Gabe Kwong, PhD

Research Program

Cancer Immunology
Phone Number

404-385-3746
Email Address

gabriel.kwong@bme.gatech.edu

Biography

Gabe A. Kwong, PhD, is an assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech School of Engineering and Emory University School of Medicine. As director of the Laboratory for Synthetic Immunity, Dr. Kwong leads a multidisciplinary team dedicated to advancing human health by merging engineering approaches with discoveries in immunology.

Dr. Kwong is a member of the Cancer Immunology Research Program at Winship Cancer Institute. He is also a member of the Institute for Electronics and Nanotechnology, Integrated Cancer Research Center, Georgia ImmunoEngineering Consortium, and the Parker H. Petit Institute for Bioengineering and Bioscience.

Education

Dr. Kwong received his PhD in Bioengineering from California Institute of Technology in Pasadena, California. He conducted postdoctoral studies at Massachusetts Institute of Technology in Cambridge, Massachusetts.

Titles & Roles

Assistant Professor, Wallace H. Coulter Department of Biomedical Engineering

Georgia Institute of Technology and Emory University

Research

Dr. Kwong's research program is conducted at the interface of the life sciences, medicine and engineering where a central focus is understanding how to harness the sophisticated defense mechanisms of immune cells to eradicate disease and provide protective immunity.

Publications

Dr. Kwong has pioneered numerous biomedical technologies and published in leading scientific journals such as Nature Biotechnology and Nature Medicine. His work has been profiled broadly including coverage in The Economist, NPR, BBC and WGBH-2, Boston's PBS station.

Title/Journal	Authors	Publication Date
AND-gated protease-activated nanosensors for programmable detection of anti-tumour immunity. Nature nanotechnology	A Sivakumar, H Phuengkham, H Rajesh, QD Mac, LC Rogers, AD Silva Trenkle, SS Bawage, R Hincapie, Z Li, S Vainikos, I Lee, M Xue, P Qiu, MG Finn, GA Kwong	03/01/2025
Quantifying UV-induced photodamage for longitudinal live-cell imaging applications of deep-UV microscopy. Biomedical optics express	V Gorti, K McCubbins, D Houston, AD Silva Trenkle, A Holberton, CE Serafini, L Wood, G Kwong, FE Robles	01/01/2025
Ultrasound Control of Genomic Regulatory Toolboxes for Cancer Immunotherapy. Nature communications	Y Wu, Z Huang, Y Liu, P He, Y Wang, L Yan, X Wang, S Gao, X Zhou, CW Yoon, K Sun, Y Situ, P Ho, Y Zeng, Z Yuan, L Zhu, Q Zhou, Y Zhao, T Liu, GA Kwong, S Chien, L Liu, Y Wang	12/01/2024
Antigen-specific T cell immunotherapy by in vivo mRNA delivery. bioRxiv : the preprint server for biology	FY Su, JC Siebart, CS Chan, MY Wang, X Yao, AS Trenkle, A Sivakumar, M Su, R Harandi, N Shahrawat, CH Nguyen, A Goenka, J Mun, MV Dhodapkar, GA Kwong	11/03/2024
In vivo gene delivery to immune cells. Current opinion in biotechnology	JC Siebart, CS Chan, X Yao, FY Su, GA Kwong	08/01/2024
Light-field flow cytometry for high-resolution, volumetric and multiparametric 3D single-cell analysis. Nature communications	X Hua, K Han, B Mandracchia, A Radmand, W Liu, H Kim, Z Yuan, SM Ehrlich, K Li, C Zheng, J Son, AD Silva Trenkle, GA Kwong, C Zhu, JE Dahlman, S Jia	03/04/2024
Rescue of NLRC5 expression restores antigen processing machinery in head and neck cancer cells lacking functional STAT1 and p53. Cancer immunology, immunotherapy : CII	BLC Kinney, S Gunti, V Kansal, CJ Parrish, NF Saba, Y Teng, MK Henry, FY Su, GA Kwong, NC Schmitt	01/17/2024
Portable light-sheet optofluidic microscopy for 3D fluorescence imaging flow cytometry. Lab on a chip	J Son, B Mandracchia, AD Silva Trenkle, GA Kwong, S Jia	02/14/2023
Embracing enzyme promiscuity with activity-based compressed biosensing. Cell reports methods	BA Holt, HS Lim, A Sivakumar, H Phuengkham, M Su, M Tuttle, Y Xu, H Liakakos, P Qiu, GA Kwong	01/23/2023
Urinary detection of early responses to checkpoint blockade and of resistance to it via protease-cleaved antibody-conjugated sensors. Nature biomedical engineering	QD Mac, A Sivakumar, H Phuengkham, C Xu, JR Bowen, FY Su, SZ Stentz, H Sim, AM Harris, TT Li, P Qiu, GA Kwong	03/01/2022
In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles. Science advances	FY Su, QH Zhao, SN Dahotre, L Gamboa, SS Bawage, AD Silva Trenkle, A Zamat, H Phuengkham, R Ahmed, PJ Santangelo, GA Kwong	02/25/2022
Dimensionless parameter predicts bacterial prodrug success. Molecular systems biology	BA Holt, M Tuttle, Y Xu, M Su, JJ Røise, X Wang, N Murthy, GA Kwong	01/01/2022
Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control. Nature biomedical engineering	IC Miller, A Zamat, LK Sun, H Phuengkham, AM Harris, L Gamboa, J Yang, JP Murad, SJ Priceman, GA Kwong	11/01/2021
Peptide-based urinary monitoring of fibrotic nonalcoholic steatohepatitis by mass-barcoded activity-based sensors. Science translational medicine	SC Cazanave, AD Warren, M Pacula, F Touti, A Zagorska, N Gural, EK Huang, S Sherman, M Cheema, S Ibarra, J Bates, AN Billin, JT Liles, GR Budas, DG Breckenridge, D Tiniakos, V Ratziu, AK Daly, O Govaere, QM Anstee, L Gelrud, J Luther, RT Chung, KE Corey, W Winckler, S Bhatia, GA Kwong	10/20/2021
Synthetic biomarkers: a twenty-first century path to early cancer detection. Nature reviews. Cancer	GA Kwong, S Ghosh, L Gamboa, C Patriotis, S Srivastava, SN Bhatia	10/01/2021
Interfacing Biomaterials with Synthetic T Cell Immunity. Advanced healthcare materials	FY Su, QD Mac, A Sivakumar, GA Kwong	08/01/2021
Synthetic Antigen-Presenting Cells for Adoptive T Cell Therapy. Advanced therapeutics	SN Dahotre, AM Romanov, FY Su, GA Kwong	08/01/2021
DNA Gold Nanoparticle Motors Demonstrate Processive Motion with Bursts of Speed Up to 50 nm Per Second. ACS nano	A Bazrafshan, ME Kyriazi, BA Holt, W Deng, S Piranej, H Su, Y Hu, AH El-Sagheer, T Brown, GA Kwong, AG Kanaras, K Salaita	05/25/2021
Protease circuits for processing biological information. Nature communications	BA Holt, GA Kwong	10/06/2020
STAR particles for enhanced topical drug and vaccine delivery. Nature medicine	AR Tadros, A Romanyuk, IC Miller, A Santiago, RK Noel, L O'Farrell, GA Kwong, MR Prausnitz	03/01/2020
Heat-Triggered Remote Control of CRISPR-dCas9 for Tunable Transcriptional Modulation. ACS chemical biology	L Gamboa, EV Phung, H Li, JP Meyers, AC Hart, IC Miller, GA Kwong	02/21/2020
Macrophage Sensors for Early Cancer Detection. Clinical chemistry	GA Kwong	02/01/2020
Synthetic immunity by remote control. Theranostics	L Gamboa, AH Zamat, GA Kwong	01/01/2020
Deconvolving multiplexed protease signatures with substrate reduction and activity clustering. PLoS computational biology	Q Zhuang, BA Holt, GA Kwong, P Qiu	09/01/2019
Non-invasive early detection of acute transplant rejection via nanosensors of granzyme B activity. Nature biomedical engineering	QD Mac, DV Mathews, JA Kahla, CM Stoffers, OM Delmas, BA Holt, AB Adams, GA Kwong	04/01/2019
DNA-Barcoded pMHC Tetramers for Detection of Single Antigen-Specific T Cells by Digital PCR. Analytical chemistry	SN Dahotre, YM Chang, AM Romanov, GA Kwong	02/19/2019
Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics. Journal of visualized experiments : JoVE	BA Holt, QD Mac, GA Kwong	07/16/2018