David Pallas, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-727-5620
Email Address

dpallas@emory.edu

Biography

David C. Pallas, PhD, is an associate professor in the Department of Biochemistry at Emory University School of Medicine in Atlanta, Georgia. Dr. Pallas is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute.

Education

Dr. Pallas received his PhD in Biochemistry from the Massachusetts Institute of Technology in Cambridge, MA. He completed his research fellowship in cellular and molecular biology and pathology at Dana-Farber Cancer Institute of Harvard Medical School in Boston, MA.

Titles & Roles

Associate Professor, Department of Biochemistry

Emory University School of Medicine

Research

The primary purpose of the research in Dr. Pallas' laboratory is to understand the molecular basis of the control of cell proliferation and of mechanisms by which this control is circumvented in neoplastic cell growth. The Pallas laboratory utilizes mammalian tumor virus models, mouse models and a variety of cellular approaches to gain new insights into signal transduction pathways involved in tumor suppression and tumorigenesis, especially signaling via the serine/threonine protein phosphatase, PP2A. This knowledge will be applied to help identify new targets for small molecule drug therapy for cancer and other diseases in which aberrant cell proliferation is involved.

Publications

Title/Journal	Authors	Publication Date
Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis. The Journal of clinical investigation	S Yun, R Hu, ME Schwaemmle, AN Scherer, Z Zhuang, AJ Koleske, DC Pallas, MA Schwartz	08/13/2019
p53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma. Molecular cancer research : MCR	Y Wei, V Maximov, SA Morrissy, MD Taylor, DC Pallas, AM Kenney	01/01/2019
Protein phosphatase 2A is crucial for sarcomere organization in Caenorhabditis elegans striated muscle. Molecular biology of the cell	H Qadota, Y Matsunaga, P Bagchi, KI Lange, KJ Carrier, WV Pols, E Swartzbaugh, KJ Wilson, M Srayko, DC Pallas, GM Benian	08/15/2018
Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis. The Journal of biological chemistry	JA Lee, Z Wang, D Sambo, KD Bunting, DC Pallas	06/22/2018
Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes. The Journal of biological chemistry	J Hwang, JA Lee, DC Pallas	09/30/2016
STRIPAK complexes: structure, biological function, and involvement in human diseases. The international journal of biochemistry & cell biology	J Hwang, DC Pallas	02/01/2014
Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent manner. Neoplasia (New York, N.Y.)	JB Jackson, DC Pallas	07/01/2012
Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3. BMC biochemistry	J Gordon, J Hwang, KJ Carrier, CA Jones, QL Kern, CS Moreno, RH Karas, DC Pallas	10/10/2011
The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit. Journal of virology	S Li, C Brignole, R Marcellus, S Thirlwell, O Binda, MJ McQuoid, D Ashby, H Chan, Z Zhang, MJ Miron, DC Pallas, PE Branton	09/01/2009
Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A. Journal of virology	Y Li, H Wei, TC Hsieh, DC Pallas	04/01/2008