weyenbergh, A Chang, JL Koff, C Flowers	01/07/2021
Linking Environmental Exposures to Molecular Pathogenesis in Non-Hodgkin Lymphoma Subtypes. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology	L Moubadder, LE McCullough, CR Flowers, JL Koff	10/01/2020
Genome-defined African ancestry is associated with distinct mutations and worse survival in patients with diffuse large B-cell lymphoma. Cancer	MJ Lee, JL Koff, JM Switchenko, CI Jhaney, RA Harkins, SP Patel, SS Dave, CR Flowers	08/01/2020
Using Informatics Tools to Identify Opportunities for Precision Medicine in Diffuse Large B-cell Lymphoma. Clinical lymphoma, myeloma & leukemia	SP Patel, RA Harkins, MJ Lee, CR Flowers, JL Koff	04/01/2020
Insurance status impacts overall survival in Burkitt lymphoma. Leukemia & lymphoma	JS Goldstein, JM Switchenko, M Behera, CR Flowers, JL Koff	12/01/2019
Characterizing Lymphoma Incidence and Disparities for a Cancer Center Catchment Region. Clinical lymphoma, myeloma & leukemia	AA Ayers, L Lyu, K Dance, KC Ward, CR Flowers, JL Koff, LE McCullough	11/01/2019
Remaining challenges in predicting patient outcomes for diffuse large B-cell lymphoma. Expert review of hematology	RA Harkins, A Chang, SP Patel, MJ Lee, JS Goldstein, S Merdan, CR Flowers, JL Koff	11/01/2019
Racial and Socioeconomic Disparities in Mantle Cell Lymphoma. Clinical lymphoma, myeloma & leukemia	NN Shah, Y Xi, Y Liu, JL Koff, CR Flowers, M Behera, JB Cohen	06/01/2019
Influenza Vaccination Documentation Rates During the First Year After Diagnosis of Diffuse Large B Cell Lymphoma. Clinical lymphoma, myeloma & leukemia	A Chang, JB Payne, PB Allen, JL Koff, R Ahmed, CR Flowers, RA Bednarczyk	04/01/2019
Improving cancer-specific outcomes in solid organ transplant recipients: Where to begin? Cancer	JL Koff, EK Waller	03/15/2019
History of autoimmune conditions and lymphoma prognosis. Blood cancer journal	G Kleinstern, MJ Maurer, M Liebow, TM Habermann, JL Koff, C Allmer, TE Witzig, GS Nowakowski, IN Micallef, PB Johnston, DJ Inwards, CA Thompson, AL Feldman, BK Link, C Flowers, SL Slager, JR Cerhan	08/01/2018
Exploring the potential cost-effectiveness of precision medicine treatment strategies for diffuse large B-cell lymphoma. Leukemia & lymphoma	Q Chen, AD Staton, T Ayer, DA Goldstein, JL Koff, CR Flowers	07/01/2018
Impact of the posttransplant lymphoproliferative disorder subtype on survival. Cancer	JL Koff, JX Li, X Zhang, JM Switchenko, CR Flowers, EK Waller	06/01/2018
Targeting the B cell receptor pathway in non-Hodgkin lymphoma. Expert opinion on investigational drugs	K Valla, CR Flowers, JL Koff	06/01/2018
Peritransplantation Red Blood Cell Transfusion Is Associated with Increased Risk of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation	S Hosoba, EK Waller, N Shenvi, M Graiser, KA Easley, Z Al-Kadhimi, A Andoh, AG Antun, S Barclay, CD Josephson, JL Koff, HJ Khoury, AA Langston, JC Zimring, JD Roback, CR Giver	05/01/2018
Effective management strategies for patients with marginal zone lymphoma. Future oncology (London, England)	CB Rosand, K Valla, CR Flowers, JL Koff	05/01/2018
Surveillance imaging in mantle cell lymphoma in first remission lacks clinical utility. Leukemia & lymphoma	DM Guidot, JM Switchenko, LJ Nastoupil, JL Koff, KA Blum, J Maly, CR Flowers, JB Cohen	04/01/2018
Characterizing Autoimmune Disease-associated Diffuse Large B-cell Lymphoma in a SEER-Medicare Cohort. Clinical lymphoma, myeloma & leukemia	JL Koff, A Rai, CR Flowers	02/01/2018
Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell	A Reddy, J Zhang, NS Davis, AB Moffitt, CL Love, A Waldrop, S Leppa, A Pasanen, L Meriranta, ML Karjalainen-Lindsberg, P Nørgaard, M Pedersen, AO Gang, E Høgdall, TB Heavican, W Lone, J Iqbal, Q Qin, G Li, SY Kim, J Healy, KL Richards, Y Fedoriw, L Bernal-Mizrachi, JL Koff, AD Staton, CR Flowers, O Paltiel, N Goldschmidt, M Calaminici, A Clear, J Gribben, E Nguyen, MB Czader, SL Ondrejka, A Collie, ED Hsi, E Tse, RKH Au-Yeung, YL Kwong, G Srivastava, WWL Choi, AM Evens, M Pilichowska, M Sengar, N Reddy, S Li, A Chadburn, LI Gordon, ES Jaffe, S Levy, R Rempel, T Tzeng, LE Happ, T Dave, D Rajagopalan, J Datta, DB Dunson, SS Dave	10/05/2017
Prognostic modeling in diffuse large B-cell lymphoma in the era of immunochemotherapy: Where do we go from here? Cancer	JL Koff, CR Flowers	09/01/2017
Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype. Oncogene	X Guo, JL Koff, AB Moffitt, M Cinar, S Ramachandiran, Z Chen, JM Switchenko, M Mosunjac, SG Neill, KP Mann, M Bagirov, Y Du, Y Natkunam, HJ Khoury, MR Rossi, W Harris, CR Flowers, IS Lossos, LH Boise, SS Dave, J Kowalski, L Bernal-Mizrachi	07/20/2017
Relations Between Residential Proximity to EPA-Designated Toxic Release Sites and Diffuse Large B-Cell Lymphoma Incidence. Southern medical journal	C Bulka, LJ Nastoupil, JL Koff, L Bernal-Mizrachi, KC Ward, JN Williams, AR Bayakly, JM Switchenko, LA Waller, CR Flowers	10/01/2016
New insights into the epidemiology of non-Hodgkin lymphoma and implications for therapy. Expert review of anticancer therapy	D Chihara, LJ Nastoupil, JN Williams, P Lee, JL Koff, CR Flowers	05/01/2015
Comparison of the effectiveness of frontline chemoimmunotherapy regimens for follicular lymphoma used in the United States. Leukemia & lymphoma	LJ Nastoupil, R Sinha, M Byrtek, R Ziemiecki, M Taylor, JW Friedberg, JL Koff, BK Link, JR Cerhan, KL Dawson, CR Flowers	05/01/2015
Novel therapies in mantle cell lymphoma: a pathway to chemotherapy-free strategies. Oncology (Williston Park, N.Y.)	LJ Nastoupil, JL Koff, CR Flowers	10/01/2013

Awards

Roy O. Rodwell Trinity Scholarship, Duke University
Phi Beta Kappa membership, Duke University
William J. Griffith University Service Award, Duke University
James L. Campbell Memorial Scholarship, Emory University School of Medicine
Society of Hematologic Oncology Travel Award, MD Anderson Cancer Center in Houston, TX
Chief Fellow of Hematology and Medical Oncology, Emory University
Nell W. and William S. Elkin Cancer Research Fellowship, Emory University
American Society of Hematology Clinical Research Training Institute, La Jolla, CA
Recognition, Emory University School of Medicine Research Appreciation Day, Atlanta, GA

Ratings & Reviews

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4.8	One star One star One star One star One half star	Provider showed concern
4.7	One star One star One star One star One half star	Provider explained things clearly
4.7	One star One star One star One star One half star	Provider discussed treatment options
4.7	One star One star One star One star One half star	Provider included you in decisions
4.7	One star One star One star One star One half star	Likelihood of recommending this provider

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One star One star One star One star One star	05/08/2025	Every member of the team was kind and EXTREMELY thorough in explaining my new diagnosis, what to expect, communication options, etc
One star One star One star One star Empty star	04/18/2025	In the course of my appointments over the years, it has been the custom at Emory to take my blood sample before my appointment with my doctor. In the case of my first appointment with Dr. Koff,, the bloodwork was taken after the interview with the doctor thus, I really did not get any medical opinion from Dr Koff on the blood work that was drawn post-appointment.
One star One star One star One star One star	03/22/2025	Dr. Koff is kind, caring, thorough, and professional.
One star One star One star One star One star	03/21/2025	Dr Kof and her assistant were excellent in explaining what was going on with the medical issue.
One star One star One star One star One star	02/27/2025	Dr Kaff is excellent!
One star One star One star One star One star	01/20/2025	Very kind y responding all my questions
One star One star One star One star One star	11/15/2024	Do to use relocating around the US, I have see. 3 oncologists and Dr Koff by far, is the most thorough and caring Dr I have seen. She explained things I never heard about during my 18 year journey with CLL.
One star One star One star One star One star	09/21/2024	Dr Koff is a talented and professional doctor.
One star One star One star One star One star	08/08/2024	I truly respect Dr Koff as an expert. She answers questions effectively and efficiently. At the same time, she is patient to address any and all of my questions. 10 out of 10.